DK2990420T3 - Anvendelse af interleukin-4-receptor-antistoffer samt sammensætninger deraf - Google Patents
Anvendelse af interleukin-4-receptor-antistoffer samt sammensætninger deraf Download PDFInfo
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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Claims (8)
1. Menneskeligt monoklonalt antistof, hvilket er i stand til inhibitering af en IL-4-induceret biologisk aktivitet, der konkurrerer med et reference-antistof til binding til en celle, eksprimerer menneskelig 11-4-receptor (IL-4R), hvor: a) den lette kæde af reference-antistoffet omfatter sekvensen SEQ ID NO:6, og den tunge kæde af reference-antistoffet omfatter sekvensen SEQ ID NO:8; eller b) den lette kæde af reference-antistoffet omfatter sekvensen SEQ ID NO:26, og den tunge kæde af reference-antistoffet omfatter sekvensen SEQ ID NO:24.
2. Antistof ifølge krav 1, hvor antistoffet yderligere er i stand til inhibering af en IL-13-induceret biologisk aktivitet.
3. Antistof ifølge krav 1 eller 2 til anvendelse ved en fremgangsmåde til behandling af dermatitis, atopisk dermatitis, kontakt-dermatitis eller astma.
4. Antistof til anvendelse ifølge krav 3, hvor antistoffet foreligger i form af en sammensætning, som yderligere indebefatter et fortyndingsmiddel, en excipient eller et bæremiddel.
5. Antistof ifølge krav 1 eller 2 eller til anvendelse ifølge krav 3 eller 4, hvor IL-4R omfatter aminosyrer 1 til 197 af SEQ ID NO:2.
6. Nukleinsyre, der koder den lette kæde af antistoffet således som angivet i krav 1 eller 2.
7. Nukleinsyre, der koder den tunge kæde af antistoffet således som angivet i krav 1 eller 2.
8. Værtscelle, der inkluderer nukleinsyren ifølge krav 6 eller 7.
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US84781601A | 2001-05-01 | 2001-05-01 | |
EP10185626.8A EP2292665B1 (en) | 2000-05-26 | 2001-05-25 | Use of interleukin-4 antibodies and compositions thereof |
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DK15168899.1T DK2990420T3 (da) | 2000-05-26 | 2001-05-25 | Anvendelse af interleukin-4-receptor-antistoffer samt sammensætninger deraf |
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US (8) | US7186809B2 (da) |
EP (4) | EP2292665B1 (da) |
AT (1) | ATE551363T1 (da) |
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CA (1) | CA2409267C (da) |
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DE (1) | DE16192152T1 (da) |
DK (1) | DK2990420T3 (da) |
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WO2001092340A2 (en) | 2001-12-06 |
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US20190023798A1 (en) | 2019-01-24 |
US7465450B2 (en) | 2008-12-16 |
EP1283851A2 (en) | 2003-02-19 |
US20090104662A1 (en) | 2009-04-23 |
ATE551363T1 (de) | 2012-04-15 |
WO2001092340A3 (en) | 2002-04-25 |
CA2409267A1 (en) | 2001-12-06 |
US9587026B2 (en) | 2017-03-07 |
US20110002913A1 (en) | 2011-01-06 |
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US20070041976A1 (en) | 2007-02-22 |
US20030124121A1 (en) | 2003-07-03 |
CY1118951T1 (el) | 2018-01-10 |
EP2990420A1 (en) | 2016-03-02 |
ES2614260T3 (es) | 2017-05-30 |
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