EA024084B1 - Вводимые перорально кортикостероидные композиции - Google Patents
Вводимые перорально кортикостероидные композиции Download PDFInfo
- Publication number
- EA024084B1 EA024084B1 EA201290171A EA201290171A EA024084B1 EA 024084 B1 EA024084 B1 EA 024084B1 EA 201290171 A EA201290171 A EA 201290171A EA 201290171 A EA201290171 A EA 201290171A EA 024084 B1 EA024084 B1 EA 024084B1
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- EA
- Eurasian Patent Office
- Prior art keywords
- pharmaceutical composition
- corticosteroid
- composition according
- approximately
- solid pharmaceutical
- Prior art date
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Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8497258B2 (en) | 2005-11-12 | 2013-07-30 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
| EP2214679B1 (en) | 2007-11-13 | 2019-03-27 | Meritage Pharma, Inc. | Corticosteroid compositions |
| US20090143343A1 (en) | 2007-11-13 | 2009-06-04 | Meritage Pharma, Inc. | Compositions for the treatment of inflammation of the gastrointestinal tract |
| US20100216754A1 (en) * | 2007-11-13 | 2010-08-26 | Meritage Pharma, Inc. | Compositions for the treatment of inflammation of the gastrointestinal tract |
| US20110097401A1 (en) * | 2009-06-12 | 2011-04-28 | Meritage Pharma, Inc. | Methods for treating gastrointestinal disorders |
| NZ624922A (en) | 2009-10-01 | 2016-05-27 | Adare Pharmaceuticals Inc | Orally administered corticosteroid compositions |
| US20120164080A1 (en) * | 2010-06-24 | 2012-06-28 | Meritage Pharma, Inc. | Methods of treatment for esophageal inflammation |
| WO2012020279A1 (en) * | 2010-08-13 | 2012-02-16 | Compagnie Gervais Danone | Product for the upper gastric sphere |
| AU2013259872B2 (en) | 2012-05-08 | 2018-06-28 | Nicox Ophthalmics, Inc. | Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof |
| US8765725B2 (en) | 2012-05-08 | 2014-07-01 | Aciex Therapeutics, Inc. | Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof |
| US9815865B2 (en) | 2013-01-07 | 2017-11-14 | Nicox Ophthalmics, Inc. | Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof |
| US10716802B2 (en) | 2013-03-15 | 2020-07-21 | The Brigham And Women's Hospital, Inc. | Compounds to modulate intestinal absorption of nutrients |
| MX365513B (es) | 2013-03-15 | 2019-06-06 | Aprecia Pharmaceuticals LLC | Forma de dosificacion de dispersion rapida que contiene levetiracetam. |
| US9339489B2 (en) | 2013-03-15 | 2016-05-17 | Aprecia Pharmaceuticals Company | Rapid disperse dosage form containing levetiracetam |
| GB201308933D0 (en) * | 2013-05-17 | 2013-07-03 | Diurnal Ltd | Paediatric composition |
| US9078853B2 (en) | 2013-06-18 | 2015-07-14 | Cmpd Licensing, Llc | Dry pharmaceutical compositions for topical delivery of oral medications, nasal delivery and to treat ear disorders |
| WO2015034678A2 (en) | 2013-09-06 | 2015-03-12 | Aptalis Pharmatech, Inc. | Corticosteroid containing orally disintegrating tablet compositions for eosinophilic esophagitis |
| WO2015152517A1 (ko) * | 2014-03-31 | 2015-10-08 | (주)세하바이오 | 항산화 물질 활성 보호를 위한 프롤라민 기반 경구용 필름 제조방법 |
| EP3047846A1 (en) | 2015-01-22 | 2016-07-27 | Ems S.A. | Dosage forms containing fluticasone propionate for the treatment of inflammatory conditions of the esophagus |
| US9980975B2 (en) | 2015-01-22 | 2018-05-29 | Ems S.A. | Dosage forms containing fluticasone propionate for the treatment of inflammatory conditions of the esophagus |
| WO2016174664A1 (en) | 2015-04-29 | 2016-11-03 | Dexcel Pharma Technologies Ltd. | Orally disintegrating compositions |
| US9867834B2 (en) | 2015-06-15 | 2018-01-16 | Banner Life Sciences Llc | Non-systemic topical compositions comprising corticosteroids |
| US9877971B2 (en) | 2015-06-15 | 2018-01-30 | Banner Life Sciences Llc | Soft lozenges comprising corticosteroids |
| US10973846B2 (en) | 2015-09-24 | 2021-04-13 | The Brigham And Women's Hospital, Inc. | Water-activated mucoadhesive compositions to reduce intestinal absorption of nutrients |
| CN105412123B (zh) * | 2015-11-06 | 2018-03-13 | 山东省千佛山医院 | 布地奈德联合三唑类抗真菌药物的应用及其产品 |
| US20190217531A1 (en) | 2016-04-06 | 2019-07-18 | Astellas Pharma Inc. | Fast-eluting three-dimensionally molded object, filament for fast-eluting three-dimensionally molded object, and material for fast-eluting three-dimensionally molded object |
| US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
| TWI728172B (zh) | 2016-08-18 | 2021-05-21 | 美商愛戴爾製藥股份有限公司 | 治療嗜伊紅性食道炎之方法 |
| US9999604B2 (en) | 2016-11-17 | 2018-06-19 | Cmpd Licensing, Llc | Compounded solutions of diclofenac and lidocaine and methods |
| US10966946B2 (en) | 2016-11-17 | 2021-04-06 | Cmpd Licensing, Llc | Compounded compositions and methods for treating pain |
| US11986448B2 (en) | 2016-11-17 | 2024-05-21 | Cmpd Licensing, Llc | Compounded compositions and methods for treating pain |
| US11737975B2 (en) | 2016-11-17 | 2023-08-29 | Cmpd Licensing, Llc | Compounded compositions and methods for treating pain |
| US10525025B2 (en) | 2016-11-17 | 2020-01-07 | Cmpd Licensing, Llc | Compounded compositions and methods for treating pain |
| CN107595765A (zh) * | 2017-09-22 | 2018-01-19 | 沈阳兴齐眼药股份有限公司 | 一种眼用缓释药物递送系统及其制备方法 |
| WO2019157453A1 (en) * | 2018-02-12 | 2019-08-15 | Trilogy Therapeutics, Inc. | Caspofungin compositions for inhalation |
| SI25373A (sl) | 2018-05-08 | 2018-08-31 | Danijela Marković | Naravna orodisperzibilna tableta |
| CN113271979A (zh) | 2018-10-24 | 2021-08-17 | 费灵有限公司 | 皮质类固醇的粘膜粘附性药物组合物 |
| WO2020227437A1 (en) | 2019-05-06 | 2020-11-12 | Axial Biotherapeutics, Inc. | Sustained release solid dosage forms for modulating the colonic microbiome |
| KR20220074915A (ko) * | 2019-10-01 | 2022-06-03 | 엘로디 파마슈티컬스, 엘.피. | 호산구성 식도염을 치료하고 칸디다증을 감소시키는 방법 |
| KR102275997B1 (ko) * | 2019-11-07 | 2021-07-13 | 연세대학교 산학협력단 | 숙주지향치료를 위한 조성물 |
| JP7720226B2 (ja) * | 2020-11-09 | 2025-08-07 | 東和薬品株式会社 | リバーロキサバン含有口腔内崩壊錠 |
| CN114146089B (zh) * | 2021-12-15 | 2023-06-16 | 安徽贝克生物制药有限公司 | 含依非韦伦、替诺福韦和恩曲他滨的药物组合物 |
| CN119997959A (zh) * | 2022-07-28 | 2025-05-13 | 威斯康星州医药大学股份有限公司 | 用于治疗反流的缓释口服福沙那韦制剂 |
| US11904046B1 (en) * | 2022-11-14 | 2024-02-20 | Eton Pharmaceuticals, Inc. | Hydrocortisone oral liquid formulations |
| CN116869927B (zh) * | 2023-09-06 | 2023-11-10 | 中国医学科学院北京协和医院 | 一种用于治疗嗜酸性食管炎的食道温敏凝胶 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040106663A1 (en) * | 2002-09-06 | 2004-06-03 | Talley John Jeffrey | Inhibitors of fungal invasion |
| US20050009848A1 (en) * | 2003-07-10 | 2005-01-13 | Icn Pharmaceuticals Switzerland Ltd. | Use of antivirals against inflammatory bowel diseases |
| US20070059361A1 (en) * | 2005-09-09 | 2007-03-15 | University Of Manitoba | Fast-disintegrating epinephrine tablets for buccal or sublingual administration |
| US20090123550A1 (en) * | 2007-11-13 | 2009-05-14 | Meritage Pharma, Inc. | Corticosteroid compositions |
| US20090169620A1 (en) * | 2007-12-21 | 2009-07-02 | Venkatesh Gopi M | Orally disintegrating tablet compositions of temazepam |
Family Cites Families (113)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1170188A (en) | 1967-09-15 | 1969-11-12 | Bayer Ag | N-trityl-imidazoles and salts and uses thereof |
| SE378109B (https=) | 1972-05-19 | 1975-08-18 | Bofors Ab | |
| DE2260384C3 (de) * | 1972-12-09 | 1979-11-29 | Hoechst Ag, 6000 Frankfurt | Oral zu applizierendes Corticosteroid-Präparat |
| US4080448A (en) | 1974-11-13 | 1978-03-21 | Mirsky Louis H | Method of treating cellular stress |
| JPS56138200A (en) * | 1980-02-15 | 1981-10-28 | Glaxo Group Ltd | Androstane carbothioate compound |
| SE8004580L (sv) | 1980-06-19 | 1981-12-20 | Draco Ab | Farmaceutisk beredning |
| ATE8790T1 (de) | 1981-02-02 | 1984-08-15 | Schering Corporation | Aromatische heterocyclische steroidester, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen, die sie enthalten. |
| GB8630913D0 (en) | 1986-12-24 | 1987-02-04 | Glaxo Group Ltd | Pharmaceutical compositions |
| US5446070A (en) | 1991-02-27 | 1995-08-29 | Nover Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
| ZA892859B (en) | 1988-04-22 | 1989-12-27 | Advanced Polymer Systems Inc | Porous particles in preparations involving immiscible phases |
| GB9002375D0 (en) | 1990-02-02 | 1990-04-04 | Pfizer Ltd | Triazole antifungal agents |
| US5278175A (en) | 1990-02-02 | 1994-01-11 | Pfizer Inc. | Triazole antifungal agents |
| GR1001529B (el) | 1990-09-07 | 1994-03-31 | Elmuquimica Farm Sl | Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης. |
| CA2101773A1 (en) | 1991-01-31 | 1992-08-01 | Toyoichi Tanaka | Interpenetrating-polymer network phase-transition gels |
| US5252337A (en) | 1991-06-25 | 1993-10-12 | Eurand America, Inc. | Controlled release calcium channel blocker microcapsules |
| CA2178473C (en) | 1993-12-20 | 2004-08-24 | Tsi-Zong Tzou | Flunisolide aerosol formulations |
| US5639475A (en) | 1995-02-03 | 1997-06-17 | Eurand America, Incorporated | Effervescent microcapsules |
| SE9501384D0 (sv) | 1995-04-13 | 1995-04-13 | Astra Ab | Process for the preparation of respirable particles |
| GB9517062D0 (en) | 1995-08-18 | 1995-10-25 | Scherer Ltd R P | Pharmaceutical compositions |
| US5863910A (en) | 1996-01-12 | 1999-01-26 | Bolonick; Joel | Treatment of chronic inflammatory disorders of the gastrointestinal tract |
| DE19606151C2 (de) | 1996-02-20 | 1999-05-12 | Losan Pharma Gmbh | Ibuprofen-Brausezubereitung sowie Verfahren zur Herstellung derselben |
| US8071128B2 (en) | 1996-06-14 | 2011-12-06 | Kyowa Hakko Kirin Co., Ltd. | Intrabuccally rapidly disintegrating tablet and a production method of the tablets |
| DK0914818T3 (da) * | 1996-06-14 | 2005-07-04 | Kyowa Hakko Kogyo Kk | Intraoralt hurtigt desintegrerbar tablet |
| HUP0000116A3 (en) | 1996-10-01 | 2000-08-28 | Stanford Res Inst Int | Taste-masked microcapsule compositions and methods of manufacture |
| SE9604486D0 (sv) | 1996-12-05 | 1996-12-05 | Astra Ab | Novel formulation |
| GB9707934D0 (en) | 1997-04-18 | 1997-06-04 | Danbiosyst Uk | Improved delivery of drugs to mucosal surfaces |
| IT1291362B1 (it) | 1997-05-13 | 1999-01-07 | Vectorpharma Int | Composizioni farmaceutiche multicomponente bifasiche contenenti sostanze atte a modificare la partizione dei principi attivi |
| RO118174B1 (ro) | 1997-08-21 | 2003-03-28 | Aventis Pharma Deutschland Gmbh | Lac de unghii şi utilizarea acestuia |
| GB9722426D0 (en) | 1997-10-23 | 1997-12-24 | Univ London Pharmacy | Controlled release formulations |
| CA2322315C (en) | 1998-03-06 | 2008-09-16 | Eurand International S.P.A. | Fast disintegrating tablets |
| SE514128C2 (sv) | 1998-03-17 | 2001-01-08 | Pharmalink Ab | Användning av en glukokortikoid för framställning av ett läkemedel för behandling av glomerulonefrit |
| FR2781156B1 (fr) * | 1998-07-20 | 2001-06-29 | Lafon Labor | Composition pharmaceutique destinee notamment a la prevention et au traitement des radiomucites et des chimiomucites |
| US6596298B2 (en) | 1998-09-25 | 2003-07-22 | Warner-Lambert Company | Fast dissolving orally comsumable films |
| US6863378B2 (en) | 1998-10-16 | 2005-03-08 | Silverbrook Research Pty Ltd | Inkjet printer having enclosed actuators |
| GB9901819D0 (en) | 1999-01-27 | 1999-03-17 | Scherer Corp R P | Pharmaceutical compositions |
| PL199123B1 (pl) | 1999-04-23 | 2008-08-29 | Leo Pharm Prod Ltd | Niewodna kompozycja farmaceutyczna do stosowania naskórnego i jej zastosowanie |
| GB9915319D0 (en) | 1999-06-30 | 1999-09-01 | Unilever Plc | Hair treatment compositions |
| AU7026800A (en) | 1999-09-11 | 2001-04-17 | Glaxo Group Limited | Pharmaceutical formulation of fluticasone propionate |
| WO2001039749A2 (en) | 1999-11-30 | 2001-06-07 | Panacea Biotec Limited | Fast dissolving composition with prolonged sweet taste |
| AU2001279284A1 (en) | 2000-07-05 | 2002-01-14 | Capricorn Pharma, Inc | Rapid-melt semi-solid compositions, methods of making same and methods of using same |
| KR100446101B1 (ko) * | 2000-12-07 | 2004-08-30 | 주식회사 삼양사 | 수난용성 약물의 서방성 제형 조성물 |
| US7125564B2 (en) | 2001-02-16 | 2006-10-24 | Lavipharm Laboratories, Inc. | Water soluble and palatable complexes |
| US20030050312A1 (en) | 2001-03-12 | 2003-03-13 | Hjorth Thyge Borup | Novel tablets and capsules and a process for its preparation |
| WO2002072150A2 (en) * | 2001-03-13 | 2002-09-19 | Angiotech Pharmaceuticals Inc. | Micellar drug delivery vehicles and uses thereof |
| US6872405B2 (en) * | 2001-05-10 | 2005-03-29 | Yamanouchi Pharmaceutical Co., Ltd. | Quick-disintegrating tablet in buccal cavity and manufacturing method thereof |
| MXPA03001838A (es) * | 2001-05-10 | 2003-09-10 | Yamanouchi Pharmaceuticals Co | Tabletas que se desintegran rapidamente en la cavidad bucal y proceso para producir las mismas. |
| US6656493B2 (en) | 2001-07-30 | 2003-12-02 | Wm. Wrigley Jr. Company | Edible film formulations containing maltodextrin |
| FR2831820B1 (fr) | 2001-11-05 | 2004-08-20 | Ethypharm Sa | Comprime orodispersible presentant une grande homogeneite et son procede de preparation |
| US20030206978A1 (en) | 2001-11-29 | 2003-11-06 | Bob Sherwood | Agglomerated particles including an active agent coprocessed with silicified microcrystalline cellulose |
| US20040009212A1 (en) | 2002-01-30 | 2004-01-15 | Pharma Power Biotec Co. Ltd. | Mucoadhesive thermoresponsive medicament-carrier composition |
| JP4173670B2 (ja) * | 2002-03-08 | 2008-10-29 | 旭化成ファーマ株式会社 | 口腔内崩壊製剤 |
| WO2003087194A1 (en) | 2002-04-05 | 2003-10-23 | United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Polyimides from 2,3,3',4'-biphenyltetracarboxylic dianhydride and aromatic diamines |
| CN1290893C (zh) * | 2002-05-03 | 2006-12-20 | 詹森药业有限公司 | 聚合物微乳状液 |
| AU2003253870A1 (en) | 2002-07-10 | 2004-01-23 | I/O Controls Corporation | Fiber optic control network and related method |
| WO2004023984A2 (en) | 2002-09-13 | 2004-03-25 | Smith C Steven | Novel composition and method for treatment of upper respiratory conditions |
| US7731947B2 (en) | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
| KR101099176B1 (ko) | 2003-01-21 | 2011-12-27 | 니뽄 신야쿠 가부시키가이샤 | 구강내 속붕성 정제 |
| JP2006516616A (ja) * | 2003-01-31 | 2006-07-06 | オレクソ・アクチエボラゲット | 即効薬剤組成物 |
| US20040208833A1 (en) * | 2003-02-04 | 2004-10-21 | Elan Pharma International Ltd. | Novel fluticasone formulations |
| US8012505B2 (en) | 2003-02-28 | 2011-09-06 | Alk-Abello A/S | Dosage form having a saccharide matrix |
| US20040265375A1 (en) | 2003-04-16 | 2004-12-30 | Platteeuw Johannes J. | Orally disintegrating tablets |
| US20060134054A1 (en) | 2003-12-19 | 2006-06-22 | Council Of Scientific And Industrial Research | Polymer composition for pH dependent dissolution behavior and process for preparation thereof |
| BRPI0508612A (pt) | 2004-03-10 | 2007-08-14 | Schering Aktiengellschaft | composições compreendendo drospirenona dispersa molecularmente |
| US8545881B2 (en) | 2004-04-19 | 2013-10-01 | Eurand Pharmaceuticals, Ltd. | Orally disintegrating tablets and methods of manufacture |
| ATE353635T1 (de) | 2004-09-09 | 2007-03-15 | Medinfar Produtos Farmaceutico | Schnell wasserdispergierbare und domperidon enthaltende tabletten |
| US20060105038A1 (en) | 2004-11-12 | 2006-05-18 | Eurand Pharmaceuticals Limited | Taste-masked pharmaceutical compositions prepared by coacervation |
| US20070020330A1 (en) | 2004-11-24 | 2007-01-25 | Medpointe Healthcare Inc. | Compositions comprising azelastine and methods of use thereof |
| US20060292099A1 (en) | 2005-05-25 | 2006-12-28 | Michael Milburn | Treatment of eye disorders with sirtuin modulators |
| US8324192B2 (en) | 2005-11-12 | 2012-12-04 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
| US8497258B2 (en) | 2005-11-12 | 2013-07-30 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
| US8679545B2 (en) | 2005-11-12 | 2014-03-25 | The Regents Of The University Of California | Topical corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract |
| JP2007158225A (ja) | 2005-12-08 | 2007-06-21 | Canon Inc | 露光装置 |
| CN1985799B (zh) | 2005-12-19 | 2011-11-09 | 量子高科（北京）研究院有限公司 | 口腔崩解制剂的制备方法 |
| JP2009521523A (ja) * | 2005-12-27 | 2009-06-04 | ジュビラント・オルガノシス・リミテッド | 口中溶解性医薬組成物およびその製造方法 |
| US20080260655A1 (en) * | 2006-11-14 | 2008-10-23 | Dov Tamarkin | Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses |
| EP1958613A1 (en) | 2007-02-15 | 2008-08-20 | Polichem S.A. | Dermal film-forming liquid formulations for drug release to skin |
| CA2721133C (en) | 2007-04-13 | 2018-11-06 | Somaxon Pharmaceuticals, Inc. | Low-dose doxepin formulations and methods of making and using the same |
| US20090123551A1 (en) * | 2007-11-13 | 2009-05-14 | Meritage Pharma, Inc. | Gastrointestinal delivery systems |
| US20100216754A1 (en) | 2007-11-13 | 2010-08-26 | Meritage Pharma, Inc. | Compositions for the treatment of inflammation of the gastrointestinal tract |
| US20150231156A1 (en) | 2007-11-13 | 2015-08-20 | Meritage Pharma, Inc. | Corticosteroid compositions |
| EP2214679B1 (en) | 2007-11-13 | 2019-03-27 | Meritage Pharma, Inc. | Corticosteroid compositions |
| CA2708152A1 (en) * | 2007-12-10 | 2009-06-18 | Eurand, Inc | Orally disintegrating tablets comprising diphenhydramine |
| JP2009173552A (ja) * | 2008-01-21 | 2009-08-06 | Lion Corp | 胃腸薬 |
| SE533435C2 (sv) | 2008-04-03 | 2010-09-28 | Hm Power Ab | Vridmomentsöverförande arrangemang vid ett vindkraftverk |
| US20090264392A1 (en) | 2008-04-21 | 2009-10-22 | Meritage Pharma, Inc. | Treating eosinophilic esophagitis |
| ES2358158T3 (es) | 2008-07-21 | 2011-05-06 | Dr. Falk Pharma Gmbh | Formulación farmacéutica para el tratamiento del tracto digestivo superior. |
| CN102112114A (zh) | 2008-08-08 | 2011-06-29 | 麦克内尔-Ppc股份有限公司 | 使用三氯蔗糖作为制粒剂 |
| ES2811051T3 (es) | 2008-08-20 | 2021-03-10 | Univ California | Corticosteroides para el tratamiento de enfermedades inflamatorias del tracto gastrointestinal |
| US8696568B2 (en) | 2009-01-15 | 2014-04-15 | Nestec S.A. | Methods, system and kit for diagnosing and treating dysphagia |
| EP2398470A4 (en) | 2009-02-23 | 2013-03-06 | Aptalis Pharmatech Inc | CONTROLLED RELEASE COMPOSITIONS COMPRISING A PROTON PUMP INHIBITOR |
| US20110097401A1 (en) | 2009-06-12 | 2011-04-28 | Meritage Pharma, Inc. | Methods for treating gastrointestinal disorders |
| CN102596237A (zh) | 2009-09-07 | 2012-07-18 | Dbv技术公司 | 治疗嗜酸细胞性食管炎的方法 |
| NZ624922A (en) | 2009-10-01 | 2016-05-27 | Adare Pharmaceuticals Inc | Orally administered corticosteroid compositions |
| BR112012012999A2 (pt) | 2009-11-30 | 2019-04-02 | Aptalis Pharmatech, Inc. | Composição farmacêutica, e composição de tablete de desintegração oral (odt) outablete de dispersão rápida (rdt) |
| US20120164080A1 (en) | 2010-06-24 | 2012-06-28 | Meritage Pharma, Inc. | Methods of treatment for esophageal inflammation |
| CA2819663C (en) | 2010-12-02 | 2019-12-24 | Adare Pharmaceuticals, Inc. | Rapidly dispersing granules, orally disintegrating tablets and methods |
| WO2012097436A1 (en) | 2011-01-18 | 2012-07-26 | Toronto Rehabilitation Institute | Method and device for swallowing impairment detection |
| SG191827A1 (en) | 2011-01-28 | 2013-08-30 | Nestec Sa | Apparatuses and methods for diagnosing swallowing dysfunction |
| US20150209432A1 (en) | 2012-07-26 | 2015-07-30 | Lupin Limited | Pharmaceutical compositions of proton pump inhibitor |
| TWI634900B (zh) | 2013-07-11 | 2018-09-11 | 再生元醫藥公司 | 藉由投與ｉｌ－４ｒ抑制劑治療嗜酸性食道炎的方法 |
| WO2015034678A2 (en) | 2013-09-06 | 2015-03-12 | Aptalis Pharmatech, Inc. | Corticosteroid containing orally disintegrating tablet compositions for eosinophilic esophagitis |
| ES2716990T5 (es) | 2013-12-23 | 2023-03-24 | Dr Falk Pharma Gmbh | Formulación farmacéutica optimizada para el tratamiento de cambios inflamatorios del esófago |
| US10294517B2 (en) | 2014-03-17 | 2019-05-21 | Children's Hospital Medical Center | Genetic test for determining susceptibility for eosinophilic esophagitis |
| US10176301B2 (en) | 2014-09-11 | 2019-01-08 | Meritage Pharma, Inc. | Systems, methods, and software for providing a patient-reported outcome measure of dysphagia patients with eosinophilic esophagitis |
| US9980975B2 (en) | 2015-01-22 | 2018-05-29 | Ems S.A. | Dosage forms containing fluticasone propionate for the treatment of inflammatory conditions of the esophagus |
| US10869592B2 (en) | 2015-02-23 | 2020-12-22 | Uroviu Corp. | Handheld surgical endoscope |
| KR102460040B1 (ko) | 2016-04-27 | 2022-11-01 | 애브비 인코포레이티드 | 항-il-13 항체를 이용한 il-13 활성이 유해한 질환의 치료 방법 |
| US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
| TWI728172B (zh) | 2016-08-18 | 2021-05-21 | 美商愛戴爾製藥股份有限公司 | 治療嗜伊紅性食道炎之方法 |
| JP2021514513A (ja) | 2018-02-21 | 2021-06-10 | アデア ファーマシューティカルズ，ユーエス，エル．ピー． | 好酸球性食道炎を管理する方法 |
| KR20220074915A (ko) | 2019-10-01 | 2022-06-03 | 엘로디 파마슈티컬스, 엘.피. | 호산구성 식도염을 치료하고 칸디다증을 감소시키는 방법 |
| WO2022020464A1 (en) | 2020-07-21 | 2022-01-27 | Ellodi Pharmaceuticals, L.P. | Modified release rapidly disintegrating compositions of proton pump inhibitors |
| CA3215388A1 (en) | 2021-04-20 | 2022-10-27 | Gina EAGLE | Methods of treating esophageal strictures |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040106663A1 (en) * | 2002-09-06 | 2004-06-03 | Talley John Jeffrey | Inhibitors of fungal invasion |
| US20050009848A1 (en) * | 2003-07-10 | 2005-01-13 | Icn Pharmaceuticals Switzerland Ltd. | Use of antivirals against inflammatory bowel diseases |
| US20070059361A1 (en) * | 2005-09-09 | 2007-03-15 | University Of Manitoba | Fast-disintegrating epinephrine tablets for buccal or sublingual administration |
| US20090123550A1 (en) * | 2007-11-13 | 2009-05-14 | Meritage Pharma, Inc. | Corticosteroid compositions |
| US20090169620A1 (en) * | 2007-12-21 | 2009-07-02 | Venkatesh Gopi M | Orally disintegrating tablet compositions of temazepam |
Non-Patent Citations (2)
| Title |
|---|
| BOWER, et al.: Manifestations and Treatment of Laryngeal Sarcoidosis Am Rev Respir Dis August 1980, Vol. 122(2), pages 325-332, abstract only * |
| WEI, et al.: Efficacy of Single-Dose Dexamethasone as Adjuvant Therapy for Acute Pharyngitis The Laryngoscope, January 2002, Vol. 112(1), pages 87-93, abstract * |
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