ATE533747T1 - Verfahren zur herstellung von tetrahydrochinolinderivaten - Google Patents
Verfahren zur herstellung von tetrahydrochinolinderivatenInfo
- Publication number
- ATE533747T1 ATE533747T1 AT07741046T AT07741046T ATE533747T1 AT E533747 T1 ATE533747 T1 AT E533747T1 AT 07741046 T AT07741046 T AT 07741046T AT 07741046 T AT07741046 T AT 07741046T AT E533747 T1 ATE533747 T1 AT E533747T1
- Authority
- AT
- Austria
- Prior art keywords
- tetrahydrocinoline
- derivatives
- producing
- tetrahydrocinoline derivatives
- producing tetrahydrocinoline
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006092783 | 2006-03-30 | ||
| JP2006322845 | 2006-11-30 | ||
| PCT/JP2007/057610 WO2007116922A1 (en) | 2006-03-30 | 2007-03-29 | A process for preparing tetrahydroquinoline derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE533747T1 true ATE533747T1 (de) | 2011-12-15 |
Family
ID=38123770
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07741046T ATE533747T1 (de) | 2006-03-30 | 2007-03-29 | Verfahren zur herstellung von tetrahydrochinolinderivaten |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8084611B2 (de) |
| EP (2) | EP2007728B1 (de) |
| JP (1) | JP5275971B2 (de) |
| AR (1) | AR060174A1 (de) |
| AT (1) | ATE533747T1 (de) |
| ES (1) | ES2374315T3 (de) |
| PE (1) | PE20071150A1 (de) |
| TW (1) | TW200808731A (de) |
| UY (1) | UY30244A1 (de) |
| WO (1) | WO2007116922A1 (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2207775T1 (sl) | 2007-11-05 | 2012-05-31 | Novartis Ag | benzilamino karboksiacil piperidinski derivati kot inhibitorji CETP uporabni za zdravljenje bolezni kot je hiperlipidemija ali arterioskleroza |
| CN101878199B (zh) * | 2007-12-03 | 2013-09-18 | 诺瓦提斯公司 | 用于治疗例如高血脂或动脉硬化疾病的作为cetp抑制剂的1，2-二取代的-4-苄基氨基-吡咯烷衍生物 |
| CN102020608B (zh) * | 2010-09-17 | 2012-09-05 | 清华大学 | 喹啉化合物的制备方法 |
| LT3180314T (lt) | 2014-08-12 | 2022-11-10 | Newamsterdam Pharma B.V. | Sintetinių tarpinių junginių, skirtų tetrahidrochinolino darinių gamybai, gavimo būdas |
| WO2017023165A1 (en) * | 2015-08-04 | 2017-02-09 | Dezima Pharma B.V. | Pharmaceutical composition and therapeutic combination comprising a cholesteryl ester transfer protein inhibitor and an atp citrate lyase inhibitor – ampk activator |
| US10085999B1 (en) | 2017-05-10 | 2018-10-02 | Arixa Pharmaceuticals, Inc. | Beta-lactamase inhibitors and uses thereof |
| US10280161B2 (en) | 2017-10-02 | 2019-05-07 | Arixa Pharmaceuticals, Inc. | Aztreonam derivatives and uses thereof |
| EP3590927A1 (de) | 2018-07-05 | 2020-01-08 | Bayer Animal Health GmbH | Neuartige verbindungen zur bekämpfung von arthropoden |
| WO2020072442A1 (en) | 2018-10-01 | 2020-04-09 | Arixa Pharmaceuticals, Inc. | Derivatives of relebactam and uses thereof |
| CN113614084A (zh) | 2019-03-12 | 2021-11-05 | 阿里萨制药公司 | 阿维巴坦衍生物的晶型 |
| US11565999B2 (en) | 2019-04-25 | 2023-01-31 | Arixa Pharmaceuticals, Inc. | Methods of synthesizing aztreonam derivatives |
| TWI825323B (zh) * | 2019-06-18 | 2023-12-11 | 美商美國禮來大藥廠 | 用於製備2-(2,6-二氯苯基)-1-[(1s,3r)-3-(羥甲基)-5-(3-羥基-3-甲基丁基)-1-甲基-3,4-二氫異喹啉-2(1h)-基]乙烯酮之方法及中間物 |
| US11591544B2 (en) | 2020-11-25 | 2023-02-28 | Akagera Medicines, Inc. | Ionizable cationic lipids |
| HUE067276T2 (hu) | 2021-03-05 | 2024-10-28 | Newamsterdam Pharma B V | Obicetrapib demenciák kezelésére |
| CN117940125A (zh) | 2021-07-26 | 2024-04-26 | 新阿姆斯特丹制药私人有限公司 | His弱应答者的治疗 |
| WO2023129595A1 (en) | 2021-12-30 | 2023-07-06 | Newamsterdam Pharma B.V. | Obicetrapib and sglt2 inhibitor combination |
| CN114516865B (zh) * | 2022-03-09 | 2023-06-23 | 成都师范学院 | 一类D-π-A型有机共轭分子及其制备方法和应用 |
| KR20250031230A (ko) | 2022-05-25 | 2025-03-06 | 아카제라 메디신즈, 인크. | 핵산 전달을 위한 지질 나노입자 및 이의 사용 방법 |
| MA71399A (fr) | 2022-07-05 | 2025-04-30 | Newamsterdam Pharma B.V. | Sels d'obicetrapib et leurs procédé de fabrication et leurs intermédiaires |
| WO2024042061A1 (en) | 2022-08-22 | 2024-02-29 | Newamsterdam Pharma B.V. | Obicetrapib and ezetimibe combination treatment and fixed dose pharmaceutical compositions |
| EP4661865A1 (de) | 2023-02-07 | 2025-12-17 | NewAmsterdam Pharma B.V. | Obicetrapib- und ezetimibkombinationsbehandlung und pharmazeutische zusammensetzungen mit fixer dosis |
| WO2025059594A1 (en) | 2023-09-15 | 2025-03-20 | Newamsterdam Pharma B.V. | METHODS FOR TREATING HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA (HeFH) |
| WO2025093129A1 (en) | 2023-11-01 | 2025-05-08 | Newamsterdam Pharma B.V. | Treatment and prevention of age-related macular degeneration using a cetp inhibitor |
| WO2025093436A1 (en) | 2023-11-01 | 2025-05-08 | Newamsterdam Pharma B.V. | Treatment and prevention of age-related macular degeneration using a cetp inhibitor |
| WO2025146415A1 (en) | 2024-01-03 | 2025-07-10 | Newamsterdam Pharma B.V. | Improvement in atherosclerotic plaque characteristics with obicetrapib |
| WO2025146262A1 (en) | 2024-01-03 | 2025-07-10 | Newamsterdam Pharma B.V. | Obicetrapib for use in the treatment of hemoglobinopathies |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI82094C (fi) | 1989-02-16 | 1997-09-09 | Valmet Corp | Anvaendning av en legering av ett metallpulver och en karbid eller nitrid innefattande belaeggningskomposition foer en i en pappersmaskin anvaendbar yankeecylinder |
| EP0386839B1 (de) | 1989-03-08 | 1997-01-15 | Merck Sharp & Dohme Ltd. | Tetrahydroquinolin-Derivate, verwendbar bei neurodegenerativen Krankheiten |
| IE902909A1 (en) | 1989-08-11 | 1991-02-27 | Ici Plc | Nitrogen compounds |
| JPH03161360A (ja) | 1989-11-21 | 1991-07-11 | Tdk Corp | サーマルヘッド |
| JPH03216566A (ja) | 1990-01-22 | 1991-09-24 | Mitsubishi Electric Corp | Ｃｃｄリニアイメージセンサのテスト装置 |
| GB9010394D0 (en) | 1990-05-09 | 1990-06-27 | Ici Plc | Heterocyclic compounds |
| IE914573A1 (en) | 1991-01-17 | 1992-07-29 | Ici Plc | Boron compounds |
| JPH05213884A (ja) | 1991-06-14 | 1993-08-24 | Upjohn Co:The | 新規な４−アミノキノリン類およびこれを有効成分とする高血圧・鬱血性心不全の予防・治療剤 |
| US5576460A (en) | 1994-07-27 | 1996-11-19 | Massachusetts Institute Of Technology | Preparation of arylamines |
| US5929281A (en) | 1996-04-19 | 1999-07-27 | Tosoh Corporation | Process for producing heterocyclic aromatic amine or arylamine |
| US6197786B1 (en) * | 1998-09-17 | 2001-03-06 | Pfizer Inc | 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines |
| GT199900147A (es) * | 1998-09-17 | 1999-09-06 | 1, 2, 3, 4- tetrahidroquinolinas 2-sustituidas 4-amino sustituidas. | |
| US6147090A (en) * | 1998-09-17 | 2000-11-14 | Pfizer Inc. | 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines |
| HN2000000203A (es) | 1999-11-30 | 2001-06-13 | Pfizer Prod Inc | Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas. |
| EP1167521A1 (de) | 2000-06-30 | 2002-01-02 | Aventis Animal Nutrition S.A. | Beschichtete enzymenthaltende Katalysator |
| WO2002008869A2 (en) | 2000-07-25 | 2002-01-31 | Digeo, Inc. | Allowance account for interactive television system |
| JP2002053557A (ja) * | 2000-08-14 | 2002-02-19 | Japan Tobacco Inc | アポリポ蛋白ａ−ｉ産生促進薬 |
| CN1325480C (zh) * | 2000-08-18 | 2007-07-11 | 味之素株式会社 | 苯基丙氨酸衍生物 |
| SE0101161D0 (sv) * | 2001-03-30 | 2001-03-30 | Astrazeneca Ab | New compounds |
| DK1383734T3 (da) | 2001-04-30 | 2006-05-15 | Pfizer Prod Inc | Forbindelser, der er anvendelige som mellemprodukter til 4-aminoquinolinderivater |
| EP1318139A3 (de) | 2001-12-07 | 2003-07-30 | Solvias AG | Verfahren zur Herstellung von 3-Aminokarbonsäuren und deren Estern |
| US6903233B2 (en) | 2002-03-11 | 2005-06-07 | Takasago International Corporation | Process for producing optically active 3-halogenocarboxylic acid ester and 3-azidocarboxylic acid ester |
| ES2277142T3 (es) | 2002-08-30 | 2007-07-01 | Japan Tobacco Inc. | Compuesto de dibencilamina y su uso medicinal. |
| MXPA05003456A (es) | 2002-10-04 | 2005-07-05 | Millennium Pharm Inc | Antagonistas del receptor de pgd2 para el tratamiento de enfermedades inflamatorias. |
| JP2004238322A (ja) | 2003-02-05 | 2004-08-26 | Sumika Fine Chemicals Co Ltd | （ｒ）−３−アミノペンタンニトリルメタンスルホン酸塩の製造方法 |
| WO2004072041A1 (en) | 2003-02-12 | 2004-08-26 | Care X S.A. | Tetrahydroquinolines as agonists of liver- x receptors |
| US7601842B2 (en) | 2003-02-18 | 2009-10-13 | Takasago International Corporation | Method for producing an optically active tetrahydroquinoline |
| BRPI0408897A (pt) | 2003-03-28 | 2006-04-18 | Pfizer Prod Inc | derivados de 1,2,3,4-tetrahidro-e 1,2-dihidro-quinolina 1,2,4-substituìdos como inibidores de cetp para o tratamento de arteroesclerose e obesidade |
| JP2004339205A (ja) | 2003-04-24 | 2004-12-02 | Ajinomoto Co Inc | 光学活性Ｎ−アリール−β−アミノ酸化合物の製造方法 |
| US7145030B2 (en) | 2003-04-24 | 2006-12-05 | Ajinomoto Co., Inc. | Production method for optically active N-aryl-β-amino acid compounds |
| WO2005028419A2 (en) | 2003-09-18 | 2005-03-31 | Takasago International Corporation | Asymmetric reductive amination of keto acid derivatives for producing amino acid derivatives |
| JP2007528403A (ja) * | 2004-03-09 | 2007-10-11 | エラン ファーマシューティカルズ，インコーポレイテッド | 二環式アスパラギン酸プロテアーゼ阻害薬を用いるアミロイドーシスの処置方法 |
| ATE433984T1 (de) | 2004-03-26 | 2009-07-15 | Lilly Co Eli | Verbindungen und verfahren zur behandlung von dyslipidämie |
| UA90269C2 (ru) | 2004-04-02 | 2010-04-26 | Мицубиси Танабе Фарма Корпорейшн | Тетрагидрохинолиновые производные и способ их получения |
| JP2005336083A (ja) | 2004-05-26 | 2005-12-08 | Sumitomo Chemical Co Ltd | 芳香族アミノ化合物の製造方法 |
| CA2570688A1 (en) | 2004-06-24 | 2006-02-02 | Eli Lilly And Company | Compounds and methods for treating dyslipidemia |
-
2007
- 2007-03-26 TW TW096110313A patent/TW200808731A/zh unknown
- 2007-03-26 UY UY30244A patent/UY30244A1/es not_active Application Discontinuation
- 2007-03-28 AR ARP070101288A patent/AR060174A1/es not_active Application Discontinuation
- 2007-03-29 WO PCT/JP2007/057610 patent/WO2007116922A1/en not_active Ceased
- 2007-03-29 JP JP2009502420A patent/JP5275971B2/ja active Active
- 2007-03-29 AT AT07741046T patent/ATE533747T1/de active
- 2007-03-29 PE PE2007000358A patent/PE20071150A1/es not_active Application Discontinuation
- 2007-03-29 EP EP07741046A patent/EP2007728B1/de active Active
- 2007-03-29 ES ES07741046T patent/ES2374315T3/es active Active
- 2007-03-29 EP EP09174862A patent/EP2154132A1/de not_active Withdrawn
- 2007-03-29 US US12/295,618 patent/US8084611B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US8084611B2 (en) | 2011-12-27 |
| EP2007728A1 (de) | 2008-12-31 |
| PE20071150A1 (es) | 2007-12-03 |
| US20090292125A1 (en) | 2009-11-26 |
| JP2009532345A (ja) | 2009-09-10 |
| ES2374315T3 (es) | 2012-02-15 |
| EP2154132A1 (de) | 2010-02-17 |
| AR060174A1 (es) | 2008-05-28 |
| UY30244A1 (es) | 2007-11-30 |
| WO2007116922A1 (en) | 2007-10-18 |
| TW200808731A (en) | 2008-02-16 |
| JP5275971B2 (ja) | 2013-08-28 |
| EP2007728B1 (de) | 2011-11-16 |
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