HK1177950A1 - Oligopeptide-free cell culture media - Google Patents

Oligopeptide-free cell culture media

Info

Publication number
HK1177950A1
HK1177950A1 HK13105678A HK13105678A HK1177950A1 HK 1177950 A1 HK1177950 A1 HK 1177950A1 HK 13105678 A HK13105678 A HK 13105678A HK 13105678 A HK13105678 A HK 13105678A HK 1177950 A1 HK1177950 A1 HK 1177950A1
Authority
HK
Hong Kong
Prior art keywords
oligopeptide
cell culture
culture media
free cell
free
Prior art date
Application number
HK13105678A
Other languages
English (en)
Chinese (zh)
Inventor
Leopold Grillberger
Manfred Reiter
Wolfgang Mundt
Artur Mitterer
Original Assignee
Baxter Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37942126&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1177950(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Baxter Int filed Critical Baxter Int
Publication of HK1177950A1 publication Critical patent/HK1177950A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/005—Protein-free medium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/32—Amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/38—Vitamins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/46—Amines, e.g. putrescine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/50—Soluble polymers, e.g. polyethyleneglycol [PEG]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24151—Methods of production or purification of viral material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
HK13105678A 2006-01-04 2013-05-13 Oligopeptide-free cell culture media HK1177950A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75641906P 2006-01-04 2006-01-04

Publications (1)

Publication Number Publication Date
HK1177950A1 true HK1177950A1 (en) 2013-08-30

Family

ID=37942126

Family Applications (1)

Application Number Title Priority Date Filing Date
HK13105678A HK1177950A1 (en) 2006-01-04 2013-05-13 Oligopeptide-free cell culture media

Country Status (18)

Country Link
US (4) US20070212770A1 (da)
EP (4) EP3121266B8 (da)
JP (6) JP5259418B2 (da)
KR (2) KR101423344B1 (da)
CN (2) CN102643777A (da)
AU (1) AU2007204044B2 (da)
CA (1) CA2633306A1 (da)
CY (1) CY1119046T1 (da)
DK (3) DK1974014T3 (da)
ES (3) ES2790887T3 (da)
HK (1) HK1177950A1 (da)
HU (1) HUE032744T2 (da)
LT (1) LT1974014T (da)
PL (3) PL1974014T3 (da)
PT (3) PT3121266T (da)
RU (3) RU2486236C2 (da)
SI (1) SI2522717T1 (da)
WO (1) WO2007077217A2 (da)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1974014T3 (da) 2006-01-04 2017-06-19 Baxalta Inc Oligopeptid-frie cellekulturmedier
EP3255152A1 (en) * 2007-12-27 2017-12-13 Baxalta GmbH Cell culture processes
CN101910401A (zh) * 2007-12-31 2010-12-08 巴克斯特国际公司 基本上无动物蛋白的重组体弗林蛋白酶及其生产方法
US8637312B2 (en) 2008-01-09 2014-01-28 Cellca Gmbh Mammalian culture media with polyamine and iron
BRPI0907539A2 (pt) 2008-02-25 2015-07-28 Baxter Int Método para produzir linhagens de células contínuas, e, linhagens de células
WO2010056584A1 (en) 2008-11-12 2010-05-20 Baxter International Inc. Method of producing serum-free insulin-free factor vii
CN102549145B (zh) * 2009-07-31 2015-05-20 巴克斯特国际公司 用于adamts蛋白表达的细胞培养基
US8580554B2 (en) * 2009-07-31 2013-11-12 Baxter International Inc. Method of producing a polypeptide or virus of interest in a continuous cell culture
ES2948612T3 (es) 2009-09-21 2023-09-14 Takeda Pharmaceuticals Co Formulaciones de ADAMTS13 líquidas y liofilizadas estabilizadas
EP2563903B1 (en) 2010-04-26 2019-08-21 Novartis AG Improved cell culture medium
PL3064508T5 (pl) 2010-07-08 2024-04-08 Takeda Pharmaceutical Company Limited Sposób wytwarzania rekombinowanego vwf o dużej masie cząsteczkowej w hodowli komórkowej
WO2012037530A1 (en) 2010-09-17 2012-03-22 Baxter International Inc. Stabilization of immunoglobulins and other proteins through aqueous formulations with sodium chloride at weak acidic to neutral ph
SG189914A1 (en) 2010-10-27 2013-06-28 Baxter Int Fviii peptides for immune tolerance induction and immunodiagnostics
WO2012149197A2 (en) 2011-04-27 2012-11-01 Abbott Laboratories Methods for controlling the galactosylation profile of recombinantly-expressed proteins
CN108210889A (zh) 2011-06-10 2018-06-29 百深有限责任公司 通过施用重组vwf治疗凝血疾病
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
US9334319B2 (en) 2012-04-20 2016-05-10 Abbvie Inc. Low acidic species compositions
WO2013158273A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Methods to modulate c-terminal lysine variant distribution
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
CN104822826B (zh) 2012-10-15 2019-04-30 百时美施贵宝公司 用于蛋白产生的哺乳动物细胞培养过程
CA2905010A1 (en) 2013-03-12 2014-09-18 Abbvie Inc. Human antibodies that bind human tnf-alpha and methods of preparing the same
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
US9217168B2 (en) 2013-03-14 2015-12-22 Momenta Pharmaceuticals, Inc. Methods of cell culture
US9499614B2 (en) 2013-03-14 2016-11-22 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides
AR095196A1 (es) * 2013-03-15 2015-09-30 Regeneron Pharma Medio de cultivo celular libre de suero
EP3052640A2 (en) 2013-10-04 2016-08-10 AbbVie Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
WO2015073884A2 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
KR101641655B1 (ko) * 2014-01-08 2016-07-21 서울대학교산학협력단 스퍼미딘 또는 스퍼민을 이용함으로써 생육 저해제에 대한 내성이 증진된 효모의 배양방법
CN107406368B (zh) * 2015-03-17 2020-06-19 帝斯曼知识产权资产管理有限公司 用于制备二氨基丁烷的工艺
TW202330904A (zh) 2015-08-04 2023-08-01 美商再生元醫藥公司 補充牛磺酸之細胞培養基及用法
DK3383894T3 (da) 2015-12-02 2020-06-02 CSL Behring Lengnau AG Forbedrede medier til eksprimering af rekombinante vitamin k-afhængige proteiner
CN106635953B (zh) * 2016-12-13 2021-02-19 昆明润什生物科技有限公司 无血清无蛋白细胞培养基
CN114075269A (zh) * 2017-07-06 2022-02-22 菲仕兰坎皮纳荷兰私人有限公司 用于制备糖蛋白的细胞培养工艺
KR20200037251A (ko) 2017-07-07 2020-04-08 박스알타 인코퍼레이티드 재조합 vwf의 투여에 의해 대기 수술을 받은 중증 폰 빌레브란트 병을 가지고 있는 환자의 치료
WO2019010497A1 (en) 2017-07-07 2019-01-10 Baxalta Incorporated TREATMENT OF GASTROINTESTINAL BLEEDING IN PATIENTS WITH A SEVERE FORM OF VON WILLEBRAND'S DISEASE BY RECOMBINANT VWF ADMINISTRATION
JP2021519280A (ja) 2018-03-21 2021-08-10 バクスアルタ インコーポレイテッド クロマトグラフィー法によるｖｗｆとｖｗｆプロペプチドの分離
EP3781943B1 (en) 2018-04-20 2022-04-27 Janssen Biotech, Inc. Chromatography column qualification in manufacturing methods for producing anti-il12/il23 antibody compositions
CN108872758B (zh) * 2018-05-10 2019-06-28 江苏大学 一种电子元器件寿命检测装置
JP2022513018A (ja) 2018-11-13 2022-02-07 ヤンセン バイオテツク，インコーポレーテツド 抗ｃｄ３８抗体の生成中の微量金属の制御
WO2020160460A1 (en) 2019-02-01 2020-08-06 Baxalta Incorporated Methods of prophylactic treatment using recombinant vwf (rvwf)
US20200291107A1 (en) 2019-03-14 2020-09-17 Janssen Biotech, Inc. Manufacturing Methods for Producing Anti-IL12/IL23 Antibody Compositions
US20220153830A1 (en) 2019-03-14 2022-05-19 Janssen Biotech, Inc. Manufacturing Methods for Producing Anti-TNF Antibody Compositions
EP3947632A1 (en) 2019-04-01 2022-02-09 The Automation Partnership (Cambridge) Ltd. Operation process for a cell cultivation system
US20220401524A1 (en) 2019-09-11 2022-12-22 Takeda Pharmaceutical Company Limited Methods of treatment related to complexes of von willebrand factor and complement c1q
JP7513034B2 (ja) * 2019-11-05 2024-07-09 味の素株式会社 タンパク質の製造方法
BR112021025432A2 (pt) 2019-12-06 2022-06-21 Regeneron Pharma Composições de proteína anti-vegf e métodos para a produção das mesmas
US20230398188A1 (en) 2020-02-04 2023-12-14 Takeda Pharmaceutical Company Limited Treatment of menorrhagia in patients with severe von willebrand disease by administration of recombinant vwf
US20230203469A1 (en) 2020-04-02 2023-06-29 Takeda Pharmaceutical Company Limited Adamts13 variant, compositions, and uses thereof
CA3202197A1 (en) 2021-01-20 2022-07-28 Reginald Smith Methods of improving protein titer in cell culture
CN113151183A (zh) * 2021-04-21 2021-07-23 赵峻岭 一种促进蛋白表达的培养基添加物及其应用
US20230042465A1 (en) 2021-07-09 2023-02-09 Janssen Biotech, Inc. Manufacturing Methods for Producing Anti-TNF Antibody Compositions
EP4367138A1 (en) 2021-07-09 2024-05-15 Janssen Biotech, Inc. Manufacturing methods for producing anti-il12/il23 antibody compositions
WO2023167871A1 (en) 2022-03-02 2023-09-07 Regeneron Pharmaceuticals, Inc. Manufacturing process for high titer antibody

Family Cites Families (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT165999B (de) 1947-06-26 1950-05-25 Delle Atel Const Electr Einirchtung zum Schutz von Drehstrommotoren gegen Überstrom
US4443540A (en) * 1980-05-09 1984-04-17 University Of Illinois Foundation Protein hydrolysis
DK207980A (da) * 1980-05-13 1981-11-14 Novo Industri As Fremgangsmaade til fremstilling af et skumnings- eller emulgeringsmiddel paa sojaproteinbasis
US4657866A (en) 1982-12-21 1987-04-14 Sudhir Kumar Serum-free, synthetic, completely chemically defined tissue culture media
FR2543158B1 (fr) 1983-03-24 1985-11-15 Inst Nat Sante Rech Med Milieu de culture de cellules animales sans serum, sans hormones et sans facteurs de croissance et procedes de culture primaire et d'obtention de lignees cellulaires utilisant ce milieu
US4767704A (en) 1983-10-07 1988-08-30 Columbia University In The City Of New York Protein-free culture medium
NZ210501A (en) 1983-12-13 1991-08-27 Kirin Amgen Inc Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence
IL74909A (en) 1984-04-20 1992-01-15 Genentech Inc Preparation of functional human factor viii and dna sequences,expression vectors,transformed microorganisms and cell lines used therein
WO1986004920A1 (en) 1985-02-13 1986-08-28 Biotechnology Research Partners, Limited Human metallothionein-ii promoter in mammalian expression system
US4978616A (en) * 1985-02-28 1990-12-18 Verax Corporation Fluidized cell cultivation process
DE3787805T2 (de) 1986-08-04 1994-02-10 Garvan Inst Med Res Serumfreies gewebekulturmedium, das ein polymerzellenschutzmittel enthält.
US5045468A (en) 1986-12-12 1991-09-03 Cell Enterprises, Inc. Protein-free culture medium which promotes hybridoma growth
JPH01503679A (ja) 1987-06-30 1989-12-14 アムジエン・インコーポレーテツド カリクレインの生産
JP2507882B2 (ja) 1988-02-17 1996-06-19 工業技術院長 外部増殖因子非依存性増殖良好細胞株の製造法
US6048728A (en) * 1988-09-23 2000-04-11 Chiron Corporation Cell culture medium for enhanced cell growth, culture longevity, and product expression
US5573937A (en) * 1989-12-07 1996-11-12 Snow Brand Milk Products Co., Ltd. Serum free culture medium
SE465222C5 (sv) 1989-12-15 1998-02-10 Pharmacia & Upjohn Ab Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning
CA2074363C (en) 1990-01-22 2004-11-09 David Thomas Vistica Co2-independent growth medium for maintenance and propagation of cells
JP2844484B2 (ja) 1990-02-22 1999-01-06 味の素株式会社 組換え蛋白質の生産方法
JP2859679B2 (ja) 1990-03-01 1999-02-17 協和醗酵工業株式会社 新規細胞株
JP2696001B2 (ja) 1991-04-15 1998-01-14 財団法人化学及血清療法研究所 組換え蛋白質産生用培地
US5378612A (en) * 1990-05-11 1995-01-03 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Culture medium for production of recombinant protein
US5122469A (en) 1990-10-03 1992-06-16 Genentech, Inc. Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
GB9022545D0 (en) * 1990-10-17 1990-11-28 Wellcome Found Culture medium
CA2053433C (en) 1990-10-19 1997-03-25 Michael Joseph Garvey Detergent compositions
JPH04228066A (ja) 1990-10-23 1992-08-18 Rikagaku Kenkyusho 外来遺伝子発現用培養細胞
EP0531562A1 (de) * 1991-09-11 1993-03-17 Doerr, Hans-Wilhelm, Prof. Dr. med. Kultivierung von Säugetierzellen
CA2078721A1 (en) 1991-09-24 1993-03-25 Hiroshi Yonemura Process for preparing human coagulation factor viii protein complex
JPH05123178A (ja) 1991-11-01 1993-05-21 Ajinomoto Co Inc Ｌ−フエニルアラニンの製造法
DE4313620A1 (de) 1993-04-26 1994-10-27 Biotechnolog Forschung Gmbh Hamsterzellinien und Verfahren zur Glykoproteingewinnung
AU7895898A (en) 1993-04-26 1998-10-08 Hans Wolf Mammal cell lines and method of obtaining glycoproteins
GB9311132D0 (en) * 1993-05-28 1993-07-14 Eisai London Res Lab Ltd Control of cell death
US5405637A (en) 1993-06-30 1995-04-11 Bristol-Myers Squibb Company Milk protein partial hydrolysate and infant formula containing same
JP2766165B2 (ja) 1993-08-02 1998-06-18 株式会社バイオポリマー・リサーチ バクテリアセルロースの製造方法
US5445956A (en) * 1993-08-13 1995-08-29 The Regents Of The University Of California Recombinant soluble epoxide hydrolase
EP0653487A1 (de) 1993-11-07 1995-05-17 Ferruccio Dr. Messi Serum- und proteinfrei wachsende Zellen
US5719050A (en) * 1993-12-24 1998-02-17 Eiken Chemical Co., Ltd. Animal cell culturing media containing N-acetyl-L-glutamic acid
US5498599A (en) * 1994-01-21 1996-03-12 Amgen Inc. Methods for stimulating platelet production
EP0666312A1 (en) 1994-02-08 1995-08-09 Wolfgang A. Renner Process for the improvement of mammalian cell growth
US5856179A (en) 1994-03-10 1999-01-05 Genentech, Inc. Polypeptide production in animal cell culture
US5789247A (en) * 1994-04-01 1998-08-04 Ballay; Annick Expression in non-tumoral human lymphoblastoid lines with an integrative vector
EP0733100A1 (de) 1994-09-09 1996-09-25 Wolfgang A. Renner Chemisches verfahren zur förderung der proliferation von tierischen zellen
ATE542891T1 (de) 1994-11-10 2012-02-15 Baxter Healthcare Sa Verfahren zur herstellung von biologischen produkten in protein-freier kultur
AT403167B (de) 1994-11-14 1997-11-25 Immuno Ag Selektion und expression von fremdproteinen mittels eines selektions-amplifikations-systems
AU4302796A (en) 1994-12-16 1996-07-03 Novartis Ag Production of recombinant secretory component
US5741705A (en) * 1995-02-23 1998-04-21 Quest International Flavors & Food Ingredients Company, Division Of Indopco, Inc. Method for in vitro cell growth of eucaryotic cells using low molecular weight peptides
JP3649249B2 (ja) 1995-02-23 2005-05-18 クエスト・インターナショナル・サービシーズ・ビー・ブイ 組織および細胞培養用ペプチド
WO1996040866A1 (en) 1995-06-07 1996-12-19 Novartis Ag Serum-free media for primitive hematopoietic cells and methods of use thereof
AUPN442295A0 (en) 1995-07-26 1995-08-17 Commonwealth Scientific And Industrial Research Organisation Regulated autocrine growth of mammalian cells
US5851800A (en) * 1996-05-14 1998-12-22 Pharmacia & Upjohn Ab Process for producing a protein
EP2221361A3 (en) 1996-08-30 2011-02-09 Life Technologies Corporation Method for producing a polypeptide in vitro in mammalian cells in a protein-free and serum-free culture medium
AU4081997A (en) 1996-08-30 1998-03-19 University Of North Carolina At Chapel Hill, The Immortalized human hepatic cell line
EP0954563B1 (en) 1996-10-10 2008-07-02 Invitrogen Corporation Animal cell culture media comprising plant-derived nutrients
US5804420A (en) * 1997-04-18 1998-09-08 Bayer Corporation Preparation of recombinant Factor VIII in a protein free medium
EP1849860B1 (en) 1997-05-28 2010-11-17 Novartis Vaccines and Diagnostics S.r.l. Process for preparing an immunogenic factor of Corynebacterium diphtheriae using a culture medium with yeast extract as aminoacid source and no protein complexes of animal origin
US6475725B1 (en) * 1997-06-20 2002-11-05 Baxter Aktiengesellschaft Recombinant cell clones having increased stability and methods of making and using the same
AT407255B (de) * 1997-06-20 2001-02-26 Immuno Ag Rekombinanter zellklon mit erhöhter stabilität in serum- und proteinfreiem medium und verfahren zur gewinnung des stabilen zellklons
DK0986644T3 (da) 1997-07-23 2007-01-29 Roche Diagnostics Gmbh Fremstilling af erythropoietin ved endogen genaktivering med virale promotorer
NZ505099A (en) 1997-11-20 2002-03-01 Weyerhaeuser Co Nutritive media and manufactured seeds comprising same
CA2318376A1 (en) 1998-01-12 1999-07-15 Betagene, Inc. Compositions and methods for regulated secretion from neuroendocrine cell lines
FR2775983B1 (fr) 1998-03-13 2000-11-10 Pasteur Merieux Serums Vacc Milieu et procede de propagation et de multiplication virales
WO1999057246A1 (en) 1998-05-01 1999-11-11 Life Technologies, Inc. Animal cell culture media comprising non-animal or plant-derived nutrients
US6537782B1 (en) * 1998-06-01 2003-03-25 Chugai Seiyaku Kabushiki Kaisha Media for culturing animal cells and process for producing protein by using the same
US6406909B1 (en) 1998-07-10 2002-06-18 Chugai Seiyaku Kabushiki Kaisha Serum-free medium for culturing animal cells
JP4266055B2 (ja) 1999-03-04 2009-05-20 雪印乳業株式会社 ポリアミン組成物の製造法
AT409379B (de) * 1999-06-02 2002-07-25 Baxter Ag Medium zur protein- und serumfreien kultivierung von zellen
DE59913565D1 (de) 1999-08-05 2006-07-27 Baxter Ag Rekombinanter stabiler zellklon, seine herstellung und verwendung
NZ517215A (en) 1999-08-25 2004-01-30 Immunex Corp Compositions and methods for improved cell culture
US6596526B1 (en) * 2000-06-09 2003-07-22 Baxter Aktiengesellschaft Furin polypeptides with improved characteristics
DK1358319T3 (da) 2000-09-25 2009-10-05 Polymun Scient Immunbio Forsch Levende influenzavaccine og fremgangsmåde til fremstilling heraf
EP1208966A1 (en) 2000-11-27 2002-05-29 Cheng-Kun Liao Manufacturing process of patio tabletop glass with broken protection
DE10059175A1 (de) 2000-11-29 2002-06-20 Siemens Ag Verfahren und Vorrichtung zur Anrufumleitung mittels eines Stellvertreters in einem Kommunikationssystem
US20030096414A1 (en) 2001-03-27 2003-05-22 Invitrogen Corporation Culture medium for cell growth and transfection
US6734289B2 (en) * 2001-03-29 2004-05-11 The University Of Chicago Gastrokines and derived peptides including inhibitors
WO2002101019A2 (en) 2001-06-13 2002-12-19 Genentech, Inc. Methods of culturing animal cells and polypeptide production in animal cells
AU2002336367A1 (en) * 2001-08-16 2003-03-03 The Regents Of The University Of Michigan Adamts13 genes and proteins and variants, and uses thereof
JP4351049B2 (ja) 2001-10-02 2009-10-28 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 真核細胞中で組換えタンパク質を生産する方法
US20030104527A1 (en) * 2001-12-03 2003-06-05 National Research Council Of Canada Methylotrophic bacterium for the production of recombinant proteins and other products
DE10161412A1 (de) 2001-12-13 2003-07-03 Aventis Pharma Gmbh Verfahren zur Bestimmung der Aktivität der Ornithin-Decarboxylase sowie zur Identifizierung von Effektoren der Ornithin-Decarboxylase-Aktivität
NZ538094A (en) * 2002-07-09 2007-01-26 Baxter Int Serum free and animal protein free culture medium for cultivation of cells
FR2846005B1 (fr) 2002-10-16 2006-06-23 Maco Pharma Sa Composition pour milieu biologique comprenant de l'erythorbate de sodium
FR2846004B1 (fr) 2002-10-16 2006-06-23 Maco Pharma Sa Composition pour culture de cellules notamment animales ou de tissus, comprenant du polyethylene glycol
DE10333675A1 (de) 2003-07-24 2005-03-03 Aventis Pharma Deutschland Gmbh Perfusionsverfahren für die Produktion von Erythropoietin
JP4740138B2 (ja) 2003-10-10 2011-08-03 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 真核生物細胞におけるポリペプチドの大規模生産方法及びそれに適した培養容器
US7294484B2 (en) 2004-08-27 2007-11-13 Wyeth Research Ireland Limited Production of polypeptides
US7598083B2 (en) 2004-10-29 2009-10-06 Centocor, Inc. Chemically defined media compositions
US20060094104A1 (en) 2004-10-29 2006-05-04 Leopold Grillberger Animal protein-free media for cultivation of cells
DK1974014T3 (da) 2006-01-04 2017-06-19 Baxalta Inc Oligopeptid-frie cellekulturmedier

Also Published As

Publication number Publication date
RU2642269C2 (ru) 2018-01-24
PT2522717E (pt) 2014-05-15
US20110151512A1 (en) 2011-06-23
RU2013112019A (ru) 2014-09-27
KR101422435B1 (ko) 2014-07-22
US20070212770A1 (en) 2007-09-13
RU2017144220A3 (da) 2021-03-01
EP2522717A1 (en) 2012-11-14
JP2020028307A (ja) 2020-02-27
PL2522717T3 (pl) 2014-08-29
ES2790887T3 (es) 2020-10-29
CA2633306A1 (en) 2007-07-12
JP2017055770A (ja) 2017-03-23
KR20080083197A (ko) 2008-09-16
RU2486236C2 (ru) 2013-06-27
JP2009521941A (ja) 2009-06-11
US20170362300A1 (en) 2017-12-21
RU2017144220A (ru) 2019-06-18
DK3121266T3 (da) 2020-05-11
EP3121266B1 (en) 2020-02-26
PL3121266T3 (pl) 2020-07-13
JP2018075032A (ja) 2018-05-17
AU2007204044B2 (en) 2012-09-27
WO2007077217A3 (en) 2007-11-08
EP1974014A2 (en) 2008-10-01
SI2522717T1 (sl) 2014-05-30
WO2007077217A2 (en) 2007-07-12
EP2522717B1 (en) 2014-04-02
ES2474573T3 (es) 2014-07-09
EP1974014B1 (en) 2017-04-19
KR20130100224A (ko) 2013-09-09
PT3121266T (pt) 2020-05-19
CN101360820A (zh) 2009-02-04
US9758568B2 (en) 2017-09-12
PL1974014T3 (pl) 2017-09-29
JP5259418B2 (ja) 2013-08-07
RU2008131953A (ru) 2010-02-10
EP3653699A1 (en) 2020-05-20
US20160068587A1 (en) 2016-03-10
DK2522717T3 (da) 2014-04-22
KR101423344B1 (ko) 2014-07-30
EP3121266A1 (en) 2017-01-25
JP2015006209A (ja) 2015-01-15
CY1119046T1 (el) 2018-01-10
ES2629304T3 (es) 2017-08-08
AU2007204044A1 (en) 2007-07-12
US10696731B2 (en) 2020-06-30
LT1974014T (lt) 2017-11-27
DK1974014T3 (da) 2017-06-19
PT1974014T (pt) 2017-05-26
HUE032744T2 (en) 2017-10-30
JP2013106616A (ja) 2013-06-06
EP3121266B8 (en) 2020-04-22
JP6567490B2 (ja) 2019-08-28
CN102643777A (zh) 2012-08-22
JP7134157B2 (ja) 2022-09-09
RU2758802C2 (ru) 2021-11-02
RU2642269C9 (ru) 2018-10-31

Similar Documents

Publication Publication Date Title
HK1177950A1 (en) Oligopeptide-free cell culture media
HK1246827A1 (zh) 細胞培養方法
GB0613756D0 (en) Cell culture medium
SG10201510384UA (en) Cell culture improvements
ZA200903170B (en) Rationally designed media for cell culture
GB0623635D0 (en) Pluripotent cell growth media
EP1997877A4 (en) CELL CULTURE SUBSTRATE
EP2028264A4 (en) CELL INCUBATOR
EP1988804A4 (en) MICRO FLUID CELL CULTURE MEDIA
GB0517382D0 (en) Cell culture
GB2435475B (en) Selective culture medium
GB0610009D0 (en) Culture medium
IL194524A0 (en) Three dimensional cell culture
GB0606671D0 (en) Cell Culture
ZA200905287B (en) A medium for a cell culture
AU2007903919A0 (en) Cell culture media
AU2006901495A0 (en) Cell culture