HRP20191435T1 - Oralno primjenjivi kortikosteroidni sastavi - Google Patents
Oralno primjenjivi kortikosteroidni sastavi Download PDFInfo
- Publication number
- HRP20191435T1 HRP20191435T1 HRP20191435T HRP20191435T1 HR P20191435 T1 HRP20191435 T1 HR P20191435T1 HR P20191435 T HRP20191435 T HR P20191435T HR P20191435 T1 HRP20191435 T1 HR P20191435T1
- Authority
- HR
- Croatia
- Prior art keywords
- odt
- corticosteroid
- cross
- linked
- less
- Prior art date
Links
- 239000003246 corticosteroid Substances 0.000 title claims 8
- 239000000203 mixture Substances 0.000 title 1
- 239000006191 orally-disintegrating tablet Substances 0.000 claims 21
- 239000002245 particle Substances 0.000 claims 8
- XPCTZQVDEJYUGT-UHFFFAOYSA-N 3-hydroxy-2-methyl-4-pyrone Chemical compound CC=1OC=CC(=O)C=1O XPCTZQVDEJYUGT-UHFFFAOYSA-N 0.000 claims 6
- 229920001577 copolymer Polymers 0.000 claims 5
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 4
- 229930006000 Sucrose Natural products 0.000 claims 4
- 229960002714 fluticasone Drugs 0.000 claims 4
- MGNNYOODZCAHBA-GQKYHHCASA-N fluticasone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(O)[C@@]2(C)C[C@@H]1O MGNNYOODZCAHBA-GQKYHHCASA-N 0.000 claims 4
- 239000008187 granular material Substances 0.000 claims 4
- 239000005720 sucrose Substances 0.000 claims 4
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 3
- HYMLWHLQFGRFIY-UHFFFAOYSA-N Maltol Natural products CC1OC=CC(=O)C1=O HYMLWHLQFGRFIY-UHFFFAOYSA-N 0.000 claims 3
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims 3
- 229930195725 Mannitol Natural products 0.000 claims 3
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims 3
- 239000000853 adhesive Substances 0.000 claims 3
- 235000010443 alginic acid Nutrition 0.000 claims 3
- 229920000615 alginic acid Polymers 0.000 claims 3
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims 3
- 150000001720 carbohydrates Chemical class 0.000 claims 3
- 239000007884 disintegrant Substances 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 239000008101 lactose Substances 0.000 claims 3
- 239000000845 maltitol Substances 0.000 claims 3
- 235000010449 maltitol Nutrition 0.000 claims 3
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims 3
- 229940035436 maltitol Drugs 0.000 claims 3
- 229940043353 maltol Drugs 0.000 claims 3
- 239000000594 mannitol Substances 0.000 claims 3
- 235000010355 mannitol Nutrition 0.000 claims 3
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- 229920000058 polyacrylate Polymers 0.000 claims 3
- 239000000600 sorbitol Substances 0.000 claims 3
- 235000010356 sorbitol Nutrition 0.000 claims 3
- 150000005846 sugar alcohols Chemical class 0.000 claims 3
- 239000000811 xylitol Substances 0.000 claims 3
- 235000010447 xylitol Nutrition 0.000 claims 3
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims 3
- 229960002675 xylitol Drugs 0.000 claims 3
- 206010061218 Inflammation Diseases 0.000 claims 2
- 229920002125 Sokalan® Polymers 0.000 claims 2
- 239000000783 alginic acid Substances 0.000 claims 2
- 229960001126 alginic acid Drugs 0.000 claims 2
- 150000004781 alginic acids Chemical class 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 2
- 229920001519 homopolymer Polymers 0.000 claims 2
- 230000004968 inflammatory condition Effects 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 239000011159 matrix material Substances 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
- 229920001661 Chitosan Polymers 0.000 claims 1
- LUKZNWIVRBCLON-GXOBDPJESA-N Ciclesonide Chemical compound C1([C@H]2O[C@@]3([C@H](O2)C[C@@H]2[C@@]3(C[C@H](O)[C@@H]3[C@@]4(C)C=CC(=O)C=C4CC[C@H]32)C)C(=O)COC(=O)C(C)C)CCCCC1 LUKZNWIVRBCLON-GXOBDPJESA-N 0.000 claims 1
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 1
- 229920000858 Cyclodextrin Polymers 0.000 claims 1
- 206010064212 Eosinophilic oesophagitis Diseases 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- 229920002774 Maltodextrin Polymers 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical group C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000001070 adhesive effect Effects 0.000 claims 1
- 229940072056 alginate Drugs 0.000 claims 1
- 125000005250 alkyl acrylate group Chemical group 0.000 claims 1
- DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 claims 1
- 229920003144 amino alkyl methacrylate copolymer Polymers 0.000 claims 1
- 229940092705 beclomethasone Drugs 0.000 claims 1
- NBMKJKDGKREAPL-DVTGEIKXSA-N beclomethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O NBMKJKDGKREAPL-DVTGEIKXSA-N 0.000 claims 1
- 229960001631 carbomer Drugs 0.000 claims 1
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229960003728 ciclesonide Drugs 0.000 claims 1
- 229960000913 crospovidone Drugs 0.000 claims 1
- 201000000708 eosinophilic esophagitis Diseases 0.000 claims 1
- 210000002409 epiglottis Anatomy 0.000 claims 1
- 210000003238 esophagus Anatomy 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- -1 flunizolid Chemical compound 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 claims 1
- 239000000314 lubricant Substances 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- 235000010981 methylcellulose Nutrition 0.000 claims 1
- 229960001664 mometasone Drugs 0.000 claims 1
- QLIIKPVHVRXHRI-CXSFZGCWSA-N mometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CCl)(O)[C@@]1(C)C[C@@H]2O QLIIKPVHVRXHRI-CXSFZGCWSA-N 0.000 claims 1
- 210000003300 oropharynx Anatomy 0.000 claims 1
- 210000002741 palatine tonsil Anatomy 0.000 claims 1
- 239000001814 pectin Substances 0.000 claims 1
- 229920001277 pectin Polymers 0.000 claims 1
- 235000010987 pectin Nutrition 0.000 claims 1
- 210000003800 pharynx Anatomy 0.000 claims 1
- 239000004584 polyacrylic acid Substances 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 150000004804 polysaccharides Chemical class 0.000 claims 1
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims 1
- 239000008109 sodium starch glycolate Substances 0.000 claims 1
- 229940079832 sodium starch glycolate Drugs 0.000 claims 1
- 229920003109 sodium starch glycolate Polymers 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 229920002554 vinyl polymer Polymers 0.000 claims 1
- 229920001285 xanthan gum Polymers 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Inorganic Chemistry (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Dispersion Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Steroid Compounds (AREA)
Claims (15)
1. Oralno razgrađujuća tableta (ODT) koja sadrži manje od ili točno 20 mg kortikosteroida, odabranog iz skupine koju čine flutikazon, flunizolid, ciklesonid, mometazon, beklometazon i solvati i njihovi esteri, i najmanje jedno sredstvo za razgradnju, pri čemu se ODT razgrađuje u roku od 60 sekundi u simuliranoj tekućini sline kada se ispituje USP <701> Testom razgradnje i prikladna je za topikalnu primjenu kortikosteroida u jednjaku.
2. ODT sukladno zahtjevu 1, pri čemu se navedena tableta razgrađuje u roku od 30 sekundi.
3. ODT sukladno patentnom zahtjevu 1 ili 2, koja nadalje sadržava adhezivno sredstvo, pri čemu je adheziv odabran iz skupine koju čine saharoza aluminij sulfatni kompleks, hitosan i njegovi derivati, polivinilpirolidon, metilceluloza, natrij karboksimetilceluloza, hidroksipropil celuloza, umreženi ili neumreženi poliakrilat, umreženi poliarilata, kiselih umreženih ili neumreženih poliakrilata, homopolimeri ili kopolimeri poliakrilna kiselina, aminoalkil metakrilatni kopolimeri, kopolimeri metakrilne kiseline/metilmetakrilata, kopolimeri alkilakrilat/alkilmetakrilat, amoniometakrilatni kopolimeri, karbomerni homopolimeri ili kopolimeri, hidrofilni polisaharidi guma, maltodekstrini, umreženi alginatni gelovi od gume, polikarboksilirani vinilni polimeri, pektini, ksantanske gume, alginska kiselina, modificirana alginska kiselina ili njihove kombinacije.
4. ODT sukladno patentnom zahtjevu 3, pri čemu su adheztivno sredstvo i kortikosteroid blisko povezani.
5. ODT sukladno patentnom zahtjevu 1, naznačena time, što je najmanje jedan dezintegrator odabran iz skupine koju čine krospovidon, natrijev škrob glikolat, umrežena karboksimetil celuloza, nisko supstituirana hidroksipropilceluloza, manitol, ksilitol, sorbitol, maltol, maltitol, laktoza, saharoza, maltoza i njihove kombinacije.
6. ODT sukladno patentnom zahtjevu 1, naznačena time, što nadalje sadrži ekscipijens odabran iz skupine koju čine manitol, ksilitol, sorbitol, maltol, maltitol, laktoza, sukroza, maltoza, ciklodekstrin i njihovih kombinacija.
7. ODT sukladno patentnom zahtjevu 1, koja ne sadrži lubrikant.
8. ODT sukladno patentnom zahtjevu 1, naznačena time, što ODT sadrži čestice lijeka i brzo razgrađujuće granule, pri čemu čestice lijeka sadrže kortikosterid, a brzo razgrađujuće granule sadrže najmanje jedno sredstvo za raspadanje i šećerni alkohol i / ili saharid, poželjno da čestice lijeka imaju prosječnu veličinu čestica manju od 400 µm, brzo razgrađujuće granule imaju prosječnu veličinu čestica manju od 300 µm, a dezintegrant i šećerni alkohol i / ili saharid imaju prosječnu veličinu čestica manje od 30 µm; ili gdje je kortikosteroid smješten na površini nekog pomoćnog sredstva, brzo razgrađujućege granule imaju prosječnu veličinu čestica manje od 300 µm, a dezintegrant i šećerni alkohol i / ili saharid imaju prosječnu veličinu čestica manje od 30 µm.
9. ODT sukladno patentnom zahtjevu 8, naznačena time, što ODT sadrži liofiliziranu matricu, pri čemu liofilizirani matriks koji sadrži kortikosteroid u kombinaciji s najmanje jednim ekscipijensom.
10. ODT sukladno patentnom zahtjevu 9, naznačena time što je pomoćni sastojak odabran iz skupine koju čine manitol, ksilitol, sorbitol, maltol, maltitol, laktoza, saharoza, maltoza i njihovih kombinacija.
11. ODT sukladno patentnom zahtjevu 10, naznačena time, što ODT sadrži 0,05-0,3 mg flutikazona.
12. ODT sukladno patentnom zahtjevu 1, naznačena time, da je kortikosteroid flutikazon ili njegov solvat ili ester.
13. ODT sukladno patentnom zahtjevu 12, naznačena time, što ODT sadrži od 0,01 mg do 20 mg, ili od 2 mg do 20 mg, flutikazona.
14. ODT sukladno patentnom zahtjevu 1, naznačen time, da se koristi u liječenju upalnih stanja gastrointestinalnog trakta.
15. ODT za uporabu sukladno zahtjevu 14, naznačena time, što navedena upalno stanje gastrointestinalnog trakta obuhvaća upalu jednjaka, eozinofilni ezofagitis, ili upalu ždrijela, epiglotisa, krajnika ili orofarinksa.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24764209P | 2009-10-01 | 2009-10-01 | |
EP18178891.0A EP3403654B1 (en) | 2009-10-01 | 2010-09-30 | Orally administered corticosteroid compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20191435T1 true HRP20191435T1 (hr) | 2019-11-15 |
Family
ID=43823361
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20181266TT HRP20181266T1 (hr) | 2009-10-01 | 2018-08-08 | Kortikosteroidni pripravci za oralnu primjenu |
HRP20191435 HRP20191435T1 (hr) | 2009-10-01 | 2019-08-08 | Oralno primjenjivi kortikosteroidni sastavi |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20181266TT HRP20181266T1 (hr) | 2009-10-01 | 2018-08-08 | Kortikosteroidni pripravci za oralnu primjenu |
Country Status (35)
Country | Link |
---|---|
US (8) | US8771729B2 (hr) |
EP (4) | EP3403654B1 (hr) |
JP (7) | JP2013506683A (hr) |
KR (3) | KR20140088236A (hr) |
CN (3) | CN107252488A (hr) |
AR (1) | AR078499A1 (hr) |
AU (1) | AU2010300550B2 (hr) |
BR (2) | BR112012007110A2 (hr) |
CA (3) | CA2940931C (hr) |
CL (1) | CL2012000794A1 (hr) |
CO (1) | CO6531427A2 (hr) |
CY (1) | CY1122713T1 (hr) |
DE (1) | DE202010018594U1 (hr) |
DK (2) | DK2482822T3 (hr) |
EA (2) | EA024084B1 (hr) |
ES (2) | ES2742525T3 (hr) |
GE (1) | GEP20156281B (hr) |
HR (2) | HRP20181266T1 (hr) |
HU (2) | HUE040119T2 (hr) |
IL (2) | IL218928A (hr) |
LT (2) | LT2482822T (hr) |
ME (1) | ME03471B (hr) |
MX (4) | MX364947B (hr) |
MY (1) | MY171317A (hr) |
NZ (2) | NZ599401A (hr) |
PL (2) | PL3403654T3 (hr) |
PT (2) | PT3403654T (hr) |
RS (2) | RS57595B1 (hr) |
SG (3) | SG10201704847WA (hr) |
SI (2) | SI2482822T1 (hr) |
TW (2) | TWI562779B (hr) |
UA (2) | UA108360C2 (hr) |
UY (1) | UY32925A (hr) |
WO (1) | WO2011041509A1 (hr) |
ZA (2) | ZA201202208B (hr) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8497258B2 (en) | 2005-11-12 | 2013-07-30 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
US20100216754A1 (en) * | 2007-11-13 | 2010-08-26 | Meritage Pharma, Inc. | Compositions for the treatment of inflammation of the gastrointestinal tract |
MX349677B (es) | 2007-11-13 | 2017-08-08 | Meritage Pharma Inc | Composiciones corticosteroides. |
US20090131386A1 (en) | 2007-11-13 | 2009-05-21 | Meritage Pharma, Inc. | Compositions for the treatment of inflammation of the gastrointestinal tract |
US20110097401A1 (en) * | 2009-06-12 | 2011-04-28 | Meritage Pharma, Inc. | Methods for treating gastrointestinal disorders |
ES2742525T3 (es) | 2009-10-01 | 2020-02-14 | Adare Pharmaceuticals Us L P | Composiciones de corticosteroides administradas oralmente |
EP3970726A1 (en) * | 2010-06-24 | 2022-03-23 | ViroPharma Biologics LLC | Methods of treatment for esophageal inflammation |
WO2012020279A1 (en) * | 2010-08-13 | 2012-02-16 | Compagnie Gervais Danone | Product for the upper gastric sphere |
US8765725B2 (en) | 2012-05-08 | 2014-07-01 | Aciex Therapeutics, Inc. | Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof |
EP2847207B1 (en) | 2012-05-08 | 2019-03-27 | Nicox Ophthalmics, Inc. | Fluticasone propionate nanocrystals |
US9815865B2 (en) | 2013-01-07 | 2017-11-14 | Nicox Ophthalmics, Inc. | Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof |
CA2906029C (en) * | 2013-03-15 | 2017-09-05 | Aprecia Pharmaceuticals Company | Rapid disperse dosage form containing levetiracetam |
US10716802B2 (en) | 2013-03-15 | 2020-07-21 | The Brigham And Women's Hospital, Inc. | Compounds to modulate intestinal absorption of nutrients |
US9339489B2 (en) | 2013-03-15 | 2016-05-17 | Aprecia Pharmaceuticals Company | Rapid disperse dosage form containing levetiracetam |
GB201308933D0 (en) * | 2013-05-17 | 2013-07-03 | Diurnal Ltd | Paediatric composition |
US9078853B2 (en) | 2013-06-18 | 2015-07-14 | Cmpd Licensing, Llc | Dry pharmaceutical compositions for topical delivery of oral medications, nasal delivery and to treat ear disorders |
WO2015034678A2 (en) * | 2013-09-06 | 2015-03-12 | Aptalis Pharmatech, Inc. | Corticosteroid containing orally disintegrating tablet compositions for eosinophilic esophagitis |
WO2015152517A1 (ko) * | 2014-03-31 | 2015-10-08 | (주)세하바이오 | 항산화 물질 활성 보호를 위한 프롤라민 기반 경구용 필름 제조방법 |
EP3047846A1 (en) | 2015-01-22 | 2016-07-27 | Ems S.A. | Dosage forms containing fluticasone propionate for the treatment of inflammatory conditions of the esophagus |
US9980975B2 (en) | 2015-01-22 | 2018-05-29 | Ems S.A. | Dosage forms containing fluticasone propionate for the treatment of inflammatory conditions of the esophagus |
EP3288556A4 (en) | 2015-04-29 | 2018-09-19 | Dexcel Pharma Technologies Ltd. | Orally disintegrating compositions |
US9867834B2 (en) | 2015-06-15 | 2018-01-16 | Banner Life Sciences Llc | Non-systemic topical compositions comprising corticosteroids |
US9877971B2 (en) | 2015-06-15 | 2018-01-30 | Banner Life Sciences Llc | Soft lozenges comprising corticosteroids |
US10973846B2 (en) | 2015-09-24 | 2021-04-13 | The Brigham And Women's Hospital, Inc. | Water-activated mucoadhesive compositions to reduce intestinal absorption of nutrients |
CN105412123B (zh) * | 2015-11-06 | 2018-03-13 | 山东省千佛山医院 | 布地奈德联合三唑类抗真菌药物的应用及其产品 |
US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
TWI728172B (zh) | 2016-08-18 | 2021-05-21 | 美商愛戴爾製藥股份有限公司 | 治療嗜伊紅性食道炎之方法 |
US9999604B2 (en) | 2016-11-17 | 2018-06-19 | Cmpd Licensing, Llc | Compounded solutions of diclofenac and lidocaine and methods |
US11737975B2 (en) | 2016-11-17 | 2023-08-29 | Cmpd Licensing, Llc | Compounded compositions and methods for treating pain |
US10525025B2 (en) | 2016-11-17 | 2020-01-07 | Cmpd Licensing, Llc | Compounded compositions and methods for treating pain |
US10966946B2 (en) | 2016-11-17 | 2021-04-06 | Cmpd Licensing, Llc | Compounded compositions and methods for treating pain |
US11986448B2 (en) | 2016-11-17 | 2024-05-21 | Cmpd Licensing, Llc | Compounded compositions and methods for treating pain |
CN107595765A (zh) * | 2017-09-22 | 2018-01-19 | 沈阳兴齐眼药股份有限公司 | 一种眼用缓释药物递送系统及其制备方法 |
WO2019157453A1 (en) * | 2018-02-12 | 2019-08-15 | Trilogy Therapeutics, Inc. | Caspofungin compositions for inhalation |
SI25373A (sl) | 2018-05-08 | 2018-08-31 | Danijela Marković | Naravna orodisperzibilna tableta |
WO2020227437A1 (en) | 2019-05-06 | 2020-11-12 | Axial Biotherapeutics, Inc. | Sustained release solid dosage forms for modulating the colonic microbiome |
US20220347189A1 (en) * | 2019-10-01 | 2022-11-03 | Ellodi Pharmaceuticals, L.P. | Methods of treating eosinophilic esophagitis and reducing candidiasis |
KR102275997B1 (ko) * | 2019-11-07 | 2021-07-13 | 연세대학교 산학협력단 | 숙주지향치료를 위한 조성물 |
CN114146089B (zh) * | 2021-12-15 | 2023-06-16 | 安徽贝克生物制药有限公司 | 含依非韦伦、替诺福韦和恩曲他滨的药物组合物 |
CN116869927B (zh) * | 2023-09-06 | 2023-11-10 | 中国医学科学院北京协和医院 | 一种用于治疗嗜酸性食管炎的食道温敏凝胶 |
Family Cites Families (96)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1170188A (en) * | 1967-09-15 | 1969-11-12 | Bayer Ag | N-trityl-imidazoles and salts and uses thereof |
SE378109B (hr) | 1972-05-19 | 1975-08-18 | Bofors Ab | |
DE2260384C3 (de) * | 1972-12-09 | 1979-11-29 | Hoechst Ag, 6000 Frankfurt | Oral zu applizierendes Corticosteroid-Präparat |
US4080448A (en) | 1974-11-13 | 1978-03-21 | Mirsky Louis H | Method of treating cellular stress |
JPS56138200A (en) * | 1980-02-15 | 1981-10-28 | Glaxo Group Ltd | Androstane carbothioate compound |
SE8004580L (sv) | 1980-06-19 | 1981-12-20 | Draco Ab | Farmaceutisk beredning |
EP0057401B1 (en) * | 1981-02-02 | 1984-08-01 | Schering Corporation | Aromatic heterocyclic esters of steroids, their preparation and pharmaceutical compositions containing them |
GB8630913D0 (en) | 1986-12-24 | 1987-02-04 | Glaxo Group Ltd | Pharmaceutical compositions |
US5446070A (en) | 1991-02-27 | 1995-08-29 | Nover Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
ZA892859B (en) | 1988-04-22 | 1989-12-27 | Advanced Polymer Systems Inc | Porous particles in preparations involving immiscible phases |
US5278175A (en) * | 1990-02-02 | 1994-01-11 | Pfizer Inc. | Triazole antifungal agents |
GB9002375D0 (en) | 1990-02-02 | 1990-04-04 | Pfizer Ltd | Triazole antifungal agents |
GR1001529B (el) * | 1990-09-07 | 1994-03-31 | Elmuquimica Farm Sl | Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης. |
CA2101773A1 (en) | 1991-01-31 | 1992-08-01 | Toyoichi Tanaka | Interpenetrating-polymer network phase-transition gels |
US5252337A (en) | 1991-06-25 | 1993-10-12 | Eurand America, Inc. | Controlled release calcium channel blocker microcapsules |
DE69424181T2 (de) | 1993-12-20 | 2000-10-19 | Minnesota Mining & Mfg | Flunisolide aerosolformulierungen |
US5639475A (en) | 1995-02-03 | 1997-06-17 | Eurand America, Incorporated | Effervescent microcapsules |
SE9501384D0 (sv) * | 1995-04-13 | 1995-04-13 | Astra Ab | Process for the preparation of respirable particles |
GB9517062D0 (en) | 1995-08-18 | 1995-10-25 | Scherer Ltd R P | Pharmaceutical compositions |
DE19606151C2 (de) | 1996-02-20 | 1999-05-12 | Losan Pharma Gmbh | Ibuprofen-Brausezubereitung sowie Verfahren zur Herstellung derselben |
US8071128B2 (en) | 1996-06-14 | 2011-12-06 | Kyowa Hakko Kirin Co., Ltd. | Intrabuccally rapidly disintegrating tablet and a production method of the tablets |
DK0914818T3 (da) | 1996-06-14 | 2005-07-04 | Kyowa Hakko Kogyo Kk | Intraoralt hurtigt desintegrerbar tablet |
AU722289B2 (en) | 1996-10-01 | 2000-07-27 | Aptalis Pharmatech, Inc. | Taste-masked microcapsule compositions and methods of manufacture |
SE9604486D0 (sv) | 1996-12-05 | 1996-12-05 | Astra Ab | Novel formulation |
GB9707934D0 (en) * | 1997-04-18 | 1997-06-04 | Danbiosyst Uk | Improved delivery of drugs to mucosal surfaces |
IT1291362B1 (it) | 1997-05-13 | 1999-01-07 | Vectorpharma Int | Composizioni farmaceutiche multicomponente bifasiche contenenti sostanze atte a modificare la partizione dei principi attivi |
RO118174B1 (ro) | 1997-08-21 | 2003-03-28 | Aventis Pharma Deutschland Gmbh | Lac de unghii şi utilizarea acestuia |
GB9722426D0 (en) | 1997-10-23 | 1997-12-24 | Univ London Pharmacy | Controlled release formulations |
AU741992B2 (en) | 1998-03-06 | 2001-12-13 | Adare Pharmaceuticals S.R.L. | Fast disintegrating tablets |
FR2781156B1 (fr) * | 1998-07-20 | 2001-06-29 | Lafon Labor | Composition pharmaceutique destinee notamment a la prevention et au traitement des radiomucites et des chimiomucites |
US6596298B2 (en) | 1998-09-25 | 2003-07-22 | Warner-Lambert Company | Fast dissolving orally comsumable films |
US6863378B2 (en) | 1998-10-16 | 2005-03-08 | Silverbrook Research Pty Ltd | Inkjet printer having enclosed actuators |
PT1178808E (pt) | 1999-04-23 | 2012-08-16 | Leo Pharma As | Composição farmacêutica não aquosa para utilização dérmica para o tratamento da psoríase compreendendo uma vitamina d, um corticosteróide e de um componente solvente |
GB9915319D0 (en) | 1999-06-30 | 1999-09-01 | Unilever Plc | Hair treatment compositions |
CA2317999C (en) | 1999-09-11 | 2004-11-09 | Glaxo Group Limited | Pharmaceutical formulation of fluticasone propionate |
KR100446101B1 (ko) * | 2000-12-07 | 2004-08-30 | 주식회사 삼양사 | 수난용성 약물의 서방성 제형 조성물 |
EP1367999A4 (en) | 2001-02-16 | 2007-04-18 | Lavipharm Lab Inc | WATER-SOLUBLE AND PALATABLE COMPLEXES |
US20030050312A1 (en) | 2001-03-12 | 2003-03-13 | Hjorth Thyge Borup | Novel tablets and capsules and a process for its preparation |
CA2440935A1 (en) * | 2001-03-13 | 2002-09-19 | Richard Liggins | Micellar drug delivery vehicles and precursors thereto and uses thereof |
US6872405B2 (en) | 2001-05-10 | 2005-03-29 | Yamanouchi Pharmaceutical Co., Ltd. | Quick-disintegrating tablet in buccal cavity and manufacturing method thereof |
CA2419290C (en) * | 2001-05-10 | 2007-03-27 | Yuuki Takaishi | Quick-disintegrating tablet in the buccal cavity and manufacturing method thereof |
US6656493B2 (en) | 2001-07-30 | 2003-12-02 | Wm. Wrigley Jr. Company | Edible film formulations containing maltodextrin |
FR2831820B1 (fr) | 2001-11-05 | 2004-08-20 | Ethypharm Sa | Comprime orodispersible presentant une grande homogeneite et son procede de preparation |
US20030206978A1 (en) | 2001-11-29 | 2003-11-06 | Bob Sherwood | Agglomerated particles including an active agent coprocessed with silicified microcrystalline cellulose |
US20040009212A1 (en) | 2002-01-30 | 2004-01-15 | Pharma Power Biotec Co. Ltd. | Mucoadhesive thermoresponsive medicament-carrier composition |
JP4173670B2 (ja) * | 2002-03-08 | 2008-10-29 | 旭化成ファーマ株式会社 | 口腔内崩壊製剤 |
US6958192B2 (en) | 2002-04-05 | 2005-10-25 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Polyimides from 2,3,3′,4′-biphenyltetracarboxylic dianhydride and aromatic diamines |
DE60318035T2 (de) * | 2002-05-03 | 2008-12-11 | Janssen Pharmaceutica N.V. | Polymermikroemulsionen |
WO2004006481A2 (en) | 2002-07-10 | 2004-01-15 | I/O Controls Corporation | Fiber optic control network and related method |
US20040106663A1 (en) * | 2002-09-06 | 2004-06-03 | Talley John Jeffrey | Inhibitors of fungal invasion |
AU2003272450A1 (en) | 2002-09-13 | 2004-04-30 | C. Steven Smith | Novel composition and method for treatment of upper respiratory conditions |
US7731947B2 (en) | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
EP1595533B1 (en) | 2003-01-21 | 2010-01-06 | Nippon Shinyaku Co., Ltd. | Tablet quickly melting in oral cavity |
ATE329594T1 (de) * | 2003-01-31 | 2006-07-15 | Orexo Ab | Schnell wirkende pharmazeutische zusammensetzung |
US20040208833A1 (en) | 2003-02-04 | 2004-10-21 | Elan Pharma International Ltd. | Novel fluticasone formulations |
US8012505B2 (en) | 2003-02-28 | 2011-09-06 | Alk-Abello A/S | Dosage form having a saccharide matrix |
US20040265375A1 (en) | 2003-04-16 | 2004-12-30 | Platteeuw Johannes J. | Orally disintegrating tablets |
US20050009848A1 (en) * | 2003-07-10 | 2005-01-13 | Icn Pharmaceuticals Switzerland Ltd. | Use of antivirals against inflammatory bowel diseases |
DE602005014227D1 (de) | 2004-03-10 | 2009-06-10 | Bayer Schering Pharma Ag | Zusammensetzungen aus drospirenon in molekularer dispersion |
US8545881B2 (en) | 2004-04-19 | 2013-10-01 | Eurand Pharmaceuticals, Ltd. | Orally disintegrating tablets and methods of manufacture |
EP1634586B1 (en) | 2004-09-09 | 2007-02-14 | Laboratorio Medinfar-Produtos Farmaceuticos, S.A. | Fast water-dispersible domperidone tablets |
US20060105038A1 (en) | 2004-11-12 | 2006-05-18 | Eurand Pharmaceuticals Limited | Taste-masked pharmaceutical compositions prepared by coacervation |
US20070020330A1 (en) | 2004-11-24 | 2007-01-25 | Medpointe Healthcare Inc. | Compositions comprising azelastine and methods of use thereof |
US20060292099A1 (en) | 2005-05-25 | 2006-12-28 | Michael Milburn | Treatment of eye disorders with sirtuin modulators |
TW200800142A (en) * | 2005-09-09 | 2008-01-01 | Univ Manitoba | Fast-disintegrating epinephrine tablets for buccal or sublingual administration |
US8497258B2 (en) * | 2005-11-12 | 2013-07-30 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
US8679545B2 (en) | 2005-11-12 | 2014-03-25 | The Regents Of The University Of California | Topical corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract |
US8324192B2 (en) | 2005-11-12 | 2012-12-04 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
CN1985799B (zh) * | 2005-12-19 | 2011-11-09 | 量子高科(北京)研究院有限公司 | 口腔崩解制剂的制备方法 |
BRPI0620578A2 (pt) | 2005-12-27 | 2011-12-06 | Jubilant Organosys Ltd | composição farmacêutica que dissolve na boca e processo para o preparo da mesma |
US20080260655A1 (en) * | 2006-11-14 | 2008-10-23 | Dov Tamarkin | Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses |
EP1958613A1 (en) | 2007-02-15 | 2008-08-20 | Polichem S.A. | Dermal film-forming liquid formulations for drug release to skin |
EP2148659A2 (en) | 2007-04-13 | 2010-02-03 | Somaxon Pharmaceuticals, Inc. | Low-dose doxepin formulations |
US20150231156A1 (en) | 2007-11-13 | 2015-08-20 | Meritage Pharma, Inc. | Corticosteroid compositions |
US20100216754A1 (en) | 2007-11-13 | 2010-08-26 | Meritage Pharma, Inc. | Compositions for the treatment of inflammation of the gastrointestinal tract |
US20090131386A1 (en) * | 2007-11-13 | 2009-05-21 | Meritage Pharma, Inc. | Compositions for the treatment of inflammation of the gastrointestinal tract |
MX349677B (es) | 2007-11-13 | 2017-08-08 | Meritage Pharma Inc | Composiciones corticosteroides. |
US20090123551A1 (en) * | 2007-11-13 | 2009-05-14 | Meritage Pharma, Inc. | Gastrointestinal delivery systems |
CA2708152A1 (en) * | 2007-12-10 | 2009-06-18 | Eurand, Inc | Orally disintegrating tablets comprising diphenhydramine |
BRPI0821761A2 (pt) * | 2007-12-21 | 2015-06-16 | Eurand Inc | Composições de comprimidos de desintegração oral de temazepam |
JP2009173552A (ja) * | 2008-01-21 | 2009-08-06 | Lion Corp | 胃腸薬 |
SE533435C2 (sv) | 2008-04-03 | 2010-09-28 | Hm Power Ab | Vridmomentsöverförande arrangemang vid ett vindkraftverk |
PL2151235T3 (pl) | 2008-07-21 | 2011-05-31 | Dr Falk Pharma Gmbh | Preparat farmaceutyczny do leczenia górnego przewodu pokarmowego |
US20100034894A1 (en) | 2008-08-08 | 2010-02-11 | Szymczak Christopher E | Use of Sucralose as a Granulating Agent |
HUE051538T2 (hu) | 2008-08-20 | 2021-03-01 | Univ California | Kortikoszteroidok a gyomor-bél traktus gyulladásos betegségeinek kezelésére |
US20110097401A1 (en) | 2009-06-12 | 2011-04-28 | Meritage Pharma, Inc. | Methods for treating gastrointestinal disorders |
ES2742525T3 (es) | 2009-10-01 | 2020-02-14 | Adare Pharmaceuticals Us L P | Composiciones de corticosteroides administradas oralmente |
US20120282335A1 (en) | 2010-12-02 | 2012-11-08 | Aptalis Pharmatech Inc. | Rapidly dispersing granules, orally disintegrating tablets and methods |
WO2015034678A2 (en) | 2013-09-06 | 2015-03-12 | Aptalis Pharmatech, Inc. | Corticosteroid containing orally disintegrating tablet compositions for eosinophilic esophagitis |
SI2886108T2 (sl) | 2013-12-23 | 2023-02-28 | Dr. Falk Pharma Gmbh | Optimizirana farmacevtska formulacija za zdravljenje vnetnih sprememb požiralnika |
US10294517B2 (en) | 2014-03-17 | 2019-05-21 | Children's Hospital Medical Center | Genetic test for determining susceptibility for eosinophilic esophagitis |
US10176301B2 (en) | 2014-09-11 | 2019-01-08 | Meritage Pharma, Inc. | Systems, methods, and software for providing a patient-reported outcome measure of dysphagia patients with eosinophilic esophagitis |
US9980975B2 (en) | 2015-01-22 | 2018-05-29 | Ems S.A. | Dosage forms containing fluticasone propionate for the treatment of inflammatory conditions of the esophagus |
TWI728172B (zh) * | 2016-08-18 | 2021-05-21 | 美商愛戴爾製藥股份有限公司 | 治療嗜伊紅性食道炎之方法 |
CN112334189A (zh) | 2018-02-21 | 2021-02-05 | 美国阿代尔制药公司 | 管理嗜酸细胞性食管炎的方法 |
US20220347189A1 (en) | 2019-10-01 | 2022-11-03 | Ellodi Pharmaceuticals, L.P. | Methods of treating eosinophilic esophagitis and reducing candidiasis |
-
2010
- 2010-09-30 ES ES18178891T patent/ES2742525T3/es active Active
- 2010-09-30 CA CA2940931A patent/CA2940931C/en active Active
- 2010-09-30 GE GEAP201012674A patent/GEP20156281B/en unknown
- 2010-09-30 SI SI201031731T patent/SI2482822T1/sl unknown
- 2010-09-30 PT PT18178891T patent/PT3403654T/pt unknown
- 2010-09-30 CN CN201710261488.7A patent/CN107252488A/zh active Pending
- 2010-09-30 HU HUE10821232A patent/HUE040119T2/hu unknown
- 2010-09-30 RS RS20180962A patent/RS57595B1/sr unknown
- 2010-09-30 LT LTEP10821232.5T patent/LT2482822T/lt unknown
- 2010-09-30 EP EP18178891.0A patent/EP3403654B1/en active Active
- 2010-09-30 EP EP20192973.4A patent/EP3760187A1/en active Pending
- 2010-09-30 KR KR1020147017747A patent/KR20140088236A/ko not_active Application Discontinuation
- 2010-09-30 BR BR112012007110-6A patent/BR112012007110A2/pt not_active Application Discontinuation
- 2010-09-30 CA CA2776164A patent/CA2776164C/en active Active
- 2010-09-30 SG SG10201704847WA patent/SG10201704847WA/en unknown
- 2010-09-30 WO PCT/US2010/050860 patent/WO2011041509A1/en active Application Filing
- 2010-09-30 PT PT10821232T patent/PT2482822T/pt unknown
- 2010-09-30 CN CN201611030531.0A patent/CN106421797A/zh active Pending
- 2010-09-30 EP EP14184844.0A patent/EP2845595A1/en active Pending
- 2010-09-30 DK DK10821232.5T patent/DK2482822T3/en active
- 2010-09-30 HU HUE18178891A patent/HUE046748T2/hu unknown
- 2010-09-30 LT LTEP18178891.0T patent/LT3403654T/lt unknown
- 2010-09-30 CA CA3037273A patent/CA3037273C/en active Active
- 2010-09-30 EA EA201290171A patent/EA024084B1/ru unknown
- 2010-09-30 SG SG10201912526TA patent/SG10201912526TA/en unknown
- 2010-09-30 DE DE202010018594.7U patent/DE202010018594U1/de not_active Expired - Lifetime
- 2010-09-30 MX MX2012003823A patent/MX364947B/es active IP Right Grant
- 2010-09-30 SI SI201031925T patent/SI3403654T1/sl unknown
- 2010-09-30 UA UAA201203919A patent/UA108360C2/ru unknown
- 2010-09-30 EP EP10821232.5A patent/EP2482822B1/en not_active Revoked
- 2010-09-30 ES ES10821232.5T patent/ES2683864T3/es active Active
- 2010-09-30 ME MEP-2019-223A patent/ME03471B/me unknown
- 2010-09-30 JP JP2012532304A patent/JP2013506683A/ja active Pending
- 2010-09-30 RS RSP20191082 patent/RS59241B1/sr unknown
- 2010-09-30 CN CN2010800470168A patent/CN102665722A/zh active Pending
- 2010-09-30 KR KR1020127010779A patent/KR20120104975A/ko active Application Filing
- 2010-09-30 KR KR1020157008676A patent/KR20150043548A/ko not_active Application Discontinuation
- 2010-09-30 MY MYPI2012001434A patent/MY171317A/en unknown
- 2010-09-30 PL PL18178891T patent/PL3403654T3/pl unknown
- 2010-09-30 EA EA201491358A patent/EA031157B9/ru unknown
- 2010-09-30 SG SG10201405886WA patent/SG10201405886WA/en unknown
- 2010-09-30 BR BR122022005637-7A patent/BR122022005637B1/pt active IP Right Grant
- 2010-09-30 UA UAA201413781A patent/UA118087C2/uk unknown
- 2010-09-30 AU AU2010300550A patent/AU2010300550B2/en active Active
- 2010-09-30 DK DK18178891.0T patent/DK3403654T3/da active
- 2010-09-30 NZ NZ599401A patent/NZ599401A/en unknown
- 2010-09-30 NZ NZ624922A patent/NZ624922A/en unknown
- 2010-09-30 PL PL10821232T patent/PL2482822T3/pl unknown
- 2010-10-01 US US12/896,005 patent/US8771729B2/en active Active
- 2010-10-01 TW TW099133628A patent/TWI562779B/zh active
- 2010-10-01 UY UY0001032925A patent/UY32925A/es not_active Application Discontinuation
- 2010-10-01 TW TW104107443A patent/TWI594754B/zh active
- 2010-10-01 AR ARP100103589A patent/AR078499A1/es unknown
-
2012
- 2012-03-27 ZA ZA2012/02208A patent/ZA201202208B/en unknown
- 2012-03-29 MX MX2019005289A patent/MX2019005289A/es unknown
- 2012-03-29 MX MX2022003132A patent/MX2022003132A/es unknown
- 2012-03-29 IL IL218928A patent/IL218928A/en active IP Right Grant
- 2012-03-29 MX MX2020007226A patent/MX2020007226A/es unknown
- 2012-03-30 CL CL2012000794A patent/CL2012000794A1/es unknown
- 2012-04-04 CO CO12056405A patent/CO6531427A2/es not_active Application Discontinuation
-
2013
- 2013-02-22 ZA ZA2013/01380A patent/ZA201301380B/en unknown
-
2014
- 2014-06-03 US US14/294,660 patent/US9486407B2/en active Active
- 2014-06-23 US US14/311,732 patent/US9387167B2/en active Active
- 2014-12-24 JP JP2014261068A patent/JP6249935B2/ja active Active
-
2015
- 2015-05-20 IL IL238915A patent/IL238915A/en active IP Right Grant
-
2016
- 2016-07-08 US US15/205,390 patent/US9849084B2/en active Active
- 2016-10-07 JP JP2016199156A patent/JP6293230B2/ja active Active
-
2017
- 2017-11-17 US US15/816,154 patent/US10632069B2/en active Active
-
2018
- 2018-02-13 JP JP2018022869A patent/JP2018100286A/ja active Pending
- 2018-08-08 HR HRP20181266TT patent/HRP20181266T1/hr unknown
-
2019
- 2019-08-08 HR HRP20191435 patent/HRP20191435T1/hr unknown
- 2019-08-19 CY CY20191100883T patent/CY1122713T1/el unknown
-
2020
- 2020-02-24 JP JP2020028900A patent/JP7042015B2/ja active Active
- 2020-03-17 US US16/821,464 patent/US11246828B2/en active Active
-
2021
- 2021-04-21 US US17/236,295 patent/US11266598B2/en active Active
-
2022
- 2022-01-05 US US17/569,047 patent/US20220339098A1/en active Pending
- 2022-03-12 JP JP2022038712A patent/JP2022078275A/ja active Pending
-
2023
- 2023-08-31 JP JP2023140872A patent/JP2023166486A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HRP20191435T1 (hr) | Oralno primjenjivi kortikosteroidni sastavi | |
JP2013506683A5 (hr) | ||
Sardo et al. | A review on 5-aminosalicylic acid colon-targeted oral drug delivery systems | |
US20090186086A1 (en) | Solid multilayer oral dosage forms | |
JP2011157401A5 (hr) | ||
Rabišková et al. | Coated chitosan pellets containing rutin intended for the treatment of inflammatory bowel disease: in vitro characteristics and in vivo evaluation | |
JP2016006108A5 (hr) | ||
RU2019100068A (ru) | Композиции перорально распадающихся таблеток, содержащие кортикостероиды, для лечения эозинофильного эзофагита | |
JP2016525572A5 (hr) | ||
JP5534004B2 (ja) | 口腔内崩壊錠 | |
JP2007517016A5 (hr) | ||
JP4634713B2 (ja) | ヘパリン又はその誘導体の経口的投与のための製薬学的組成物 | |
CN101628002B (zh) | 一种微粉化的含左炔诺孕酮的组合物 | |
CN101721385B (zh) | 一种美沙拉嗪口服控释药物组合物 | |
RU2012131949A (ru) | Фармацевтическая композиция реина или диацереина и способ ее получения | |
JP5614445B2 (ja) | 経口投与用粒子状医薬組成物 | |
Panday et al. | Calcium silicate‐reinforced pH‐sensitive alginate‐gellan gum composite hydrogels for prolonged drug delivery | |
CN102727456B (zh) | 药物口腔崩解片及其制备方法 | |
CA2877190C (en) | Medicament form for release of active ingredients | |
WO2012147101A2 (en) | Pharmaceutical compositions of raltegravir, methods of preparation and use thereof | |
US20140370105A1 (en) | Treatment of inflammatory bowel disease with 6-mercaptopurine | |
JP2010506855A5 (hr) | ||
CN102358749B (zh) | 一种罗红霉素氨溴索片剂组合物及其制备方法 | |
IT201800005908A1 (it) | Compressa gastroresistente rivestita con film per il rilascio protratto di acido butirrico | |
CN103083314A (zh) | 具有胃肠道保护作用的复方布洛芬 |