ES2078277T3 - Una nueva arginina desiminasa, su metodo de fabricacion y un agente anti-cancer que contiene esta enzima como un ingrediente eficaz. - Google Patents
Una nueva arginina desiminasa, su metodo de fabricacion y un agente anti-cancer que contiene esta enzima como un ingrediente eficaz.Info
- Publication number
- ES2078277T3 ES2078277T3 ES90114846T ES90114846T ES2078277T3 ES 2078277 T3 ES2078277 T3 ES 2078277T3 ES 90114846 T ES90114846 T ES 90114846T ES 90114846 T ES90114846 T ES 90114846T ES 2078277 T3 ES2078277 T3 ES 2078277T3
- Authority
- ES
- Spain
- Prior art keywords
- enzyme
- manufacturing
- cancer agent
- desiminase
- effective ingredient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
DICHO COMPUESTO, DE APROXIMADAMENTE 45.000 DE PESO MOLELCULAR, DERIVADO DE MICROPLASMA, TIENE CAPACIDAD EN LA DESCOMPOSICION DE ARGININA. SE DESCRIBE TAMBIEN, EL METODO DE FABRICAR ESTE NUEVO ENZIMA DE MICROPLASMA. ESTE ENZIMA ES UN AGENTE ANTICANCERIGENO MUY EFECTIVO, TANTO IN VITRO COMO EN VIVO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP20090289 | 1989-08-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2078277T3 true ES2078277T3 (es) | 1995-12-16 |
Family
ID=16432163
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90114846T Expired - Lifetime ES2078277T3 (es) | 1989-08-02 | 1990-08-02 | Una nueva arginina desiminasa, su metodo de fabricacion y un agente anti-cancer que contiene esta enzima como un ingrediente eficaz. |
Country Status (12)
Country | Link |
---|---|
US (1) | US5474928A (es) |
EP (1) | EP0414007B1 (es) |
JP (1) | JP2900279B2 (es) |
AT (1) | ATE125295T1 (es) |
CA (1) | CA2022177C (es) |
DE (1) | DE69020979T2 (es) |
DK (1) | DK0414007T3 (es) |
ES (1) | ES2078277T3 (es) |
FI (1) | FI903826A0 (es) |
IE (1) | IE62120B1 (es) |
NO (1) | NO178734C (es) |
PT (1) | PT94882B (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU5192498A (en) * | 1996-12-03 | 1998-06-29 | Kyowa Hakko Kogyo Co. Ltd. | Tissue fibrosis inhibitor |
US5804183A (en) * | 1997-01-31 | 1998-09-08 | Enzon, Inc. | Arginine deminase derived from mycoplasma arthritidis and polymer conjugates containing the same |
US6183738B1 (en) * | 1997-05-12 | 2001-02-06 | Phoenix Pharamacologics, Inc. | Modified arginine deiminase |
US6635462B1 (en) | 1997-05-12 | 2003-10-21 | Phoenix Pharmacologies, Inc. | Mutated form of arginine deiminase |
US6180387B1 (en) * | 1997-08-11 | 2001-01-30 | Smithkline Beecham Corporation | Arginine deiminase |
IT1298918B1 (it) | 1998-02-20 | 2000-02-07 | Mendes Srl | Uso di batteri dotati di arginina deiminasi per indurre apoptosi e/o ridurre una reazione infiammatoria e composizioni farmaceutiche |
AU2001275810A1 (en) * | 2000-07-27 | 2002-02-13 | Angiolab, Inc. | The pharmaceutical composition comprising arginine deiminase for inhibiting angiogenesis |
EP1599217B1 (en) | 2002-11-18 | 2014-04-16 | Polaris Group | Methods for inhibiting viral replication in vivo |
FR2884717B1 (fr) | 2005-04-25 | 2009-07-03 | Erytech Pharma Soc Par Actions | Erythrocytes renfermant de l'arginine deiminase |
CN101002945B (zh) | 2006-01-20 | 2012-09-05 | 清华大学 | 一种用于肿瘤治疗的新型复合物 |
FR2919804B1 (fr) | 2007-08-08 | 2010-08-27 | Erytech Pharma | Composition et vaccin therapeutique anti-tumoral |
EP2295560A1 (en) | 2009-09-14 | 2011-03-16 | RWTH Aachen University | Directed evolution of arginine deiminase for increased activity at physiological pH |
USRE48805E1 (en) | 2013-03-06 | 2021-11-02 | Vision Global Holdings Ltd. | Method for cancer targeting treatment and detection of arginine using albumin-binding arginine deiminase fusion protein |
US9255262B2 (en) * | 2013-03-06 | 2016-02-09 | Vision Global Holdings Ltd. | Albumin-binding arginine deminase and the use thereof |
BR112015021483A2 (pt) | 2013-03-15 | 2017-10-10 | Polaris Group | arginina deiminase com reduzida reatividade cruzada para anticorpos adi-peg 20 para o tratamento do câncer |
EP3119421B1 (en) | 2014-03-18 | 2019-10-02 | TDW Group | Engineered chimeric pegylated adi and methods of use |
EP3344575B1 (en) | 2015-09-04 | 2020-04-15 | SQZ Biotechnologies Company | Intracellular delivery of biomolecules to cells comprising a cell wall |
WO2019042628A1 (en) | 2017-08-31 | 2019-03-07 | Erytech Pharma | ARGININE DEIMINASE ENCAPSULATED WITHIN ERYTHROCYTES AND THEIR USE IN THE TREATMENT OF CANCER AND ARGINASE-1 DEFICIENCY |
EP3449935A1 (en) | 2017-08-31 | 2019-03-06 | Erytech Pharma | Arginine deiminase encapsulated inside erythrocytes and their use in treating cancer and arginase-1 deficiency |
-
1990
- 1990-07-25 JP JP2197068A patent/JP2900279B2/ja not_active Expired - Fee Related
- 1990-07-27 CA CA002022177A patent/CA2022177C/en not_active Expired - Fee Related
- 1990-07-31 IE IE277190A patent/IE62120B1/en not_active IP Right Cessation
- 1990-08-01 PT PT94882A patent/PT94882B/pt not_active IP Right Cessation
- 1990-08-01 FI FI903826A patent/FI903826A0/fi not_active Application Discontinuation
- 1990-08-01 NO NO903398A patent/NO178734C/no unknown
- 1990-08-02 EP EP90114846A patent/EP0414007B1/en not_active Expired - Lifetime
- 1990-08-02 ES ES90114846T patent/ES2078277T3/es not_active Expired - Lifetime
- 1990-08-02 DK DK90114846.0T patent/DK0414007T3/da active
- 1990-08-02 DE DE69020979T patent/DE69020979T2/de not_active Expired - Lifetime
- 1990-08-02 AT AT90114846T patent/ATE125295T1/de not_active IP Right Cessation
-
1994
- 1994-02-25 US US08/201,724 patent/US5474928A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JPH03164173A (ja) | 1991-07-16 |
DE69020979D1 (de) | 1995-08-24 |
PT94882B (pt) | 1997-07-31 |
NO178734C (no) | 1996-05-22 |
EP0414007A2 (en) | 1991-02-27 |
NO903398L (no) | 1991-02-04 |
CA2022177C (en) | 2001-02-27 |
IE902771A1 (en) | 1991-02-27 |
EP0414007B1 (en) | 1995-07-19 |
US5474928A (en) | 1995-12-12 |
FI903826A0 (fi) | 1990-08-01 |
PT94882A (pt) | 1991-05-22 |
CA2022177A1 (en) | 1991-02-03 |
ATE125295T1 (de) | 1995-08-15 |
JP2900279B2 (ja) | 1999-06-02 |
DE69020979T2 (de) | 1996-01-04 |
NO903398D0 (no) | 1990-08-01 |
IE62120B1 (en) | 1994-12-14 |
NO178734B (no) | 1996-02-12 |
EP0414007A3 (en) | 1991-03-20 |
DK0414007T3 (da) | 1995-09-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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