DK169724B1 - Fremgangsmåde til fremstilling af et polypeptidfragment af faktor VIII:C, DNA-sekvens, som koder herfor, og ekstrachromosomalt element indeholdende en sådan DNA-sekvens - Google Patents

Fremgangsmåde til fremstilling af et polypeptidfragment af faktor VIII:C, DNA-sekvens, som koder herfor, og ekstrachromosomalt element indeholdende en sådan DNA-sekvens Download PDF

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Publication number
DK169724B1
DK169724B1 DK150992A DK150992A DK169724B1 DK 169724 B1 DK169724 B1 DK 169724B1 DK 150992 A DK150992 A DK 150992A DK 150992 A DK150992 A DK 150992A DK 169724 B1 DK169724 B1 DK 169724B1
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DK
Denmark
Prior art keywords
dna sequence
protein
polypeptide
preparing
factor viiic
Prior art date
Application number
DK150992A
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English (en)
Other versions
DK150992A (da
Inventor
George Kuo
Frank R Masiarz
Martha Truett
Pablo Valenzuela
Mirella Ezban Rasmussen
Jennifer Favaloro
Original Assignee
Chiron Corp
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27075219&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK169724(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/570,062 external-priority patent/US5004804A/en
Application filed by Chiron Corp, Novo Nordisk As filed Critical Chiron Corp
Publication of DK150992A publication Critical patent/DK150992A/da
Application granted granted Critical
Publication of DK169724B1 publication Critical patent/DK169724B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Cosmetics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK150992A 1984-01-12 1992-12-17 Fremgangsmåde til fremstilling af et polypeptidfragment af faktor VIII:C, DNA-sekvens, som koder herfor, og ekstrachromosomalt element indeholdende en sådan DNA-sekvens DK169724B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/570,062 US5004804A (en) 1984-01-12 1984-01-12 Method and composition for preparation of factor VIIIC
US66491984A 1984-10-26 1984-10-26

Publications (2)

Publication Number Publication Date
DK150992A DK150992A (da) 1992-12-17
DK169724B1 true DK169724B1 (da) 1995-01-23

Family

ID=27075219

Family Applications (3)

Application Number Title Priority Date Filing Date
DK013585A DK165506C (da) 1984-01-12 1985-01-11 Proteinpraeparat med koagulationsaktivitet samt fremgangsmaade til fremstilling deraf
DK038892A DK169708B1 (da) 1984-01-12 1992-03-25 Komplex sonde, DNA-sekvens, som hybridiserer med sonden, og som koder for en fysiologisk aktiv del af faktor VIII:C, og ekstrachromosomalt element indeholdende en sådan DNA-sekvens
DK150992A DK169724B1 (da) 1984-01-12 1992-12-17 Fremgangsmåde til fremstilling af et polypeptidfragment af faktor VIII:C, DNA-sekvens, som koder herfor, og ekstrachromosomalt element indeholdende en sådan DNA-sekvens

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DK013585A DK165506C (da) 1984-01-12 1985-01-11 Proteinpraeparat med koagulationsaktivitet samt fremgangsmaade til fremstilling deraf
DK038892A DK169708B1 (da) 1984-01-12 1992-03-25 Komplex sonde, DNA-sekvens, som hybridiserer med sonden, og som koder for en fysiologisk aktiv del af faktor VIII:C, og ekstrachromosomalt element indeholdende en sådan DNA-sekvens

Country Status (7)

Country Link
EP (3) EP1006182A3 (da)
JP (5) JPH0826078B2 (da)
AT (2) ATE78871T1 (da)
DE (6) DE3588242T2 (da)
DK (3) DK165506C (da)
LU (4) LU91014I2 (da)
NL (4) NL300118I2 (da)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4657894A (en) * 1983-03-31 1987-04-14 Scripps Clinic & Research Foundation New factor VIII coagulant polypeptides
JPH07106156B2 (ja) * 1983-10-28 1995-11-15 ジェネティックス、インスティチュ−ト ファクタ−▲ｖｉｉｉ▼および関連生産物の製造
US7138505B1 (en) 1984-01-12 2006-11-21 Novartis Vaccines And Diagnostics, Inc. Factor VIII:C nucleic acid molecules
ZA852099B (en) * 1984-03-26 1985-12-24 Meloy Lab Recombinant factor viii-c.
US4965199A (en) * 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
FI86885C (fi) * 1984-04-20 1992-10-26 Genentech Inc Foerfarande foer framstaellning av human rekombinantfaktor viii och nukleinsyrasekvenser och vektorer anvaend daertill
EP0182448A3 (en) * 1984-08-24 1987-10-28 Genetics Institute, Inc. Production of factor viii and related products
SE8501050D0 (sv) * 1985-03-05 1985-03-05 Kabivitrum Ab Biologically active fragments of human antihemophilic factor and method for preparation thereof
CA1341174C (en) * 1985-04-12 2001-01-30 John J. Toole Jr. Procoagulant proteins derived from factor viii: c
KR910006424B1 (ko) * 1985-08-21 1991-08-24 인코텍스 비.브이 편성브리프(brief) 제조방법
US5198349A (en) * 1986-01-03 1993-03-30 Genetics Institute, Inc. Method for producing factor VIII:C and analogs
FI98829C (fi) * 1986-01-27 1997-08-25 Chiron Corp Menetelmä rekombinoidun proteiinikompleksin valmistamiseksi, jolla on humaanitekijä VIII:C-aktiivisuutta
US5595886A (en) 1986-01-27 1997-01-21 Chiron Corporation Protein complexes having Factor VIII:C activity and production thereof
EP0251843A1 (fr) * 1986-06-06 1988-01-07 Transgene S.A. Procédé de préparation de facteur VIII à partir de cellules de mammifères
JP2593500B2 (ja) * 1986-06-24 1997-03-26 ノルデイスク ゲントフテ エー／エス ▲ｖｉｉｉ▼因子フラグメントの凝固活性複合物の製造方法
ATE63335T1 (de) 1986-07-11 1991-05-15 Miles Inc Herstellung von rekombinantem protein.
IL83192A (en) * 1986-07-18 1992-11-15 Gist Brocades Nv Method for the preparation of proteins with factor viii activity by microbial host cells;expression vectors,host cells,antibodies
IL84168A0 (en) * 1986-10-15 1988-03-31 Rorer Int Overseas Human factor viii-c analogs,process for the preparation thereof and pharmaceutical compositions containing the same
AU606925B2 (en) * 1987-01-30 1991-02-21 Biogen, Inc. A method for producing factor viii in high yield
CA1339946C (en) * 1987-03-31 1998-07-07 Michael J. Griffith Ultrapurification process for polypeptides
EP0294910B1 (en) 1987-06-12 1996-09-11 Immuno Ag Novel proteins with factor VIII activity, process for their preparation using genetically engineered cells and pharmaceutical compositions containing them
DE3737239A1 (de) * 1987-11-03 1989-10-12 Behringwerke Ag Gentechnische herstellung von anticoagulatorischem protein pp4
US6544771B1 (en) * 1987-12-11 2003-04-08 Cell Genesys, Inc. Retroviral gene therapy vectors and therapeutic methods based thereon
US6140111A (en) * 1987-12-11 2000-10-31 Whitehead Institute For Biomedical Research Retroviral gene therapy vectors and therapeutic methods based thereon
WO1991004059A2 (en) * 1989-09-14 1991-04-04 Baxter International Inc. Method and useful apparatus for preparing pharmaceutical compositions
US5610033A (en) * 1990-04-25 1997-03-11 Novo Nordisk A/S Method of producing proteins with FVIII activity and/or FVIII derivatives
DK53792D0 (da) * 1992-04-24 1992-04-24 Novo Nordisk As Fremgangsmaade til fremstilling af proteiner
US5910481A (en) * 1995-11-13 1999-06-08 Immuno Ag Hybrid proteins with modified activity
WO1998029453A1 (fr) * 1996-12-27 1998-07-09 Mochida Pharmaceutical Co., Ltd. Medicaments diriges vers la membrane cellulaire
CN101810854A (zh) 1999-02-22 2010-08-25 巴克斯特国际公司 新的无白蛋白的因子viii制剂
WO2003013244A1 (en) 2001-08-03 2003-02-20 The Government Of The United State Of America, As Represented By The Secretary Of The Department Of Health And Human Services Oral treatment of hemophilia
WO2004035789A1 (en) * 2002-10-18 2004-04-29 Lg Life Sciences Ltd. Gene families associated with cancers
EP1707634A1 (en) 2005-03-29 2006-10-04 Octapharma AG Method for isolation of recombinantly produced proteins
EP1739179A1 (en) 2005-06-30 2007-01-03 Octapharma AG Serum-free stable transfection and production of recombinant human proteins in human cell lines
JP5779780B2 (ja) 2008-11-07 2015-09-16 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ 第ｖｉｉｉ因子製剤
WO2011095604A1 (en) 2010-02-04 2011-08-11 Octapharma Biopharmaceuticals Gmbh Half-life prolongation of proteins

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4657894A (en) * 1983-03-31 1987-04-14 Scripps Clinic & Research Foundation New factor VIII coagulant polypeptides
FI841281A (fi) * 1983-03-31 1984-10-01 Scripps Clinic Res Ny faktor foer viii koagulenta polypeptider och deras monoklonala antikroppar.
US4663280A (en) * 1983-05-19 1987-05-05 Public Health Research Institute Of The City Of New York Expression and secretion vectors and method of constructing vectors
JPH07106156B2 (ja) * 1983-10-28 1995-11-15 ジェネティックス、インスティチュ−ト ファクタ−▲ｖｉｉｉ▼および関連生産物の製造
ZA852099B (en) * 1984-03-26 1985-12-24 Meloy Lab Recombinant factor viii-c.
FI86885C (fi) * 1984-04-20 1992-10-26 Genentech Inc Foerfarande foer framstaellning av human rekombinantfaktor viii och nukleinsyrasekvenser och vektorer anvaend daertill
JPH0634760A (ja) * 1992-07-15 1994-02-10 Hamamatsu Photonics Kk 放射線計測装置及び核医学診断装置

Also Published As

Publication number Publication date
LU91014I2 (fr) 2003-06-19
JPH04218399A (ja) 1992-08-07
DK13585A (da) 1985-09-11
EP0150735A2 (en) 1985-08-07
EP0150735B1 (en) 1992-07-29
EP0150735A3 (en) 1987-07-01
DE122004000028I1 (de) 2004-09-30
DE3588242T2 (de) 2004-03-11
DK165506B (da) 1992-12-07
EP0466199B1 (en) 2002-09-18
DK13585D0 (da) 1985-01-11
EP0466199A1 (en) 1992-01-15
EP1006182A2 (en) 2000-06-07
DE3588242D1 (de) 2002-10-31
DE10399011I1 (de) 2003-10-23
JP2002186487A (ja) 2002-07-02
ATE78871T1 (de) 1992-08-15
DK150992A (da) 1992-12-17
NL300118I2 (nl) 2004-06-01
DE10399010I1 (de) 2003-10-23
DE10399009I1 (de) 2003-10-23
DE3586402T3 (de) 2004-12-23
DE3586402T2 (de) 1993-01-07
LU91013I2 (fr) 2003-06-19
EP1006182A3 (en) 2000-06-14
DE3586402D1 (de) 1992-09-03
JPH0634760B2 (ja) 1994-05-11
DK38892D0 (da) 1992-03-25
JP2000023670A (ja) 2000-01-25
NL300119I1 (nl) 2003-06-02
EP0150735B2 (en) 2004-01-07
DK38892A (da) 1992-03-25
DK169708B1 (da) 1995-01-16
NL300120I1 (nl) 2003-06-02
NL300153I1 (nl) 2004-09-01
NL300118I1 (nl) 2003-06-02
ATE224445T1 (de) 2002-10-15
DK165506C (da) 1993-04-19
LU91015I2 (fr) 2003-06-19
LU91087I2 (fr) 2004-08-26
JPS60185723A (ja) 1985-09-21
JPH0826078B2 (ja) 1996-03-13
JPH06105688A (ja) 1994-04-19

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Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired