DE68922537D1 - Antipsychotische 3-Piperazinylbenzazolderivate. - Google Patents

Antipsychotische 3-Piperazinylbenzazolderivate.

Info

Publication number
DE68922537D1
DE68922537D1 DE68922537T DE68922537T DE68922537D1 DE 68922537 D1 DE68922537 D1 DE 68922537D1 DE 68922537 T DE68922537 T DE 68922537T DE 68922537 T DE68922537 T DE 68922537T DE 68922537 D1 DE68922537 D1 DE 68922537D1
Authority
DE
Germany
Prior art keywords
compounds
antipsychotic
piperazinylbenzazole
derivatives
6alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68922537T
Other languages
English (en)
Other versions
DE68922537T2 (de
Inventor
Ludo Edmond Josephine Kennis
Jan Vandenberk
Josephus Carolus Mertens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Application granted granted Critical
Publication of DE68922537D1 publication Critical patent/DE68922537D1/de
Publication of DE68922537T2 publication Critical patent/DE68922537T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
DE68922537T 1988-08-05 1989-07-28 Antipsychotische 3-Piperazinylbenzazolderivate. Expired - Fee Related DE68922537T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22841788A 1988-08-05 1988-08-05

Publications (2)

Publication Number Publication Date
DE68922537D1 true DE68922537D1 (de) 1995-06-14
DE68922537T2 DE68922537T2 (de) 1995-09-14

Family

ID=22857091

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68922537T Expired - Fee Related DE68922537T2 (de) 1988-08-05 1989-07-28 Antipsychotische 3-Piperazinylbenzazolderivate.

Country Status (20)

Country Link
EP (1) EP0353821B1 (de)
JP (1) JP2779216B2 (de)
KR (1) KR0145706B1 (de)
CN (1) CN1023602C (de)
AT (1) ATE122348T1 (de)
AU (1) AU619877B2 (de)
CA (1) CA1331609C (de)
DE (1) DE68922537T2 (de)
DK (1) DK175124B1 (de)
ES (1) ES2074462T3 (de)
FI (1) FI90238C (de)
HU (1) HU206341B (de)
IE (1) IE66198B1 (de)
IL (1) IL91194A (de)
NO (1) NO176051C (de)
NZ (1) NZ230045A (de)
PH (1) PH26550A (de)
PT (1) PT91364B (de)
SU (1) SU1687030A3 (de)
ZA (1) ZA895978B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5776963A (en) * 1989-05-19 1998-07-07 Hoechst Marion Roussel, Inc. 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
US5364866A (en) 1989-05-19 1994-11-15 Hoechst-Roussel Pharmaceuticals, Inc. Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics
US5561128A (en) * 1989-05-19 1996-10-01 Hoechst-Roussel Pharmaceuticals, Inc. N-[(4-(heteroaryl)-1-piperidinyl)alkyl]-10,11-dihydro-5H-dibenz[B,F]azepines and related compounds and their therapeutic utility
US4954503A (en) * 1989-09-11 1990-09-04 Hoechst-Roussel Pharmaceuticals, Inc. 3-(1-substituted-4-piperazinyl)-1H-indazoles
FR2671350A1 (fr) * 1991-01-08 1992-07-10 Adir Nouveaux derives de benzisoxazole et de benzisothiazole, leur procede de preparation, et les compositions pharmaceutiques les renfermant.
US5041445A (en) * 1990-05-21 1991-08-20 Hoechst-Roussel Pharmaceuticals Incorporated 3-[1-thiazolidinylbutyl-4-piperazinyl]-1H-indazoles
JPH08827B2 (ja) * 1991-09-25 1996-01-10 フアイザー・インコーポレイテツド 精神弛緩剤の２−置換パーヒドロ−１Ｈ−ピリド［１，２−ａピラジン
GB9202915D0 (en) * 1992-02-12 1992-03-25 Wellcome Found Chemical compounds
EP0635506A4 (de) * 1993-02-04 1995-04-12 Meiji Seika Co Verbindung mit antipsychotischerwirkung.
WO1996016968A1 (fr) * 1994-11-25 1996-06-06 Meiji Seika Kabushiki Kaisha Compose thiazole bicyclique
US6187774B1 (en) * 1996-03-04 2001-02-13 Yoshitomi Pharmaceutical Industries, Ltd. Fused heterocyclic compounds and pharmaceutical applications thereof
WO2002079157A1 (en) 2001-03-29 2002-10-10 Schering Corporation Aryl oxime-piperazines useful as ccr5 antagonists
CN102164927A (zh) * 2008-09-23 2011-08-24 弗·哈夫曼-拉罗切有限公司 用作多巴胺d3受体调节剂的异唑并[4,5]吡啶-3-基-哌嗪衍生物
US11676855B2 (en) * 2020-02-26 2023-06-13 Taiwan Semiconductor Manufacturing Co., Ltd. Patterning interconnects and other structures by photo-sensitizing method
CN114634479A (zh) * 2020-12-16 2022-06-17 北京盈科瑞创新药物研究有限公司 一种派嗪衍生物、其制备方法及应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4411901A (en) * 1981-12-23 1983-10-25 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4452799A (en) 1981-12-23 1984-06-05 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
HU198036B (en) * 1983-08-22 1989-07-28 Hoechst Roussel Pharma Process for production of derivatives of 3-piperidil-/1h/-indasole and medical preparatives containing them
US4524206A (en) 1983-09-12 1985-06-18 Mead Johnson & Company 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives
US4590196A (en) 1984-08-23 1986-05-20 Bristol-Myers Company Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
EP0302423A3 (de) 1987-08-07 1991-01-09 Hoechst-Roussel Pharmaceuticals Incorporated 1-Phenyl-3-(1-piperazinyl)-1H-Indazole, Verfahren und Zwischenprodukte zu deren Herstellung und deren Anwendung als Arzneimittel

Also Published As

Publication number Publication date
EP0353821A3 (de) 1991-07-17
CA1331609C (en) 1994-08-23
JP2779216B2 (ja) 1998-07-23
PH26550A (en) 1992-08-19
SU1687030A3 (ru) 1991-10-23
JPH0288572A (ja) 1990-03-28
ATE122348T1 (de) 1995-05-15
FI90238C (fi) 1994-01-10
EP0353821A2 (de) 1990-02-07
ZA895978B (en) 1991-04-24
DK175124B1 (da) 2004-06-07
DE68922537T2 (de) 1995-09-14
ES2074462T3 (es) 1995-09-16
NO176051B (no) 1994-10-17
IL91194A0 (en) 1990-03-19
CN1040194A (zh) 1990-03-07
KR0145706B1 (ko) 1998-08-17
IE66198B1 (en) 1995-12-13
DK383689A (da) 1990-02-06
CN1023602C (zh) 1994-01-26
NO176051C (no) 1995-01-25
PT91364A (pt) 1990-03-08
FI893701A (fi) 1990-02-06
NO893168D0 (no) 1989-08-04
AU3917189A (en) 1990-03-08
PT91364B (pt) 1995-03-31
IE892535L (en) 1990-02-05
EP0353821B1 (de) 1995-05-10
AU619877B2 (en) 1992-02-06
IL91194A (en) 1994-04-12
DK383689D0 (da) 1989-08-04
HU206341B (en) 1992-10-28
FI90238B (fi) 1993-09-30
KR900003155A (ko) 1990-03-23
HUT55385A (en) 1991-05-28
FI893701A0 (fi) 1989-08-04
NZ230045A (en) 1990-11-27
NO893168L (no) 1990-02-06

Similar Documents

Publication Publication Date Title
DE69008366T2 (de) 2-Aminopyrimidinon-Derivate.
ES2070126T3 (es) Derivados de piridazinamina.
EP0151824A3 (en) N-(4-piperidinyl) bicyclic condesed 2-imidazolamine derivatives
ATE122348T1 (de) Antipsychotische 3-piperazinylbenzazolderivate.
ATE124410T1 (de) Antihypertensive 3-piperidinylindazol-derivate.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee