EA025852B1 - ТЕРАПЕВТИЧЕСКИЕ КОМПОЗИЦИИ, СОДЕРЖАЩИЕ РИЛПИВИРИН HCl И ТЕНОФОВИРА ДИЗОПРОКСИЛФУМАРАТ - Google Patents
ТЕРАПЕВТИЧЕСКИЕ КОМПОЗИЦИИ, СОДЕРЖАЩИЕ РИЛПИВИРИН HCl И ТЕНОФОВИРА ДИЗОПРОКСИЛФУМАРАТ Download PDFInfo
- Publication number
- EA025852B1 EA025852B1 EA201390651A EA201390651A EA025852B1 EA 025852 B1 EA025852 B1 EA 025852B1 EA 201390651 A EA201390651 A EA 201390651A EA 201390651 A EA201390651 A EA 201390651A EA 025852 B1 EA025852 B1 EA 025852B1
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- EA
- Eurasian Patent Office
- Prior art keywords
- layer
- tablet
- tablet according
- rilpivirin
- microcrystalline cellulose
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Classifications
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- A—HUMAN NECESSITIES
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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| EA201390651A EA025852B1 (ru) | 2010-11-19 | 2011-11-18 | ТЕРАПЕВТИЧЕСКИЕ КОМПОЗИЦИИ, СОДЕРЖАЩИЕ РИЛПИВИРИН HCl И ТЕНОФОВИРА ДИЗОПРОКСИЛФУМАРАТ |
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| TWI471145B (zh) | 2005-06-13 | 2015-02-01 | Bristol Myers Squibb & Gilead Sciences Llc | 單一式藥學劑量型 |
| EA201691695A1 (ru) | 2010-11-19 | 2017-11-30 | Джилид Сайэнс, Инк. | Терапевтические композиции, содержащие рилпивирин hcl и тенофовира дизопроксилфумарат |
| DK2744810T4 (da) | 2011-08-16 | 2023-11-20 | Gilead Sciences Inc | Tenofovir-alafenamid-hemifumarat |
| CA2779052A1 (en) * | 2012-05-31 | 2013-11-30 | Pharmascience Inc. | Pharmaceutical composition of entecavir and process of manufacturing |
| MX344879B (es) | 2012-12-21 | 2017-01-11 | Gilead Sciences Inc | Compuestos de carbamoilpiridona policiclicos y su uso farmaceutico. |
| EP2832351A1 (en) * | 2013-07-29 | 2015-02-04 | Sanovel Ilac Sanayi ve Ticaret A.S. | Multilayer Tablet Formulations Comprising Tenofovir and Entecavir |
| CZ2013985A3 (cs) * | 2013-12-09 | 2015-06-17 | Zentiva, K.S. | Stabilní farmaceutická kompozice obsahující tenofovir disoproxil fumarát |
| WO2015152433A1 (en) * | 2014-03-31 | 2015-10-08 | Hanmi Pharm. Co., Ltd. | Amorphous solid dispersion comprising paclitaxel, tablet comprising the same, and method for preparing the same |
| LT3236972T (lt) | 2014-12-26 | 2021-11-10 | Emory University | Antivirusiniai n4-hidroksicitidino dariniai |
| US9839212B2 (en) | 2015-04-16 | 2017-12-12 | Bio-Lab, Inc. | Multicomponent and multilayer compacted tablets |
| KR20170003063A (ko) * | 2015-06-30 | 2017-01-09 | 한미약품 주식회사 | 테노포비어 디소프록실 함유 경구용 고형제제 및 그 제조방법 |
| CA2921336A1 (en) * | 2015-06-30 | 2016-12-30 | Gilead Sciences, Inc. | Pharmaceutical formulations |
| KR102606625B1 (ko) | 2015-11-09 | 2023-11-27 | 길리애드 사이언시즈, 인코포레이티드 | 인간 면역결핍 바이러스의 치료를 위한 치료 조성물 |
| WO2017175855A1 (en) * | 2016-04-08 | 2017-10-12 | Shionogi & Co., Ltd. | Stabilized solid dosage form |
| TR201617448A2 (tr) * | 2016-11-29 | 2018-06-21 | Arven Ilac Sanayi Ve Ticaret Anonim Sirketi | Tenofovi̇r ve emtri̇si̇tabi̇n i̇çeren kati oral farmasöti̇k bi̇leşi̇mler |
| US10561614B2 (en) * | 2017-01-27 | 2020-02-18 | Steerlife India Private Limited | Tenofovir granules |
| RU2755710C2 (ru) * | 2017-06-30 | 2021-09-20 | Вайв Хелткер Компани | Комбинация, ее применение и способы лечения с использованием указанной комбинации |
| LT3706762T (lt) | 2017-12-07 | 2024-12-27 | Emory University | N4-hidroksicitidinas ir jo dariniai bei susiję naudojimo prieš virusus būdai |
| CN114126655A (zh) * | 2019-07-03 | 2022-03-01 | 爱尔兰詹森科学公司 | 用利匹韦林治疗儿科患者的hiv的方法 |
| CN112137981A (zh) * | 2020-11-02 | 2020-12-29 | 成都晶富医药科技有限公司 | 富马酸丙酚替诺福韦片及其制备工艺 |
| WO2024211882A1 (en) * | 2023-04-07 | 2024-10-10 | Navinta, Llc | Stable compositions of rilpivirine hcl in combination with other anti-retroviral agents |
| CN119174735A (zh) * | 2024-09-03 | 2024-12-24 | 安徽贝克生物制药有限公司 | 一种含利匹韦林的复方片及制备方法 |
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| WO2006135933A2 (en) * | 2005-06-13 | 2006-12-21 | Bristol-Myers Squibb & Gilead Sciences, Llc | Stable fixed-dose unitary formulations containing tenofovir, a surfactant, efavirenz and emtricitabine |
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| IL100965A (en) | 1991-02-22 | 1999-12-31 | Univ Emory | 2-Hydroxymethyl-5-(5-fluorocytosin-l-yl)-1,3-oxathiolane its resolution and pharmaceutical compositions containing it |
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| AU2002359518A1 (en) | 2001-11-27 | 2003-06-10 | Bristol-Myers Squibb Company | Efavirenz tablet formulation having unique biopharmaceutical characteristics |
| JP4996241B2 (ja) | 2003-01-14 | 2012-08-08 | ギリアード サイエンシーズ， インコーポレイテッド | 組み合わせ抗ウイルス治療のための組成物および方法 |
| CN104586850A (zh) | 2004-09-02 | 2015-05-06 | 詹森药业有限公司 | 4-[[4-[[4-(2-氰基乙烯基)-2,6-二甲基苯基]氨基]-2-嘧啶基]氨基]苄腈的盐酸盐 |
| PL1632232T6 (pl) | 2004-09-02 | 2022-06-27 | Janssen Pharmaceutica Nv | Sól 4-[[4-[[4-(2-cyjanoetenylo)-2,6-dimetylofenylo]amino]-2-pirymidynylo]amino]benzonitrylu |
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| CN101778855A (zh) * | 2007-05-22 | 2010-07-14 | 阿尔迪默菲克斯技术有限责任公司 | 替诺福韦酯半富马酸共晶体 |
| WO2009037449A1 (en) | 2007-09-18 | 2009-03-26 | Cipla Limited | Solid pharmaceutical compositions comprising one or more herpes virus inhibitors and one or more reverse transcriptase inhibitors |
| WO2009106960A2 (en) | 2008-02-27 | 2009-09-03 | Aurobindo Pharma Limited | Stable compositions of lamivudine, tenofovir and efavirenz |
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| BRPI1008664A2 (pt) | 2009-02-06 | 2016-03-08 | Gilead Sciences Inc | comprimidos para a terapia de combinação |
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Patent Citations (3)
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| WO2005021001A1 (en) * | 2003-09-03 | 2005-03-10 | Tibotec Pharmaceuticals Ltd. | Combinations of a pyrimidine containing nnrti with rt inhibitors |
| WO2006135932A2 (en) * | 2005-06-13 | 2006-12-21 | Gilead Sciences, Inc. | Stable fixed-dose formulations containing a combination of antivirals, method for producing thereof using dry granulation |
| WO2006135933A2 (en) * | 2005-06-13 | 2006-12-21 | Bristol-Myers Squibb & Gilead Sciences, Llc | Stable fixed-dose unitary formulations containing tenofovir, a surfactant, efavirenz and emtricitabine |
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| A. MATHIAS, M. MENNING, X. WEI, A. DAVE, S. CHUCK, B.P. KEARNEY: "Bioequivalence of the co-formulation of emtricitabine/rilpivirine/tenofovir DF", XVIII INTERNATIONAL AIDS CONFERENCE, JULY 18-23, 2010, VIENNA, AUSTRIA, 18 July 2010 (2010-07-18) - 23 July 2010 (2010-07-23), XP009151551 * |
| REPORTED BY JULES LEVIN: "Bioequivalence of the Co-Formulation of Emtricitabine/Rilpivirine/Tenofovir DF", XVIII INTERNATIONAL AIDS CONFERENCE, JULY 18-23, 2010, VIENNA, AUSTRIA, 18 July 2010 (2010-07-18), XP009151549, Retrieved from the Internet <URL:http://www.natap.org/2010/IAS/IAS_99.htm> [retrieved on 20110825] * |
| S. COLLINS: "Rilpivirine vs. efavirenz in treatment naive patients: phase 3 results", HIV TREATMENT BULLETIN, WORLD AIDS VIENNA, vol. Conference reports, 26 August 2010 (2010-08-26), pages 1 - 3, XP002666571, Retrieved from the Internet <URL:http://i-base.info/htb/13816> [retrieved on 20120104] * |
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