IT8821322A0 - Processo per la sintesi del levodopa - Google Patents
Processo per la sintesi del levodopaInfo
- Publication number
- IT8821322A0 IT8821322A0 IT8821322A IT2132288A IT8821322A0 IT 8821322 A0 IT8821322 A0 IT 8821322A0 IT 8821322 A IT8821322 A IT 8821322A IT 2132288 A IT2132288 A IT 2132288A IT 8821322 A0 IT8821322 A0 IT 8821322A0
- Authority
- IT
- Italy
- Prior art keywords
- levodopa
- synthesis
- Prior art date
Links
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 title 1
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 229960004502 levodopa Drugs 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/34—Preparation of optical isomers by separation of optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
- C07C255/43—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms the carbon skeleton being further substituted by singly-bound oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (23)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT8821322A IT1226902B (it) | 1988-07-12 | 1988-07-12 | Processo per la sintesi del levodopa |
IL90844A IL90844A0 (en) | 1988-07-12 | 1989-07-03 | Process and intermediates for the synthesis of levodopa |
US07/375,131 US4962223A (en) | 1988-07-12 | 1989-07-03 | Process for the synthesis of the levodopa |
AT89830316T ATE111439T1 (de) | 1988-07-12 | 1989-07-07 | Verfahren zur herstellung von levodopa. |
ES89830316T ES2063837T3 (es) | 1988-07-12 | 1989-07-07 | Nuevo procedimiento para la sintesis de la levodopa. |
DE68918207T DE68918207T2 (de) | 1988-07-12 | 1989-07-07 | Verfahren zur Herstellung von Levodopa. |
EP89830316A EP0357565B1 (en) | 1988-07-12 | 1989-07-07 | New process for the synthesis of the levodopa |
FI893368A FI101534B (fi) | 1988-07-12 | 1989-07-11 | Uusi menetelmä levodopan syntetisoimiseksi |
DD89330685A DD284674A5 (de) | 1988-07-12 | 1989-07-11 | Verfahren zur synthese von levodopa |
AR89314355A AR248267A1 (es) | 1988-07-12 | 1989-07-11 | Procedimiento para la sintesis del acido l-(-)-2-amino-3-(3, 4-dihidroxifenil)propionico, e intermediarios en el procedimiento y que no tienen aplicacion terapeutica. |
NO892861A NO174293C (no) | 1988-07-12 | 1989-07-11 | Fremgangsmåte og mellomprodukter ved syntese av levodopa |
HU893486A HU203318B (en) | 1988-07-12 | 1989-07-11 | Process for producing levodopa active component for pharmaceutical compositions |
IE222789A IE65956B1 (en) | 1988-07-12 | 1989-07-11 | New process for the synthesis of the levodopa |
PL89280528A PL160103B1 (pl) | 1988-07-12 | 1989-07-11 | Sposób wytwarzania kwasu L-/-/-2-amino-3-/3,4-dwuhydroksyfenylo/propionowego PL PL PL PL PL |
NZ229910A NZ229910A (en) | 1988-07-12 | 1989-07-11 | Synthesis of l-(-)-2-amino-3-(3,4-dihydroxyphenyl)- propanoic acid, and intermediates therefor |
ZA895255A ZA895255B (en) | 1988-07-12 | 1989-07-11 | New process for the synthesis of the levodopa |
DK342489A DK172106B1 (da) | 1988-07-12 | 1989-07-11 | Ny fremgangsmåde og mellemprodukter og anvendelse heraf til syntese af levodopa |
PT91144A PT91144B (pt) | 1988-07-12 | 1989-07-12 | Processo para a sintese de levodopa |
JP1180152A JP2507069B2 (ja) | 1988-07-12 | 1989-07-12 | L―(―)―2―アミノ―3―(3,4―ジヒドロキシフェニル)プロパン酸の合成方法 |
CA000605420A CA1338672C (en) | 1988-07-12 | 1989-07-12 | Process for the synthesis of the levodopa |
YU139989A YU47907B (sh) | 1988-07-12 | 1989-07-12 | Proces za sintezu l-(-)-2-amino-3-(3,4-dihidroksifenil)propionske kiseline |
KR1019890009905A KR960004185B1 (ko) | 1988-07-12 | 1989-07-12 | 새로운 레보도파 합성방법 |
AU38057/89A AU615083B2 (en) | 1988-07-12 | 1989-07-12 | New process for the synthesis of the levodopa |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT8821322A IT1226902B (it) | 1988-07-12 | 1988-07-12 | Processo per la sintesi del levodopa |
Publications (2)
Publication Number | Publication Date |
---|---|
IT8821322A0 true IT8821322A0 (it) | 1988-07-12 |
IT1226902B IT1226902B (it) | 1991-02-21 |
Family
ID=11180092
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT8821322A IT1226902B (it) | 1988-07-12 | 1988-07-12 | Processo per la sintesi del levodopa |
Country Status (23)
Country | Link |
---|---|
US (1) | US4962223A (it) |
EP (1) | EP0357565B1 (it) |
JP (1) | JP2507069B2 (it) |
KR (1) | KR960004185B1 (it) |
AR (1) | AR248267A1 (it) |
AT (1) | ATE111439T1 (it) |
AU (1) | AU615083B2 (it) |
CA (1) | CA1338672C (it) |
DD (1) | DD284674A5 (it) |
DE (1) | DE68918207T2 (it) |
DK (1) | DK172106B1 (it) |
ES (1) | ES2063837T3 (it) |
FI (1) | FI101534B (it) |
HU (1) | HU203318B (it) |
IE (1) | IE65956B1 (it) |
IL (1) | IL90844A0 (it) |
IT (1) | IT1226902B (it) |
NO (1) | NO174293C (it) |
NZ (1) | NZ229910A (it) |
PL (1) | PL160103B1 (it) |
PT (1) | PT91144B (it) |
YU (1) | YU47907B (it) |
ZA (1) | ZA895255B (it) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5459145A (en) * | 1988-01-19 | 1995-10-17 | Pfizer Inc. | Calcium independent camp phosphodiesterase inhibitor antidepressant |
IT1226903B (it) * | 1988-07-12 | 1991-02-21 | Mini Ricerca Scient Tecnolog | Processo per la sintesi di aminoacidi otticamente attivi |
US5395935A (en) * | 1992-05-08 | 1995-03-07 | Pfizer Inc. | Endo-bicyclo[2.2.1]heptan-2-ol and derived pharmaceutical agents |
DE19502967A1 (de) * | 1995-01-31 | 1996-08-01 | Basf Ag | Verfahren zur Racemattrennung von 2-Aryl-2-omega-alkylaminoalkannitrilen |
JP3634207B2 (ja) * | 1999-09-14 | 2005-03-30 | 独立行政法人科学技術振興機構 | 光学活性なα−アミノニトリル並びにα−アミノ酸類の製造方法 |
US20040002615A1 (en) * | 2002-06-28 | 2004-01-01 | Allen David Robert | Preparation of chiral amino-nitriles |
KR20050083750A (ko) * | 2002-10-11 | 2005-08-26 | 디포메드 디벨롭먼트 리미티드 | 위-체류성 레보도파 전달 형태 |
DE10261807A1 (de) * | 2002-12-19 | 2004-07-01 | Turicum Drug Development Ag | Deuterierte Catecholaminderivate sowie diese Verbindungen enthaltende Arzneimittel |
WO2004069146A2 (en) * | 2003-02-07 | 2004-08-19 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | L-dopa amide derivatives and uses thereof |
EP3101001B1 (en) | 2006-02-17 | 2020-04-01 | Teva Pharmaceuticals International GmbH | Deuterated catecholamine derivatives and medicaments comprising said compounds |
US10258585B2 (en) | 2014-03-13 | 2019-04-16 | Neuroderm, Ltd. | DOPA decarboxylase inhibitor compositions |
BR112016021034A8 (pt) | 2014-03-13 | 2021-06-29 | Neuroderm Ltd | composição farmacêutica, uso da mesma e kit |
CN113164494B (zh) | 2018-09-28 | 2024-08-27 | 格里菲斯大学 | 用于调节病原体活性的剂和方法 |
US11331293B1 (en) | 2020-11-17 | 2022-05-17 | Neuroderm, Ltd. | Method for treatment of Parkinson's disease |
US11844754B2 (en) | 2020-11-17 | 2023-12-19 | Neuroderm, Ltd. | Methods for treatment of Parkinson's disease |
US11213502B1 (en) | 2020-11-17 | 2022-01-04 | Neuroderm, Ltd. | Method for treatment of parkinson's disease |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA504449A (en) * | 1954-07-20 | C. Britton Edgar | Alpha-amino-beta-alkoxy-butyronitriles and method of making same | |
BE638485A (it) * | 1962-10-11 | |||
US3845076A (en) * | 1971-04-20 | 1974-10-29 | Sagami Chem Res | Method of preparing aldehydes |
JPS4920305A (it) * | 1972-06-21 | 1974-02-22 | ||
HU165026B (it) * | 1972-08-11 | 1974-06-28 | ||
US4072698A (en) * | 1976-12-02 | 1978-02-07 | The Upjohn Company | Resolution of aminonitriles |
YU93877A (en) * | 1977-04-08 | 1982-06-30 | Krka | Process for the resolution of racemic alpha-aminonitrils |
IL59048A (en) * | 1979-12-27 | 1984-01-31 | Plantex Ltd | Process for the preparation of alpha-amino-3-phenyl-propionitriles and novel benzylidene amino acetonitriles as intermediates therefor |
DE3002543A1 (de) * | 1980-01-25 | 1981-07-30 | Basf Ag, 6700 Ludwigshafen | 4-tert.-butoxyphenylglycinnitril sowie verfahren zur herstellung von d-(-)- und l-(+)-4-hydroxyphenylglycin |
JPS56115749A (en) * | 1980-02-18 | 1981-09-11 | Sagami Chem Res Center | Dopa derivative |
JPS61275253A (ja) * | 1985-05-30 | 1986-12-05 | Nippon Kayaku Co Ltd | 3−(3,4−ジヒドロキシフエニル)−2−メチルアラニンの製造法 |
FR2614626B1 (fr) * | 1987-04-30 | 1989-07-21 | Ranoux Claude | Conteneur pour fecondation des ovocytes et replacement des embryons chez l'homme et l'animal |
-
1988
- 1988-07-12 IT IT8821322A patent/IT1226902B/it active
-
1989
- 1989-07-03 IL IL90844A patent/IL90844A0/xx not_active IP Right Cessation
- 1989-07-03 US US07/375,131 patent/US4962223A/en not_active Expired - Fee Related
- 1989-07-07 ES ES89830316T patent/ES2063837T3/es not_active Expired - Lifetime
- 1989-07-07 DE DE68918207T patent/DE68918207T2/de not_active Expired - Fee Related
- 1989-07-07 AT AT89830316T patent/ATE111439T1/de not_active IP Right Cessation
- 1989-07-07 EP EP89830316A patent/EP0357565B1/en not_active Expired - Lifetime
- 1989-07-11 IE IE222789A patent/IE65956B1/en not_active IP Right Cessation
- 1989-07-11 ZA ZA895255A patent/ZA895255B/xx unknown
- 1989-07-11 NO NO892861A patent/NO174293C/no not_active IP Right Cessation
- 1989-07-11 FI FI893368A patent/FI101534B/fi not_active IP Right Cessation
- 1989-07-11 DK DK342489A patent/DK172106B1/da not_active IP Right Cessation
- 1989-07-11 AR AR89314355A patent/AR248267A1/es active
- 1989-07-11 NZ NZ229910A patent/NZ229910A/en unknown
- 1989-07-11 DD DD89330685A patent/DD284674A5/de not_active IP Right Cessation
- 1989-07-11 HU HU893486A patent/HU203318B/hu not_active IP Right Cessation
- 1989-07-11 PL PL89280528A patent/PL160103B1/pl unknown
- 1989-07-12 KR KR1019890009905A patent/KR960004185B1/ko not_active IP Right Cessation
- 1989-07-12 AU AU38057/89A patent/AU615083B2/en not_active Ceased
- 1989-07-12 JP JP1180152A patent/JP2507069B2/ja not_active Expired - Lifetime
- 1989-07-12 YU YU139989A patent/YU47907B/sh unknown
- 1989-07-12 CA CA000605420A patent/CA1338672C/en not_active Expired - Fee Related
- 1989-07-12 PT PT91144A patent/PT91144B/pt not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IT8920124A0 (it) | Processo per la produzione di allumine boemitiche. | |
IT1217923B (it) | Macchina perfezionata per la produzione di granita | |
IT8821322A0 (it) | Processo per la sintesi del levodopa | |
BR8906363A (pt) | Processo para producao de tricloromonosilano | |
IT8423280A1 (it) | Processo per la sintesi di 2-metossi-6-bromo-naftalene | |
BR8401999A (pt) | Processo de sintese de polimeros:processo de homopolimerizacao de meta-diisopropenilbenzeno | |
BR8900171A (pt) | Processo para producao de catalisador zeolitico | |
IT9020580A0 (it) | procedimento per la produzione | |
BR8904840A (pt) | Processo para producao de n-fosfonometilglicina | |
IT1226300B (it) | Processo per la preparazione di intermedi per la sintesi del diltiazem. | |
IT8620655A1 (it) | Processo per la sintesi di mono- o di-idrossifluoroalcani | |
BR8904728A (pt) | Processo para a sintese catalisada de acrilamidas n-substituidas | |
IT1222186B (it) | Macchine per la produzione di catene ornamentali del tipo detto "fiocco" | |
IT1229214B (it) | Processo per la sintesi della n metil 3,4 dimetossifeniletilamina | |
IT9048217A0 (it) | Procedimento per la produzione di filato | |
IT8621002A1 (it) | Processo per la sintesi del tiamfenicolo | |
IT8821479A0 (it) | Processo per la preparazione di intermedi per la sintesi del diltiazem. | |
IT8619943A1 (it) | Processo per la produzione di tricloromelammina | |
FR2639346B1 (fr) | Procede de production d'(alpha)-olefines | |
IT8620606A1 (it) | Processo per la sintesi d idrossilammin-disolfonato | |
IT8823097A0 (it) | Nuovo procedimento per la sintesi della n a-fluorenilmetossicarbonil- ng-tritil-arginina | |
IT1235649B (it) | Processo per la preparazione del 2-metossi-6-propionil-naftalene per acilazione del 2-metossi-naftalene | |
IT8620526A1 (it) | Processo per la preparazione del 3,4-dimetossifenilacetone | |
BR8904843A (pt) | Processo para producao de alcadienois | |
ITMI922793A0 (it) | Processo per la sintesi di cefami |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19940707 |