DK3781561T3 - Modulatorer af methylmodificerende enzymer, sammensætninger og anvendelser deraf - Google Patents

Modulatorer af methylmodificerende enzymer, sammensætninger og anvendelser deraf Download PDF

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Publication number
DK3781561T3
DK3781561T3 DK19722363.9T DK19722363T DK3781561T3 DK 3781561 T3 DK3781561 T3 DK 3781561T3 DK 19722363 T DK19722363 T DK 19722363T DK 3781561 T3 DK3781561 T3 DK 3781561T3
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Prior art keywords
modulators
compositions
methyl
modifying enzymes
enzymes
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DK19722363.9T
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Danish (da)
English (en)
Inventor
Victor S Gehling
Avinash Khanna
Ludivine Moine
Jacob I Stuckey
Alexandre Côté
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Constellation Pharmaceuticals Inc
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Publication of DK3781561T3 publication Critical patent/DK3781561T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
DK19722363.9T 2018-04-18 2019-04-17 Modulatorer af methylmodificerende enzymer, sammensætninger og anvendelser deraf DK3781561T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862659408P 2018-04-18 2018-04-18
PCT/US2019/027932 WO2019204490A1 (en) 2018-04-18 2019-04-17 Modulators of methyl modifying enzymes, compositions and uses thereof

Publications (1)

Publication Number Publication Date
DK3781561T3 true DK3781561T3 (da) 2024-06-17

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US (4) US10689371B2 (enExample)
EP (2) EP4421072A1 (enExample)
JP (2) JP7256823B2 (enExample)
KR (2) KR102798145B1 (enExample)
CN (2) CN111989325B (enExample)
AR (1) AR114793A1 (enExample)
AU (1) AU2019255310B2 (enExample)
BR (1) BR112020021194A2 (enExample)
CL (1) CL2020002698A1 (enExample)
CO (1) CO2020014217A2 (enExample)
CR (1) CR20200553A (enExample)
DK (1) DK3781561T3 (enExample)
EA (1) EA202092490A1 (enExample)
ES (1) ES2983344T3 (enExample)
FI (1) FI3781561T3 (enExample)
HR (1) HRP20240793T1 (enExample)
HU (1) HUE066783T2 (enExample)
IL (1) IL278013B2 (enExample)
LT (1) LT3781561T (enExample)
MA (1) MA52288B1 (enExample)
MD (1) MD3781561T2 (enExample)
MX (1) MX2020010999A (enExample)
MY (1) MY208662A (enExample)
PE (1) PE20201448A1 (enExample)
PH (1) PH12020551578A1 (enExample)
PL (1) PL3781561T3 (enExample)
PT (1) PT3781561T (enExample)
RS (1) RS65621B1 (enExample)
SG (1) SG11202009438UA (enExample)
SI (1) SI3781561T1 (enExample)
SM (1) SMT202400233T1 (enExample)
TW (1) TWI828677B (enExample)
UA (1) UA127357C2 (enExample)
WO (1) WO2019204490A1 (enExample)

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KR102689665B1 (ko) 2019-02-19 2024-07-31 한미약품 주식회사 신규한 헤테로트리시클릭 유도체 화합물 및 이의 용도
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KR20220041130A (ko) * 2019-07-24 2022-03-31 콘스텔레이션 파마슈티칼스, 인크. 암 치료를 위한 병용 요법에서의 ezh2 억제
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