DK175703B1 - Human vævsfaktor-relaterede DNA-segmenter, polypeptider og antistoffer, hybridomaer, bestemmelsesmetoder, diagnostiske systemer og metoder, isoleringsmetoder og fremstillingsmetoder - Google Patents

Human vævsfaktor-relaterede DNA-segmenter, polypeptider og antistoffer, hybridomaer, bestemmelsesmetoder, diagnostiske systemer og metoder, isoleringsmetoder og fremstillingsmetoder Download PDF

Info

Publication number
DK175703B1
DK175703B1 DK198806668A DK666888A DK175703B1 DK 175703 B1 DK175703 B1 DK 175703B1 DK 198806668 A DK198806668 A DK 198806668A DK 666888 A DK666888 A DK 666888A DK 175703 B1 DK175703 B1 DK 175703B1
Authority
DK
Denmark
Prior art keywords
protein
hutfh
residue
hutf
coagulation
Prior art date
Application number
DK198806668A
Other languages
Danish (da)
English (en)
Other versions
DK666888D0 (da
DK666888A (da
Inventor
Thomas S Edgington
James H Morrissey
Original Assignee
Scripps Clinic Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27364291&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK175703(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US07/067,103 external-priority patent/US5110730A/en
Application filed by Scripps Clinic Res filed Critical Scripps Clinic Res
Publication of DK666888D0 publication Critical patent/DK666888D0/da
Publication of DK666888A publication Critical patent/DK666888A/da
Priority to DK200401498A priority Critical patent/DK176220B1/da
Application granted granted Critical
Publication of DK175703B1 publication Critical patent/DK175703B1/da

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745Blood coagulation or fibrinolysis factors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745Assays involving non-enzymic blood coagulation factors
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y10S530/809Fused cells, e.g. hybridoma

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK198806668A 1987-03-31 1988-11-29 Human vævsfaktor-relaterede DNA-segmenter, polypeptider og antistoffer, hybridomaer, bestemmelsesmetoder, diagnostiske systemer og metoder, isoleringsmetoder og fremstillingsmetoder DK175703B1 (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK200401498A DK176220B1 (da) 1987-03-31 2004-10-01 Monoklonalt antistof, som binder human vævsfaktor-protein, samt dets anvendelse

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US3304787A 1987-03-31 1987-03-31
US3304787 1987-03-31
US07/067,103 US5110730A (en) 1987-03-31 1987-06-25 Human tissue factor related DNA segments
US6710387 1987-06-25
US07/165,939 US5223427A (en) 1987-03-31 1988-03-09 Hybridomas producing monoclonal antibodies reactive with human tissue-factor glycoprotein heavy chain
US16593988 1988-03-09
PCT/US1988/000998 WO1988007543A1 (en) 1987-03-31 1988-03-29 Human tissue factor related dna segments, polypeptides and antibodies
US8800998 1988-03-29

Publications (3)

Publication Number Publication Date
DK666888D0 DK666888D0 (da) 1988-11-29
DK666888A DK666888A (da) 1989-01-31
DK175703B1 true DK175703B1 (da) 2005-01-24

Family

ID=27364291

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198806668A DK175703B1 (da) 1987-03-31 1988-11-29 Human vævsfaktor-relaterede DNA-segmenter, polypeptider og antistoffer, hybridomaer, bestemmelsesmetoder, diagnostiske systemer og metoder, isoleringsmetoder og fremstillingsmetoder

Country Status (13)

Country Link
US (2) US5223427A (no)
EP (2) EP1364969A3 (no)
JP (1) JP2809415B2 (no)
AT (1) ATE246200T1 (no)
AU (1) AU605864B2 (no)
CA (1) CA1340544C (no)
DE (1) DE3856560T2 (no)
DK (1) DK175703B1 (no)
ES (1) ES2009590A6 (no)
FI (2) FI100184B (no)
NO (1) NO305211B1 (no)
PT (1) PT87138B (no)
WO (1) WO1988007543A1 (no)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6994988B1 (en) 1987-02-12 2006-02-07 Genetech, Inc. Methods and deoxyribonucleic acid for the preparation of tissue factor protein
US7084251B1 (en) 1987-02-12 2006-08-01 Genentech, Inc. Methods and Deoxyribonucleic acid for the preparation of tissue factor protein
US6001978A (en) * 1987-03-31 1999-12-14 The Scripps Research Institute Human tissue factor related DNA segments polypeptides and antibodies
IL87172A (en) * 1987-07-23 1994-12-29 Univ Washington A method of inhibiting the isolation of a purer tissue factor
DK299889A (da) * 1988-06-17 1989-12-18 Sinai School Medicine Kloning og ekspression af human vaevsfaktor
US5472850A (en) * 1991-04-10 1995-12-05 Oklahoma Medical Research Foundation Quantitative clotting assay for activated factor VII
US5298599A (en) * 1988-12-30 1994-03-29 Oklahoma Medical Research Foundation Expression and purification of recombinant soluble tissue factor
US5314695A (en) 1990-11-13 1994-05-24 Corvas International, Inc. Tissue factor based prothrombin time reagent
US6203816B1 (en) * 1990-11-13 2001-03-20 Corvas International, Inc. Tissue factor based prothrombin time reagent
AU658604B2 (en) * 1991-01-10 1995-04-27 Teijin Limited Highly sensitive assay of tissue factor and kit therefor
US5374617A (en) * 1992-05-13 1994-12-20 Oklahoma Medical Research Foundation Treatment of bleeding with modified tissue factor in combination with FVIIa
US5504064A (en) * 1991-04-10 1996-04-02 Oklahoma Medical Research Foundation Treatment of bleeding with modified tissue factor in combination with an activator of FVII
US6093399A (en) * 1992-03-05 2000-07-25 Board Of Regents, The University Of Texas System Methods and compositions for the specific coagulation of vasculature
US6036955A (en) * 1992-03-05 2000-03-14 The Scripps Research Institute Kits and methods for the specific coagulation of vasculature
US6004555A (en) * 1992-03-05 1999-12-21 Board Of Regents, The University Of Texas System Methods for the specific coagulation of vasculature
US5877289A (en) * 1992-03-05 1999-03-02 The Scripps Research Institute Tissue factor compositions and ligands for the specific coagulation of vasculature
US6749853B1 (en) * 1992-03-05 2004-06-15 Board Of Regents, The University Of Texas System Combined methods and compositions for coagulation and tumor treatment
US6063764A (en) * 1992-06-01 2000-05-16 Washington University & Chiron Corp. Method for using lipoprotein associated coagulation inhibitor to treat sepsis
US20030171292A1 (en) * 1992-06-01 2003-09-11 Creasey Abla A. Method for using lipoprotein associated coagulation inhibitor to treat sepsis
US20010048924A1 (en) * 1998-06-22 2001-12-06 Del Zoppo Gregory J. Method for inhibiting cerebral tissue factor mediated reperfusion damage
US5879677A (en) * 1992-12-09 1999-03-09 The Scripps Research Institute Method for inhibition of cerebral tissue factor mediated reperfusion damage
EP0738156A1 (en) * 1993-12-27 1996-10-23 Hamilton Civic Hospitals Research Development, Inc. Methods and compositions for inhibiting thrombogenesis
JP4423680B2 (ja) * 1995-06-07 2010-03-03 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド Cdr−グラフト化抗組織因子抗体及びその使用
US5837684A (en) * 1995-06-07 1998-11-17 Nycomed Imaging As Peptides
US6379975B1 (en) 1996-11-27 2002-04-30 T.A.C. Thrombosis And Coagulation Aktiebolag Methods and reagents for determining protein S
EP0988056B1 (en) 1997-01-22 2003-07-09 Board Of Regents, The University Of Texas System Tissue factor methods and compositions for coagulation and tumor treatment
US20030109680A1 (en) * 2001-11-21 2003-06-12 Sunol Molecular Corporation Antibodies for inhibiting blood coagulation and methods of use thereof
US20060235209A9 (en) * 1997-03-10 2006-10-19 Jin-An Jiao Use of anti-tissue factor antibodies for treating thromboses
US7749498B2 (en) * 1997-03-10 2010-07-06 Genentech, Inc. Antibodies for inhibiting blood coagulation and methods of use thereof
US5986065A (en) * 1997-03-10 1999-11-16 Sunol Molecular Corporation Antibodies for inhibiting blood coagulation and methods of use thereof
US20040229282A1 (en) * 1997-03-10 2004-11-18 Sunol Molecular Corporation Antibodies for inhibiting blood coagulation and methods of use thereof
DE69832628T2 (de) * 1997-04-23 2006-09-07 Instrumentation Laboratory S.P.A. Rekombinant-kaninchengewebefaktor basiertes prothrombinzeitreagenz
HUP0101160A2 (hu) * 1998-04-03 2001-08-28 Chugai Seiyaku Kabushiki Kaisha Humán szöveti faktor (TF) elleni humanizált antitest és eljárás előállítására
JP2002520297A (ja) 1998-07-13 2002-07-09 ボード オブ リージェンツ, ザ ユニバーシティ オブ テキサス システム アミノリン脂質に結合する治療結合体を用いる癌処置方法
US6818213B1 (en) 1998-07-13 2004-11-16 Board Of Regents, The University Of Texas System Cancer treatment compositions comprising therapeutic conjugates that bind to aminophospholipids
AU766970B2 (en) * 1998-07-15 2003-10-30 Genentech Inc. Tissue factor protein variants with increased affinity for coagulation factor FVII/FVIIa
US7764130B2 (en) * 1999-01-22 2010-07-27 Multigig Inc. Electronic circuitry
SK4442002A3 (en) 1999-10-01 2003-04-01 Chugai Pharmaceutical Co Ltd Prevention and treatment of diseases associated with blood coagulation
ATE337403T1 (de) 1999-12-24 2006-09-15 Genentech Inc Verfahren und verbindungen zur verlängerung der halbwertzeiten bei der ausscheidung von biowirksamen verbindungen
US6703494B2 (en) * 2000-03-16 2004-03-09 Genentech, Inc. Anti-tissue factor antibodies with enhanced anticoagulant potency
US6855509B2 (en) * 2000-12-19 2005-02-15 Instrumentation Laboratory Company Protein S functional assay and kit therefor
US20030143225A1 (en) * 2001-03-08 2003-07-31 Genentech, Inc. Combinations of anti-tissue factor antibodies and anticoagulant and/or antiplatelet agents
US20030211075A1 (en) * 2001-09-27 2003-11-13 Thorpe Philip E. Combined compositions for tumor vasculature coagulation and treatment
CZ2004454A3 (cs) * 2001-10-02 2004-09-15 Novo Nordisk A/S Protilátky lidského tkáňového faktoru
HUP0501111A2 (en) * 2001-10-15 2007-12-28 Chiron Corp Treatment of severe pneumonia by administration of tissue factor pathway inhibitor
AU2002350623A1 (en) * 2001-10-26 2003-05-06 The Scripps Research Institute Targeted thrombosis by tissue factor polypeptides
US20030190705A1 (en) * 2001-10-29 2003-10-09 Sunol Molecular Corporation Method of humanizing immune system molecules
US7541150B2 (en) * 2002-04-08 2009-06-02 University Of Louisville Research Foundation, Inc Method for the diagnosis and prognosis of malignant diseases
US7357928B2 (en) 2002-04-08 2008-04-15 University Of Louisville Research Foundation, Inc. Method for the diagnosis and prognosis of malignant diseases
US7579000B2 (en) 2002-05-01 2009-08-25 Bayer Schering Pharma Ag Tissue factor targeted antibodies as anticoagulants
ES2323056T3 (es) * 2002-05-01 2009-07-06 Bayer Schering Pharma Aktiengesellschaft Anticuerpos dirigidos contra factor tisular como anticoagulantes.
US20050106139A1 (en) * 2002-10-31 2005-05-19 Ivan Svendsen Humanized tissue factor antibodies
US20040198660A1 (en) * 2002-11-06 2004-10-07 Petersen Lars Christian Tissue factor antagonist and protein C polypeptide compositions
JP2006516564A (ja) * 2003-01-22 2006-07-06 ノボ ノルディスク アクティーゼルスカブ Tf結合薬剤及びそれらの使用
US7425328B2 (en) * 2003-04-22 2008-09-16 Purdue Pharma L.P. Tissue factor antibodies and uses thereof
JP2006526641A (ja) * 2003-05-30 2006-11-24 セントカー・インコーポレーテツド 抗−組織因子抗体を用いる腫瘍成長を抑制する方法
US9708410B2 (en) 2003-05-30 2017-07-18 Janssen Biotech, Inc. Anti-tissue factor antibodies and compositions
US7605235B2 (en) 2003-05-30 2009-10-20 Centocor, Inc. Anti-tissue factor antibodies and compositions
ES2527102T3 (es) * 2003-06-19 2015-01-20 Genentech, Inc. Composiciones y métodos para el tratamiento de trastornos relacionados con la coagulación
EP1667718A4 (en) * 2003-08-29 2007-05-02 Centocor Inc METHOD FOR STIMULATING THE SURVIVAL OF A GRAFT WITH ANTI-TISSUE FACTOR ANTIBODY
CN101426520A (zh) * 2004-03-17 2009-05-06 诺华疫苗和诊断公司 通过给予组织因子途径抑制剂(tfpi)治疗社区获得性重症肺炎
US7790405B2 (en) * 2004-04-26 2010-09-07 Centocor, Inc. Solution phase biopanning method using engineered decoy proteins
ES2391097T3 (es) * 2004-04-26 2012-11-21 Janssen Biotech, Inc. Procedimiento de panning en fase en solución usando proteínas señuelo modificadas por ingeniería genética
US7514539B2 (en) * 2004-04-26 2009-04-07 Centocor, Inc. Epitope directed selection of antibodies to murine tissue factor
WO2005118646A2 (en) * 2004-04-26 2005-12-15 Centocor, Inc. Epitope directed selection of antibodies to murine tissue factor
EP1676574A3 (en) 2004-12-30 2006-07-26 Johnson & Johnson Vision Care, Inc. Methods for promoting survival of transplanted tissues and cells
EP1945261A4 (en) * 2005-11-07 2010-05-12 Scripps Research Inst COMPOSITIONS AND METHODS FOR CONTROLLING THE SPECIFICITY OF TISSUE FACTOR SIGNALING
UA109633C2 (uk) 2008-12-09 2015-09-25 Антитіло людини проти тканинного фактора
JP6174320B2 (ja) 2009-11-17 2017-08-02 エムユーエスシー ファウンデーション フォー リサーチ ディベロップメント ヒトヌクレオリンに対するヒトモノクローナル抗体
EP2380905A1 (en) 2010-04-19 2011-10-26 Thrombotargets Europe, S.L. Phospholipid-enriched vesicles bearing tissue factor having haemostatic activities and uses thereof
WO2011157741A2 (en) * 2010-06-15 2011-12-22 Genmab A/S Human antibody drug conjugates against tissue factor
WO2012033518A1 (en) * 2010-09-09 2012-03-15 The Scripps Research Institute Methods and compositions for treating metabolic disorders
US8722044B2 (en) * 2011-03-15 2014-05-13 Janssen Biotech, Inc. Human tissue factor antibody and uses thereof
EP3011974B1 (en) 2011-06-02 2018-08-08 University Of Louisville Research Foundation, Inc. Anti-nucleolin agent-conjugated nanoparticles
CN103566378B (zh) * 2013-09-09 2016-09-14 南京海智生物工程有限公司 基于组织因子的肿瘤核酸疫苗、制备方法及其应用
KR102372245B1 (ko) * 2013-11-21 2022-03-08 젠맵 에이/에스 항체-약물 접합체 동결건조 제제
WO2016179394A1 (en) 2015-05-05 2016-11-10 Malik Mohammad Tariq Anti-nucleolin agent-conjugated nanoparticles as radio-sensitizers and mri and/or x-ray contrast agents
PE20191842A1 (es) 2017-05-08 2019-12-31 Gritstone Oncology Inc Vectores de neoantigeno de alfavirus
KR101989954B1 (ko) * 2017-10-16 2019-06-17 고려대학교 산학협력단 돼지 조직인자 세포외 도메인 단백질을 특이적으로 인식하는 단일클론항체 및 이의 용도
EP3735271A4 (en) * 2018-01-04 2022-06-15 Iconic Therapeutics, Inc. ANTI-TISSUE FACTOR ANTIBODIES, ANTIBODY DRUG CONJUGATES AND RELATED METHODS
TW202110870A (zh) 2019-05-30 2021-03-16 美商葛利史東腫瘤科技公司 經修飾之腺病毒
CN116438308A (zh) 2020-08-06 2023-07-14 磨石生物公司 多表位疫苗盒

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4548904A (en) * 1982-12-03 1985-10-22 Molecular Genetics Research & Development Protein sequencing method
IE81149B1 (en) * 1987-02-12 2000-05-03 Genentech Inc Methods and deoxyribonucleic acid for the preparation of tissue factor protein
AU1948388A (en) * 1987-06-12 1989-01-04 Mount Sinai School Of Medicine Of The City University Of New York, The Cloning and expression of human tissue factor

Also Published As

Publication number Publication date
NO885326L (no) 1989-01-30
AU1627488A (en) 1988-11-02
FI97813C (fi) 1997-02-25
FI885543A (fi) 1988-11-29
PT87138A (pt) 1988-04-01
DE3856560T2 (de) 2004-08-05
US5622931A (en) 1997-04-22
EP0309548A4 (en) 1991-08-07
EP1364969A2 (en) 2003-11-26
FI885543A0 (fi) 1988-11-29
NO885326D0 (no) 1988-11-29
NO305211B1 (no) 1999-04-19
CA1340544C (en) 1999-05-18
WO1988007543A1 (en) 1988-10-06
FI97813B (fi) 1996-11-15
ATE246200T1 (de) 2003-08-15
EP0309548B1 (en) 2003-07-30
EP0309548A1 (en) 1989-04-05
JP2809415B2 (ja) 1998-10-08
US5223427A (en) 1993-06-29
ES2009590A6 (es) 1989-10-01
PT87138B (pt) 1992-07-31
DE3856560D1 (de) 2003-09-04
DK666888D0 (da) 1988-11-29
DK666888A (da) 1989-01-31
FI954347A (fi) 1995-09-15
EP1364969A3 (en) 2004-12-29
JPH01503438A (ja) 1989-11-22
FI100184B (fi) 1997-10-15
FI954347A0 (fi) 1995-09-15
AU605864B2 (en) 1991-01-24

Similar Documents

Publication Publication Date Title
DK175703B1 (da) Human vævsfaktor-relaterede DNA-segmenter, polypeptider og antistoffer, hybridomaer, bestemmelsesmetoder, diagnostiske systemer og metoder, isoleringsmetoder og fremstillingsmetoder
US5110730A (en) Human tissue factor related DNA segments
US5437864A (en) Method of inhibiting blood coagulation in extracorporeal circulation by inhibiting human tissue factor
US6001978A (en) Human tissue factor related DNA segments polypeptides and antibodies
JP3420747B2 (ja) 血小板の粘着を阻害するペプチド及び抗体
HU228068B1 (en) Protein for blocking platelet adhesion
Chamekh et al. Diagnostic value of a synthetic peptide derived from Echinococcus granulosus recombinant protein.
JPH02479A (ja) snRNP−A抗原及びそのフラグメント
EP0972781B1 (en) Proteins polypeptides and uses thereof
JP4714265B2 (ja) ニューログロビン酵素免疫測定キット及びその使用
EP0592600B1 (en) Proteins s polypeptides and uses thereof
DK176220B1 (da) Monoklonalt antistof, som binder human vævsfaktor-protein, samt dets anvendelse
US20030022350A1 (en) Antithrombosis enzyme from the snake venom of Agkistrodon acutus
IE20040562A1 (en) Human tissue factor related DNA segments, polypeptides and antibodies.
PT91500A (pt) Processo para a preparacao de antigenio de nefrite clonado
IE83847B1 (en) Human tissue factor related DNA segments, polypeptides and antibodies
WO1991003251A1 (en) Cr2 ligand compositions and methods for modulating immune cell functions
JPH03173899A (ja) 生体由来のタンパク質
WO2004019883A2 (en) Tick polypeptides as anticoagulants and vaccines
JPH1033171A (ja) モノクローナル抗体および抗線溶剤
JPH0995500A (ja) モノクローナル抗体および血栓溶解促進剤
JPH08325298A (ja) モノクローナル抗体
JPH0570492A (ja) ペプチドおよびその塩

Legal Events

Date Code Title Description
PUP Patent expired