DK2836511T3 - Polypeptid, der kan anvendes til adoptiv celleterapi - Google Patents
Polypeptid, der kan anvendes til adoptiv celleterapi Download PDFInfo
- Publication number
- DK2836511T3 DK2836511T3 DK13717833.1T DK13717833T DK2836511T3 DK 2836511 T3 DK2836511 T3 DK 2836511T3 DK 13717833 T DK13717833 T DK 13717833T DK 2836511 T3 DK2836511 T3 DK 2836511T3
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- cell
- cells
- polypeptide
- rituximab
- poi
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Classifications
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
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- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
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Claims (14)
1. Polypeptid med formlen: St-Rl-Sl-Q-S2-R2 hvor St er en stængelsekvens, der, når polypeptidet udtrykkes på overfladen af en målcelle, forårsager, at R- og Q-epitoperne rager frem fra celleoverfladen; RI og R2 er rituximabbindende epitoper, der hver har en aminosyresekvens valgt fra gruppen, der består af SEQ ID NO: 1, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15 og 16; SI og S2 er spacersekvenser, der kan være ens eller forskellige; og som har en samlet længde på mindst ca. 10 aminosyrer, således at afstanden mellem RI og R2 er for lang til, at polypeptidet kan binde begge antigenbindingsteder for rituximab samtidigt; og Q er en QBEndlO-bindende epitop med aminosyresekvensen, der er vist som SEQ ID NO: 2.
2. Polypeptid ifølge krav 1, hvor afstanden mellem RI og R2 er mere end 76,57 Å.
3. Polypeptid ifølge krav 1 eller 2, der omfatter sekvensen, der er vist som SEQ ID NO: 4.
4. Fusionsprotein, der omfatter et polypeptid ifølge et hvilket som helst af ovennævnte krav fusioneret til et protein of interesse (POI).
5. Nukleinsyresekvens, der er i stand til at kode for et polypeptid ifølge et hvilket som helst af kravene 1 til 3 eller fusionsproteinet ifølge krav 4.
6. Vektor, der omfatter en nukleinsyresekvens ifølge krav 5.
7. Celle, der udtrykker et polypeptid ifølge et hvilket som helst af kravene 1 til 3.
8. Celle, der omfatter en nukleinsyresekvens ifølge krav 5.
9. Fremgangsmåde til fremstilling af en celle ifølge krav 7 eller 8, der omfatter trinet transduktion eller transfektion af en celle ex vivo med en vektor ifølge krav 6.
10. Ex vivo-fremgangsmåde til undersøgelse af transduktionseffektiviteten af en genterapimetode, der omfatter trinet påvisning af ekspression af den QBEndlO-bindende epitop på overfladen af celler transficeret eller transduceret ex vivo med en vektor ifølge krav 6.
11. Fremgangsmåde til selektion af celler, der udtrykker et POI, som omfatter følgende trin: (i) påvisning af ekspression af den QBEndlO-bindende epitop på overfladen af celler transficeret eller transduceret ex vivo med en vector ifølge krav 6; og (ii) selektion af celler, der identificeres som udtrykkende den QBEndlO-bindende epitop.
12. Fremgangsmåde til fremstilling af en oprenset population af celler, der er beriget med celler, der udtrykker et POI, som omfatter trinet selektion af celler, der udtrykker et POI, fra en population af celler ved anvendelse af en fremgangsmåde ifølge krav 11.
13. Cellepopulation, der er beriget med celler, der udtrykker et polypeptid ifølge et hvilket som helst af kravene 1 til 3, og således er beriget med celler, der udtrykker et POI.
14. Celle ifølge krav 7 eller 8 eller cellepopulation ifølge krav 13 til anvendelse til adoptiv celleoverførsel.
Applications Claiming Priority (2)
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| GBGB1206559.5A GB201206559D0 (en) | 2012-04-13 | 2012-04-13 | Polypeptide |
| PCT/GB2013/050935 WO2013153391A1 (en) | 2012-04-13 | 2013-04-11 | Polypeptide useful in adoptive cell therapy |
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|---|---|
| DK2836511T3 true DK2836511T3 (da) | 2018-03-05 |
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ID=46209048
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| Application Number | Title | Priority Date | Filing Date |
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| DK13717833.1T DK2836511T3 (da) | 2012-04-13 | 2013-04-11 | Polypeptid, der kan anvendes til adoptiv celleterapi |
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| EP (1) | EP2836511B1 (da) |
| JP (1) | JP6257584B2 (da) |
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| PT (1) | PT2836511T (da) |
| TR (1) | TR201802560T4 (da) |
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| US621147A (en) * | 1899-03-14 | Presser-foot for sewing-machines | ||
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| TW202021980A (zh) * | 2007-02-02 | 2020-06-16 | 美商艾瑟勒朗法瑪公司 | 衍生自ActRIIB的變體與其用途 |
| GB201403972D0 (en) | 2014-03-06 | 2014-04-23 | Ucl Business Plc | Chimeric antigen receptor |
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| CA2870233A1 (en) | 2013-10-17 |
| CA2870233C (en) | 2023-03-28 |
| CN104379599B (zh) | 2018-04-10 |
| US20150093401A1 (en) | 2015-04-02 |
| US20240156926A1 (en) | 2024-05-16 |
| JP2015518479A (ja) | 2015-07-02 |
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