DK174739B1 - Bærer-lægemiddelkonjugater og deres fremstiling - Google Patents

Bærer-lægemiddelkonjugater og deres fremstiling Download PDF

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Publication number
DK174739B1
DK174739B1 DK198806025A DK602588A DK174739B1 DK 174739 B1 DK174739 B1 DK 174739B1 DK 198806025 A DK198806025 A DK 198806025A DK 602588 A DK602588 A DK 602588A DK 174739 B1 DK174739 B1 DK 174739B1
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DK
Denmark
Prior art keywords
formula
compound
defined above
divalent
group
Prior art date
Application number
DK198806025A
Other languages
Danish (da)
English (en)
Other versions
DK602588A (da
DK602588D0 (da
Inventor
William James Mcgahren
Martin Leon Sassiver
George A Ellestad
Philip R Hamann
Lois M Hinman
Janis Upeslacis
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of DK602588D0 publication Critical patent/DK602588D0/da
Publication of DK602588A publication Critical patent/DK602588A/da
Application granted granted Critical
Publication of DK174739B1 publication Critical patent/DK174739B1/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
    • A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK198806025A 1987-10-30 1988-10-28 Bærer-lægemiddelkonjugater og deres fremstiling DK174739B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11494087A 1987-10-30 1987-10-30
US11494087 1987-10-30

Publications (3)

Publication Number Publication Date
DK602588D0 DK602588D0 (da) 1988-10-28
DK602588A DK602588A (da) 1989-05-01
DK174739B1 true DK174739B1 (da) 2003-10-13

Family

ID=22358378

Family Applications (2)

Application Number Title Priority Date Filing Date
DK602488A DK602488A (da) 1987-10-30 1988-10-28 Disvovlanaloge af ll-e33288 2-i og deres anvendelse som middel mod tumorer
DK198806025A DK174739B1 (da) 1987-10-30 1988-10-28 Bærer-lægemiddelkonjugater og deres fremstiling

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK602488A DK602488A (da) 1987-10-30 1988-10-28 Disvovlanaloge af ll-e33288 2-i og deres anvendelse som middel mod tumorer

Country Status (19)

Country Link
EP (2) EP0313874B1 (ko)
JP (2) JP2820256B2 (ko)
KR (2) KR0133130B1 (ko)
AR (1) AR246083A1 (ko)
AT (2) ATE112172T1 (ko)
AU (2) AU612714B2 (ko)
BR (1) BR1100939A (ko)
CA (1) CA1321582C (ko)
DE (2) DE3889063T2 (ko)
DK (2) DK602488A (ko)
ES (2) ES2061586T3 (ko)
FI (2) FI95204C (ko)
HK (2) HK131897A (ko)
IE (2) IE65053B1 (ko)
IL (2) IL87947A (ko)
NO (2) NO176480C (ko)
NZ (2) NZ226727A (ko)
PT (2) PT88882B (ko)
ZA (2) ZA888123B (ko)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5079233A (en) * 1987-01-30 1992-01-07 American Cyanamid Company N-acyl derivatives of the LL-E33288 antitumor antibiotics, composition and methods for using the same
US5606040A (en) * 1987-10-30 1997-02-25 American Cyanamid Company Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group
IL115770A (en) * 1989-04-14 1999-03-12 American Cyanamid Co Substituted disulfides of formula q-sp-ss-w their preparation and use for inhibiting the growth of tumours and for treating bacterial infections
GB9007384D0 (en) * 1990-04-02 1990-05-30 Duncan Ruth Coupling between polymers and other organic molecular entities utilising thiol-specific reactive groups
US5712374A (en) * 1995-06-07 1998-01-27 American Cyanamid Company Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
US5714586A (en) * 1995-06-07 1998-02-03 American Cyanamid Company Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
US20040009535A1 (en) 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
PT2261335T (pt) 1998-11-27 2017-09-08 Ucb Pharma Sa Composições e métodos para aumentar a mineralização óssea
NZ511705A (en) * 2001-05-14 2004-03-26 Horticulture & Food Res Inst Methods and rapid immunoassay device for detecting progesterone and other steroids
MEP2808A (xx) 2003-06-16 2010-02-10 Celltech R & D Inc Antitijela specifična za sklerositin i metode za povećanje mineralizacije kostiju
US8841092B2 (en) * 2006-08-30 2014-09-23 Wisconsin Alumni Research Foundation Reversible natural product glycosyltransferase-catalyzed reactions, compounds and related methods
KR100979928B1 (ko) * 2008-07-16 2010-09-03 한주학 수직축형 부력풍차
SI3066074T1 (sl) * 2013-11-04 2020-03-31 Pfizer Inc. Intermediati in postopki za sintetizacijo derivatov kaliheamicina
EP3573995A1 (en) * 2017-01-24 2019-12-04 Pfizer Inc. Calicheamicin derivatives and antibody drug conjugates thereof
EP3924387A2 (en) * 2019-02-15 2021-12-22 University Of Southern California Lym-1 and lym-2 antibody compositions and improved car constructs

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2430943A1 (fr) * 1978-07-13 1980-02-08 Toyo Jozo Kk Nouveaux derives disulfures
DE3175151D1 (en) * 1980-05-21 1986-09-25 Teijin Ltd Reactive polymer and process for the preparation thereof
US4530835A (en) * 1983-07-08 1985-07-23 Warner-Lambert Company CL-1577 Antibiotic compounds and their production
CA1314245C (en) * 1984-05-23 1993-03-09 Franz Jansen Process for the preparation of conjugates in which a monovalent carboxylic ionophore is associated by means of a covalent bond with a macromolecule, which are useful as immunotoxin potentiators
DE3588213T2 (de) * 1984-11-16 1999-09-30 American Cyanamid Co Antitumorale Antibiotika (Komplex LL-E-33288)
EP0330874A3 (en) * 1988-02-29 1989-10-18 American Cyanamid Company Antibacterial and antitumor agents LL-E33288 epsilon-I and LL-E33288-epsilonBr, with processes and intermediates for producing said agents
EP0342341A3 (en) * 1988-05-17 1991-07-24 American Cyanamid Company Process for producing antitumor antibiotic ll-e33288gamma2

Also Published As

Publication number Publication date
HK131897A (en) 1997-10-03
NO176480C (no) 1995-04-12
EP0313874A3 (en) 1990-05-09
IE883261L (en) 1989-04-30
AU2449488A (en) 1989-05-04
NO176480B (no) 1995-01-02
FI884983A0 (fi) 1988-10-28
JP2720933B2 (ja) 1998-03-04
NO884834D0 (no) 1988-10-28
NO884833D0 (no) 1988-10-28
FI91262B (fi) 1994-02-28
KR970011385B1 (ko) 1997-07-10
DK602488D0 (da) 1988-10-28
ATE104309T1 (de) 1994-04-15
JP2820256B2 (ja) 1998-11-05
NO884834L (no) 1989-05-02
NO173506C (no) 1993-12-22
ZA888127B (en) 1989-07-26
DE3889063T2 (de) 1994-12-01
ATE112172T1 (de) 1994-10-15
IL87946A0 (en) 1989-03-31
DE3851682T2 (de) 1995-05-04
AR246083A1 (es) 1994-03-30
PT88882B (pt) 1993-01-29
KR890006245A (ko) 1989-06-12
DK602588A (da) 1989-05-01
IL87947A (en) 1995-05-26
FI884984A0 (fi) 1988-10-28
IE883262L (en) 1989-04-30
DK602588D0 (da) 1988-10-28
IL87947A0 (en) 1989-03-31
CA1321582C (en) 1993-08-24
IL87946A (en) 1995-06-29
AU612714B2 (en) 1991-07-18
FI95204B (fi) 1995-09-29
HK131997A (en) 1997-10-03
JPH01193282A (ja) 1989-08-03
DE3889063D1 (de) 1994-05-19
EP0313873B1 (en) 1994-09-28
AU618763B2 (en) 1992-01-09
AU2448988A (en) 1989-05-04
NO173506B (no) 1993-09-13
EP0313874A2 (en) 1989-05-03
NZ226726A (en) 1991-08-27
PT88881B (pt) 1993-01-29
NZ226727A (en) 1991-12-23
IE65989B1 (en) 1995-11-29
FI884984A (fi) 1989-05-01
ZA888123B (en) 1989-07-26
EP0313874B1 (en) 1994-04-13
ES2061586T3 (es) 1994-12-16
FI884983A (fi) 1989-05-01
DE3851682D1 (de) 1994-11-03
ES2059464T3 (es) 1994-11-16
DK602488A (da) 1989-05-01
FI95204C (fi) 1996-01-10
EP0313873A1 (en) 1989-05-03
KR0133130B1 (ko) 1998-04-17
KR890006244A (ko) 1989-06-12
FI91262C (fi) 1994-06-10
BR1100939A (pt) 1999-08-31
IE65053B1 (en) 1995-10-04
JPH0296599A (ja) 1990-04-09
NO884833L (no) 1989-05-02

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PUP Patent expired