DK2734186T3 - COMPOSITION - Google Patents
COMPOSITION Download PDFInfo
- Publication number
- DK2734186T3 DK2734186T3 DK12740119.8T DK12740119T DK2734186T3 DK 2734186 T3 DK2734186 T3 DK 2734186T3 DK 12740119 T DK12740119 T DK 12740119T DK 2734186 T3 DK2734186 T3 DK 2734186T3
- Authority
- DK
- Denmark
- Prior art keywords
- compound
- composition
- compositions
- pharmaceutically acceptable
- purin
- Prior art date
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- 239000000203 mixture Substances 0.000 title description 62
- 150000001875 compounds Chemical class 0.000 claims description 55
- 150000003839 salts Chemical class 0.000 claims description 22
- 206010039085 Rhinitis allergic Diseases 0.000 claims description 7
- 201000009961 allergic asthma Diseases 0.000 claims description 7
- 208000026935 allergic disease Diseases 0.000 claims description 7
- 201000010105 allergic rhinitis Diseases 0.000 claims description 7
- 208000006673 asthma Diseases 0.000 claims description 7
- 230000004968 inflammatory condition Effects 0.000 claims description 7
- 239000000243 solution Substances 0.000 description 24
- LFMPVTVPXHNXOT-HNNXBMFYSA-N 6-amino-2-[(2s)-pentan-2-yl]oxy-9-(5-piperidin-1-ylpentyl)-7h-purin-8-one Chemical compound C12=NC(O[C@@H](C)CCC)=NC(N)=C2NC(=O)N1CCCCCN1CCCCC1 LFMPVTVPXHNXOT-HNNXBMFYSA-N 0.000 description 15
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- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 1
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- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Otolaryngology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US201161510624P | 2011-07-22 | 2011-07-22 | |
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| DK2734186T3 true DK2734186T3 (en) | 2019-01-07 |
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| JP2014520874A (ja) | 2011-07-22 | 2014-08-25 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 組成物 |
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| WO2014081645A1 (en) | 2012-11-20 | 2014-05-30 | Glaxosmithkline Llc | Novel compounds |
| AU2013348216B2 (en) | 2012-11-20 | 2016-10-13 | Glaxosmithkline Llc | Novel compounds |
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-
2012
- 2012-07-19 JP JP2014520661A patent/JP2014520874A/ja active Pending
- 2012-07-19 US US14/234,070 patent/US10112946B2/en not_active Expired - Fee Related
- 2012-07-19 SI SI201231421T patent/SI2734186T1/sl unknown
- 2012-07-19 LT LTEP12740119.8T patent/LT2734186T/lt unknown
- 2012-07-19 KR KR1020147004436A patent/KR101916928B1/ko not_active Expired - Fee Related
- 2012-07-19 CN CN201280036096.6A patent/CN103841958A/zh active Pending
- 2012-07-19 WO PCT/EP2012/064139 patent/WO2013014052A1/en not_active Ceased
- 2012-07-19 RS RS20181346A patent/RS57995B1/sr unknown
- 2012-07-19 AU AU2012289042A patent/AU2012289042A1/en not_active Abandoned
- 2012-07-19 EP EP12740119.8A patent/EP2734186B1/en active Active
- 2012-07-19 PT PT12740119T patent/PT2734186T/pt unknown
- 2012-07-19 SM SM20180642T patent/SMT201800642T1/it unknown
- 2012-07-19 HR HRP20181667TT patent/HRP20181667T1/hr unknown
- 2012-07-19 DK DK12740119.8T patent/DK2734186T3/en active
- 2012-07-19 BR BR112014001425A patent/BR112014001425A2/pt not_active IP Right Cessation
- 2012-07-19 ES ES12740119.8T patent/ES2693122T3/es active Active
- 2012-07-19 RU RU2013157398A patent/RU2631482C2/ru not_active IP Right Cessation
- 2012-07-19 PL PL12740119T patent/PL2734186T3/pl unknown
- 2012-07-19 CA CA2841361A patent/CA2841361A1/en not_active Abandoned
-
2016
- 2016-04-20 AU AU2016202513A patent/AU2016202513B2/en not_active Ceased
-
2018
- 2018-09-27 US US16/143,969 patent/US20190023707A1/en not_active Abandoned
- 2018-10-31 CY CY181101125T patent/CY1120802T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20181667T1 (hr) | 2018-12-14 |
| JP2014520874A (ja) | 2014-08-25 |
| LT2734186T (lt) | 2018-12-10 |
| ES2693122T3 (es) | 2018-12-07 |
| SMT201800642T1 (it) | 2019-01-11 |
| RU2631482C2 (ru) | 2017-09-22 |
| SI2734186T1 (sl) | 2018-11-30 |
| EP2734186B1 (en) | 2018-09-12 |
| KR101916928B1 (ko) | 2018-11-08 |
| AU2012289042A1 (en) | 2014-03-13 |
| BR112014001425A2 (pt) | 2017-11-21 |
| US20190023707A1 (en) | 2019-01-24 |
| PT2734186T (pt) | 2018-12-17 |
| CN103841958A (zh) | 2014-06-04 |
| WO2013014052A1 (en) | 2013-01-31 |
| KR20140049001A (ko) | 2014-04-24 |
| RS57995B1 (sr) | 2019-01-31 |
| EP2734186A1 (en) | 2014-05-28 |
| CA2841361A1 (en) | 2013-01-31 |
| US20140288099A1 (en) | 2014-09-25 |
| AU2016202513B2 (en) | 2018-03-22 |
| RU2013157398A (ru) | 2015-08-27 |
| US10112946B2 (en) | 2018-10-30 |
| PL2734186T3 (pl) | 2019-01-31 |
| CY1120802T1 (el) | 2019-12-11 |
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