PE20131303A1 - Proceso para producir 3-oxo-pregn-4-eno-21,17-carbolactonas por oxidacion libre de metales de 17-(3-hidroxipropil)-3,17-dihidroxiandrostanos - Google Patents
Proceso para producir 3-oxo-pregn-4-eno-21,17-carbolactonas por oxidacion libre de metales de 17-(3-hidroxipropil)-3,17-dihidroxiandrostanosInfo
- Publication number
- PE20131303A1 PE20131303A1 PE2009001215A PE2009001215A PE20131303A1 PE 20131303 A1 PE20131303 A1 PE 20131303A1 PE 2009001215 A PE2009001215 A PE 2009001215A PE 2009001215 A PE2009001215 A PE 2009001215A PE 20131303 A1 PE20131303 A1 PE 20131303A1
- Authority
- PE
- Peru
- Prior art keywords
- oxo
- group
- dihydroxyandrostanes
- carbolactones
- pregn
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- C07J53/004—3 membered carbocyclic rings
- C07J53/008—3 membered carbocyclic rings in position 15/16
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
SE REFIERE A UN PROCEDIMIENTO DE PREPARACION DE UN COMPUESTO DE FORMULA III DONDE: R6a ES H, JUNTO CON R7a ES UN GRUPO -CH2; R6b ES H, JUNTO CON R7b ES UN GRUPO -CH2, DOBLE UNION; R7a ES H, ALQUILO C1-C4, ALCOXICARBONILO C1-C4; R7b ES H, JUNTO CON R6b ES UN GRUPO -CH2; R9 ES H, JUNTO CON R11 ES UNA DOBLE UNION; R10 ES H, METILO, ETILO; R11 ES H, JUNTO CON R9 ES UNA DOBLE UNION O FORMA UN GRUPO EPOXI -O-; R13 ES H, METILO, ETILO; R15 ES H, ALQUILO C1-C4, ENTRE OTROS; R16 ES H, JUNTO CON R15 FORMA CH2 O DOBLE UNION, QUE COMPRENDE EN HACER REACCIONAR UN COMPUESTO DE FORMULA I : DONDE R5 ES HIDROXI, R6a, R6b, R7a, R7b, R10, R11, R13, R15, R16 TIENE EL MISMO SIGNIFICADO QUE EN LA FORMULA III, CON POR LO MENOS 3 EQUIVALENTES MOLARES DE UN HIPOCLORITO ORGANICO EN PRESENCIA DE CANTIDADES CATALITICAS DE UN DERIVADO DE N-OXIDO DE 2,2,6,6-TETRAMETILPIPERIDINA-N-OXIDO A UN pH DE POR LO MENOS 8. UN COMPUESTO PREFERIDO ES HEMISOLVATO EN DICLOROMETANO DE 6 BETHA,7BETHA,15BETHA,16BETHA-DIMETILENO-3-OXO-17ALPHA-PREGNAN-5BETHA-OL-21,17-CARBOLACTONA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05090214.7A EP1746101B2 (de) | 2005-07-21 | 2005-07-21 | Verfahren zur Herstellung von 3-Oxo-pregn-4-en-21,17-carbolactonen durch die metallfreie Oxidation von 17-(3-hydroxypropyl)-3,17-dihydroxyandrostanen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20131303A1 true PE20131303A1 (es) | 2013-11-27 |
Family
ID=35744678
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2009001215A PE20131303A1 (es) | 2005-07-21 | 2006-07-20 | Proceso para producir 3-oxo-pregn-4-eno-21,17-carbolactonas por oxidacion libre de metales de 17-(3-hidroxipropil)-3,17-dihidroxiandrostanos |
| PE2006000875A PE20070215A1 (es) | 2005-07-21 | 2006-07-20 | Proceso para producir 3-oxo-pregn-4-eno-21,17-carbolactonas por oxidacion libre de metales de 17-(3-hidroxipropil)-3,17-dihidroxiandrostanos |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2006000875A PE20070215A1 (es) | 2005-07-21 | 2006-07-20 | Proceso para producir 3-oxo-pregn-4-eno-21,17-carbolactonas por oxidacion libre de metales de 17-(3-hidroxipropil)-3,17-dihidroxiandrostanos |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US20070049747A1 (es) |
| EP (1) | EP1746101B2 (es) |
| JP (2) | JP5345843B2 (es) |
| CN (1) | CN101223186B (es) |
| AR (1) | AR055993A1 (es) |
| AT (1) | ATE403668T1 (es) |
| CY (1) | CY1110411T1 (es) |
| DE (1) | DE502005004948D1 (es) |
| DK (1) | DK1746101T4 (es) |
| DO (1) | DOP2006000172A (es) |
| ES (1) | ES2311927T5 (es) |
| GT (1) | GT200600321A (es) |
| MY (1) | MY147795A (es) |
| PE (2) | PE20131303A1 (es) |
| PL (1) | PL1746101T5 (es) |
| PT (1) | PT1746101E (es) |
| SI (1) | SI1746101T2 (es) |
| SV (1) | SV2007002621A (es) |
| TW (1) | TWI392683B (es) |
| UA (1) | UA100092C2 (es) |
| UY (1) | UY29686A1 (es) |
| ZA (1) | ZA200801674B (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE403668T1 (de) * | 2005-07-21 | 2008-08-15 | Bayer Schering Pharma Ag | Verfahren zur herstellung von 3-oxo-pregn-4-en-21,17-carbolactonen durch die metallfreie oxidation von 17-(3-hydroxypropyl)-3,17- dihydroxyandrostanen |
| EP2265629B1 (en) * | 2008-03-05 | 2015-06-24 | Evestra, Inc. | Bismethylene-17 carbolactones and related uses |
| DE102008026793A1 (de) * | 2008-06-02 | 2009-12-03 | Bayer Schering Pharma Aktiengesellschaft | C-Ring-substituierte Pregn-4-en-21,17-carbolactone, sowie diese enthaltende pharmazeutische Präparate |
| US8222237B2 (en) * | 2008-11-25 | 2012-07-17 | Evestra, Inc. | Progestational 3-(6,6-ethylene-17B-hydroxy-3-oxo-17A-pregna-4-ene-17A-yl)propionic acid G-lactones |
| US8334375B2 (en) * | 2009-04-10 | 2012-12-18 | Evestra, Inc. | Methods for the preparation of drospirenone |
| EP2266998B1 (en) | 2009-06-16 | 2013-07-24 | Crystal Pharma, S.A.U. | Process for obtaining 17-spirolactones in steroids |
| CN101775057B (zh) * | 2010-02-09 | 2014-07-16 | 浙江仙琚制药股份有限公司 | 屈螺酮及其中间体的制备方法 |
| CN101830959B (zh) * | 2010-05-27 | 2012-07-18 | 杭州龙山化工有限公司 | 一种曲螺酮的合成方法 |
| US11351122B1 (en) | 2010-07-28 | 2022-06-07 | Laboratorios Leon Farma Sa | Synthetic progestogens and pharmaceutical compositions comprising the same |
| US10849857B2 (en) | 2010-07-28 | 2020-12-01 | Laboratorios Leon Farma Sa | Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same |
| AR081670A1 (es) | 2010-06-29 | 2012-10-10 | Leon Farma Sa Lab | Composicion farmaceutica que comprende drospirenona y kit anticonceptivo |
| WO2012107513A1 (en) | 2011-02-10 | 2012-08-16 | Crystal Pharma, S.A.U. | Process for obtaining drospirenone |
| CN102746370A (zh) * | 2011-04-22 | 2012-10-24 | 天津金耀集团有限公司 | 一种氧化合成孕甾11位酮基的新工艺 |
| DE202012013283U1 (de) * | 2012-01-13 | 2015-11-23 | Saint-Gobain Glass France | Abstandshalter für Isolierverglasungen |
| CN102887934B (zh) * | 2012-09-20 | 2015-05-27 | 杭州福斯特药业有限公司 | 一种屈螺酮的制备方法 |
| BR112015025816B1 (pt) * | 2013-04-12 | 2021-02-02 | Industriale Chimica S.R.L | processo para a preparação de drospirenona |
| CN104163846A (zh) * | 2013-05-17 | 2014-11-26 | 上海创诺制药有限公司 | 一种制备曲螺酮的方法 |
| US10190359B2 (en) | 2013-12-12 | 2019-01-29 | Saint-Gobain Glass France | Double glazing having improved sealing |
| WO2015086459A1 (de) | 2013-12-12 | 2015-06-18 | Saint-Gobain Glass France | Abstandshalter für isolierverglasungen mit extrudiertem dichtprofil |
| CN104788524B (zh) * | 2014-01-16 | 2016-07-06 | 浙江仙居君业药业有限公司 | 一种19-去甲-4-雄甾烯-3,17-二酮的制备方法 |
| TR201815606T4 (tr) | 2014-06-27 | 2018-11-21 | Saint Gobain | Mesafe parçasına sahip yalıtım cam kaplaması ve bunun imal edilmesi için yöntem ve ayrıca bunun bina cam kaplaması olarak kullanımı. |
| US10301868B2 (en) | 2014-06-27 | 2019-05-28 | Saint-Gobain Glass France | Insulated glazing comprising a spacer, and production method |
| EP3198101B1 (de) | 2014-09-25 | 2018-08-15 | Saint-Gobain Glass France | Abstandshalter für isolierverglasungen |
| CA2977207C (en) | 2015-03-02 | 2019-12-31 | Saint-Gobain Glass France | Glass-fiber-reinforced spacer for insulating glazing unit |
| EP3108889A1 (en) | 2015-06-23 | 2016-12-28 | Philippe Perrin | Drospirenone-based contraceptive for a female patient affected with excess weight |
| AU2016282863B2 (en) | 2015-06-23 | 2021-05-27 | Laboratorios Leon Farma Sa | Drospirenone-based contraceptive for a female patient affected with excess weight |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4069219A (en) | 1976-12-27 | 1978-01-17 | G. D. Searle & Co. | 7ξ-(Alkoxycarbonyl)-6ξ-alkyl/halo-17-hydroxy-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactones and corresponding 21-carboxylic acids, their salts, and esters |
| DE3026783C2 (de) | 1980-07-11 | 1982-07-29 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von 5β-Hydroxy-δ↑6↑-steroiden |
| DE3042136A1 (de) | 1980-11-03 | 1982-06-09 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur herstellung von 3 (beta), 7 (beta) -dihydroxy- (delta) (pfeil hoch)5(pfeil hoch) -steroiden |
| EP0075189B1 (en) | 1981-09-21 | 1985-08-28 | Schering Aktiengesellschaft | 3-beta,7-beta,15-alpha-trihydroxy-5-androsten-17-one, its 3,15-dipivalate, and its preparation |
| US5106995A (en) | 1989-05-05 | 1992-04-21 | Isp Investments Inc. | Production of lactones from diols |
| DE3916112A1 (de) * | 1989-05-16 | 1990-11-22 | Schering Ag | Dihydrospirorenon als antiandrogen |
| DE19633685C1 (de) * | 1996-08-12 | 1997-10-09 | Schering Ag | Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha-(3-Hydroxy-1-propyl)-6beta,7beta;15beta, 16beta-dimethylen-5beta-androstan-3beta,5,17beta-triol (ZK 92836) und 6beta,7beta;15beta,16beta-dimethylen-5beta-hydroxy-3-oxo-17alpha-androstan-21,17-carbolacton (90965) als Zwischenprodukte des Verfahrens |
| DE60308388T2 (de) * | 2002-08-16 | 2007-09-20 | Pharmacia & Upjohn Co. Llc, Kalamazoo | 5-Androsten-3beta-ol-Steroide und Verfahren für ihre Herstellung |
| JP2005027184A (ja) * | 2003-07-04 | 2005-01-27 | Seiko Epson Corp | 高周波複合部品 |
| ITMI20040367A1 (it) | 2004-03-01 | 2004-06-01 | Ind Chimica Srl | Processo per la preparazione di drospirenone |
| ITMI20042338A1 (it) | 2004-12-06 | 2005-03-06 | Ind Chimica Srl | Processo per la preparazione di drospirenone |
| ATE403668T1 (de) * | 2005-07-21 | 2008-08-15 | Bayer Schering Pharma Ag | Verfahren zur herstellung von 3-oxo-pregn-4-en-21,17-carbolactonen durch die metallfreie oxidation von 17-(3-hydroxypropyl)-3,17- dihydroxyandrostanen |
| US7319154B2 (en) * | 2005-07-21 | 2008-01-15 | Bayer Schering Pharma Ag | Process for the production of 3-oxo-pregn-4-ene-21, 17-carbolactones by the metal free oxidation of 17-(3-hydroxypropyl)-3, 17-dihydroxyandrostanes |
| US20080032147A1 (en) * | 2005-08-26 | 2008-02-07 | Thomas Neel | Medium density fibreboard |
-
2005
- 2005-07-21 AT AT05090214T patent/ATE403668T1/de active
- 2005-07-21 SI SI200530441T patent/SI1746101T2/sl unknown
- 2005-07-21 PL PL05090214T patent/PL1746101T5/pl unknown
- 2005-07-21 ES ES05090214.7T patent/ES2311927T5/es active Active
- 2005-07-21 DK DK05090214.7T patent/DK1746101T4/da active
- 2005-07-21 DE DE502005004948T patent/DE502005004948D1/de active Active
- 2005-07-21 PT PT05090214T patent/PT1746101E/pt unknown
- 2005-07-21 EP EP05090214.7A patent/EP1746101B2/de active Active
-
2006
- 2006-07-19 DO DO2006000172A patent/DOP2006000172A/es unknown
- 2006-07-20 PE PE2009001215A patent/PE20131303A1/es active IP Right Grant
- 2006-07-20 UA UAA200802003A patent/UA100092C2/ru unknown
- 2006-07-20 CN CN2006800263528A patent/CN101223186B/zh active Active
- 2006-07-20 TW TW095126463A patent/TWI392683B/zh active
- 2006-07-20 UY UY29686A patent/UY29686A1/es active IP Right Grant
- 2006-07-20 AR ARP060103115A patent/AR055993A1/es not_active Application Discontinuation
- 2006-07-20 MY MYPI20063479A patent/MY147795A/en unknown
- 2006-07-20 SV SV2006002621A patent/SV2007002621A/es active IP Right Grant
- 2006-07-20 JP JP2008521908A patent/JP5345843B2/ja active Active
- 2006-07-20 PE PE2006000875A patent/PE20070215A1/es active IP Right Grant
- 2006-07-20 GT GT200600321A patent/GT200600321A/es unknown
- 2006-07-21 US US11/490,543 patent/US20070049747A1/en not_active Abandoned
-
2008
- 2008-02-20 ZA ZA200801674A patent/ZA200801674B/xx unknown
- 2008-11-06 CY CY20081101259T patent/CY1110411T1/el unknown
-
2011
- 2011-07-21 US US13/187,672 patent/US8658788B2/en active Active
-
2013
- 2013-06-12 JP JP2013123726A patent/JP2013177450A/ja active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |