DE3851973D1 - Heparine mit niedrigem Molekulargewicht und regelmässiger Struktur, ihre Herstellung und biologische Verwendungen. - Google Patents

Heparine mit niedrigem Molekulargewicht und regelmässiger Struktur, ihre Herstellung und biologische Verwendungen.

Info

Publication number
DE3851973D1
DE3851973D1 DE3851973T DE3851973T DE3851973D1 DE 3851973 D1 DE3851973 D1 DE 3851973D1 DE 3851973 T DE3851973 T DE 3851973T DE 3851973 T DE3851973 T DE 3851973T DE 3851973 D1 DE3851973 D1 DE 3851973D1
Authority
DE
Germany
Prior art keywords
heparins
manufacture
molecular weight
low molecular
regular structure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3851973T
Other languages
English (en)
Other versions
DE3851973T2 (de
Inventor
Jean-Claude Lormeau
Maurice Petitou
Jean Choay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of DE3851973D1 publication Critical patent/DE3851973D1/de
Application granted granted Critical
Publication of DE3851973T2 publication Critical patent/DE3851973T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
DE3851973T 1987-04-16 1988-04-15 Heparine mit niedrigem Molekulargewicht und regelmässiger Struktur, ihre Herstellung und biologische Verwendungen. Expired - Lifetime DE3851973T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8705457A FR2614026B1 (fr) 1987-04-16 1987-04-16 Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques

Publications (2)

Publication Number Publication Date
DE3851973D1 true DE3851973D1 (de) 1994-12-08
DE3851973T2 DE3851973T2 (de) 1995-06-08

Family

ID=9350219

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3851973T Expired - Lifetime DE3851973T2 (de) 1987-04-16 1988-04-15 Heparine mit niedrigem Molekulargewicht und regelmässiger Struktur, ihre Herstellung und biologische Verwendungen.

Country Status (18)

Country Link
US (1) US4990502A (de)
EP (1) EP0287477B1 (de)
JP (1) JPS63278901A (de)
KR (1) KR880012644A (de)
AR (1) AR243205A1 (de)
AT (1) ATE113611T1 (de)
AU (1) AU601566B2 (de)
CA (1) CA1327968C (de)
DE (1) DE3851973T2 (de)
DK (1) DK173982B1 (de)
FI (1) FI88046C (de)
FR (1) FR2614026B1 (de)
IE (1) IE64884B1 (de)
IL (1) IL86091A0 (de)
NO (1) NO170940C (de)
NZ (1) NZ224275A (de)
PT (1) PT87261B (de)
ZA (1) ZA882662B (de)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1234826B (it) * 1989-01-30 1992-05-29 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
IT1237518B (it) * 1989-11-24 1993-06-08 Renato Conti Eparine supersolfatate
FR2663639B1 (fr) * 1990-06-26 1994-03-18 Rhone Poulenc Sante Melanges de polysaccharides de bas poids moleculaires procede de preparation et utilisation.
USRE38743E1 (en) 1990-06-26 2005-06-14 Aventis Pharma S.A. Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events
FR2669932B1 (fr) * 1990-12-03 1994-07-01 Sanofi Sa Nouvel heparosane-n,o-sulfate, son procede de preparation et les compositions pharmaceutiques qui le contiennent.
US5280016A (en) * 1991-03-29 1994-01-18 Glycomed Incorporated Non-anticoagulant heparin derivatives
FI921689A (fi) * 1991-04-16 1992-10-17 Seikagagu Kogyo Kabushiki Kais Oligosackarid med affinitet foer fibroblasttillvaextfaktor och foerfarande foer framstaellning av denna
SE9101155D0 (sv) * 1991-04-18 1991-04-18 Kabi Pharmacia Ab Novel heparin derivatives
CZ232593A3 (en) * 1991-05-02 1994-07-13 Yeda Res & Dev Pharmaceutical preparation for preventing and/or therapy of pathological states
US5861382A (en) * 1992-05-01 1999-01-19 Yeda Research And Development Co. Ltd. Methods for regulation of active TNF-α
US6750207B1 (en) 1992-05-01 2004-06-15 Yeda Research And Development Co. Ltd. Compositions for the regulation of cytokine activity
FR2691066B1 (fr) * 1992-05-15 1995-06-09 Sanofi Elf Utilisation de glycosaminoglycanes exogenes, de leurs analogues ainsi que de leurs fragments, fractions et derives, pour la preparation de medicaments destines au traitement de thrombopenies.
AU699624B2 (en) * 1992-11-10 1998-12-10 Yeda Research And Development Co. Ltd. Compositions for the regulation of cytokine activity
US5696100A (en) * 1992-12-22 1997-12-09 Glycomed Incorporated Method for controlling O-desulfation of heparin and compositions produced thereby
US5650389A (en) * 1993-03-01 1997-07-22 University Of Alabama At Birmingham Research Foundation Methods for the inhibition of complement activation
FR2704226B1 (fr) * 1993-04-22 1995-07-21 Sanofi Elf 3-desoxy oligosaccharides, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
IT1264709B1 (it) * 1993-07-12 1996-10-04 Italfarmaco Spa Derivati eparinici ad attivita' antimetastatica
US5583121A (en) * 1994-01-12 1996-12-10 Michigan State University Non-anticoagulant chemically modified heparinoids for treating hypovolemic shock and related shock syndromes
US6127347A (en) * 1994-01-12 2000-10-03 Univ Michigan Non-anticoagulant chemically modified heparinoids for treating hypovolemic shock and related shock syndromes
JPH09512822A (ja) * 1994-05-06 1997-12-22 グリコメド・インコーポレイテッド Ｏ−脱硫酸化ヘパリン誘導体とその製造法および使用
US5639469A (en) * 1994-06-15 1997-06-17 Minnesota Mining And Manufacturing Company Transmucosal delivery system
US5744457A (en) * 1995-03-31 1998-04-28 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5763427A (en) * 1995-03-31 1998-06-09 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US6001820A (en) * 1995-03-31 1999-12-14 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
EP0735050B1 (de) * 1995-03-31 2002-09-25 Hamilton Civic Hospitals Research Development, Inc. Zusammensetzung zur Hemmung der Thromboseentstehung
CA2235223A1 (en) 1995-10-30 1997-05-09 Massachusetts Institute Of Technology Rationally designed polysaccharide lyases derived from heparinase i
US6562781B1 (en) * 1995-11-30 2003-05-13 Hamilton Civic Hospitals Research Development Inc. Glycosaminoglycan-antithrombin III/heparin cofactor II conjugates
US7045585B2 (en) * 1995-11-30 2006-05-16 Hamilton Civic Hospital Research Development Inc. Methods of coating a device using anti-thrombin heparin
US6491965B1 (en) 1995-11-30 2002-12-10 Hamilton Civic Hospitals Research Development, Inc. Medical device comprising glycosaminoglycan-antithrombin III/heparin cofactor II conjugates
US5767269A (en) * 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
FR2763848B1 (fr) 1997-05-28 2000-01-28 Rhone Poulenc Rorer Sa Utilisation des heparines de bas poids moleculaire pour la prevention et le traitement du trauma du systeme nerveux central
EP0986581A1 (de) * 1997-06-06 2000-03-22 Hamilton Civic Hospitals Research Development, Inc. Modifiziertes, niedermolekulares heparin, das gerinnselzugehörige gerinnungsfaktoren verhindert
AU1173599A (en) 1997-11-20 1999-06-15 Ikuo Yamashina Low-molecular heparin modification and remedy for skin ulcer
DE69931038T2 (de) * 1998-02-26 2006-11-23 Seikagaku Corp. Neue polysaccharidderivate, verfahren zu ihrer herstellung und medizinische zusammensetzungen die diese als aktives bestandteil enthalten
US6028061A (en) * 1998-06-18 2000-02-22 Children's Medical Center Corp Angiogenesis inhibitors and use thereof
US7056504B1 (en) 1998-08-27 2006-06-06 Massachusetts Institute Of Technology Rationally designed heparinases derived from heparinase I and II
EP1109919A2 (de) * 1998-08-27 2001-06-27 Massachusetts Institute Of Technology Von heparinase i und ii abgeleitete heparinasen
JP4633223B2 (ja) * 1999-03-31 2011-02-16 生化学工業株式会社 血管内皮細胞増殖因子依存性血管内皮細胞増殖の抑制剤
WO2000065521A2 (en) 1999-04-23 2000-11-02 Massachusetts Institute Of Technology System and method for polymer notation
KR20020032444A (ko) * 1999-06-30 2002-05-03 잭 허쉬 응괴 연관된 응고 인자를 억제하는 헤파린 조성물
US7781416B2 (en) * 2000-01-25 2010-08-24 Sigma-Tau Research Switzerland S.A. Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect
US20080139503A1 (en) * 2000-01-25 2008-06-12 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect
IT1316986B1 (it) * 2000-01-25 2003-05-26 Sigma Tau Ind Farmaceuti Derivati glicosamminoglicani parzialmente desolfatati nonanticoagulanti ad attivita' antiangiogenica.
WO2001066772A2 (en) * 2000-03-08 2001-09-13 Massachusetts Institute Of Technology Heparinase iii and uses thereof
JP4633233B2 (ja) * 2000-06-29 2011-02-16 生化学工業株式会社 クラミジア感染症処置剤
JP2004507562A (ja) * 2000-09-08 2004-03-11 ハミルトン　シビック　ホスピタルズ　リサーチ　ディベロップメント　インコーポレイテッド 抗血栓性組成物
JP4911865B2 (ja) 2000-09-12 2012-04-04 マサチューセッツ インスティテュート オブ テクノロジー 低分子量ヘパリンに関連する方法および生成物
CA2423469A1 (en) * 2000-10-18 2002-04-25 Massachusetts Institute Of Technology Methods and products related to pulmonary delivery of polysaccharides
MXPA04002217A (es) * 2001-09-12 2004-07-08 Sigma Tau Ind Farmaceuti Derivados de glucosaminoglucanas parcialmente desulfatados como inhibidores de heparanasa, dotados con actividad antiangiogenica y libres de efectos anticoagulantes.
US7285536B2 (en) 2001-12-05 2007-10-23 Yeda Research And Development Co., Ltd. Anti-cancer therapeutic compounds
EP2284535A1 (de) 2002-03-11 2011-02-16 Momenta Pharmaceuticals, Inc. Heparine mit niedrigem Molekulargewicht
JP2006501815A (ja) * 2002-04-25 2006-01-19 モメンタ ファーマシューティカルズ インコーポレイテッド 粘膜送達のための方法および製品
ITMI20031679A1 (it) * 2003-08-29 2005-02-28 Opocrin Spa Processo per la produzione di eparine a basso peso
EP1582531A1 (de) 2004-03-24 2005-10-05 Aventis Pharma S.A. Verfahren zur Oxydierung nicht-fraktionierten Heparins und die Detektion der Anwesenheit oder Abwesenheit von Glykoserin in Heparin und in von Heparin abgeleiteten Produkten
WO2007019554A2 (en) * 2005-08-08 2007-02-15 Momenta Pharmaceuticals, Inc. Polysaccharides for delivery of active agents
ATE552004T1 (de) 2005-11-30 2012-04-15 Istituto G Ronzoni Oral verabreichbare heparinderivate
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
WO2009007224A1 (en) * 2007-07-10 2009-01-15 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Low molecular weight heparin derivatives having neuroprotective activity
US8592393B2 (en) 2007-11-02 2013-11-26 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
US8569262B2 (en) * 2007-11-02 2013-10-29 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
WO2009059284A2 (en) * 2007-11-02 2009-05-07 Momenta Pharmaceuticals, Inc. Non-anticoagulant polysaccharide compositions
CA2724840A1 (en) * 2008-05-20 2009-11-26 Crystal Clear Partnership Separation of polysaccharides by charge density gradient
US8614314B2 (en) 2008-05-30 2013-12-24 Momenta Pharmaceuticals, Inc. Saccharide structures and methods of making and using such structures
WO2011090948A1 (en) * 2010-01-19 2011-07-28 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
EP2558506B1 (de) 2010-04-16 2019-06-26 Momenta Pharmaceuticals, Inc. Gewebeanzielung
WO2011159770A2 (en) 2010-06-17 2011-12-22 Momenta Pharmaceuticals, Inc. Methods and compositions for modulating hair growth
WO2012115952A1 (en) 2011-02-21 2012-08-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
WO2013095215A1 (en) 2011-12-19 2013-06-27 Dilaforette Ab Low anticoagulant heparins
ES2656613T3 (es) * 2011-12-19 2018-02-27 Dilafor Ab Glicosaminoglicanos no anticoagulantes que comprenden unidades de repetición de disacáridos y su uso médico
WO2013147689A1 (en) * 2012-03-26 2013-10-03 Dilafor Ab Combination treatment comprising sulphated glycosaminoglycans for inducing labor
WO2014193818A1 (en) 2013-05-28 2014-12-04 Momenta Pharmaceuticals, Inc. Pharmaceutical compositions
GB2515315A (en) * 2013-06-19 2014-12-24 Dilafor Ab New Processes
CN108424474B (zh) * 2017-02-15 2023-07-25 清华大学 去抗凝肝素衍生物及其用于炎症性肠病的治疗
AU2020310172A1 (en) 2019-07-09 2022-03-03 Optimvia Llc Methods for synthesizing anticoagulant polysaccharides
EP4182452A1 (de) 2020-07-14 2023-05-24 Optimvia, LLC Verfahren zur synthese von nicht-antikoagulierendem heparansulfat

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE620906A (de) *
FR2440376A1 (fr) * 1978-11-06 1980-05-30 Choay Sa Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir
CA1136620A (en) * 1979-01-08 1982-11-30 Ulf P.F. Lindahl Heparin fragments having selective anticoagulation activity
US4826827A (en) * 1979-10-05 1989-05-02 Choay S.A. Short chained oligosaccharides having biological properties, a process for making the same and the use thereof as drugs
CA1171375A (en) * 1980-09-15 1984-07-24 Ulf P.F. Lindahl Oligosaccharides having selective anticoagulation activity
US4801583A (en) * 1982-01-15 1989-01-31 Choay S.A. Oligosaccharides and their biological applications
US4533549A (en) * 1983-01-04 1985-08-06 Lasker Sigmund E Antithrombotic agent
IT1195497B (it) * 1983-03-08 1988-10-19 Opocrin Spa Procedimento per la preparazione di frazioni oligosaccaridiche dotate di proprieta' farmacologiche per degradazione chimica di eparina
US4687765A (en) * 1983-07-25 1987-08-18 Choay S.A. Method and composition for thrombolytic treatment
FR2568774B2 (fr) * 1984-05-30 1989-05-19 Choay Sa Medicaments favorisant les proprietes d'ecoulement du sang et leur utilisation en therapeutique
FR2584606A1 (fr) * 1985-07-12 1987-01-16 Dropic Utilisation de poly- et oligosaccharides pour l'obtention de medicaments actifs dans les pathologies du tissu conjonctif
US4788307A (en) * 1986-04-30 1988-11-29 Choay S.A. Oligosaccharidic fractions devoid or practically devoid of antithrombotic activity
US4745106A (en) * 1986-08-20 1988-05-17 Griffin Charles C Heparin derivatives having improved anti-Xa specificity

Also Published As

Publication number Publication date
NO881660D0 (no) 1988-04-15
PT87261B (pt) 1992-08-31
NO170940B (no) 1992-09-21
IE64884B1 (en) 1995-09-20
FI88046B (fi) 1992-12-15
DK210388D0 (da) 1988-04-18
FI88046C (fi) 1993-03-25
IE881150L (en) 1988-10-16
AU601566B2 (en) 1990-09-13
NO881660L (no) 1988-10-17
ZA882662B (en) 1988-10-14
EP0287477B1 (de) 1994-11-02
FI881783A0 (fi) 1988-04-15
FI881783A (fi) 1988-10-17
EP0287477A3 (en) 1989-07-26
DK210388A (da) 1988-10-17
AR243205A1 (es) 1993-07-30
CA1327968C (fr) 1994-03-22
NO170940C (no) 1992-12-30
US4990502A (en) 1991-02-05
AU1466388A (en) 1988-10-20
ATE113611T1 (de) 1994-11-15
IL86091A0 (en) 1988-09-30
DK173982B1 (da) 2002-03-25
JPS63278901A (ja) 1988-11-16
FR2614026A1 (fr) 1988-10-21
EP0287477A2 (de) 1988-10-19
DE3851973T2 (de) 1995-06-08
NZ224275A (en) 1991-02-26
FR2614026B1 (fr) 1992-04-17
KR880012644A (ko) 1988-11-28
PT87261A (pt) 1988-05-01

Similar Documents

Publication Publication Date Title
DE3851973D1 (de) Heparine mit niedrigem Molekulargewicht und regelmässiger Struktur, ihre Herstellung und biologische Verwendungen.
DE3785936T2 (de) Makrolid-derivate, ihre herstellung und ihre verwendung.
DE3884095T2 (de) Polymerteilchen und ihre Herstellung.
DE3851132D1 (de) Polymerteilchen und ihre Herstellung.
DE3885534D1 (de) Arylphosphorderivate, ihre Herstellung und Verwendung.
DE3777366D1 (de) 2,3-dihydro-cumaron-derivate, ihre herstellung und verwendung.
DE69008454T2 (de) Nitrolsothiolderivate, ihre Herstellung und Verwendung.
DE3765682D1 (de) Thiolactam-n-essigsaeure-derivate, ihre herstellung und verwendung.
DE3869257D1 (de) N-aminobutyl-n-phenylarylamid-derivate, ihre herstellung und ihre verwendung in der heilkunde.
ATE73805T1 (de) Makrolid-verbindungen, ihre herstellung und ihre verwendung.
DE3784602D1 (de) Inonos-derivate, ihre herstellung und verwendung.
DE58908788D1 (de) Modifizierte Blockpolymerisate, ihre Herstellung und Verwendung.
DE3889980D1 (de) Reaktivfarbstoffe, deren Herstellung und Verwendung.
DE3883297T2 (de) Phenolderivate, ihre Herstellung und Verwendung.
DE68919259T2 (de) N-Phenylimide, ihre Herstellung und Verwendung.
ATE45164T1 (de) Steroido(3,2-c>-pyrazole, als antiandrogene und ihre herstellung.
DE3870764D1 (de) Anilinophenylthioharnstoffe, -isothioharnstoffe und -carbodiimide, ihre herstellung und verwendung in der schaedlingsbekaempfung.
DE3868287D1 (de) Reaktivfarbstoffe, deren herstellung und verwendung.
DE3872337D1 (de) Reaktivfarbstoffe, deren herstellung und verwendung.
DE3879328D1 (de) Stannosilikate, ihre herstellung und verwendung.
DE3865049D1 (de) Reaktivfarbstoffe, deren herstellung und verwendung.
DE3770299D1 (de) 1,2,4-triazinonderivate, ihre herstellung und verwendung.
DE3781256T2 (de) Polymere, ihre herstellung und verwendungen.
DE3762741D1 (de) Benzoylharnstoffe, ihre herstellung und verwendung.
DE3868104D1 (de) Reaktivfarbstoffe, deren herstellung und verwendung.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-SYNTHELABO, PARIS, FR

8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-AVENTIS, PARIS, FR