DK175124B1 - 3-piperazinylbenzazolderivater, fremstilling deraf og anvendelse deraf i et antipsykotisk præparat - Google Patents

3-piperazinylbenzazolderivater, fremstilling deraf og anvendelse deraf i et antipsykotisk præparat Download PDF

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Publication number
DK175124B1
DK175124B1 DK198903836A DK383689A DK175124B1 DK 175124 B1 DK175124 B1 DK 175124B1 DK 198903836 A DK198903836 A DK 198903836A DK 383689 A DK383689 A DK 383689A DK 175124 B1 DK175124 B1 DK 175124B1
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formula
alkyl
hydrogen
alk
parts
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DK198903836A
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Danish (da)
English (en)
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DK383689A (da
DK383689D0 (da
Inventor
Ludo Edmond Josephine Kennis
Jan Vandenberk
Josephus Carolus Mertens
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Janssen Pharmaceutica Nv
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Publication of DK383689D0 publication Critical patent/DK383689D0/da
Publication of DK383689A publication Critical patent/DK383689A/da
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
DK198903836A 1988-08-05 1989-08-04 3-piperazinylbenzazolderivater, fremstilling deraf og anvendelse deraf i et antipsykotisk præparat DK175124B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22841788A 1988-08-05 1988-08-05
US22841788 1988-08-05

Publications (3)

Publication Number Publication Date
DK383689D0 DK383689D0 (da) 1989-08-04
DK383689A DK383689A (da) 1990-02-06
DK175124B1 true DK175124B1 (da) 2004-06-07

Family

ID=22857091

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198903836A DK175124B1 (da) 1988-08-05 1989-08-04 3-piperazinylbenzazolderivater, fremstilling deraf og anvendelse deraf i et antipsykotisk præparat

Country Status (20)

Country Link
EP (1) EP0353821B1 (xx)
JP (1) JP2779216B2 (xx)
KR (1) KR0145706B1 (xx)
CN (1) CN1023602C (xx)
AT (1) ATE122348T1 (xx)
AU (1) AU619877B2 (xx)
CA (1) CA1331609C (xx)
DE (1) DE68922537T2 (xx)
DK (1) DK175124B1 (xx)
ES (1) ES2074462T3 (xx)
FI (1) FI90238C (xx)
HU (1) HU206341B (xx)
IE (1) IE66198B1 (xx)
IL (1) IL91194A (xx)
NO (1) NO176051C (xx)
NZ (1) NZ230045A (xx)
PH (1) PH26550A (xx)
PT (1) PT91364B (xx)
SU (1) SU1687030A3 (xx)
ZA (1) ZA895978B (xx)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5561128A (en) * 1989-05-19 1996-10-01 Hoechst-Roussel Pharmaceuticals, Inc. N-[(4-(heteroaryl)-1-piperidinyl)alkyl]-10,11-dihydro-5H-dibenz[B,F]azepines and related compounds and their therapeutic utility
US5364866A (en) * 1989-05-19 1994-11-15 Hoechst-Roussel Pharmaceuticals, Inc. Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics
US5776963A (en) * 1989-05-19 1998-07-07 Hoechst Marion Roussel, Inc. 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
US4954503A (en) * 1989-09-11 1990-09-04 Hoechst-Roussel Pharmaceuticals, Inc. 3-(1-substituted-4-piperazinyl)-1H-indazoles
FR2671350A1 (fr) * 1991-01-08 1992-07-10 Adir Nouveaux derives de benzisoxazole et de benzisothiazole, leur procede de preparation, et les compositions pharmaceutiques les renfermant.
US5041445A (en) * 1990-05-21 1991-08-20 Hoechst-Roussel Pharmaceuticals Incorporated 3-[1-thiazolidinylbutyl-4-piperazinyl]-1H-indazoles
US5565453A (en) * 1991-09-25 1996-10-15 Pfizer Inc. Neuroleptic 2-substituted perhydro-1-h-pyrido[1,2-a]pyrazines
GB9202915D0 (en) * 1992-02-12 1992-03-25 Wellcome Found Chemical compounds
CN1050604C (zh) * 1993-02-04 2000-03-22 明治制果株式会社 具有抗精神病作用的化合物
EP0794185A4 (en) * 1994-11-25 1998-03-25 Meiji Seika Co BICYCLIC THIAZOLE COMPOUND
US6187774B1 (en) * 1996-03-04 2001-02-13 Yoshitomi Pharmaceutical Industries, Ltd. Fused heterocyclic compounds and pharmaceutical applications thereof
ATE418542T1 (de) 2001-03-29 2009-01-15 Schering Corp Als ccr5-antagonisten verwendbare aryloxim- piperazine
KR20110076944A (ko) * 2008-09-23 2011-07-06 에프. 호프만-라 로슈 아게 도파민 ｄ3 수용체의 조절제로서 유용한 이속사졸로〔4,5〕피리딘-3-일-피페라진 유도체
US11676855B2 (en) * 2020-02-26 2023-06-13 Taiwan Semiconductor Manufacturing Co., Ltd. Patterning interconnects and other structures by photo-sensitizing method
CN114634479A (zh) * 2020-12-16 2022-06-17 北京盈科瑞创新药物研究有限公司 一种派嗪衍生物、其制备方法及应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4411901A (en) * 1981-12-23 1983-10-25 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4452799A (en) 1981-12-23 1984-06-05 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
HU198036B (en) * 1983-08-22 1989-07-28 Hoechst Roussel Pharma Process for production of derivatives of 3-piperidil-/1h/-indasole and medical preparatives containing them
US4524206A (en) 1983-09-12 1985-06-18 Mead Johnson & Company 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives
US4590196A (en) 1984-08-23 1986-05-20 Bristol-Myers Company Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives
US4804663A (en) 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
EP0302423A3 (en) 1987-08-07 1991-01-09 Hoechst-Roussel Pharmaceuticals Incorporated 1-phenyl-3-(1-piperazinyl)-1h-indazoles, a process and intermediates for their preparation, and the use thereof as medicaments

Also Published As

Publication number Publication date
NO176051C (no) 1995-01-25
ATE122348T1 (de) 1995-05-15
PH26550A (en) 1992-08-19
SU1687030A3 (ru) 1991-10-23
CA1331609C (en) 1994-08-23
KR900003155A (ko) 1990-03-23
IE66198B1 (en) 1995-12-13
KR0145706B1 (ko) 1998-08-17
JP2779216B2 (ja) 1998-07-23
ES2074462T3 (es) 1995-09-16
IL91194A0 (en) 1990-03-19
NZ230045A (en) 1990-11-27
PT91364A (pt) 1990-03-08
AU619877B2 (en) 1992-02-06
IL91194A (en) 1994-04-12
FI90238C (fi) 1994-01-10
HU206341B (en) 1992-10-28
CN1023602C (zh) 1994-01-26
FI893701A (fi) 1990-02-06
EP0353821A3 (en) 1991-07-17
FI90238B (fi) 1993-09-30
EP0353821B1 (en) 1995-05-10
AU3917189A (en) 1990-03-08
NO893168D0 (no) 1989-08-04
IE892535L (en) 1990-02-05
PT91364B (pt) 1995-03-31
DK383689A (da) 1990-02-06
DK383689D0 (da) 1989-08-04
JPH0288572A (ja) 1990-03-28
FI893701A0 (fi) 1989-08-04
EP0353821A2 (en) 1990-02-07
HUT55385A (en) 1991-05-28
ZA895978B (en) 1991-04-24
DE68922537D1 (de) 1995-06-14
NO176051B (no) 1994-10-17
NO893168L (no) 1990-02-06
CN1040194A (zh) 1990-03-07
DE68922537T2 (de) 1995-09-14

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