DK342489A - Fremgangsmaade og mellemprodukter til syntese af l-(-)-2-amino-3-(3,4-dihydroxyphenyl)-propionsyre - Google Patents
Fremgangsmaade og mellemprodukter til syntese af l-(-)-2-amino-3-(3,4-dihydroxyphenyl)-propionsyre Download PDFInfo
- Publication number
- DK342489A DK342489A DK342489A DK342489A DK342489A DK 342489 A DK342489 A DK 342489A DK 342489 A DK342489 A DK 342489A DK 342489 A DK342489 A DK 342489A DK 342489 A DK342489 A DK 342489A
- Authority
- DK
- Denmark
- Prior art keywords
- dihydroxyphenyl
- intermediates
- synthesis
- amino
- propionic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/34—Preparation of optical isomers by separation of optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
- C07C255/43—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms the carbon skeleton being further substituted by singly-bound oxygen atoms
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT8821322A IT1226902B (it) | 1988-07-12 | 1988-07-12 | Processo per la sintesi del levodopa |
| IT2132288 | 1988-07-12 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK342489D0 DK342489D0 (da) | 1989-07-11 |
| DK342489A true DK342489A (da) | 1990-01-13 |
| DK172106B1 DK172106B1 (da) | 1997-10-27 |
Family
ID=11180092
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK342489A DK172106B1 (da) | 1988-07-12 | 1989-07-11 | Ny fremgangsmåde og mellemprodukter og anvendelse heraf til syntese af levodopa |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US4962223A (da) |
| EP (1) | EP0357565B1 (da) |
| JP (1) | JP2507069B2 (da) |
| KR (1) | KR960004185B1 (da) |
| AR (1) | AR248267A1 (da) |
| AT (1) | ATE111439T1 (da) |
| AU (1) | AU615083B2 (da) |
| CA (1) | CA1338672C (da) |
| DD (1) | DD284674A5 (da) |
| DE (1) | DE68918207T2 (da) |
| DK (1) | DK172106B1 (da) |
| ES (1) | ES2063837T3 (da) |
| FI (1) | FI101534B (da) |
| HU (1) | HU203318B (da) |
| IE (1) | IE65956B1 (da) |
| IL (1) | IL90844A0 (da) |
| IT (1) | IT1226902B (da) |
| NO (1) | NO174293C (da) |
| NZ (1) | NZ229910A (da) |
| PL (1) | PL160103B1 (da) |
| PT (1) | PT91144B (da) |
| YU (1) | YU47907B (da) |
| ZA (1) | ZA895255B (da) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5459145A (en) * | 1988-01-19 | 1995-10-17 | Pfizer Inc. | Calcium independent camp phosphodiesterase inhibitor antidepressant |
| IT1226903B (it) * | 1988-07-12 | 1991-02-21 | Mini Ricerca Scient Tecnolog | Processo per la sintesi di aminoacidi otticamente attivi |
| US5395935A (en) * | 1992-05-08 | 1995-03-07 | Pfizer Inc. | Endo-bicyclo[2.2.1]heptan-2-ol and derived pharmaceutical agents |
| DE19502967A1 (de) * | 1995-01-31 | 1996-08-01 | Basf Ag | Verfahren zur Racemattrennung von 2-Aryl-2-omega-alkylaminoalkannitrilen |
| JP3634207B2 (ja) * | 1999-09-14 | 2005-03-30 | 独立行政法人科学技術振興機構 | 光学活性なα−アミノニトリル並びにα−アミノ酸類の製造方法 |
| US20040002615A1 (en) * | 2002-06-28 | 2004-01-01 | Allen David Robert | Preparation of chiral amino-nitriles |
| US20040180086A1 (en) * | 2002-10-11 | 2004-09-16 | Zebunnissa Ramtoola | Gastro-retentive levodopa delivery form |
| DE10261807A1 (de) | 2002-12-19 | 2004-07-01 | Turicum Drug Development Ag | Deuterierte Catecholaminderivate sowie diese Verbindungen enthaltende Arzneimittel |
| WO2004069146A2 (en) * | 2003-02-07 | 2004-08-19 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | L-dopa amide derivatives and uses thereof |
| USRE46555E1 (en) | 2006-02-17 | 2017-09-19 | Teva Pharmaceuticals International Gmbh | Deuterated catecholamine derivatives and medicaments comprising said compounds |
| US10258585B2 (en) | 2014-03-13 | 2019-04-16 | Neuroderm, Ltd. | DOPA decarboxylase inhibitor compositions |
| ES2967693T3 (es) | 2014-03-13 | 2024-05-03 | Neuroderm Ltd | Composiciones del inhibidor de la dopa descarboxilasa |
| EP3856196B1 (en) | 2018-09-28 | 2023-11-15 | Griffith University | Phenylpropionic acid derivatives for modulating pathogen activity |
| US11331293B1 (en) | 2020-11-17 | 2022-05-17 | Neuroderm, Ltd. | Method for treatment of Parkinson's disease |
| US11844754B2 (en) | 2020-11-17 | 2023-12-19 | Neuroderm, Ltd. | Methods for treatment of Parkinson's disease |
| US11213502B1 (en) | 2020-11-17 | 2022-01-04 | Neuroderm, Ltd. | Method for treatment of parkinson's disease |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA504449A (en) * | 1954-07-20 | C. Britton Edgar | Alpha-amino-beta-alkoxy-butyronitriles and method of making same | |
| NL299155A (da) * | 1962-10-11 | |||
| US3845076A (en) * | 1971-04-20 | 1974-10-29 | Sagami Chem Res | Method of preparing aldehydes |
| JPS4920305A (da) * | 1972-06-21 | 1974-02-22 | ||
| HU165026B (da) * | 1972-08-11 | 1974-06-28 | ||
| US4072698A (en) * | 1976-12-02 | 1978-02-07 | The Upjohn Company | Resolution of aminonitriles |
| YU93877A (en) * | 1977-04-08 | 1982-06-30 | Krka | Process for the resolution of racemic alpha-aminonitrils |
| IL59048A (en) * | 1979-12-27 | 1984-01-31 | Plantex Ltd | Process for the preparation of alpha-amino-3-phenyl-propionitriles and novel benzylidene amino acetonitriles as intermediates therefor |
| DE3002543A1 (de) * | 1980-01-25 | 1981-07-30 | Basf Ag, 6700 Ludwigshafen | 4-tert.-butoxyphenylglycinnitril sowie verfahren zur herstellung von d-(-)- und l-(+)-4-hydroxyphenylglycin |
| JPS56115749A (en) * | 1980-02-18 | 1981-09-11 | Sagami Chem Res Center | Dopa derivative |
| JPS61275253A (ja) * | 1985-05-30 | 1986-12-05 | Nippon Kayaku Co Ltd | ３−（３，４−ジヒドロキシフエニル）−２−メチルアラニンの製造法 |
| FR2614626B1 (fr) * | 1987-04-30 | 1989-07-21 | Ranoux Claude | Conteneur pour fecondation des ovocytes et replacement des embryons chez l'homme et l'animal |
-
1988
- 1988-07-12 IT IT8821322A patent/IT1226902B/it active
-
1989
- 1989-07-03 IL IL90844A patent/IL90844A0/xx not_active IP Right Cessation
- 1989-07-03 US US07/375,131 patent/US4962223A/en not_active Expired - Fee Related
- 1989-07-07 DE DE68918207T patent/DE68918207T2/de not_active Expired - Fee Related
- 1989-07-07 EP EP89830316A patent/EP0357565B1/en not_active Expired - Lifetime
- 1989-07-07 AT AT89830316T patent/ATE111439T1/de not_active IP Right Cessation
- 1989-07-07 ES ES89830316T patent/ES2063837T3/es not_active Expired - Lifetime
- 1989-07-11 DK DK342489A patent/DK172106B1/da not_active IP Right Cessation
- 1989-07-11 FI FI893368A patent/FI101534B/fi not_active IP Right Cessation
- 1989-07-11 PL PL89280528A patent/PL160103B1/pl unknown
- 1989-07-11 IE IE222789A patent/IE65956B1/en not_active IP Right Cessation
- 1989-07-11 ZA ZA895255A patent/ZA895255B/xx unknown
- 1989-07-11 NO NO892861A patent/NO174293C/no not_active IP Right Cessation
- 1989-07-11 AR AR89314355A patent/AR248267A1/es active
- 1989-07-11 HU HU893486A patent/HU203318B/hu not_active IP Right Cessation
- 1989-07-11 DD DD89330685A patent/DD284674A5/de not_active IP Right Cessation
- 1989-07-11 NZ NZ229910A patent/NZ229910A/en unknown
- 1989-07-12 CA CA000605420A patent/CA1338672C/en not_active Expired - Fee Related
- 1989-07-12 PT PT91144A patent/PT91144B/pt not_active IP Right Cessation
- 1989-07-12 YU YU139989A patent/YU47907B/sh unknown
- 1989-07-12 AU AU38057/89A patent/AU615083B2/en not_active Ceased
- 1989-07-12 JP JP1180152A patent/JP2507069B2/ja not_active Expired - Lifetime
- 1989-07-12 KR KR1019890009905A patent/KR960004185B1/ko not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) | ||
| PBP | Patent lapsed |