PE20071150A1 - Un proceso para preparar derivados de tetrahidroquinolina - Google Patents
Un proceso para preparar derivados de tetrahidroquinolinaInfo
- Publication number
- PE20071150A1 PE20071150A1 PE2007000358A PE2007000358A PE20071150A1 PE 20071150 A1 PE20071150 A1 PE 20071150A1 PE 2007000358 A PE2007000358 A PE 2007000358A PE 2007000358 A PE2007000358 A PE 2007000358A PE 20071150 A1 PE20071150 A1 PE 20071150A1
- Authority
- PE
- Peru
- Prior art keywords
- trifluoromethyl
- ethyl
- ona
- quinolin
- dihydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
SE REFIERE A UN PROCEDIMIENTO DE PREPARACION DE UN COMPUESTO DE FORMULA (I-a) O (2R,4S)-2-ETIL-6-TRIFLUOROMETIL-1,2,3,4-TETRAHIDROQUINOLIN-4-ILAMINA, QUE COMPRENDE: A) HACER REACCIONAR ACIDO (R)-3-AMINOVALERICO O SU ESTER ALQUILICO CON UN COMPUESTO DE FORMULA (I-f) PARA FORMAR ACIDO (R)-3-(4-TRIFLUOROMETIL-FENILAMINO)-VALERICO, DONDE L ES UN GRUPO SALIENTE; B) HACER REACCIONAR ACIDO (R)-3-(4-TRIFLUOROMETIL-FENILAMINO)-VALERICO CON PENTOXIDO DE FOSFORO EN PRESENCIA DE ACIDO METANSULFONICO PARA FORMAR (R)-2-ETIL-6-TRIFLUOROMETIL-2,3-DIHIDRO-1H-QUINOLIN-4-ONA; C) CONVERTIR (R)-2-ETIL-6-TRIFLUOROMETIL-2,3-DIHIDRO-1H-QUINOLIN-4-ONA EN OXIMA DE (R)-2-ETIL-6-TRIFLUOROMETIL-2,3-DIHIDRO-1H-QUINOLIN-4-ONA O EN O-ALQUIALQUIL-OXIMA DE (R)-2-ETIL-6-TRIFLUOROMETIL-2,3-DIHIDRO-1H-QUINOLIN-4-ONA; Y D) REALIZAR UNA REDUCCION CATALITICA DE LA OXIMA U O-ALQUIALQUIL-OXIMA EN PRESENCIA DEL CATALIZADOR DE PALADIO-CARBONO. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION DE COMPUESTOS DE FORMULA (I), (II), ENTRE OTROS. DICHO COMPUESTO OBTENIDO ES INHIBIDOR DE LA PROTEINA DE TRANSFERENCIA DE ESTER DE COLESTERILO (CETP) SIENDO UTIL EN EL TRATAMIENTO DE HIPERLIPIDEMIA
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006092783 | 2006-03-30 | ||
JP2006322845 | 2006-11-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20071150A1 true PE20071150A1 (es) | 2007-12-03 |
Family
ID=38123770
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2007000358A PE20071150A1 (es) | 2006-03-30 | 2007-03-29 | Un proceso para preparar derivados de tetrahidroquinolina |
Country Status (10)
Country | Link |
---|---|
US (1) | US8084611B2 (es) |
EP (2) | EP2007728B1 (es) |
JP (1) | JP5275971B2 (es) |
AR (1) | AR060174A1 (es) |
AT (1) | ATE533747T1 (es) |
ES (1) | ES2374315T3 (es) |
PE (1) | PE20071150A1 (es) |
TW (1) | TW200808731A (es) |
UY (1) | UY30244A1 (es) |
WO (1) | WO2007116922A1 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2008324243B2 (en) * | 2007-11-05 | 2012-03-08 | Novartis Ag | 4-benzylamino-1-carboxyacyl-piperidine derivatives as CETP inhibitors useful for the treatment of diseases such as hyperlipidemia or arteriosclerosis |
EP2404901B1 (en) * | 2007-12-03 | 2013-05-22 | Novartis AG | 1,2-Disubstituted 4-benzylamino-pyrrolidine derivatives as CETP inhibitors useful for the treatment of diseases such as hyperlipidemia or arteriosclerosis |
CN102020608B (zh) * | 2010-09-17 | 2012-09-05 | 清华大学 | 喹啉化合物的制备方法 |
DK3180314T3 (da) * | 2014-08-12 | 2022-08-29 | Newamsterdam Pharma B V | Fremgangsmåde til fremstilling af syntetiske mellemprodukter til fremstilling af tetrahydroquinolin-derivater |
WO2017023165A1 (en) * | 2015-08-04 | 2017-02-09 | Dezima Pharma B.V. | Pharmaceutical composition and therapeutic combination comprising a cholesteryl ester transfer protein inhibitor and an atp citrate lyase inhibitor – ampk activator |
US10085999B1 (en) | 2017-05-10 | 2018-10-02 | Arixa Pharmaceuticals, Inc. | Beta-lactamase inhibitors and uses thereof |
KR102455390B1 (ko) | 2017-10-02 | 2022-10-17 | 아릭사 파마슈티컬스 인코포레이티드 | 아즈트레오남 유도체 및 이의 용도 |
EP3590927A1 (en) | 2018-07-05 | 2020-01-08 | Bayer Animal Health GmbH | Novel compounds for controlling arthropods |
CA3114618C (en) | 2018-10-01 | 2023-09-05 | Arixa Pharmaceuticals, Inc. | Derivatives of relebactam and uses thereof |
CN113614084A (zh) | 2019-03-12 | 2021-11-05 | 阿里萨制药公司 | 阿维巴坦衍生物的晶型 |
US11565999B2 (en) | 2019-04-25 | 2023-01-31 | Arixa Pharmaceuticals, Inc. | Methods of synthesizing aztreonam derivatives |
TWI825323B (zh) * | 2019-06-18 | 2023-12-11 | 美商美國禮來大藥廠 | 用於製備2-(2,6-二氯苯基)-1-[(1s,3r)-3-(羥甲基)-5-(3-羥基-3-甲基丁基)-1-甲基-3,4-二氫異喹啉-2(1h)-基]乙烯酮之方法及中間物 |
JP2023553343A (ja) | 2020-11-25 | 2023-12-21 | アカゲラ・メディスンズ,インコーポレイテッド | 核酸を送達するための脂質ナノ粒子および関連する使用方法 |
WO2022185120A1 (en) | 2021-03-05 | 2022-09-09 | Newamsterdam Pharma B.V. | Obicetrapib for treatment of dementias |
WO2023006657A1 (en) | 2021-07-26 | 2023-02-02 | Newamsterdam Pharma B.V. | Treatment of his hyporesponders |
WO2023129595A1 (en) | 2021-12-30 | 2023-07-06 | Newamsterdam Pharma B.V. | Obicetrapib and sglt2 inhibitor combination |
CN114516865B (zh) * | 2022-03-09 | 2023-06-23 | 成都师范学院 | 一类D-π-A型有机共轭分子及其制备方法和应用 |
WO2024009144A1 (en) | 2022-07-05 | 2024-01-11 | Newamsterdam Pharma B.V. | Salts of obicetrapib and processes for their manufacture and intermediates thereof |
WO2024042061A1 (en) | 2022-08-22 | 2024-02-29 | Newamsterdam Pharma B.V. | Obicetrapib and ezetimibe combination treatment and fixed dose pharmaceutical compositions |
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FI82094C (fi) | 1989-02-16 | 1997-09-09 | Valmet Corp | Anvaendning av en legering av ett metallpulver och en karbid eller nitrid innefattande belaeggningskomposition foer en i en pappersmaskin anvaendbar yankeecylinder |
EP0386839B1 (en) | 1989-03-08 | 1997-01-15 | Merck Sharp & Dohme Ltd. | Tetrahydroquinoline derivatives useful for neurodegenerative disorders |
PL286445A1 (en) | 1989-08-11 | 1991-04-22 | Ici Plc | Method of obtaining novel quinoline derivatives |
JPH03161360A (ja) | 1989-11-21 | 1991-07-11 | Tdk Corp | サーマルヘッド |
JPH03216566A (ja) | 1990-01-22 | 1991-09-24 | Mitsubishi Electric Corp | Ccdリニアイメージセンサのテスト装置 |
GB9010394D0 (en) | 1990-05-09 | 1990-06-27 | Ici Plc | Heterocyclic compounds |
IE914573A1 (en) | 1991-01-17 | 1992-07-29 | Ici Plc | Boron compounds |
JPH05213884A (ja) | 1991-06-14 | 1993-08-24 | Upjohn Co:The | 新規な4−アミノキノリン類およびこれを有効成分とする高血圧・鬱血性心不全の予防・治療剤 |
US5576460A (en) | 1994-07-27 | 1996-11-19 | Massachusetts Institute Of Technology | Preparation of arylamines |
US5929281A (en) | 1996-04-19 | 1999-07-27 | Tosoh Corporation | Process for producing heterocyclic aromatic amine or arylamine |
GT199900147A (es) | 1998-09-17 | 1999-09-06 | 1, 2, 3, 4- tetrahidroquinolinas 2-sustituidas 4-amino sustituidas. | |
US6147090A (en) * | 1998-09-17 | 2000-11-14 | Pfizer Inc. | 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines |
US6197786B1 (en) | 1998-09-17 | 2001-03-06 | Pfizer Inc | 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines |
HN2000000203A (es) | 1999-11-30 | 2001-06-13 | Pfizer Prod Inc | Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas. |
EP1167521A1 (en) | 2000-06-30 | 2002-01-02 | Aventis Animal Nutrition S.A. | Coated enzyme-containing catalyst |
WO2002008869A2 (en) | 2000-07-25 | 2002-01-31 | Digeo, Inc. | Allowance account for interactive television system |
JP2002053557A (ja) * | 2000-08-14 | 2002-02-19 | Japan Tobacco Inc | アポリポ蛋白a−i産生促進薬 |
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EP1318139A3 (en) | 2001-12-07 | 2003-07-30 | Solvias AG | Processes for the preparation of 3-aminocarboxylic acids and their esters |
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JP2004238322A (ja) | 2003-02-05 | 2004-08-26 | Sumika Fine Chemicals Co Ltd | (r)−3−アミノペンタンニトリルメタンスルホン酸塩の製造方法 |
WO2004072041A1 (en) | 2003-02-12 | 2004-08-26 | Care X S.A. | Tetrahydroquinolines as agonists of liver- x receptors |
JP4644658B2 (ja) | 2003-02-18 | 2011-03-02 | 高砂香料工業株式会社 | 光学活性テトラヒドロキノリン類の製造方法 |
EP1622872A1 (en) | 2003-03-28 | 2006-02-08 | Pfizer Products Inc. | 1,2,4-substituerte 1,2,3,4-tetrahydro-and 1,2 dihydro-quinoline and 1,2,3,4-tetrahydro-quinoxaline derivatives as cetp inhibitors for the treatment of atherosclerosis and obesity |
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JP2004339205A (ja) | 2003-04-24 | 2004-12-02 | Ajinomoto Co Inc | 光学活性N−アリール−β−アミノ酸化合物の製造方法 |
DE602004025132D1 (de) | 2003-09-18 | 2010-03-04 | Takasago Perfumery Co Ltd | Asymmetrische reduktive aminierung von ketosäurederivaten zur herstellung von aminosäurederivaten |
CA2556826A1 (en) * | 2004-03-09 | 2005-09-22 | Elan Pharmaceuticals, Inc. | Methods of treatment of amyloidosis using bi-cyclic aspartyl protease inhibitors |
DE602005014955D1 (de) | 2004-03-26 | 2009-07-30 | Lilly Co Eli | Verbindungen und verfahren zur behandlung von dyslipidämie |
UA90269C2 (ru) | 2004-04-02 | 2010-04-26 | Мицубиси Танабе Фарма Корпорейшн | Тетрагидрохинолиновые производные и способ их получения |
JP2005336083A (ja) | 2004-05-26 | 2005-12-08 | Sumitomo Chemical Co Ltd | 芳香族アミノ化合物の製造方法 |
JP2008504266A (ja) | 2004-06-24 | 2008-02-14 | イーライ リリー アンド カンパニー | 異脂肪血症を治療するための化合物及び方法 |
-
2007
- 2007-03-26 TW TW096110313A patent/TW200808731A/zh unknown
- 2007-03-26 UY UY30244A patent/UY30244A1/es not_active Application Discontinuation
- 2007-03-28 AR ARP070101288A patent/AR060174A1/es not_active Application Discontinuation
- 2007-03-29 ES ES07741046T patent/ES2374315T3/es active Active
- 2007-03-29 EP EP07741046A patent/EP2007728B1/en active Active
- 2007-03-29 AT AT07741046T patent/ATE533747T1/de active
- 2007-03-29 EP EP09174862A patent/EP2154132A1/en not_active Withdrawn
- 2007-03-29 JP JP2009502420A patent/JP5275971B2/ja active Active
- 2007-03-29 US US12/295,618 patent/US8084611B2/en active Active
- 2007-03-29 WO PCT/JP2007/057610 patent/WO2007116922A1/en active Application Filing
- 2007-03-29 PE PE2007000358A patent/PE20071150A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP2007728B1 (en) | 2011-11-16 |
WO2007116922A1 (en) | 2007-10-18 |
AR060174A1 (es) | 2008-05-28 |
UY30244A1 (es) | 2007-11-30 |
TW200808731A (en) | 2008-02-16 |
US8084611B2 (en) | 2011-12-27 |
ATE533747T1 (de) | 2011-12-15 |
JP5275971B2 (ja) | 2013-08-28 |
ES2374315T3 (es) | 2012-02-15 |
EP2154132A1 (en) | 2010-02-17 |
JP2009532345A (ja) | 2009-09-10 |
US20090292125A1 (en) | 2009-11-26 |
EP2007728A1 (en) | 2008-12-31 |
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