DK173982B1 - Depolymeriserede heparinderivater, fremgangsmåde til fremstilling deraf og farmaceutisk præparat samt biologisk reagens med indhold heraf - Google Patents

Depolymeriserede heparinderivater, fremgangsmåde til fremstilling deraf og farmaceutisk præparat samt biologisk reagens med indhold heraf Download PDF

Info

Publication number
DK173982B1
DK173982B1 DK198802103A DK210388A DK173982B1 DK 173982 B1 DK173982 B1 DK 173982B1 DK 198802103 A DK198802103 A DK 198802103A DK 210388 A DK210388 A DK 210388A DK 173982 B1 DK173982 B1 DK 173982B1
Authority
DK
Denmark
Prior art keywords
heparin
fragments
approx
daltons
molecular weight
Prior art date
Application number
DK198802103A
Other languages
Danish (da)
English (en)
Other versions
DK210388D0 (da
DK210388A (da
Inventor
Maurice Petitou
Jean Choay
Jean-Glaude Lormeau
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of DK210388D0 publication Critical patent/DK210388D0/da
Publication of DK210388A publication Critical patent/DK210388A/da
Application granted granted Critical
Publication of DK173982B1 publication Critical patent/DK173982B1/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078Degradation products

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Materials For Medical Uses (AREA)
DK198802103A 1987-04-16 1988-04-18 Depolymeriserede heparinderivater, fremgangsmåde til fremstilling deraf og farmaceutisk præparat samt biologisk reagens med indhold heraf DK173982B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8705457 1987-04-16
FR8705457A FR2614026B1 (fr) 1987-04-16 1987-04-16 Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques

Publications (3)

Publication Number Publication Date
DK210388D0 DK210388D0 (da) 1988-04-18
DK210388A DK210388A (da) 1988-10-17
DK173982B1 true DK173982B1 (da) 2002-03-25

Family

ID=9350219

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198802103A DK173982B1 (da) 1987-04-16 1988-04-18 Depolymeriserede heparinderivater, fremgangsmåde til fremstilling deraf og farmaceutisk præparat samt biologisk reagens med indhold heraf

Country Status (18)

Country Link
US (1) US4990502A (xx)
EP (1) EP0287477B1 (xx)
JP (1) JPS63278901A (xx)
KR (1) KR880012644A (xx)
AR (1) AR243205A1 (xx)
AT (1) ATE113611T1 (xx)
AU (1) AU601566B2 (xx)
CA (1) CA1327968C (xx)
DE (1) DE3851973T2 (xx)
DK (1) DK173982B1 (xx)
FI (1) FI88046C (xx)
FR (1) FR2614026B1 (xx)
IE (1) IE64884B1 (xx)
IL (1) IL86091A0 (xx)
NO (1) NO170940C (xx)
NZ (1) NZ224275A (xx)
PT (1) PT87261B (xx)
ZA (1) ZA882662B (xx)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1234826B (it) * 1989-01-30 1992-05-29 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
IT1237518B (it) * 1989-11-24 1993-06-08 Renato Conti Eparine supersolfatate
USRE38743E1 (en) 1990-06-26 2005-06-14 Aventis Pharma S.A. Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events
FR2663639B1 (fr) * 1990-06-26 1994-03-18 Rhone Poulenc Sante Melanges de polysaccharides de bas poids moleculaires procede de preparation et utilisation.
FR2669932B1 (fr) * 1990-12-03 1994-07-01 Sanofi Sa Nouvel heparosane-n,o-sulfate, son procede de preparation et les compositions pharmaceutiques qui le contiennent.
US5280016A (en) * 1991-03-29 1994-01-18 Glycomed Incorporated Non-anticoagulant heparin derivatives
MX9201801A (es) * 1991-04-16 1992-10-30 Seikagaku Kogyo Co Ltd Oligosacarido que tiene afinidad para el factor de desarrollo del fibroplasto y procedimiento para producirlo.
SE9101155D0 (sv) * 1991-04-18 1991-04-18 Kabi Pharmacia Ab Novel heparin derivatives
KR100235782B1 (ko) * 1991-05-02 1999-12-15 파울리나 벤-아미 병리학적 과정의 예방 또는 치료를 위한 성분물
US6750207B1 (en) 1992-05-01 2004-06-15 Yeda Research And Development Co. Ltd. Compositions for the regulation of cytokine activity
WO1994011006A1 (en) * 1992-11-10 1994-05-26 Yeda Research And Development Co. Ltd. Compositions for the regulation of cytokine activity
US5861382A (en) * 1992-05-01 1999-01-19 Yeda Research And Development Co. Ltd. Methods for regulation of active TNF-α
FR2691066B1 (fr) * 1992-05-15 1995-06-09 Sanofi Elf Utilisation de glycosaminoglycanes exogenes, de leurs analogues ainsi que de leurs fragments, fractions et derives, pour la preparation de medicaments destines au traitement de thrombopenies.
US5696100A (en) * 1992-12-22 1997-12-09 Glycomed Incorporated Method for controlling O-desulfation of heparin and compositions produced thereby
US5650389A (en) * 1993-03-01 1997-07-22 University Of Alabama At Birmingham Research Foundation Methods for the inhibition of complement activation
FR2704226B1 (fr) * 1993-04-22 1995-07-21 Sanofi Elf 3-desoxy oligosaccharides, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
IT1264709B1 (it) * 1993-07-12 1996-10-04 Italfarmaco Spa Derivati eparinici ad attivita' antimetastatica
US5583121A (en) * 1994-01-12 1996-12-10 Michigan State University Non-anticoagulant chemically modified heparinoids for treating hypovolemic shock and related shock syndromes
US6127347A (en) * 1994-01-12 2000-10-03 Univ Michigan Non-anticoagulant chemically modified heparinoids for treating hypovolemic shock and related shock syndromes
CA2189038A1 (en) * 1994-05-06 1995-11-09 Kevin R. Holme O-desulfated heparin derivatives, methods of making and uses thereof
US5639469A (en) * 1994-06-15 1997-06-17 Minnesota Mining And Manufacturing Company Transmucosal delivery system
US6001820A (en) * 1995-03-31 1999-12-14 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
DE69623840D1 (de) * 1995-03-31 2002-10-31 Hamilton Civic Hospitals Res Zusammensetzung zur Hemmung der Thromboseentstehung
US5744457A (en) * 1995-03-31 1998-04-28 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5763427A (en) * 1995-03-31 1998-06-09 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
WO1997016556A1 (en) 1995-10-30 1997-05-09 Massachusetts Institute Of Technology Rationally designed polysaccharide lyases derived from heparinase i
US6562781B1 (en) * 1995-11-30 2003-05-13 Hamilton Civic Hospitals Research Development Inc. Glycosaminoglycan-antithrombin III/heparin cofactor II conjugates
US7045585B2 (en) * 1995-11-30 2006-05-16 Hamilton Civic Hospital Research Development Inc. Methods of coating a device using anti-thrombin heparin
US6491965B1 (en) 1995-11-30 2002-12-10 Hamilton Civic Hospitals Research Development, Inc. Medical device comprising glycosaminoglycan-antithrombin III/heparin cofactor II conjugates
US5767269A (en) * 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
FR2763848B1 (fr) 1997-05-28 2000-01-28 Rhone Poulenc Rorer Sa Utilisation des heparines de bas poids moleculaire pour la prevention et le traitement du trauma du systeme nerveux central
CA2293595A1 (en) * 1997-06-06 1998-12-10 Hamilton Civic Hospitals Research Development, Inc. Modified low molecular weight heparin that inhibits clot associated coagulation factors
AU1173599A (en) 1997-11-20 1999-06-15 Ikuo Yamashina Low-molecular heparin modification and remedy for skin ulcer
EP1059304B1 (en) * 1998-02-26 2006-04-26 Seikagaku Corporation Novel polysaccharide derivatives, process for the production thereof and medicinal compositions containing the same as the active ingredient
US6028061A (en) * 1998-06-18 2000-02-22 Children's Medical Center Corp Angiogenesis inhibitors and use thereof
JP2003527822A (ja) * 1998-08-27 2003-09-24 マサチューセッツ インスティテュート オブ テクノロジー ヘパリナーゼiおよびii由来の合理的に設計されたヘパリナーゼ
US7056504B1 (en) 1998-08-27 2006-06-06 Massachusetts Institute Of Technology Rationally designed heparinases derived from heparinase I and II
JP4633223B2 (ja) * 1999-03-31 2011-02-16 生化学工業株式会社 血管内皮細胞増殖因子依存性血管内皮細胞増殖の抑制剤
WO2000065521A2 (en) * 1999-04-23 2000-11-02 Massachusetts Institute Of Technology System and method for polymer notation
JP2003504428A (ja) * 1999-06-30 2003-02-04 ハミルトン シビック ホスピタルズ リサーチ ディベロップメント インコーポレイテッド クロット関連凝固因子を阻害するヘパリン組成物
IT1316986B1 (it) * 2000-01-25 2003-05-26 Sigma Tau Ind Farmaceuti Derivati glicosamminoglicani parzialmente desolfatati nonanticoagulanti ad attivita' antiangiogenica.
US20080139503A1 (en) * 2000-01-25 2008-06-12 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect
US7781416B2 (en) * 2000-01-25 2010-08-24 Sigma-Tau Research Switzerland S.A. Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect
CA2402160C (en) 2000-03-08 2012-02-14 Massachusetts Institute Of Technology Heparinase iii and uses thereof
JP4633233B2 (ja) * 2000-06-29 2011-02-16 生化学工業株式会社 クラミジア感染症処置剤
IL154771A0 (en) * 2000-09-08 2003-10-31 Hamilton Civic Hospitals Res Antithrombotic compositions
WO2002023190A2 (en) * 2000-09-12 2002-03-21 Massachusetts Institute Of Technology Methods and products related to low molecular weight heparin
AU2002224408B2 (en) * 2000-10-18 2007-08-23 Massachusetts Institute Of Technology Methods and products related to pulmonary delivery of polysaccharides
EP2343077B1 (en) * 2001-09-12 2013-07-17 SIGMA-TAU Research Switzerland S.A. Derivatives of totally N-desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect
US7285536B2 (en) 2001-12-05 2007-10-23 Yeda Research And Development Co., Ltd. Anti-cancer therapeutic compounds
EP2284535A1 (en) * 2002-03-11 2011-02-16 Momenta Pharmaceuticals, Inc. Low molecular weight heparins
EP1551852A4 (en) * 2002-04-25 2007-03-21 Momenta Pharmaceuticals Inc METHOD AND PRODUCTS FOR MUCOSAL DELIVERY
ITMI20031679A1 (it) * 2003-08-29 2005-02-28 Opocrin Spa Processo per la produzione di eparine a basso peso
EP1582531A1 (en) 2004-03-24 2005-10-05 Aventis Pharma S.A. Process for oxidizing unfractionated heparins and detecting presence or absence of glycoserine in heparin and heparin products
WO2007019554A2 (en) * 2005-08-08 2007-02-15 Momenta Pharmaceuticals, Inc. Polysaccharides for delivery of active agents
EP1792621B1 (en) 2005-11-30 2012-04-04 Istituto di Ricerche Chimiche e Biochimiche "G. Ronzoni" Orally administrable heparin derivatives
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
WO2009007224A1 (en) * 2007-07-10 2009-01-15 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Low molecular weight heparin derivatives having neuroprotective activity
ES2567079T3 (es) * 2007-11-02 2016-04-19 Momenta Pharmaceuticals, Inc. Composiciones de polisacáridos que no son anticoagulantes
US8569262B2 (en) 2007-11-02 2013-10-29 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
US8592393B2 (en) 2007-11-02 2013-11-26 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
WO2009141821A1 (en) * 2008-05-20 2009-11-26 Crystal Clear Partnership Separation of polysaccharides by charge density gradient
CN102046781A (zh) 2008-05-30 2011-05-04 动量制药公司 糖结构以及制造和使用此类结构的方法
CN102791742B (zh) * 2010-01-19 2014-12-24 动量制药公司 评价肝素制剂
US9387256B2 (en) 2010-04-16 2016-07-12 Momenta Pharmaceuticals, Inc. Tissue targeting
US10017585B2 (en) 2010-06-17 2018-07-10 Momenta Pharmaceuticals, Inc. Methods and compositions for promoting hair growth
WO2012115952A1 (en) 2011-02-21 2012-08-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
EP2794665B1 (en) * 2011-12-19 2017-11-22 Dilafor AB Non anti-coagulative glycosaminoglycans comprising repeating disaccharide unit and their medical use
WO2013095215A1 (en) 2011-12-19 2013-06-27 Dilaforette Ab Low anticoagulant heparins
SG11201406119WA (en) * 2012-03-26 2014-11-27 Dilafor Ab Combination treatment comprising sulphated glycosaminoglycans for inducing labor
WO2014193818A1 (en) 2013-05-28 2014-12-04 Momenta Pharmaceuticals, Inc. Pharmaceutical compositions
GB2515315A (en) * 2013-06-19 2014-12-24 Dilafor Ab New Processes
CN108424474B (zh) * 2017-02-15 2023-07-25 清华大学 去抗凝肝素衍生物及其用于炎症性肠病的治疗
BR112022000255A8 (pt) 2019-07-09 2022-03-22 Optimvia Llc Métodos para sintetizar polissacarídeos anticoagulantes
EP4182452A4 (en) 2020-07-14 2024-07-31 Optimvia Llc METHOD FOR THE SYNTHESIS OF NON-ANTICOAGULATING HEPARAN SULFATE

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE620906A (xx) *
FR2440376A1 (fr) * 1978-11-06 1980-05-30 Choay Sa Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir
CA1136620A (en) * 1979-01-08 1982-11-30 Ulf P.F. Lindahl Heparin fragments having selective anticoagulation activity
US4826827A (en) * 1979-10-05 1989-05-02 Choay S.A. Short chained oligosaccharides having biological properties, a process for making the same and the use thereof as drugs
CA1171375A (en) * 1980-09-15 1984-07-24 Ulf P.F. Lindahl Oligosaccharides having selective anticoagulation activity
US4801583A (en) * 1982-01-15 1989-01-31 Choay S.A. Oligosaccharides and their biological applications
US4533549A (en) * 1983-01-04 1985-08-06 Lasker Sigmund E Antithrombotic agent
IT1195497B (it) * 1983-03-08 1988-10-19 Opocrin Spa Procedimento per la preparazione di frazioni oligosaccaridiche dotate di proprieta' farmacologiche per degradazione chimica di eparina
US4687765A (en) * 1983-07-25 1987-08-18 Choay S.A. Method and composition for thrombolytic treatment
FR2568774B2 (fr) * 1984-05-30 1989-05-19 Choay Sa Medicaments favorisant les proprietes d'ecoulement du sang et leur utilisation en therapeutique
FR2584606A1 (fr) * 1985-07-12 1987-01-16 Dropic Utilisation de poly- et oligosaccharides pour l'obtention de medicaments actifs dans les pathologies du tissu conjonctif
US4788307A (en) * 1986-04-30 1988-11-29 Choay S.A. Oligosaccharidic fractions devoid or practically devoid of antithrombotic activity
US4745106A (en) * 1986-08-20 1988-05-17 Griffin Charles C Heparin derivatives having improved anti-Xa specificity

Also Published As

Publication number Publication date
DE3851973D1 (de) 1994-12-08
FI881783A (fi) 1988-10-17
NO170940B (no) 1992-09-21
EP0287477B1 (fr) 1994-11-02
NO881660D0 (no) 1988-04-15
FI88046C (fi) 1993-03-25
AU601566B2 (en) 1990-09-13
PT87261B (pt) 1992-08-31
DK210388D0 (da) 1988-04-18
AR243205A1 (es) 1993-07-30
NO881660L (no) 1988-10-17
FI881783A0 (fi) 1988-04-15
PT87261A (pt) 1988-05-01
IL86091A0 (en) 1988-09-30
DE3851973T2 (de) 1995-06-08
IE64884B1 (en) 1995-09-20
NZ224275A (en) 1991-02-26
NO170940C (no) 1992-12-30
US4990502A (en) 1991-02-05
JPS63278901A (ja) 1988-11-16
IE881150L (en) 1988-10-16
ATE113611T1 (de) 1994-11-15
CA1327968C (fr) 1994-03-22
KR880012644A (ko) 1988-11-28
EP0287477A3 (en) 1989-07-26
ZA882662B (en) 1988-10-14
FR2614026B1 (fr) 1992-04-17
FI88046B (fi) 1992-12-15
EP0287477A2 (fr) 1988-10-19
DK210388A (da) 1988-10-17
AU1466388A (en) 1988-10-20
FR2614026A1 (fr) 1988-10-21

Similar Documents

Publication Publication Date Title
DK173982B1 (da) Depolymeriserede heparinderivater, fremgangsmåde til fremstilling deraf og farmaceutisk præparat samt biologisk reagens med indhold heraf
US5280016A (en) Non-anticoagulant heparin derivatives
US5013724A (en) Process for the sulfation of glycosaminoglycans, the sulfated glycosaminoglycans and their biological applications
US5250519A (en) Non-anticoagulant heparin derivatives
US5767269A (en) Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
Casu et al. Structural and conformational aspects of the anticoagulant and antithrombotic activity of heparin and dermatan sulfate
HU210925B (en) Process to prepare polisaccharide mixtures wita low moleculare weight and pharmaceutical compns. contg. them
ES2668273T3 (es) Uso de derivados de heparina químicamente modificada en drepanocitosis
JP5351770B2 (ja) ビオチンまたはビオチン誘導体との少なくとも1つの共有結合を含む低分子量ヘパリン、これらの作製方法およびそれらの使用。
WO1998014481A9 (en) Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
JPH09512822A (ja) O−脱硫酸化ヘパリン誘導体とその製造法および使用
PT99671B (pt) Processo para a preparacao de heparosanos-n,o-sulfatados e de composicoes farmaceuticas que os contem
US5721357A (en) Preparation of sulfated polysaccharides for treatment or prevention of thromboses
US20240041918A1 (en) Oligosaccharide Compound for Inhibiting Intrinsic Coagulation Factor X-Enzyme Complex, and Preparation Method Therefor and Uses Thereof
DK174284B1 (da) Biologisk aktive tetrasaccharider
US5849721A (en) Sulfated polysaccharides obtained from heparin, preparation process, pharmaceutical composition and use thereof
EP0408770B1 (en) New sulfated polysaccharide, pharmaceutically acceptable salts thereof, preparation thereof, and drug containing the same as active ingredient
CN108285498A (zh) 一种抑制内源性凝血因子x酶复合物的寡糖化合物及其制备方法与用途
NZ242431A (en) Mixture of sulphated oligosaccharides derived from depolymerised heparin, and pharmaceutical compositions
RU2451515C2 (ru) Композиции гепарина низкой молекулярной массы и их применение
Van Boeckel et al. The action of serpins and heparin as leads in drug discovery

Legal Events

Date Code Title Description
PUP Patent expired