DK200200339U3 - Racemisk tamsulosin og tamsulosin i form af en fri base - Google Patents

Racemisk tamsulosin og tamsulosin i form af en fri base Download PDF

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Publication number
DK200200339U3
DK200200339U3 DK200200339U DKBA200200339U DK200200339U3 DK 200200339 U3 DK200200339 U3 DK 200200339U3 DK 200200339 U DK200200339 U DK 200200339U DK BA200200339 U DKBA200200339 U DK BA200200339U DK 200200339 U3 DK200200339 U3 DK 200200339U3
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DK
Denmark
Prior art keywords
tamsulosin
free base
racemic
solvent
salt
Prior art date
Application number
DK200200339U
Other languages
Danish (da)
English (en)
Inventor
Hoorn Hans Jan
Peters Theodorus Hend Antonius
Pis Jaroslav
Original Assignee
Synthon Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Synthon Bv filed Critical Synthon Bv
Publication of DK200200339U1 publication Critical patent/DK200200339U1/da
Application granted granted Critical
Publication of DK200200339U3 publication Critical patent/DK200200339U3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/20—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/42—Separation; Purification; Stabilisation; Use of additives
    • C07C303/44—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK200200339U 2001-10-31 2002-10-30 Racemisk tamsulosin og tamsulosin i form af en fri base DK200200339U3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33081701P 2001-10-31 2001-10-31
US10/208,009 US6835853B2 (en) 2001-10-31 2002-07-31 Process for resolution of tamsulosin and compounds, compositions, and processes associated therewith

Publications (2)

Publication Number Publication Date
DK200200339U1 DK200200339U1 (da) 2003-01-31
DK200200339U3 true DK200200339U3 (da) 2003-06-13

Family

ID=26902810

Family Applications (2)

Application Number Title Priority Date Filing Date
DK200200338U DK200200338U3 (da) 2001-10-31 2002-10-30 Forbindelser og sammensætninger til tilvejebringelse af optisk berigede bundfald eller opløsninger af sulfonatsaltet af tamsulosin
DK200200339U DK200200339U3 (da) 2001-10-31 2002-10-30 Racemisk tamsulosin og tamsulosin i form af en fri base

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK200200338U DK200200338U3 (da) 2001-10-31 2002-10-30 Forbindelser og sammensætninger til tilvejebringelse af optisk berigede bundfald eller opløsninger af sulfonatsaltet af tamsulosin

Country Status (17)

Country Link
US (2) US6835853B2 (fr)
EP (2) EP1444198A1 (fr)
CN (2) CN100343227C (fr)
AT (2) ATE417822T1 (fr)
AU (2) AU2002330774B9 (fr)
CA (2) CA2464648C (fr)
CH (3) CH697034A5 (fr)
CZ (2) CZ13392U1 (fr)
DE (3) DE60230438D1 (fr)
DK (2) DK200200338U3 (fr)
FI (2) FI5816U1 (fr)
FR (2) FR2832147B1 (fr)
IL (2) IL161449A0 (fr)
IS (2) IS6602A (fr)
NL (2) NL1021671C2 (fr)
NO (1) NO20042256L (fr)
WO (2) WO2003037850A1 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2200699B1 (es) * 2002-07-12 2005-10-01 Ragactives, S.L Procedimiento para la separacion de r(-) y s(+)-5-(2-((2-(etoxifenoxi)etil)amino)propil-2-metoxibenceno-sulfonamida.
USH2154H1 (en) * 2003-10-08 2006-04-04 Farmak, A.S. Process for preparing R- and S-isomers of (R)-5-(2-( (2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide
SI21656A (sl) * 2003-12-29 2005-06-30 LEK farmacevtska družba d.d. Priprava (R)-5-(2-(2-(2-etoksifenoksi) etilamino)-1-propil)-2-metoksibenzensulfonamida hidroklorida z visoko kemijsko čistoto
SI21702A (en) * 2004-01-29 2005-08-31 Lek Farmacevtska Druzba Dd Preparation of amorphous form of tamsulosin
WO2005089511A2 (fr) * 2004-03-19 2005-09-29 Transform Pharmaceuticals, Inc. Nouvelles formes pharmaceutiques, procedes de fabrication et modes d'utilisation
CN100545148C (zh) 2004-08-16 2009-09-30 神隆新加坡私人有限公司 一种抗良性前列腺肥大药物坦索罗辛之合成方法
US7238839B2 (en) 2004-10-07 2007-07-03 Divi's Laboratories Limited Process for the resolution of racemic (R,S) -5-(2-(2-(2- ethoxyphenoxy) ethylamino)Propyl)-2-methoxybenzene sulfonamide (tamsulosin), its novel R and S isomers and their salts and processes for their preparation
PT103216B (pt) 2004-12-06 2010-05-19 Hovione Farmaciencia S A Preparação de tamsulosin
WO2006117662A2 (fr) * 2005-05-03 2006-11-09 Ranbaxy Laboratories Limited Formes polymorphes de (r)-(-)-tamsulosine
US20090137844A1 (en) * 2005-06-15 2009-05-28 Fermion Oy Crystallization process
EP2026766A1 (fr) 2006-05-17 2009-02-25 Synthon B.V. Composition en comprimé pour la libération prolongée de la tamsulosine
US20080312328A1 (en) * 2007-06-14 2008-12-18 Protia, Llc Deuterium-enriched tamsulosin
DE102008002409A1 (de) * 2008-06-13 2009-12-17 Evonik Goldschmidt Gmbh Enzymatische Synthese von Sphingolipiden
US8465770B2 (en) * 2008-12-24 2013-06-18 Synthon Bv Low dose controlled release tablet
EP2338876A1 (fr) 2009-12-22 2011-06-29 LEK Pharmaceuticals d.d. Le sel adipate de tamsulosine pour une utilisation pharmaceutique
KR101525493B1 (ko) * 2013-01-02 2015-06-03 보령제약 주식회사 고순도 탐술로신 또는 이의 염 제조방법
CN104926699B (zh) * 2015-07-02 2018-09-25 成都丽凯手性技术有限公司 一种高光学纯度盐酸坦索罗辛的制备方法
CN106631918B (zh) * 2016-10-13 2018-07-13 深圳万和制药有限公司 拆分坦索罗辛对映异构体的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH383998A (de) * 1959-08-05 1964-11-15 Ciba Geigy Verfahren zur Herstellung neuer sekundärer Amine
US3261829A (en) * 1964-08-12 1966-07-19 Searle & Co Spiro(steroidal-6,3'-1-pyrazolines) and process
CA1147342A (fr) 1977-10-12 1983-05-31 Kazuo Imai Procede de preparation de nouveaux derives de la phenylethanolamine
JPS56110665A (en) 1980-02-08 1981-09-01 Yamanouchi Pharmaceut Co Ltd Sulfamoyl-substituted phenetylamine derivative and its preparation
US5391825A (en) * 1980-02-08 1995-02-21 Yamanouchi Pharmaceutical Co., Ltd. Sulfamoyl substituted phenethylamine intermediates
JPH066565B2 (ja) 1986-07-21 1994-01-26 山之内製薬株式会社 光学活性なベンゼンスルホンアミド誘導体の製造法
ATE146775T1 (de) * 1993-02-23 1997-01-15 Hoechst Ag Substituierte benzolsulfonylharnstoffe und - thioharnstoffe- verfahren zu ihrer herstellung und ihre verwendung als pharmazeutika
US5877218A (en) * 1994-01-10 1999-03-02 Teva Pharmaceutical Industries, Ltd. Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives

Also Published As

Publication number Publication date
DK200200338U1 (da) 2003-01-31
DK200200338U3 (da) 2003-07-11
CH697164A5 (de) 2008-05-30
CN1578762A (zh) 2005-02-09
NL1021678C2 (nl) 2003-05-15
CZ13580U1 (cs) 2003-08-18
FR2832147A1 (fr) 2003-05-16
DE60230438D1 (de) 2009-01-29
AU2002330776B2 (en) 2009-03-12
DE20216835U1 (de) 2003-09-25
CA2464917A1 (fr) 2003-05-08
IL161449A0 (en) 2004-09-27
IL161490A0 (en) 2004-09-27
CH696665A5 (de) 2007-09-14
AT6687U1 (de) 2004-02-25
FIU20020421U0 (fi) 2002-10-23
AU2002330774B9 (en) 2010-01-07
EP1444199A1 (fr) 2004-08-11
DE20216779U1 (de) 2003-09-04
CZ13392U1 (cs) 2003-06-24
EP1444198A1 (fr) 2004-08-11
FIU20020420U0 (fi) 2002-10-23
FR2832146A1 (fr) 2003-05-16
WO2003037850A1 (fr) 2003-05-08
CA2464917C (fr) 2009-06-02
AU2002330774B2 (en) 2009-06-04
CN100343227C (zh) 2007-10-17
FI5816U1 (fi) 2003-06-06
FR2832146B1 (fr) 2006-05-26
IS6603A (is) 2003-05-02
WO2003037851A1 (fr) 2003-05-08
NO20042256L (no) 2004-07-28
ATE417822T1 (de) 2009-01-15
FI5957U1 (fi) 2003-09-30
US20050096394A1 (en) 2005-05-05
IS6602A (is) 2003-05-02
FR2832147B1 (fr) 2006-06-02
CN1578761A (zh) 2005-02-09
CN100579958C (zh) 2010-01-13
EP1444199B1 (fr) 2008-12-17
DK200200339U1 (da) 2003-01-31
CA2464648C (fr) 2009-07-14
CH697034A5 (de) 2008-03-31
US20030109752A1 (en) 2003-06-12
CA2464648A1 (fr) 2003-05-08
NL1021671C2 (nl) 2003-05-15
US6965051B2 (en) 2005-11-15
US6835853B2 (en) 2004-12-28

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