DK2265607T3 - Pyrimidin-2-aminforbindelser og deres anvendelse som inhibitorer af jak-kinaser - Google Patents
Pyrimidin-2-aminforbindelser og deres anvendelse som inhibitorer af jak-kinaser Download PDFInfo
- Publication number
- DK2265607T3 DK2265607T3 DK09710734.6T DK09710734T DK2265607T3 DK 2265607 T3 DK2265607 T3 DK 2265607T3 DK 09710734 T DK09710734 T DK 09710734T DK 2265607 T3 DK2265607 T3 DK 2265607T3
- Authority
- DK
- Denmark
- Prior art keywords
- optionally substituted
- substitueret
- eventuelt
- alkyl
- heterocyclyl
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2926508P | 2008-02-15 | 2008-02-15 | |
US3867208P | 2008-03-21 | 2008-03-21 | |
US11204608P | 2008-11-06 | 2008-11-06 | |
PCT/US2009/034159 WO2009103032A1 (en) | 2008-02-15 | 2009-02-13 | Pyrimidine-2-amine compounds and their use as inhibitors of jak kinases |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2265607T3 true DK2265607T3 (da) | 2017-03-13 |
Family
ID=40591956
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK09710734.6T DK2265607T3 (da) | 2008-02-15 | 2009-02-13 | Pyrimidin-2-aminforbindelser og deres anvendelse som inhibitorer af jak-kinaser |
Country Status (20)
Country | Link |
---|---|
US (3) | US8309566B2 (da) |
EP (1) | EP2265607B1 (da) |
JP (2) | JP5711537B2 (da) |
KR (1) | KR101700454B1 (da) |
CN (1) | CN102007124B (da) |
AU (1) | AU2009214440B2 (da) |
CA (1) | CA2715658C (da) |
CY (1) | CY1118969T1 (da) |
DK (1) | DK2265607T3 (da) |
ES (1) | ES2617622T3 (da) |
HR (1) | HRP20170317T1 (da) |
HU (1) | HUE030912T2 (da) |
IL (1) | IL207609A (da) |
LT (1) | LT2265607T (da) |
MX (1) | MX2010008926A (da) |
NZ (1) | NZ587589A (da) |
PL (1) | PL2265607T3 (da) |
PT (1) | PT2265607T (da) |
SI (1) | SI2265607T1 (da) |
WO (1) | WO2009103032A1 (da) |
Families Citing this family (39)
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EP2114955B1 (en) | 2006-12-29 | 2013-02-13 | Rigel Pharmaceuticals, Inc. | Bridged bicyclic aryl and bridged bicyclic heteroaryl substituted triazoles useful as axl inhibitors |
ES2406930T3 (es) | 2006-12-29 | 2013-06-10 | Rigel Pharmaceuticals, Inc. | Triazoles sustituidos con arilo bicíclico y heteroarilo bicíclico útiles como inhibidores de AXL |
JP2010514810A (ja) * | 2006-12-29 | 2010-05-06 | ライジェル ファーマシューティカルズ, インコーポレイテッド | Axlインヒビターとして有用な置換トリアゾール |
AU2007342005A1 (en) | 2006-12-29 | 2008-07-10 | Rigel Pharmaceuticals, Inc. | N3-heteroaryl substituted triazoles and N5-heteroaryl substituted triazoles useful as Axl inhibitors |
US7709482B2 (en) | 2006-12-29 | 2010-05-04 | Rigel Pharmaceuticals, Inc. | Polycyclic heteroaryl substituted triazoles useful as Axl inhibitors |
CA2698511C (en) * | 2007-09-04 | 2016-10-11 | The Scripps Research Institute | Substituted pyrimidinyl-amines as protein kinase inhibitors |
WO2009054864A1 (en) * | 2007-10-26 | 2009-04-30 | Rigel Pharmaceuticals, Inc. | Polycyclic aryl substituted triazoles and polycyclic heteroaryl substituted triazoles useful as axl inhibitors |
SI2265607T1 (sl) * | 2008-02-15 | 2017-06-30 | Rigel Pharmaceuticals, Inc. | Spojine pirimidin-2-amina in njihova uporaba kot inhibitorji JAK kinaz |
CA2730231C (en) | 2008-07-09 | 2016-10-18 | Rigel Pharmaceuticals, Inc. | Polycyclic heteroaryl substituted triazoles useful as axl inhibitors |
JP5613156B2 (ja) | 2008-07-09 | 2014-10-22 | ライジェル ファーマシューティカルズ, インコーポレイテッド | Axl阻害剤として有用な架橋二環ヘテロアリール置換トリアゾール |
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CN104414427A (zh) * | 2013-08-26 | 2015-03-18 | 皇家飞利浦有限公司 | 用于准备食物的具有带滑动机构的抽屉的装置 |
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- 2009-02-13 EP EP09710734.6A patent/EP2265607B1/en active Active
- 2009-02-13 KR KR1020107020561A patent/KR101700454B1/ko active IP Right Grant
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- 2009-02-13 AU AU2009214440A patent/AU2009214440B2/en not_active Ceased
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- 2009-02-13 DK DK09710734.6T patent/DK2265607T3/da active
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- 2009-02-13 WO PCT/US2009/034159 patent/WO2009103032A1/en active Application Filing
- 2009-02-13 ES ES09710734.6T patent/ES2617622T3/es active Active
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- 2009-02-13 CA CA2715658A patent/CA2715658C/en active Active
- 2009-02-13 US US12/371,550 patent/US8309566B2/en active Active
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US8309566B2 (en) | 2012-11-13 |
CA2715658A1 (en) | 2009-08-20 |
CY1118969T1 (el) | 2018-01-10 |
AU2009214440A1 (en) | 2009-08-20 |
US20090258864A1 (en) | 2009-10-15 |
JP2015061846A (ja) | 2015-04-02 |
CN102007124A (zh) | 2011-04-06 |
AU2009214440B2 (en) | 2014-09-25 |
KR20100124292A (ko) | 2010-11-26 |
EP2265607B1 (en) | 2016-12-14 |
CA2715658C (en) | 2016-07-19 |
SI2265607T1 (sl) | 2017-06-30 |
US9624229B2 (en) | 2017-04-18 |
US20140213585A1 (en) | 2014-07-31 |
PT2265607T (pt) | 2017-03-08 |
US20130018041A1 (en) | 2013-01-17 |
CN102007124B (zh) | 2014-06-18 |
LT2265607T (lt) | 2017-03-27 |
IL207609A0 (en) | 2010-12-30 |
HRP20170317T1 (hr) | 2017-04-21 |
JP5711537B2 (ja) | 2015-05-07 |
NZ587589A (en) | 2012-10-26 |
IL207609A (en) | 2015-08-31 |
PL2265607T3 (pl) | 2017-07-31 |
KR101700454B1 (ko) | 2017-01-26 |
ES2617622T3 (es) | 2017-06-19 |
HUE030912T2 (en) | 2017-06-28 |
WO2009103032A1 (en) | 2009-08-20 |
JP2011512361A (ja) | 2011-04-21 |
EP2265607A1 (en) | 2010-12-29 |
MX2010008926A (es) | 2011-02-23 |
US8735418B2 (en) | 2014-05-27 |
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