DE68918207T2 - Verfahren zur Herstellung von Levodopa. - Google Patents

Verfahren zur Herstellung von Levodopa.

Info

Publication number
DE68918207T2
DE68918207T2 DE68918207T DE68918207T DE68918207T2 DE 68918207 T2 DE68918207 T2 DE 68918207T2 DE 68918207 T DE68918207 T DE 68918207T DE 68918207 T DE68918207 T DE 68918207T DE 68918207 T2 DE68918207 T2 DE 68918207T2
Authority
DE
Germany
Prior art keywords
levodopa
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68918207T
Other languages
English (en)
Other versions
DE68918207D1 (de
Inventor
Vincenzo Cannata
Giancarlo Tamerlani
Mauro Morotti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MINI RICERCA SCIENT TECNOLOG
Ministero dell Universita e della Ricerca Scientifica e Tecnologica (MURST)
Original Assignee
MINI RICERCA SCIENT TECNOLOG
Ministero dell Universita e della Ricerca Scientifica e Tecnologica (MURST)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MINI RICERCA SCIENT TECNOLOG, Ministero dell Universita e della Ricerca Scientifica e Tecnologica (MURST) filed Critical MINI RICERCA SCIENT TECNOLOG
Publication of DE68918207D1 publication Critical patent/DE68918207D1/de
Application granted granted Critical
Publication of DE68918207T2 publication Critical patent/DE68918207T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/34—Preparation of optical isomers by separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
    • C07C255/43—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms the carbon skeleton being further substituted by singly-bound oxygen atoms
DE68918207T 1988-07-12 1989-07-07 Verfahren zur Herstellung von Levodopa. Expired - Fee Related DE68918207T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8821322A IT1226902B (it) 1988-07-12 1988-07-12 Processo per la sintesi del levodopa

Publications (2)

Publication Number Publication Date
DE68918207D1 DE68918207D1 (de) 1994-10-20
DE68918207T2 true DE68918207T2 (de) 1995-05-11

Family

ID=11180092

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68918207T Expired - Fee Related DE68918207T2 (de) 1988-07-12 1989-07-07 Verfahren zur Herstellung von Levodopa.

Country Status (23)

Country Link
US (1) US4962223A (de)
EP (1) EP0357565B1 (de)
JP (1) JP2507069B2 (de)
KR (1) KR960004185B1 (de)
AR (1) AR248267A1 (de)
AT (1) ATE111439T1 (de)
AU (1) AU615083B2 (de)
CA (1) CA1338672C (de)
DD (1) DD284674A5 (de)
DE (1) DE68918207T2 (de)
DK (1) DK172106B1 (de)
ES (1) ES2063837T3 (de)
FI (1) FI101534B1 (de)
HU (1) HU203318B (de)
IE (1) IE65956B1 (de)
IL (1) IL90844A0 (de)
IT (1) IT1226902B (de)
NO (1) NO174293C (de)
NZ (1) NZ229910A (de)
PL (1) PL160103B1 (de)
PT (1) PT91144B (de)
YU (1) YU47907B (de)
ZA (1) ZA895255B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5459145A (en) * 1988-01-19 1995-10-17 Pfizer Inc. Calcium independent camp phosphodiesterase inhibitor antidepressant
IT1226903B (it) * 1988-07-12 1991-02-21 Mini Ricerca Scient Tecnolog Processo per la sintesi di aminoacidi otticamente attivi
US5395935A (en) * 1992-05-08 1995-03-07 Pfizer Inc. Endo-bicyclo[2.2.1]heptan-2-ol and derived pharmaceutical agents
DE19502967A1 (de) * 1995-01-31 1996-08-01 Basf Ag Verfahren zur Racemattrennung von 2-Aryl-2-omega-alkylaminoalkannitrilen
JP3634207B2 (ja) * 1999-09-14 2005-03-30 独立行政法人科学技術振興機構 光学活性なα−アミノニトリル並びにα−アミノ酸類の製造方法
US20040002615A1 (en) * 2002-06-28 2004-01-01 Allen David Robert Preparation of chiral amino-nitriles
EP1560569A4 (de) * 2002-10-11 2006-03-22 Depomed Dev Ltd Gastroretentive levodopa-abgabeform
DE10261807A1 (de) 2002-12-19 2004-07-01 Turicum Drug Development Ag Deuterierte Catecholaminderivate sowie diese Verbindungen enthaltende Arzneimittel
EP1596808A4 (de) * 2003-02-07 2007-04-04 Yissum Res Dev Co L-dopa-amidderivate und ihre verwendung
UA97795C2 (uk) 2006-02-17 2012-03-26 Бьордз Фарма Гмбх Бероліна Інновейтів Ресерч Унд Девелопмент Сервісіз Дейтеровані похідні катехоламіну і медикаменти, що містять згадані сполуки
US10258585B2 (en) 2014-03-13 2019-04-16 Neuroderm, Ltd. DOPA decarboxylase inhibitor compositions
PL3116475T3 (pl) 2014-03-13 2021-02-08 Neuroderm Ltd Kompozycje inhibitora dekarboksylazy dopa
SG11202103183PA (en) 2018-09-28 2021-04-29 Univ Griffith Agents and methods for modulating pathogen activity
US11844754B2 (en) 2020-11-17 2023-12-19 Neuroderm, Ltd. Methods for treatment of Parkinson's disease
US11213502B1 (en) 2020-11-17 2022-01-04 Neuroderm, Ltd. Method for treatment of parkinson's disease
US11331293B1 (en) 2020-11-17 2022-05-17 Neuroderm, Ltd. Method for treatment of Parkinson's disease

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA504449A (en) * 1954-07-20 C. Britton Edgar Alpha-amino-beta-alkoxy-butyronitriles and method of making same
BE638485A (de) * 1962-10-11
US3845076A (en) * 1971-04-20 1974-10-29 Sagami Chem Res Method of preparing aldehydes
JPS4920305A (de) * 1972-06-21 1974-02-22
HU165026B (de) * 1972-08-11 1974-06-28
US4072698A (en) * 1976-12-02 1978-02-07 The Upjohn Company Resolution of aminonitriles
YU93877A (en) * 1977-04-08 1982-06-30 Krka Process for the resolution of racemic alpha-aminonitrils
IL59048A (en) * 1979-12-27 1984-01-31 Plantex Ltd Process for the preparation of alpha-amino-3-phenyl-propionitriles and novel benzylidene amino acetonitriles as intermediates therefor
DE3002543A1 (de) * 1980-01-25 1981-07-30 Basf Ag, 6700 Ludwigshafen 4-tert.-butoxyphenylglycinnitril sowie verfahren zur herstellung von d-(-)- und l-(+)-4-hydroxyphenylglycin
JPS56115749A (en) * 1980-02-18 1981-09-11 Sagami Chem Res Center Dopa derivative
JPS61275253A (ja) * 1985-05-30 1986-12-05 Nippon Kayaku Co Ltd ３−（３，４−ジヒドロキシフエニル）−２−メチルアラニンの製造法
FR2614626B1 (fr) * 1987-04-30 1989-07-21 Ranoux Claude Conteneur pour fecondation des ovocytes et replacement des embryons chez l'homme et l'animal

Also Published As

Publication number Publication date
DK342489D0 (da) 1989-07-11
EP0357565A3 (de) 1991-09-25
IE892227L (en) 1990-01-12
AU615083B2 (en) 1991-09-19
NO892861D0 (no) 1989-07-11
FI101534B (fi) 1998-07-15
PL160103B1 (pl) 1993-02-26
HUT51596A (en) 1990-05-28
FI893368A (fi) 1990-01-13
DE68918207D1 (de) 1994-10-20
PT91144A (pt) 1990-02-08
IT8821322A0 (it) 1988-07-12
YU139989A (en) 1990-12-31
ZA895255B (en) 1990-04-25
ATE111439T1 (de) 1994-09-15
YU47907B (sh) 1996-05-20
CA1338672C (en) 1996-10-22
IL90844A0 (en) 1990-02-09
AR248267A1 (es) 1995-07-12
EP0357565B1 (de) 1994-09-14
NZ229910A (en) 1991-04-26
ES2063837T3 (es) 1995-01-16
JP2507069B2 (ja) 1996-06-12
AU3805789A (en) 1990-01-25
EP0357565A2 (de) 1990-03-07
NO174293B (no) 1994-01-03
HU203318B (en) 1991-07-29
DK342489A (da) 1990-01-13
NO174293C (no) 1994-04-13
KR960004185B1 (ko) 1996-03-27
FI101534B1 (fi) 1998-07-15
NO892861L (no) 1990-01-15
FI893368A0 (fi) 1989-07-11
DD284674A5 (de) 1990-11-21
KR900001641A (ko) 1990-02-27
IT1226902B (it) 1991-02-21
JPH02231457A (ja) 1990-09-13
US4962223A (en) 1990-10-09
PT91144B (pt) 1995-01-31
DK172106B1 (da) 1997-10-27
IE65956B1 (en) 1995-11-29

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee