DK1746101T4 - Fremgangsmåde til fremstilling af 3-oxo-pregn-4-en-21,17-carbolactoner ved metalfri oxidation af 17-(3-hydroxypropyl)-3,17-dihydroxyandrostaner - Google Patents
Fremgangsmåde til fremstilling af 3-oxo-pregn-4-en-21,17-carbolactoner ved metalfri oxidation af 17-(3-hydroxypropyl)-3,17-dihydroxyandrostanerInfo
- Publication number
- DK1746101T4 DK1746101T4 DK05090214.7T DK05090214T DK1746101T4 DK 1746101 T4 DK1746101 T4 DK 1746101T4 DK 05090214 T DK05090214 T DK 05090214T DK 1746101 T4 DK1746101 T4 DK 1746101T4
- Authority
- DK
- Denmark
- Prior art keywords
- dihydroxyandrostanes
- carbolactones
- pregn
- ene
- oxo
- Prior art date
Links
- BMAXQBBOPJUDSD-OHPXTLHMSA-N (5S,8R,9S,10S,13S,14S)-17-(3-hydroxypropyl)-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthrene-3,17-diol Chemical class OCCCC1(CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CC[C@H]2CC(CC[C@]12C)O)O BMAXQBBOPJUDSD-OHPXTLHMSA-N 0.000 title 1
- UWBICEKKOYXZRG-LHZXLZLDSA-N (8r,9s,10r,13s,14s,17s)-10,13-dimethylspiro[2,6,7,8,9,11,12,14,15,16-decahydro-1h-cyclopenta[a]phenanthrene-17,5'-oxolane]-2',3-dione Chemical class C([C@H]1[C@H]2[C@@H]([C@]3(CCC(=O)C=C3CC2)C)CC[C@@]11C)C[C@]11CCC(=O)O1 UWBICEKKOYXZRG-LHZXLZLDSA-N 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 230000003647 oxidation Effects 0.000 title 1
- 238000007254 oxidation reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- C07J53/004—3 membered carbocyclic rings
- C07J53/008—3 membered carbocyclic rings in position 15/16
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05090214.7A EP1746101B2 (de) | 2005-07-21 | 2005-07-21 | Verfahren zur Herstellung von 3-Oxo-pregn-4-en-21,17-carbolactonen durch die metallfreie Oxidation von 17-(3-hydroxypropyl)-3,17-dihydroxyandrostanen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK1746101T3 DK1746101T3 (da) | 2008-11-24 |
| DK1746101T4 true DK1746101T4 (da) | 2014-08-11 |
Family
ID=35744678
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK05090214.7T DK1746101T4 (da) | 2005-07-21 | 2005-07-21 | Fremgangsmåde til fremstilling af 3-oxo-pregn-4-en-21,17-carbolactoner ved metalfri oxidation af 17-(3-hydroxypropyl)-3,17-dihydroxyandrostaner |
Country Status (22)
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1746101T2 (sl) * | 2005-07-21 | 2014-09-30 | Bayer Pharma Aktiengesellschaft | Postopek za pripravo 3-okso-pregn-4-en-21,17-karbolaktonov z oksidacijo 17-(3-hidroksipropil)-3,17-dihidroksiandrostanov brez uporabe kovine |
| EP2265629B1 (en) * | 2008-03-05 | 2015-06-24 | Evestra, Inc. | Bismethylene-17 carbolactones and related uses |
| DE102008026793A1 (de) * | 2008-06-02 | 2009-12-03 | Bayer Schering Pharma Aktiengesellschaft | C-Ring-substituierte Pregn-4-en-21,17-carbolactone, sowie diese enthaltende pharmazeutische Präparate |
| US8222237B2 (en) * | 2008-11-25 | 2012-07-17 | Evestra, Inc. | Progestational 3-(6,6-ethylene-17B-hydroxy-3-oxo-17A-pregna-4-ene-17A-yl)propionic acid G-lactones |
| US8334375B2 (en) * | 2009-04-10 | 2012-12-18 | Evestra, Inc. | Methods for the preparation of drospirenone |
| ES2432063T3 (es) | 2009-06-16 | 2013-11-29 | Crystal Pharma, S.A.U. | Procedimiento para la obtención de 17-espirolactonas en esteroides |
| CN101775057B (zh) * | 2010-02-09 | 2014-07-16 | 浙江仙琚制药股份有限公司 | 屈螺酮及其中间体的制备方法 |
| CN101830959B (zh) * | 2010-05-27 | 2012-07-18 | 杭州龙山化工有限公司 | 一种曲螺酮的合成方法 |
| AR081670A1 (es) | 2010-06-29 | 2012-10-10 | Leon Farma Sa Lab | Composicion farmaceutica que comprende drospirenona y kit anticonceptivo |
| US10849857B2 (en) | 2010-07-28 | 2020-12-01 | Laboratorios Leon Farma Sa | Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same |
| US11351122B1 (en) | 2010-07-28 | 2022-06-07 | Laboratorios Leon Farma Sa | Synthetic progestogens and pharmaceutical compositions comprising the same |
| WO2012107513A1 (en) | 2011-02-10 | 2012-08-16 | Crystal Pharma, S.A.U. | Process for obtaining drospirenone |
| CN102746370A (zh) * | 2011-04-22 | 2012-10-24 | 天津金耀集团有限公司 | 一种氧化合成孕甾11位酮基的新工艺 |
| KR101672109B1 (ko) * | 2012-01-13 | 2016-11-02 | 쌩-고벵 글래스 프랑스 | 단열 창유리 유닛용 스페이서 |
| CN102887934B (zh) * | 2012-09-20 | 2015-05-27 | 杭州福斯特药业有限公司 | 一种屈螺酮的制备方法 |
| WO2014167386A1 (en) * | 2013-04-12 | 2014-10-16 | Industriale Chimica S.R.L. | Process for the preparation of drospirenone |
| CN104163846A (zh) * | 2013-05-17 | 2014-11-26 | 上海创诺制药有限公司 | 一种制备曲螺酮的方法 |
| KR20160095128A (ko) | 2013-12-12 | 2016-08-10 | 쌩-고벵 글래스 프랑스 | 개선된 밀봉을 갖는 이중 글레이징 |
| WO2015086459A1 (de) | 2013-12-12 | 2015-06-18 | Saint-Gobain Glass France | Abstandshalter für isolierverglasungen mit extrudiertem dichtprofil |
| CN104788524B (zh) * | 2014-01-16 | 2016-07-06 | 浙江仙居君业药业有限公司 | 一种19-去甲-4-雄甾烯-3,17-二酮的制备方法 |
| WO2015197491A1 (de) | 2014-06-27 | 2015-12-30 | Saint-Gobain Glass France | Isolierverglasung mit abstandhalter und verfahren zur herstellung |
| PL3161237T3 (pl) | 2014-06-27 | 2018-12-31 | Saint-Gobain Glass France | Oszklenie zespolone z elementem dystansowym i sposób wytwarzania takiego oszklenia oraz jego zastosowanie jako oszklenia budynku |
| BR112017003684B1 (pt) | 2014-09-25 | 2022-04-05 | Saint-Gobain Glass France | Espaçador para unidades de envidraçamento isolantes |
| KR20170109616A (ko) | 2015-03-02 | 2017-09-29 | 쌩-고벵 글래스 프랑스 | 절연 글레이징용 유리 섬유-강화 스페이서 |
| CN113750108B (zh) | 2015-06-23 | 2025-08-19 | 莱昂实验室制药股份有限公司 | 用于过重女性患者的基于屈螺酮的避孕药 |
| EP3108889A1 (en) | 2015-06-23 | 2016-12-28 | Philippe Perrin | Drospirenone-based contraceptive for a female patient affected with excess weight |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4069219A (en) | 1976-12-27 | 1978-01-17 | G. D. Searle & Co. | 7ξ-(Alkoxycarbonyl)-6ξ-alkyl/halo-17-hydroxy-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactones and corresponding 21-carboxylic acids, their salts, and esters |
| DE3026783C2 (de) | 1980-07-11 | 1982-07-29 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von 5β-Hydroxy-δ↑6↑-steroiden |
| DE3042136A1 (de) | 1980-11-03 | 1982-06-09 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur herstellung von 3 (beta), 7 (beta) -dihydroxy- (delta) (pfeil hoch)5(pfeil hoch) -steroiden |
| ATE15206T1 (de) | 1981-09-21 | 1985-09-15 | Schering Ag | 3-beta,7-beta,15-alpha-trihydroxy-5-androsten-1 - one, ihre 3,15-trimethylessigsaeure-ester und ihre herstellung. |
| US5106995A (en) | 1989-05-05 | 1992-04-21 | Isp Investments Inc. | Production of lactones from diols |
| DE3916112A1 (de) * | 1989-05-16 | 1990-11-22 | Schering Ag | Dihydrospirorenon als antiandrogen |
| DE19633685C1 (de) * | 1996-08-12 | 1997-10-09 | Schering Ag | Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha-(3-Hydroxy-1-propyl)-6beta,7beta;15beta, 16beta-dimethylen-5beta-androstan-3beta,5,17beta-triol (ZK 92836) und 6beta,7beta;15beta,16beta-dimethylen-5beta-hydroxy-3-oxo-17alpha-androstan-21,17-carbolacton (90965) als Zwischenprodukte des Verfahrens |
| WO2004016640A2 (en) * | 2002-08-16 | 2004-02-26 | Pharmacia & Upjohn Company Llc | 5 ANDROSTEN-3β-OL STEROID INTERMEDIATES AND PROCESSES FOR THEIR PREPARATION |
| JP2005027184A (ja) * | 2003-07-04 | 2005-01-27 | Seiko Epson Corp | 高周波複合部品 |
| ITMI20040367A1 (it) * | 2004-03-01 | 2004-06-01 | Ind Chimica Srl | Processo per la preparazione di drospirenone |
| ITMI20042338A1 (it) * | 2004-12-06 | 2005-03-06 | Ind Chimica Srl | Processo per la preparazione di drospirenone |
| US7319154B2 (en) * | 2005-07-21 | 2008-01-15 | Bayer Schering Pharma Ag | Process for the production of 3-oxo-pregn-4-ene-21, 17-carbolactones by the metal free oxidation of 17-(3-hydroxypropyl)-3, 17-dihydroxyandrostanes |
| SI1746101T2 (sl) * | 2005-07-21 | 2014-09-30 | Bayer Pharma Aktiengesellschaft | Postopek za pripravo 3-okso-pregn-4-en-21,17-karbolaktonov z oksidacijo 17-(3-hidroksipropil)-3,17-dihidroksiandrostanov brez uporabe kovine |
| US20080032147A1 (en) * | 2005-08-26 | 2008-02-07 | Thomas Neel | Medium density fibreboard |
-
2005
- 2005-07-21 SI SI200530441T patent/SI1746101T2/sl unknown
- 2005-07-21 ES ES05090214.7T patent/ES2311927T5/es not_active Expired - Lifetime
- 2005-07-21 AT AT05090214T patent/ATE403668T1/de active
- 2005-07-21 EP EP05090214.7A patent/EP1746101B2/de not_active Expired - Lifetime
- 2005-07-21 DK DK05090214.7T patent/DK1746101T4/da active
- 2005-07-21 DE DE502005004948T patent/DE502005004948D1/de not_active Expired - Lifetime
- 2005-07-21 PT PT05090214T patent/PT1746101E/pt unknown
- 2005-07-21 PL PL05090214T patent/PL1746101T5/pl unknown
-
2006
- 2006-07-19 DO DO2006000172A patent/DOP2006000172A/es unknown
- 2006-07-20 PE PE2006000875A patent/PE20070215A1/es active IP Right Grant
- 2006-07-20 UY UY29686A patent/UY29686A1/es active IP Right Grant
- 2006-07-20 JP JP2008521908A patent/JP5345843B2/ja active Active
- 2006-07-20 PE PE2009001215A patent/PE20131303A1/es active IP Right Grant
- 2006-07-20 MY MYPI20063479A patent/MY147795A/en unknown
- 2006-07-20 GT GT200600321A patent/GT200600321A/es unknown
- 2006-07-20 CN CN2006800263528A patent/CN101223186B/zh active Active
- 2006-07-20 UA UAA200802003A patent/UA100092C2/ru unknown
- 2006-07-20 TW TW095126463A patent/TWI392683B/zh active
- 2006-07-20 AR ARP060103115A patent/AR055993A1/es not_active Application Discontinuation
- 2006-07-20 SV SV2006002621A patent/SV2007002621A/es active IP Right Grant
- 2006-07-21 US US11/490,543 patent/US20070049747A1/en not_active Abandoned
-
2008
- 2008-02-20 ZA ZA200801674A patent/ZA200801674B/xx unknown
- 2008-11-06 CY CY20081101259T patent/CY1110411T1/el unknown
-
2011
- 2011-07-21 US US13/187,672 patent/US8658788B2/en active Active
-
2013
- 2013-06-12 JP JP2013123726A patent/JP2013177450A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1746101T3 (da) | Fremgangsmåde til fremstilling af 3-oxo-pregn-4-en-21, 17-carbolactoner ved metalfri oxidation af 17-(3-hydroxypropyl)-3,17-dihydroxyandrostaner | |
| DK1893586T3 (da) | Fremgangsmåde til fremstilling af 1-alkyl-3-phenyluraciler | |
| DK1778668T3 (da) | Fremgangsmåde til fremstilling af dihydropteridion | |
| DK2046767T3 (da) | Fremgangsmåde til fremstilling af diaminophenothiaziniumforbindelser | |
| DK2086944T3 (da) | Fremgangsmåde til fremstilling af difluormethylpyrazolylcarboxylater | |
| DK1945271T3 (da) | Fremgangsmåde til fremstilling af polymerbelagte mikropartikler | |
| CL2008000322A1 (es) | Proceso para la preparacion de un compuesto derivado de 2-tiazol-2-il-quinolina; compuestos intermediarios; y proceso de preparacion de dichos compuestos intermediarios. | |
| DK1852430T3 (da) | Fremgangsmåde til fremstilling af proanthocyanidinoligomer | |
| DK1856024T4 (da) | Fremgangsmåde til fremstilling af substituerede biphenyler | |
| DK2094366T3 (da) | Fremgangsmåde til oprensning af sialyllactose ved chromatografi | |
| DK1756049T3 (da) | Fremgangsmåde til fremstilling af 1,4-diphenylazetidinon-derivater | |
| DK1885337T3 (da) | Lægemiddel, især kræfthæmmende middel, til behandling ved hjælp af immunterapi, især autolog | |
| DK1846376T3 (da) | Fremgangsmåde til fremstilling af 10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepin-5-carboxamid | |
| DK1843977T3 (da) | Fremgangsmåde til fremstilling af cæsiumhydroxidopløsninger | |
| CL2007002727A1 (es) | Proceso de preparacion de anastrozol; y compuestos intermediarios. | |
| IL188619A (en) | Process for Preparation of 3-Oxo-Pargen-4-Ann-21, 17-Carbolactones by Non-Metal Oxidation of 17- (3-Hydroxypropyl) -17,3-Dihydroxyandrostanes | |
| DK1831223T3 (da) | Fremgangsmåde til fremstilling af L-biopterin | |
| DK1881830T3 (da) | 4-phenyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin-derivater til behandling af infertilitet | |
| DK1805316T3 (da) | Fremgangsmåde til fremstilling af de enantiomere former af cis-3-hydroxycy- | |
| DK1866297T3 (da) | Fremgangsmåde til fremstilling af en aminomethyl-thiazolforbindelse | |
| DK1912961T3 (da) | Fremgangsmåde til fremstilling af bepromolin | |
| DK1756075T3 (da) | Forbindelse til fremstilling af thiazol ved aminomethylering | |
| DK1931618T3 (da) | Fremgangsmåde til fremstilling af aniliner | |
| DK1937662T3 (da) | Fremgangsmåde til fremstilling af duloxetin | |
| DK2121649T3 (da) | Fremgangsmåde til fremstilling af benzofuran-2-carboxamider |