DK1761542T3 - Octahydropyrrolo[3,4-C] pyrrolderivater og anvendelsen deraf som antivirusmidler - Google Patents

Octahydropyrrolo[3,4-C] pyrrolderivater og anvendelsen deraf som antivirusmidler

Info

Publication number
DK1761542T3
DK1761542T3 DK05754708T DK05754708T DK1761542T3 DK 1761542 T3 DK1761542 T3 DK 1761542T3 DK 05754708 T DK05754708 T DK 05754708T DK 05754708 T DK05754708 T DK 05754708T DK 1761542 T3 DK1761542 T3 DK 1761542T3
Authority
DK
Denmark
Prior art keywords
octahydropyrrolo
antiviral agents
pyrrole derivatives
pyrrole
derivatives
Prior art date
Application number
DK05754708T
Other languages
Danish (da)
English (en)
Inventor
Eun Kyung Lee
Chris Richard Melville
David Mark Rotstein
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK1761542T3 publication Critical patent/DK1761542T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK05754708T 2004-06-09 2005-06-01 Octahydropyrrolo[3,4-C] pyrrolderivater og anvendelsen deraf som antivirusmidler DK1761542T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57875904P 2004-06-09 2004-06-09
PCT/EP2005/005895 WO2005121145A2 (en) 2004-06-09 2005-06-01 Octahydro-pyrrolo[3,4-c] derivatives and their use as antiviral compounds

Publications (1)

Publication Number Publication Date
DK1761542T3 true DK1761542T3 (da) 2008-04-28

Family

ID=35431500

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05754708T DK1761542T3 (da) 2004-06-09 2005-06-01 Octahydropyrrolo[3,4-C] pyrrolderivater og anvendelsen deraf som antivirusmidler

Country Status (21)

Country Link
US (2) US7164019B2 (ja)
EP (1) EP1761542B1 (ja)
JP (1) JP2008501743A (ja)
CN (1) CN101001860A (ja)
AR (1) AR049209A1 (ja)
AT (1) ATE382623T1 (ja)
AU (1) AU2005251891A1 (ja)
BR (1) BRPI0511982A (ja)
CA (1) CA2569910A1 (ja)
DE (1) DE602005004144T2 (ja)
DK (1) DK1761542T3 (ja)
ES (1) ES2297727T3 (ja)
IL (1) IL179534A0 (ja)
MX (1) MXPA06014404A (ja)
NO (1) NO20070137L (ja)
PL (1) PL1761542T3 (ja)
PT (1) PT1761542E (ja)
RU (1) RU2006146608A (ja)
TW (1) TW200701981A (ja)
WO (1) WO2005121145A2 (ja)
ZA (1) ZA200609837B (ja)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20080056220A (ko) 2005-10-19 2008-06-20 에프. 호프만-라 로슈 아게 페닐-아세트아마이드 ｎｎｒｔ 저해제
RU2008136763A (ru) * 2006-02-15 2010-03-20 Ф.Хоффманн-Ля Рош Аг (Ch) Гетероциклические противовирусные соединения
AU2007216543A1 (en) * 2006-02-15 2007-08-23 F. Hoffmann-La Roche Ag Hetero-bycyclic antiviral compounds
PT2057125E (pt) 2006-08-16 2011-05-31 Hoffmann La Roche Inibidores n?o nucle?sidos de transcriptase inversa
WO2008030853A2 (en) * 2006-09-06 2008-03-13 Incyte Corporation Combination therapy for human immunodeficiency virus infection
DE602007007497D1 (de) * 2006-09-18 2010-08-12 Hoffmann La Roche Octahydropyrroloä3,4-cüpyrrolderivate und ihre verwendung als antivirale mittel
TWI404532B (zh) * 2006-11-02 2013-08-11 Targacept Inc 菸鹼乙醯膽鹼受體亞型選擇性之二氮雜雙環烷類醯胺
ES2550152T3 (es) 2006-12-13 2015-11-04 F. Hoffmann-La Roche Ag Derivados de 2-(piperidin-4-il)-4-fenoxi-o fenilamino-pirimidina como inhibidores no nucleósidos de transcriptasa inversa
US8464207B2 (en) * 2007-10-12 2013-06-11 Novell Intellectual Property Holdings, Inc. System and method for tracking software changes
GB0724251D0 (en) 2007-12-12 2008-02-06 Univ Edinburgh Therapeutic compounds and their use
GB0804685D0 (en) 2008-03-13 2008-04-16 Univ Edinburgh Therapeutic compounds and their use
WO2011033255A1 (en) 2009-09-16 2011-03-24 The University Of Edinburgh (4-phenyl-piperidin-1-yl)-[5-1h-pyrazol-4yl)-thiophen-3-yl]-methanone compounds and their use
MX2012007935A (es) 2010-01-07 2012-08-15 Du Pont Compuestos heterociclicos fungicidas.
MX344142B (es) 2010-04-29 2016-12-07 The Univ Of Edinburgh (8-aza-biciclico[3.2.1]oct-8-il)-[5-(1h-pirazol-4-il)-tiofen-3-il ]-metanonas 3, 3-disubstituidas como inhibidores de 1(beta)-hsd1.
DE102010025663A1 (de) * 2010-06-30 2012-01-05 Karl-Heinz Glüsenkamp Neue beta-Aminoaldehyd-Derivate, Verfahren zu ihrer Herstellung und ihre chemische Verwendung als reaktive Intermediate
AU2013276617B9 (en) 2012-06-13 2018-03-29 F. Hoffmann-La Roche Ag New diazaspirocycloalkane and azaspirocycloalkane
SI2900669T1 (sl) * 2012-09-25 2019-12-31 F. Hoffmann-La Roche Ag Derivati heksahidropirolo(3,4-C)pirola in sorodne spojine kot zaviralci avtotaksina (ATX) in kot zaviralci tvorbe lizofosfatidne kisline (LPA) za zdravljenje npr. bolezni ledvic
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
JP6546596B2 (ja) * 2013-09-26 2019-07-17 カデント セラピューティクス，インコーポレーテッド Ｎｒ２ｂの選択的オクタヒドロ−シクロペンタ［ｃ］ピロール負調節因子
MY187449A (en) 2013-11-26 2021-09-22 Hoffmann La Roche New octahydro-cyclobuta [1,2-c;3,4-c']dipyrrol-2-yl
CN104744451A (zh) * 2013-12-30 2015-07-01 中国科学院上海药物研究所 一种1-(3-氨基丙基)取代环状胺类化合物、其制备方法、药物组合物及用途
DK3122750T3 (da) 2014-03-26 2019-11-04 Hoffmann La Roche Bicykliske forbindelser som autotaxin (ATX)- og lysofosfatidsyre (LPA)-produktionshæmmere
PE20161223A1 (es) 2014-03-26 2016-11-12 Hoffmann La Roche Compuestos condensados de [1,4]diazepina como inhibidores de la produccion de autotaxina (atx) y acido lisofosfatidico (lpa)
JO3579B1 (ar) * 2014-09-26 2020-07-05 Luc Therapeutics Inc مُعدِلات تفاغرية سالبة لمستقبل nr2b من المركب n-ألكيل أريل-5-أوكسي أريل-ثامن هيدرو-خماسي الحلقة [c] بيرول
MA41898A (fr) 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
JP6886967B2 (ja) 2015-09-04 2021-06-16 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ フェノキシメチル誘導体
JP6876685B2 (ja) 2015-09-24 2021-05-26 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ａｔｘ阻害剤としての二環式化合物
CN107614505B (zh) 2015-09-24 2021-05-07 豪夫迈·罗氏有限公司 作为双重atx/ca抑制剂的新型二环化合物
BR112018006024A2 (pt) 2015-09-24 2020-05-12 F. Hoffmann-La Roche Ag Compostos bicíclicos como inibidores de atx
MA42923A (fr) 2015-09-24 2021-04-28 Hoffmann La Roche Composés bicycliques comme inhibiteurs mixtes de atx/ca
RU2019100559A (ru) 2016-07-14 2020-07-14 Пфайзер Инк. Новые пиримидиновые карбоксамиды в качестве ингибиторов фермента ванин-1
RU2019132254A (ru) 2017-03-16 2021-04-16 Ф. Хоффманн-Ля Рош Аг Гетероциклические соединения, пригодные в качестве дуальных ингибиторов atx/ca
WO2018167113A1 (en) 2017-03-16 2018-09-20 F. Hoffmann-La Roche Ag New bicyclic compounds as atx inhibitors
US11629196B2 (en) 2020-04-27 2023-04-18 Incelldx, Inc. Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions
EP4164616A1 (en) * 2020-06-10 2023-04-19 Cyxone AB Oral formulation comprising a crystalline form of rabeximod
CN113845439B (zh) * 2021-10-11 2024-02-09 杭州师范大学 双苄酰胺类cxcr4拮抗剂及其制备和应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3930266A1 (de) 1989-09-11 1991-03-14 Thomae Gmbh Dr K Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE4338396A1 (de) 1993-11-10 1995-05-11 Basf Ag N-Substituierte Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
DE4341403A1 (de) 1993-12-04 1995-06-08 Basf Ag N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
US5457121A (en) 1994-09-02 1995-10-10 Eli Lilly And Company Cis-hexahydro-5-(1,2,3,4-tetrahydro-2-naphthalenyl)pyrrolo<3,4-c>pyrroles as inhibitors of serotonin reuptake
DE59610771D1 (de) * 1995-02-27 2003-11-20 Hoffmann La Roche Dioxopyrrolo-pyrrolderivate
GB9519563D0 (en) 1995-09-26 1995-11-29 Merck Sharp & Dohme Therapeutic agents
CZ48299A3 (cs) 1996-08-13 1999-07-14 Merck & Co., Inc. Způsob výroby indolových derivátů
PE20001420A1 (es) 1998-12-23 2000-12-18 Pfizer Moduladores de ccr5
US7217714B1 (en) 1998-12-23 2007-05-15 Agouron Pharmaceuticals, Inc. CCR5 modulators
WO2000055143A1 (en) * 1999-03-17 2000-09-21 F. Hoffmann-La Roche Ag Oxazolone derivatives and their use as alpha-1 adrenoreceptor modulators
KR100439358B1 (ko) 1999-05-04 2004-07-07 쉐링 코포레이션 Ｃｃｒ5 길항제로서 유용한 피페라진 유도체
HUP0203528A3 (en) 1999-05-04 2003-11-28 Schering Corp Piperidine derivatives useful as ccr5 antagonists, pharmaceutical compositions containing them and their use
JP4721087B2 (ja) * 1999-12-03 2011-07-13 小野薬品工業株式会社 トリアザスピロ［５．５］ウンデカン誘導体およびそれらを有効成分とする薬剤
JP2003516988A (ja) 1999-12-14 2003-05-20 ニューロサーチ、アクティーゼルスカブ 新規ヘテロアリール−ジアザビシクロアルカン類
EP1122257B1 (en) 2000-01-05 2005-10-12 Pfizer Inc. Benzimidazole compounds as ORL1-receptor agonists
JP3693957B2 (ja) 2000-05-26 2005-09-14 ファイザー・インク 療法において有用なトロパン誘導体
EP1304926B1 (en) 2000-07-21 2005-12-21 AK Food Technology, Inc Liquid infusion and tenderization process, apparatus, and product
SE0100326D0 (sv) * 2001-02-02 2001-02-02 Astrazeneca Ab New compounds
EP1368354A1 (en) * 2001-03-07 2003-12-10 Pfizer Products Inc. Modulators of chemokine receptor activity
GB0211418D0 (en) * 2002-05-17 2002-06-26 Glaxo Group Ltd Compounds
AR042628A1 (es) 2002-12-20 2005-06-29 Astrazeneca Ab Derivados de piperidina como moduladores del receptor ccr5

Also Published As

Publication number Publication date
JP2008501743A (ja) 2008-01-24
PT1761542E (pt) 2008-03-26
MXPA06014404A (es) 2007-02-19
BRPI0511982A (pt) 2008-01-22
TW200701981A (en) 2007-01-16
ATE382623T1 (de) 2008-01-15
EP1761542B1 (en) 2008-01-02
CA2569910A1 (en) 2005-12-22
US7714018B2 (en) 2010-05-11
CN101001860A (zh) 2007-07-18
WO2005121145A3 (en) 2006-03-02
PL1761542T3 (pl) 2008-06-30
EP1761542A2 (en) 2007-03-14
AR049209A1 (es) 2006-07-05
RU2006146608A (ru) 2008-07-20
NO20070137L (no) 2007-03-06
US20070117859A1 (en) 2007-05-24
IL179534A0 (en) 2007-05-15
AU2005251891A1 (en) 2005-12-22
DE602005004144T2 (de) 2009-01-29
DE602005004144D1 (de) 2008-02-14
US20060014767A1 (en) 2006-01-19
US7164019B2 (en) 2007-01-16
ZA200609837B (en) 2008-09-25
WO2005121145A2 (en) 2005-12-22
ES2297727T3 (es) 2008-05-01

Similar Documents

Publication Publication Date Title
DK1761542T3 (da) Octahydropyrrolo[3,4-C] pyrrolderivater og anvendelsen deraf som antivirusmidler
NO20054330D0 (no) 8-substituerte-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-on-derivater
NO20053955D0 (no) Pyrazolo [1,5-A] pyrimidinderivater
NO20054331D0 (no) Substituerte-8-perfluoralkyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-on-derivater
DK1966202T3 (da) Heteroarylsubstituerede pyrrolo[2,3-b]pyridiner og pyrrolo[2,3-d]pyrimidiner som Januskinaseinhibitorer
IS8403A (is) Pýrrólafleiður með bakteríueyðandi virkni
EP2223921B8 (en) 2-Thiophen-2-yl-oxazole, 2-Thiophen-2-yl-thiazole and 2-Thiophen-2-yl-1H-imidazole derivatives as antiviral agents
HK1103730A1 (en) Pyrrolopyridine derivatives and their use as crth2antagonists
IS8575A (is) 3-ß-D-ríbófúranósýlþíasóló [4,5-d]pýridímínnúkleósíð og notkun þeirra
PT1773768T (pt) Derivados de pirrol como agentes farmacêuticos
IS7872A (is) Pýrrólópýrimidín afleiður
ATE384725T1 (de) Pyrimido 4,5-d pyrimidinderivate mitantikrebswirkung
NO20054905D0 (no) 2-acylamino-4-fenyltiazolderivater, fremgangsmate for deres fremstilling og anvendelse av de samme som i terapeutika
IS7913A (is) Pýrasóló[3,4-b]pýridín efnasambönd, og notkun þeirra sem fosfórdíesterasa hindrar
IL182610A0 (en) Tetracyclic indole derivatives as antiviral agents
SI1824855T1 (sl) Novi pirolo derivati d pirimidin ona in njihova uporaba pri zdravljenju
EP1653969A4 (en) PYRROLO 1,2-B PYRIDAZINE DERIVATIVES
ATE360632T1 (de) Substituierte 8&#39;-pyri(mi)dinyl-dihydrospiro- (cycloalkylamin)-pyrimido(1,2a)pyrimidin-6- onderivate
IL177263A0 (en) 2-pyridinylethylcarboxamide derivatives and their use as fungicides
ZA200700352B (en) Pyrrole derivatives as pharmaceutical agents
DK1814880T3 (da) Imidazo[1,2-a]pyridinforbindelser, og sammensætninger, anvendelser og fremgangsmåder, der er forbundet dermed
IL180682A0 (en) N-hydroxamide derivatives, their preparation and use
NL1030503A1 (nl) Octahydropyrrolo[3,4-c]-pyrroolderivaten.
ATE512148T1 (de) Pyrazolo- und imidazopyrimidinderivate
IL198239A0 (en) Substituted 8-piperidinyl-2-pyridinyl-pyrimido [1,2-a] pyrimidin -6- one and 8-piperidinyl-2- pyrimidinyl [1,2-a] pyrimidin -6- one derivatives