AR060174A1 - Un proceso para preparar derivados de tetrahidroquinolina - Google Patents

Un proceso para preparar derivados de tetrahidroquinolina

Info

Publication number
AR060174A1
AR060174A1 ARP070101288A ARP070101288A AR060174A1 AR 060174 A1 AR060174 A1 AR 060174A1 AR P070101288 A ARP070101288 A AR P070101288A AR P070101288 A ARP070101288 A AR P070101288A AR 060174 A1 AR060174 A1 AR 060174A1
Authority
AR
Argentina
Prior art keywords
tetrahydroquinoline
trifluoromethyl
ethyl
prepare derivatives
quinolin
Prior art date
Application number
ARP070101288A
Other languages
English (en)
Inventor
T Hamada
H Kubota
T Higashijima
N Hayashi
M Okamoto
A Sakuragi
Y Nakamura
Y Mori
Original Assignee
Tanabe Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co
Publication of AR060174A1 publication Critical patent/AR060174A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Reivindicacion 1: Un proceso para preparar (2R,4S)-2-etil-6-trifluorometil-1,2,3,4-tetrahidroquinolin-4-ilamina caracterizado por la formula (1-a) o una de sus sales, que comprende la reduccion catalítica de oxima de (R)-2-etil-6-trifluorometil-2,3- dihidro-1H-quinolin-4-ona u O-alquialquil-oxima de (R)-2-etil-6-trifluorometil-2, 3-dihidro-1H-quinolin-4-ona en presencia de un catalizador de paladio, seguido de conversion del producto en una de sus sales, si se desea.
ARP070101288A 2006-03-30 2007-03-28 Un proceso para preparar derivados de tetrahidroquinolina AR060174A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006092783 2006-03-30
JP2006322845 2006-11-30

Publications (1)

Publication Number Publication Date
AR060174A1 true AR060174A1 (es) 2008-05-28

Family

ID=38123770

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070101288A AR060174A1 (es) 2006-03-30 2007-03-28 Un proceso para preparar derivados de tetrahidroquinolina

Country Status (10)

Country Link
US (1) US8084611B2 (es)
EP (2) EP2007728B1 (es)
JP (1) JP5275971B2 (es)
AR (1) AR060174A1 (es)
AT (1) ATE533747T1 (es)
ES (1) ES2374315T3 (es)
PE (1) PE20071150A1 (es)
TW (1) TW200808731A (es)
UY (1) UY30244A1 (es)
WO (1) WO2007116922A1 (es)

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WO2017023165A1 (en) * 2015-08-04 2017-02-09 Dezima Pharma B.V. Pharmaceutical composition and therapeutic combination comprising a cholesteryl ester transfer protein inhibitor and an atp citrate lyase inhibitor – ampk activator
US10085999B1 (en) 2017-05-10 2018-10-02 Arixa Pharmaceuticals, Inc. Beta-lactamase inhibitors and uses thereof
JP6991345B2 (ja) 2017-10-02 2022-01-12 アリクサ ファーマシューティカルズ、インコーポレイテッド アズトレオナム誘導体およびその使用
EP3590927A1 (en) 2018-07-05 2020-01-08 Bayer Animal Health GmbH Novel compounds for controlling arthropods
US11180500B2 (en) 2018-10-01 2021-11-23 Arixa Pharmaceuticals, Inc. Derivatives of relebactam and uses thereof
CN113614084A (zh) 2019-03-12 2021-11-05 阿里萨制药公司 阿维巴坦衍生物的晶型
US11565999B2 (en) 2019-04-25 2023-01-31 Arixa Pharmaceuticals, Inc. Methods of synthesizing aztreonam derivatives
TWI825323B (zh) * 2019-06-18 2023-12-11 美商美國禮來大藥廠 用於製備2-(2,6-二氯苯基)-1-[(1s,3r)-3-(羥甲基)-5-(3-羥基-3-甲基丁基)-1-甲基-3,4-二氫異喹啉-2(1h)-基]乙烯酮之方法及中間物
MX2023006056A (es) 2020-11-25 2023-06-06 Akagera Medicines Inc Nanoparticulas lipidicas para suministro de acidos nucleicos y metodos de uso de las mismas.
CA3212483A1 (en) 2021-03-05 2022-09-09 Newamsterdam Pharma B.V. Obicetrapib for treatment of dementias
KR20240040767A (ko) 2021-07-26 2024-03-28 뉴암스테르담 파마 비.브이. His 저감반응자의 치료
WO2023129595A1 (en) 2021-12-30 2023-07-06 Newamsterdam Pharma B.V. Obicetrapib and sglt2 inhibitor combination
CN114516865B (zh) * 2022-03-09 2023-06-23 成都师范学院 一类D-π-A型有机共轭分子及其制备方法和应用
TW202409008A (zh) 2022-07-05 2024-03-01 荷蘭商新阿姆斯特丹製藥公司 奧比特拉(obicetrapib)鹽及彼等之製造方法與中間體
WO2024042061A1 (en) 2022-08-22 2024-02-29 Newamsterdam Pharma B.V. Obicetrapib and ezetimibe combination treatment and fixed dose pharmaceutical compositions

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Also Published As

Publication number Publication date
PE20071150A1 (es) 2007-12-03
TW200808731A (en) 2008-02-16
US8084611B2 (en) 2011-12-27
EP2007728A1 (en) 2008-12-31
ATE533747T1 (de) 2011-12-15
ES2374315T3 (es) 2012-02-15
EP2154132A1 (en) 2010-02-17
EP2007728B1 (en) 2011-11-16
US20090292125A1 (en) 2009-11-26
UY30244A1 (es) 2007-11-30
JP2009532345A (ja) 2009-09-10
WO2007116922A1 (en) 2007-10-18
JP5275971B2 (ja) 2013-08-28

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