DK2522717T3 - Oligopeptid-frie cellekulturmedier - Google Patents

Oligopeptid-frie cellekulturmedier

Info

Publication number
DK2522717T3
DK2522717T3 DK12160789T DK12160789T DK2522717T3 DK 2522717 T3 DK2522717 T3 DK 2522717T3 DK 12160789 T DK12160789 T DK 12160789T DK 12160789 T DK12160789 T DK 12160789T DK 2522717 T3 DK2522717 T3 DK 2522717T3
Authority
DK
Denmark
Prior art keywords
oligopeptide
cell culture
culture media
free cell
free
Prior art date
Application number
DK12160789T
Other languages
English (en)
Inventor
Leopold Grillberger
Manfred Reiter
Wolfgang Mundt
Artur Mitterer
Original Assignee
Baxter Int
Baxter Healthcare Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37942126&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2522717(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Baxter Int, Baxter Healthcare Sa filed Critical Baxter Int
Application granted granted Critical
Publication of DK2522717T3 publication Critical patent/DK2522717T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/005—Protein-free medium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/32—Amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/38—Vitamins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/46—Amines, e.g. putrescine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/50—Soluble polymers, e.g. polyethyleneglycol [PEG]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24151—Methods of production or purification of viral material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
DK12160789T 2006-01-04 2007-01-03 Oligopeptid-frie cellekulturmedier DK2522717T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75641906P 2006-01-04 2006-01-04
EP07702574.0A EP1974014B1 (en) 2006-01-04 2007-01-03 Oligopeptide-free cell culture media

Publications (1)

Publication Number Publication Date
DK2522717T3 true DK2522717T3 (da) 2014-04-22

Family

ID=37942126

Family Applications (3)

Application Number Title Priority Date Filing Date
DK12160789T DK2522717T3 (da) 2006-01-04 2007-01-03 Oligopeptid-frie cellekulturmedier
DK07702574.0T DK1974014T3 (da) 2006-01-04 2007-01-03 Oligopeptid-frie cellekulturmedier
DK16183987.3T DK3121266T3 (da) 2006-01-04 2007-01-03 Oligopeptid-frie cellekulturmedier

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK07702574.0T DK1974014T3 (da) 2006-01-04 2007-01-03 Oligopeptid-frie cellekulturmedier
DK16183987.3T DK3121266T3 (da) 2006-01-04 2007-01-03 Oligopeptid-frie cellekulturmedier

Country Status (18)

Country Link
US (4) US20070212770A1 (da)
EP (4) EP3653699A1 (da)
JP (6) JP5259418B2 (da)
KR (2) KR101423344B1 (da)
CN (2) CN102643777A (da)
AU (1) AU2007204044B2 (da)
CA (1) CA2633306A1 (da)
CY (1) CY1119046T1 (da)
DK (3) DK2522717T3 (da)
ES (3) ES2790887T3 (da)
HK (1) HK1177950A1 (da)
HU (1) HUE032744T2 (da)
LT (1) LT1974014T (da)
PL (3) PL3121266T3 (da)
PT (3) PT1974014T (da)
RU (3) RU2486236C2 (da)
SI (1) SI2522717T1 (da)
WO (1) WO2007077217A2 (da)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2790887T3 (es) 2006-01-04 2020-10-29 Baxalta Inc Medio de cultivo celular sin oligopéptidos
AU2008345231B2 (en) 2007-12-27 2014-09-11 Takeda Pharmaceutical Company Limited Cell culture processes
KR101618144B1 (ko) * 2007-12-31 2016-05-17 박스알타 인코퍼레이티드 실질적으로 동물 단백질-부재인 재조합 푸린 및 이의 제조 방법
CN102317440B (zh) * 2008-01-09 2014-12-03 塞尔卡有限公司 改进的培养基添加剂及其应用方法
JP5653223B2 (ja) * 2008-02-25 2015-01-14 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ 連続細胞系の生成方法
DK2356247T4 (da) 2008-11-12 2019-06-03 Baxalta GmbH Fremgangsmåde til fremstilling af serum-frit insulin-frit faktor vii
US8580554B2 (en) * 2009-07-31 2013-11-12 Baxter International Inc. Method of producing a polypeptide or virus of interest in a continuous cell culture
EA023193B1 (ru) 2009-07-31 2016-05-31 Бакстер Интернэшнл Инк. Среда для культивирования клеток для экспрессии белков adamts
FI3834841T3 (fi) 2009-09-21 2023-06-05 Takeda Pharmaceuticals Co Stabiloituja neste- ja lyofilisoituja ADAMTS13-formulaatioita
CN105331659B (zh) 2010-04-26 2019-07-16 诺华股份有限公司 改进的细胞培养基
PT2591094T (pt) 2010-07-08 2018-11-20 Baxalta Inc Método de produção de adamts13 recombinante em cultura celular
ES2959479T3 (es) 2010-09-17 2024-02-26 Takeda Pharmaceuticals Co Estabilización de inmunoglobulinas a través de formulación acuosa con histidina a pH ácido débil a neutro
CN104926947A (zh) 2010-10-27 2015-09-23 巴克斯特国际公司 用于免疫耐受性诱导和免疫诊断的fviii肽
WO2012149197A2 (en) 2011-04-27 2012-11-01 Abbott Laboratories Methods for controlling the galactosylation profile of recombinantly-expressed proteins
LT2717905T (lt) 2011-06-10 2018-10-10 Baxalta GmbH Krešėjimo ligos gydymas skiriant rekombinantinį vwf
US9181572B2 (en) 2012-04-20 2015-11-10 Abbvie, Inc. Methods to modulate lysine variant distribution
WO2013158279A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Protein purification methods to reduce acidic species
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
ES2633960T3 (es) 2012-10-15 2017-09-26 Bristol-Myers Squibb Company Procesos de cultivo de células de mamífero para la producción de proteínas
CA2905010A1 (en) 2013-03-12 2014-09-18 Abbvie Inc. Human antibodies that bind human tnf-alpha and methods of preparing the same
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
US9217168B2 (en) 2013-03-14 2015-12-22 Momenta Pharmaceuticals, Inc. Methods of cell culture
WO2014151878A2 (en) 2013-03-14 2014-09-25 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides
AR095196A1 (es) 2013-03-15 2015-09-30 Regeneron Pharma Medio de cultivo celular libre de suero
WO2015051293A2 (en) 2013-10-04 2015-04-09 Abbvie, Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
WO2015073884A2 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
KR101641655B1 (ko) * 2014-01-08 2016-07-21 서울대학교산학협력단 스퍼미딘 또는 스퍼민을 이용함으로써 생육 저해제에 대한 내성이 증진된 효모의 배양방법
WO2016146627A1 (en) * 2015-03-17 2016-09-22 Dsm Ip Assets B.V. Process for the preparation of diaminobutane
TW202330904A (zh) 2015-08-04 2023-08-01 美商再生元醫藥公司 補充牛磺酸之細胞培養基及用法
EP3383894B1 (en) 2015-12-02 2020-05-06 CSL Behring Lengnau AG Improved media for the expression of recombinant vitamin k-dependent proteins
CN106635953B (zh) * 2016-12-13 2021-02-19 昆明润什生物科技有限公司 无血清无蛋白细胞培养基
KR20210084695A (ko) * 2017-07-06 2021-07-07 리제너론 파마슈티칼스 인코포레이티드 당단백질을 만들기 위한 세포 배양 과정
EP3648787A1 (en) 2017-07-07 2020-05-13 Baxalta Incorporated Treatment of patients with severe von willebrand disease undergoing elective surgery by administration of recombinant vwf
KR20200037235A (ko) 2017-07-07 2020-04-08 박스알타 인코퍼레이티드 재조합 vwf의 투여에 의해 중증 폰 빌레브란트 병을 가지고 있는 환자에서 위장 출혈의 치료
JP2021519280A (ja) 2018-03-21 2021-08-10 バクスアルタ インコーポレイテッド クロマトグラフィー法によるｖｗｆとｖｗｆプロペプチドの分離
EP4063850A1 (en) 2018-04-20 2022-09-28 Janssen Biotech, Inc. Chromatography column qualification device with transition analysis
CN108872758B (zh) * 2018-05-10 2019-06-28 江苏大学 一种电子元器件寿命检测装置
MX2021005611A (es) 2018-11-13 2021-06-30 Janssen Biotech Inc Control de metales traza durante la produccion de anticuerpos anti-cd38.
CN113645993A (zh) 2019-02-01 2021-11-12 武田药品工业株式会社 使用重组VWF(rVWF)进行预防性治疗的方法
KR20210141990A (ko) 2019-03-14 2021-11-23 얀센 바이오테크 인코포레이티드 항-il12/il23 항체 조성물을 생성하기 위한 제조 방법
KR20210142002A (ko) 2019-03-14 2021-11-23 얀센 바이오테크 인코포레이티드 항-tnf 항체 조성물을 생성하기 위한 제조 방법
WO2020201296A1 (en) 2019-04-01 2020-10-08 The Automation Partnership (Cambridge) Ltd. Operation process for a cell cultivation system
WO2021050718A1 (en) 2019-09-11 2021-03-18 Baxalta Incorporated Methods of treatment related to complexes of von willebrand factor and complement c1q
WO2021090888A1 (ja) 2019-11-05 2021-05-14 味の素株式会社 タンパク質の製造方法
MX2021014863A (es) 2019-12-06 2022-09-28 Regeneron Pharma Composiciones de proteina anti-vegf y metodos para producir la misma.
KR20220150303A (ko) 2020-02-04 2022-11-10 다케다 야쿠힌 고교 가부시키가이샤 재조합 vwf의 투여에 의한 중증 폰 빌레브란트병 환자의 월경과다 치료
AU2021248679A1 (en) 2020-04-02 2022-10-27 Takeda Pharmaceutical Company Limited ADAMTS13 variant, compositions, and uses thereof
EP4281542A1 (en) 2021-01-20 2023-11-29 Regeneron Pharmaceuticals, Inc. Methods of improving protein titer in cell culture
CN113151183A (zh) * 2021-04-21 2021-07-23 赵峻岭 一种促进蛋白表达的培养基添加物及其应用
EP4367137A1 (en) 2021-07-09 2024-05-15 Janssen Biotech, Inc. Manufacturing methods for producing anti-tnf antibody compositions
AU2022306973A1 (en) 2021-07-09 2024-02-22 Janssen Biotech, Inc. Manufacturing methods for producing anti-il12/il23 antibody compositions
WO2023167857A1 (en) 2022-03-02 2023-09-07 Regeneron Pharmaceuticals, Inc. Cell culture methods for antibody production

Family Cites Families (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT165999B (de) 1947-06-26 1950-05-25 Delle Atel Const Electr Einirchtung zum Schutz von Drehstrommotoren gegen Überstrom
US4443540A (en) * 1980-05-09 1984-04-17 University Of Illinois Foundation Protein hydrolysis
DK207980A (da) * 1980-05-13 1981-11-14 Novo Industri As Fremgangsmaade til fremstilling af et skumnings- eller emulgeringsmiddel paa sojaproteinbasis
US4657866A (en) 1982-12-21 1987-04-14 Sudhir Kumar Serum-free, synthetic, completely chemically defined tissue culture media
FR2543158B1 (fr) 1983-03-24 1985-11-15 Inst Nat Sante Rech Med Milieu de culture de cellules animales sans serum, sans hormones et sans facteurs de croissance et procedes de culture primaire et d'obtention de lignees cellulaires utilisant ce milieu
US4767704A (en) 1983-10-07 1988-08-30 Columbia University In The City Of New York Protein-free culture medium
NZ210501A (en) 1983-12-13 1991-08-27 Kirin Amgen Inc Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence
FI86885C (fi) 1984-04-20 1992-10-26 Genentech Inc Foerfarande foer framstaellning av human rekombinantfaktor viii och nukleinsyrasekvenser och vektorer anvaend daertill
AU580145B2 (en) 1985-02-13 1989-01-05 Scios Nova Inc. Human metallothionein-ii promoter in mammalian expression system
US4978616A (en) * 1985-02-28 1990-12-18 Verax Corporation Fluidized cell cultivation process
WO1988000967A1 (en) 1986-08-04 1988-02-11 The University Of New South Wales Serum free tissue culture medium containing polymeric cell-protective agent
US5045468A (en) 1986-12-12 1991-09-03 Cell Enterprises, Inc. Protein-free culture medium which promotes hybridoma growth
AU627427B2 (en) 1987-06-30 1992-08-27 Amgen, Inc. Production of kallikrein
JP2507882B2 (ja) 1988-02-17 1996-06-19 工業技術院長 外部増殖因子非依存性増殖良好細胞株の製造法
US6048728A (en) * 1988-09-23 2000-04-11 Chiron Corporation Cell culture medium for enhanced cell growth, culture longevity, and product expression
US5573937A (en) * 1989-12-07 1996-11-12 Snow Brand Milk Products Co., Ltd. Serum free culture medium
SE465222C5 (sv) 1989-12-15 1998-02-10 Pharmacia & Upjohn Ab Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning
DK0512066T3 (da) 1990-01-22 1996-12-02 Us Health CO2-uafhængigt vækstmedium til opretholdelse og opformering af celler
JP2844484B2 (ja) 1990-02-22 1999-01-06 味の素株式会社 組換え蛋白質の生産方法
JP2859679B2 (ja) 1990-03-01 1999-02-17 協和醗酵工業株式会社 新規細胞株
JP2696001B2 (ja) 1991-04-15 1998-01-14 財団法人化学及血清療法研究所 組換え蛋白質産生用培地
US5378612A (en) * 1990-05-11 1995-01-03 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Culture medium for production of recombinant protein
US5122469A (en) 1990-10-03 1992-06-16 Genentech, Inc. Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
GB9022545D0 (en) * 1990-10-17 1990-11-28 Wellcome Found Culture medium
AU643077B2 (en) 1990-10-19 1993-11-04 Unilever Plc Detergent compositions
JPH04228066A (ja) 1990-10-23 1992-08-18 Rikagaku Kenkyusho 外来遺伝子発現用培養細胞
EP0531562A1 (de) * 1991-09-11 1993-03-17 Doerr, Hans-Wilhelm, Prof. Dr. med. Kultivierung von Säugetierzellen
CA2078721A1 (en) 1991-09-24 1993-03-25 Hiroshi Yonemura Process for preparing human coagulation factor viii protein complex
JPH05123178A (ja) 1991-11-01 1993-05-21 Ajinomoto Co Inc Ｌ−フエニルアラニンの製造法
DE4313620A1 (de) 1993-04-26 1994-10-27 Biotechnolog Forschung Gmbh Hamsterzellinien und Verfahren zur Glykoproteingewinnung
AU7895898A (en) 1993-04-26 1998-10-08 Hans Wolf Mammal cell lines and method of obtaining glycoproteins
GB9311132D0 (en) * 1993-05-28 1993-07-14 Eisai London Res Lab Ltd Control of cell death
US5405637A (en) 1993-06-30 1995-04-11 Bristol-Myers Squibb Company Milk protein partial hydrolysate and infant formula containing same
JP2766165B2 (ja) 1993-08-02 1998-06-18 株式会社バイオポリマー・リサーチ バクテリアセルロースの製造方法
US5445956A (en) * 1993-08-13 1995-08-29 The Regents Of The University Of California Recombinant soluble epoxide hydrolase
EP0653487A1 (de) 1993-11-07 1995-05-17 Ferruccio Dr. Messi Serum- und proteinfrei wachsende Zellen
US5719050A (en) * 1993-12-24 1998-02-17 Eiken Chemical Co., Ltd. Animal cell culturing media containing N-acetyl-L-glutamic acid
US5498599A (en) * 1994-01-21 1996-03-12 Amgen Inc. Methods for stimulating platelet production
EP0666312A1 (en) * 1994-02-08 1995-08-09 Wolfgang A. Renner Process for the improvement of mammalian cell growth
US5856179A (en) 1994-03-10 1999-01-05 Genentech, Inc. Polypeptide production in animal cell culture
US5789247A (en) * 1994-04-01 1998-08-04 Ballay; Annick Expression in non-tumoral human lymphoblastoid lines with an integrative vector
WO1996007730A2 (de) 1994-09-09 1996-03-14 Renner Wolfgang A Chemisches verfahren zur förderung der proliferation von tierischen zellen
DK1213030T3 (da) 1994-11-10 2009-07-20 Baxter Healthcare Sa Fremgangsmåde til fremstilling af biologiske produkter i protein-fri kultur
AT403167B (de) 1994-11-14 1997-11-25 Immuno Ag Selektion und expression von fremdproteinen mittels eines selektions-amplifikations-systems
WO1996018734A1 (en) 1994-12-16 1996-06-20 Novartis Ag Production of recombinant secretory component
US5741705A (en) * 1995-02-23 1998-04-21 Quest International Flavors & Food Ingredients Company, Division Of Indopco, Inc. Method for in vitro cell growth of eucaryotic cells using low molecular weight peptides
JP3649249B2 (ja) 1995-02-23 2005-05-18 クエスト・インターナショナル・サービシーズ・ビー・ブイ 組織および細胞培養用ペプチド
AU6125396A (en) 1995-06-07 1996-12-30 Novartis Ag Serum-free media for primitive hematopoietic cells and metho ds of use thereof
AUPN442295A0 (en) 1995-07-26 1995-08-17 Commonwealth Scientific And Industrial Research Organisation Regulated autocrine growth of mammalian cells
US5851800A (en) * 1996-05-14 1998-12-22 Pharmacia & Upjohn Ab Process for producing a protein
AU4081997A (en) 1996-08-30 1998-03-19 University Of North Carolina At Chapel Hill, The Immortalized human hepatic cell line
EP2243827B2 (en) 1996-08-30 2017-11-22 Life Technologies Corporation Serum-free mammalian cell culture medium, and uses thereof
EP0954563B1 (en) 1996-10-10 2008-07-02 Invitrogen Corporation Animal cell culture media comprising plant-derived nutrients
US5804420A (en) 1997-04-18 1998-09-08 Bayer Corporation Preparation of recombinant Factor VIII in a protein free medium
ATE488574T1 (de) 1997-05-28 2010-12-15 Novartis Vaccines & Diagnostic Verfahren zur herstellung eines immunogenen faktors von corynebacterium diphtheriae unter verwendung eines kulturmediums mit hefeextrakt als aminosäurenquelle und ohne proteinkomplexe tierischer herkunft
AT407255B (de) * 1997-06-20 2001-02-26 Immuno Ag Rekombinanter zellklon mit erhöhter stabilität in serum- und proteinfreiem medium und verfahren zur gewinnung des stabilen zellklons
US6475725B1 (en) * 1997-06-20 2002-11-05 Baxter Aktiengesellschaft Recombinant cell clones having increased stability and methods of making and using the same
EP0986644B1 (de) 1997-07-23 2006-10-04 Boehringer Mannheim GmbH Herstellung von erythropoietin durch endogene genaktivierung mit viralen promotoren
AU731857B2 (en) 1997-11-20 2001-04-05 Weyerhaeuser Company Nutritive media and manufactured seeds comprising same
AU2455199A (en) 1998-01-12 1999-07-26 Betagene, Inc. Compositions and methods for regulated secretion from neuroendocrine cell lines
FR2775983B1 (fr) 1998-03-13 2000-11-10 Pasteur Merieux Serums Vacc Milieu et procede de propagation et de multiplication virales
WO1999057246A1 (en) 1998-05-01 1999-11-11 Life Technologies, Inc. Animal cell culture media comprising non-animal or plant-derived nutrients
US6537782B1 (en) * 1998-06-01 2003-03-25 Chugai Seiyaku Kabushiki Kaisha Media for culturing animal cells and process for producing protein by using the same
US6406909B1 (en) 1998-07-10 2002-06-18 Chugai Seiyaku Kabushiki Kaisha Serum-free medium for culturing animal cells
JP4266055B2 (ja) 1999-03-04 2009-05-20 雪印乳業株式会社 ポリアミン組成物の製造法
AT409379B (de) * 1999-06-02 2002-07-25 Baxter Ag Medium zur protein- und serumfreien kultivierung von zellen
AU780810B2 (en) 1999-08-05 2005-04-21 Baxalta GmbH Recombinant stable cell clone, its production and use thereof
ES2272318T3 (es) 1999-08-25 2007-05-01 Immunex Corporation Composiciones y metodos para el cultivo celular mejorado.
US6596526B1 (en) * 2000-06-09 2003-07-22 Baxter Aktiengesellschaft Furin polypeptides with improved characteristics
KR20030061810A (ko) 2000-09-25 2003-07-22 폴리문 사이언티픽 임무노이비오로기쉐 포르슝 게엠베하 생균 백신과 제조 방법
EP1208966A1 (en) 2000-11-27 2002-05-29 Cheng-Kun Liao Manufacturing process of patio tabletop glass with broken protection
DE10059175A1 (de) 2000-11-29 2002-06-20 Siemens Ag Verfahren und Vorrichtung zur Anrufumleitung mittels eines Stellvertreters in einem Kommunikationssystem
US20030096414A1 (en) 2001-03-27 2003-05-22 Invitrogen Corporation Culture medium for cell growth and transfection
US6734289B2 (en) * 2001-03-29 2004-05-11 The University Of Chicago Gastrokines and derived peptides including inhibitors
CA2447791A1 (en) 2001-06-13 2002-12-19 Neslihan Delacruz Methods of culturing animal cells and polypeptide production in animal cells
WO2003016492A2 (en) * 2001-08-16 2003-02-27 The Regents Of The University Of Michigan Adamts13 genes and proteins and variants, and uses thereof
JP4351049B2 (ja) 2001-10-02 2009-10-28 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 真核細胞中で組換えタンパク質を生産する方法
US20030104527A1 (en) * 2001-12-03 2003-06-05 National Research Council Of Canada Methylotrophic bacterium for the production of recombinant proteins and other products
DE10161412A1 (de) 2001-12-13 2003-07-03 Aventis Pharma Gmbh Verfahren zur Bestimmung der Aktivität der Ornithin-Decarboxylase sowie zur Identifizierung von Effektoren der Ornithin-Decarboxylase-Aktivität
DK2287288T3 (da) 2002-07-09 2013-01-07 Baxter Int Medium frit for animalsk protein til dyrkning af celler
FR2846004B1 (fr) 2002-10-16 2006-06-23 Maco Pharma Sa Composition pour culture de cellules notamment animales ou de tissus, comprenant du polyethylene glycol
FR2846005B1 (fr) 2002-10-16 2006-06-23 Maco Pharma Sa Composition pour milieu biologique comprenant de l'erythorbate de sodium
DE10333675A1 (de) 2003-07-24 2005-03-03 Aventis Pharma Deutschland Gmbh Perfusionsverfahren für die Produktion von Erythropoietin
ES2565077T3 (es) 2003-10-10 2016-03-31 Novo Nordisk Health Care Ag Método para producción en gran escala de un polipéptido en células eucariotas
US7294484B2 (en) 2004-08-27 2007-11-13 Wyeth Research Ireland Limited Production of polypeptides
CA2585547A1 (en) 2004-10-29 2006-05-11 Centocor, Inc. Chemically defined media compositions
US20060094104A1 (en) 2004-10-29 2006-05-04 Leopold Grillberger Animal protein-free media for cultivation of cells
ES2790887T3 (es) 2006-01-04 2020-10-29 Baxalta Inc Medio de cultivo celular sin oligopéptidos

Also Published As

Publication number Publication date
HK1177950A1 (en) 2013-08-30
WO2007077217A2 (en) 2007-07-12
EP2522717B1 (en) 2014-04-02
HUE032744T2 (en) 2017-10-30
EP3121266B1 (en) 2020-02-26
ES2790887T3 (es) 2020-10-29
KR101423344B1 (ko) 2014-07-30
JP5259418B2 (ja) 2013-08-07
EP3121266A1 (en) 2017-01-25
LT1974014T (lt) 2017-11-27
PL3121266T3 (pl) 2020-07-13
DK3121266T3 (da) 2020-05-11
RU2017144220A (ru) 2019-06-18
JP6567490B2 (ja) 2019-08-28
AU2007204044B2 (en) 2012-09-27
EP1974014B1 (en) 2017-04-19
JP2015006209A (ja) 2015-01-15
CA2633306A1 (en) 2007-07-12
JP7134157B2 (ja) 2022-09-09
JP2017055770A (ja) 2017-03-23
US20170362300A1 (en) 2017-12-21
RU2642269C2 (ru) 2018-01-24
CN102643777A (zh) 2012-08-22
PT3121266T (pt) 2020-05-19
EP3121266B8 (en) 2020-04-22
KR20130100224A (ko) 2013-09-09
PT2522717E (pt) 2014-05-15
EP3653699A1 (en) 2020-05-20
JP2013106616A (ja) 2013-06-06
RU2008131953A (ru) 2010-02-10
ES2474573T3 (es) 2014-07-09
CY1119046T1 (el) 2018-01-10
US9758568B2 (en) 2017-09-12
AU2007204044A1 (en) 2007-07-12
KR20080083197A (ko) 2008-09-16
EP2522717A1 (en) 2012-11-14
JP2020028307A (ja) 2020-02-27
KR101422435B1 (ko) 2014-07-22
ES2629304T3 (es) 2017-08-08
RU2013112019A (ru) 2014-09-27
JP2018075032A (ja) 2018-05-17
JP2009521941A (ja) 2009-06-11
US20070212770A1 (en) 2007-09-13
DK1974014T3 (da) 2017-06-19
WO2007077217A3 (en) 2007-11-08
CN101360820A (zh) 2009-02-04
US20160068587A1 (en) 2016-03-10
RU2758802C2 (ru) 2021-11-02
PL1974014T3 (pl) 2017-09-29
PT1974014T (pt) 2017-05-26
PL2522717T3 (pl) 2014-08-29
RU2642269C9 (ru) 2018-10-31
US20110151512A1 (en) 2011-06-23
US10696731B2 (en) 2020-06-30
SI2522717T1 (sl) 2014-05-30
RU2486236C2 (ru) 2013-06-27
EP1974014A2 (en) 2008-10-01
RU2017144220A3 (da) 2021-03-01

Similar Documents

Publication Publication Date Title
DK3121266T3 (da) Oligopeptid-frie cellekulturmedier
GB0613756D0 (en) Cell culture medium
DE602007004421D1 (de) Zellkulturvorrichtung
CR10781A (es) Medios disenado racionalmente para cultivo celular
BRPI0716762A2 (pt) melhorias da cultura celular
DK2574677T3 (da) Fremgangsmåder til celledyrkning
DK3192865T3 (da) Enkelt pluripotent stamcelle-kultur
EP1997877A4 (en) CELL CULTURE SUBSTRATE
DE112007002407B8 (de) Brennstoffzelle
EP2028264A4 (en) CELL INCUBATOR
DE112007001371B8 (de) Brennstoffzelle
DE602008000048D1 (de) Brennstoffzelle
EP1988804A4 (en) MICRO FLUID CELL CULTURE MEDIA
DK2027150T3 (da) Allo-begrænsede peptid-specifikke t-celler
DE602007008627D1 (de) Zellkulturmedium
GB2435475B (en) Selective culture medium
DK2511369T3 (da) Proteasestabile cellevægslyserende enzymer
GB0610009D0 (en) Culture medium
GB0606764D0 (en) Three dimensional cell culture
DE112007003333A5 (de) Fermenter
GB0606671D0 (en) Cell Culture
DE602007007302D1 (de) Brennstoffzelle
FI20070190A (fi) Bioreaktori
DE602007014056D1 (de) Brennstoffzelle
TH0601006029A (th) อาหารเลี้ยงเชื้อสำหรับแบคทีเรียสายพันธุ์ Enterobacter radicintans Culture Medium for Enterobacter radicincitans