EA005890B1 - СПОСОБЫ ЛЕЧЕНИЯ ИНФЕКЦИЙ, ВЫЗЫВАЕМЫХ ВИРУСОМ ГЕПАТИТА ДЕЛЬТА, С ИСПОЛЬЗОВАНИЕМ β-L-2'-ДЕЗОКСИНУКЛЕОЗИДОВ - Google Patents

Info

Publication number

EA005890B1

EA005890B1 EA200201263A EA200201263A EA005890B1 EA 005890 B1 EA005890 B1 EA 005890B1 EA 200201263 A EA200201263 A EA 200201263A EA 200201263 A EA200201263 A EA 200201263A EA 005890 B1 EA005890 B1 EA 005890B1

Authority

EA

Eurasian Patent Office

Prior art keywords

deoxy

acyl

triphosphate

mono

pharmaceutically acceptable

Prior art date

2000-05-26

Links

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• Global Dossier
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• 238000000034 method Methods 0.000 title claims abstract description 56
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• 230000009385 viral infection Effects 0.000 title description 6
• 150000003839 salts Chemical class 0.000 claims abstract description 83
• 239000000651 prodrug Substances 0.000 claims abstract description 66
• 229940002612 prodrug Drugs 0.000 claims abstract description 66
• 239000000203 mixture Substances 0.000 claims abstract description 58
• 238000011282 treatment Methods 0.000 claims abstract description 29
• 150000001875 compounds Chemical class 0.000 claims description 119
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• 235000011178 triphosphate Nutrition 0.000 claims description 59
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• 125000002252 acyl group Chemical group 0.000 claims description 48
• 125000000217 alkyl group Chemical group 0.000 claims description 37
• 229910052739 hydrogen Inorganic materials 0.000 claims description 37
• 208000006454 hepatitis Diseases 0.000 claims description 30
• 125000000539 amino acid group Chemical group 0.000 claims description 28
• 125000004390 alkyl sulfonyl group Chemical group 0.000 claims description 26
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• 125000004391 aryl sulfonyl group Chemical group 0.000 claims description 25
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• KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims description 11
• KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims description 11
• 229910052736 halogen Inorganic materials 0.000 claims description 11
• 150000002367 halogens Chemical class 0.000 claims description 11
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• 239000001257 hydrogen Substances 0.000 claims 9
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• IQFYYKKMVGJFEH-CSMHCCOUSA-N telbivudine Chemical compound O=C1NC(=O)C(C)=CN1[C@H]1O[C@@H](CO)[C@H](O)C1 IQFYYKKMVGJFEH-CSMHCCOUSA-N 0.000 claims 1
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