DE3586402T2 - Proteinzusammensetzung mit koagulations-wirkung und verfahren zu ihrer herstellung. - Google Patents

Proteinzusammensetzung mit koagulations-wirkung und verfahren zu ihrer herstellung.

Info

Publication number
DE3586402T2
DE3586402T2 DE8585100223T DE3586402T DE3586402T2 DE 3586402 T2 DE3586402 T2 DE 3586402T2 DE 8585100223 T DE8585100223 T DE 8585100223T DE 3586402 T DE3586402 T DE 3586402T DE 3586402 T2 DE3586402 T2 DE 3586402T2
Authority
DE
Germany
Prior art keywords
protein
factor viiic
compsn
polypeptide
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8585100223T
Other languages
English (en)
Other versions
DE3586402D1 (de
DE3586402T3 (de
Inventor
George Kuo
Frank R Masiarz
Martha Truett
Pablo Valenzuela
Mirella Ezban Rasmussen
Jennifer Favaloro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nordisk Gentofte AS
Novartis Vaccines and Diagnostics Inc
Original Assignee
Nordisk Gentofte AS
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27075219&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3586402(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/570,062 external-priority patent/US5004804A/en
Application filed by Nordisk Gentofte AS, Chiron Corp filed Critical Nordisk Gentofte AS
Publication of DE3586402D1 publication Critical patent/DE3586402D1/de
Publication of DE3586402T2 publication Critical patent/DE3586402T2/de
Application granted granted Critical
Publication of DE3586402T3 publication Critical patent/DE3586402T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE3586402T 1984-01-12 1985-01-11 Proteinzusammensetzung mit Koagulations-wirkung und Verfahren zu ihrer Herstellung. Expired - Lifetime DE3586402T3 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US570062 1984-01-12
US06/570,062 US5004804A (en) 1984-01-12 1984-01-12 Method and composition for preparation of factor VIIIC
US66491984A 1984-10-26 1984-10-26
US664919 1984-10-26

Publications (3)

Publication Number Publication Date
DE3586402D1 DE3586402D1 (de) 1992-09-03
DE3586402T2 true DE3586402T2 (de) 1993-01-07
DE3586402T3 DE3586402T3 (de) 2004-12-23

Family

ID=27075219

Family Applications (6)

Application Number Title Priority Date Filing Date
DE2003199011 Pending DE10399011I1 (de) 1984-01-12 1985-01-11 F}r Fakton-VIIIc kodierende DNA-Sequenzen und ver wandte DNA-Konstruktionen
DE2003199010 Pending DE10399010I1 (de) 1984-01-12 1985-01-11 F}r Faktor-VIIIc kodierende DNA-Sequenzen und verwandte DNA-Konstruktionen
DE3588242T Expired - Lifetime DE3588242T2 (de) 1984-01-12 1985-01-11 Für Faktor-VIIIc kodierende DNA-Sequenzen und verwandte DNA-Konstruktionen
DE2003199009 Pending DE10399009I1 (de) 1984-01-12 1985-01-11 F}r Faktor-VIIIc kodierende DNA-Sequenzen und verwandte DNA-Konstruktionen
DE200412000028 Pending DE122004000028I1 (de) 1984-01-12 1985-01-11 F}r Faktor-VIIIc kodierende DNA-Sequenzen und verwandte DNA-Konstruktionen.
DE3586402T Expired - Lifetime DE3586402T3 (de) 1984-01-12 1985-01-11 Proteinzusammensetzung mit Koagulations-wirkung und Verfahren zu ihrer Herstellung.

Family Applications Before (5)

Application Number Title Priority Date Filing Date
DE2003199011 Pending DE10399011I1 (de) 1984-01-12 1985-01-11 F}r Fakton-VIIIc kodierende DNA-Sequenzen und ver wandte DNA-Konstruktionen
DE2003199010 Pending DE10399010I1 (de) 1984-01-12 1985-01-11 F}r Faktor-VIIIc kodierende DNA-Sequenzen und verwandte DNA-Konstruktionen
DE3588242T Expired - Lifetime DE3588242T2 (de) 1984-01-12 1985-01-11 Für Faktor-VIIIc kodierende DNA-Sequenzen und verwandte DNA-Konstruktionen
DE2003199009 Pending DE10399009I1 (de) 1984-01-12 1985-01-11 F}r Faktor-VIIIc kodierende DNA-Sequenzen und verwandte DNA-Konstruktionen
DE200412000028 Pending DE122004000028I1 (de) 1984-01-12 1985-01-11 F}r Faktor-VIIIc kodierende DNA-Sequenzen und verwandte DNA-Konstruktionen.

Country Status (7)

Country Link
EP (3) EP0150735B2 (de)
JP (5) JPH0826078B2 (de)
AT (2) ATE224445T1 (de)
DE (6) DE10399011I1 (de)
DK (3) DK165506C (de)
LU (4) LU91014I2 (de)
NL (4) NL300120I1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4657894A (en) * 1983-03-31 1987-04-14 Scripps Clinic & Research Foundation New factor VIII coagulant polypeptides
WO1985001961A1 (en) * 1983-10-28 1985-05-09 Genetics Institute Production of factor viii and related products
US7138505B1 (en) 1984-01-12 2006-11-21 Novartis Vaccines And Diagnostics, Inc. Factor VIII:C nucleic acid molecules
ZA852099B (en) * 1984-03-26 1985-12-24 Meloy Lab Recombinant factor viii-c.
US4965199A (en) * 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
IL74909A (en) * 1984-04-20 1992-01-15 Genentech Inc Preparation of functional human factor viii and dna sequences,expression vectors,transformed microorganisms and cell lines used therein
EP0182448A3 (de) * 1984-08-24 1987-10-28 Genetics Institute, Inc. Verfahren zur Herstellung von Faktor VIII und verwandte Produkte
SE8501050D0 (sv) * 1985-03-05 1985-03-05 Kabivitrum Ab Biologically active fragments of human antihemophilic factor and method for preparation thereof
AU5772886A (en) * 1985-04-12 1986-11-05 Genetics Institute Inc. Novel procoagulant proteins
KR910006424B1 (ko) * 1985-08-21 1991-08-24 인코텍스 비.브이 편성브리프(brief) 제조방법
US5198349A (en) * 1986-01-03 1993-03-30 Genetics Institute, Inc. Method for producing factor VIII:C and analogs
US5595886A (en) 1986-01-27 1997-01-21 Chiron Corporation Protein complexes having Factor VIII:C activity and production thereof
FI98829C (fi) * 1986-01-27 1997-08-25 Chiron Corp Menetelmä rekombinoidun proteiinikompleksin valmistamiseksi, jolla on humaanitekijä VIII:C-aktiivisuutta
EP0251843A1 (de) * 1986-06-06 1988-01-07 Transgene S.A. Verfahren zur Herstellung von Faktor VIII aus Säugerzellen
JP2593500B2 (ja) * 1986-06-24 1997-03-26 ノルデイスク ゲントフテ エー／エス ▲ｖｉｉｉ▼因子フラグメントの凝固活性複合物の製造方法
EP0254076B1 (de) 1986-07-11 1991-05-08 Miles Inc. Herstellung von rekombinantem Protein
IL83192A (en) * 1986-07-18 1992-11-15 Gist Brocades Nv Method for the preparation of proteins with factor viii activity by microbial host cells;expression vectors,host cells,antibodies
IL84168A0 (en) * 1986-10-15 1988-03-31 Rorer Int Overseas Human factor viii-c analogs,process for the preparation thereof and pharmaceutical compositions containing the same
AU606925B2 (en) * 1987-01-30 1991-02-21 Biogen, Inc. A method for producing factor viii in high yield
CA1339946C (en) * 1987-03-31 1998-07-07 Michael J. Griffith Ultrapurification process for polypeptides
EP0690126B1 (de) 1987-06-12 2001-11-28 Baxter Aktiengesellschaft Proteine mit Faktor VIII Aktivität, Verfahren zu deren Herstellung unter Verwendung von genetisch modifizierten Zellen und diese enthaltende Zusammensetzungen
DE3737239A1 (de) * 1987-11-03 1989-10-12 Behringwerke Ag Gentechnische herstellung von anticoagulatorischem protein pp4
US6140111A (en) * 1987-12-11 2000-10-31 Whitehead Institute For Biomedical Research Retroviral gene therapy vectors and therapeutic methods based thereon
US6544771B1 (en) * 1987-12-11 2003-04-08 Cell Genesys, Inc. Retroviral gene therapy vectors and therapeutic methods based thereon
IE903354A1 (en) * 1989-09-14 1991-04-10 Baxter Int Method and useful apparatus for preparing pharmaceutical¹compositions
US5610033A (en) * 1990-04-25 1997-03-11 Novo Nordisk A/S Method of producing proteins with FVIII activity and/or FVIII derivatives
DK53792D0 (da) * 1992-04-24 1992-04-24 Novo Nordisk As Fremgangsmaade til fremstilling af proteiner
US5910481A (en) * 1995-11-13 1999-06-08 Immuno Ag Hybrid proteins with modified activity
US6500646B1 (en) * 1996-12-27 2002-12-31 Mochida Pharmaceutical Co., Ltd. Cell membrane-directed drugs
DK2130554T3 (da) 1999-02-22 2012-12-03 Univ Connecticut Albuminfrie faktor VIII-præparater
US7220718B2 (en) 2001-08-03 2007-05-22 United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Oral treatment of hemophilia
WO2004035789A1 (en) * 2002-10-18 2004-04-29 Lg Life Sciences Ltd. Gene families associated with cancers
EP1707634A1 (de) 2005-03-29 2006-10-04 Octapharma AG Verfahren zur Isolierung von rekombinant hergestellten Proteinen
EP1739179A1 (de) 2005-06-30 2007-01-03 Octapharma AG Serumfreie stabile Transfektion und Produktion von rekombinanten humanen Proteinen in humanen Zelllinien
EP2385825B1 (de) 2008-11-07 2018-10-10 University of Connecticut Faktor-viii-formulierungen
WO2011095604A1 (en) 2010-02-04 2011-08-11 Octapharma Biopharmaceuticals Gmbh Half-life prolongation of proteins

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4657894A (en) * 1983-03-31 1987-04-14 Scripps Clinic & Research Foundation New factor VIII coagulant polypeptides
FI841281A (fi) * 1983-03-31 1984-10-01 Scripps Clinic Res Ny faktor foer viii koagulenta polypeptider och deras monoklonala antikroppar.
US4663280A (en) * 1983-05-19 1987-05-05 Public Health Research Institute Of The City Of New York Expression and secretion vectors and method of constructing vectors
WO1985001961A1 (en) * 1983-10-28 1985-05-09 Genetics Institute Production of factor viii and related products
ZA852099B (en) * 1984-03-26 1985-12-24 Meloy Lab Recombinant factor viii-c.
IL74909A (en) * 1984-04-20 1992-01-15 Genentech Inc Preparation of functional human factor viii and dna sequences,expression vectors,transformed microorganisms and cell lines used therein
JPH0634760A (ja) * 1992-07-15 1994-02-10 Hamamatsu Photonics Kk 放射線計測装置及び核医学診断装置

Also Published As

Publication number Publication date
JPH0826078B2 (ja) 1996-03-13
EP0466199B1 (de) 2002-09-18
DE122004000028I1 (de) 2004-09-30
DE3588242T2 (de) 2004-03-11
NL300118I1 (nl) 2003-06-02
DK165506B (da) 1992-12-07
NL300153I1 (nl) 2004-09-01
EP0150735A3 (en) 1987-07-01
NL300119I1 (nl) 2003-06-02
DK38892D0 (da) 1992-03-25
JPH04218399A (ja) 1992-08-07
JPH06105688A (ja) 1994-04-19
LU91013I2 (fr) 2003-06-19
DK13585A (da) 1985-09-11
LU91015I2 (fr) 2003-06-19
NL300118I2 (nl) 2004-06-01
DK38892A (da) 1992-03-25
JP2002186487A (ja) 2002-07-02
EP0150735B2 (de) 2004-01-07
DE3588242D1 (de) 2002-10-31
DK13585D0 (da) 1985-01-11
EP0466199A1 (de) 1992-01-15
ATE224445T1 (de) 2002-10-15
JPH0634760B2 (ja) 1994-05-11
DE10399009I1 (de) 2003-10-23
DK169724B1 (da) 1995-01-23
EP0150735B1 (de) 1992-07-29
DE10399011I1 (de) 2003-10-23
DE3586402D1 (de) 1992-09-03
LU91087I2 (fr) 2004-08-26
DE10399010I1 (de) 2003-10-23
LU91014I2 (fr) 2003-06-19
JPS60185723A (ja) 1985-09-21
JP2000023670A (ja) 2000-01-25
EP1006182A2 (de) 2000-06-07
ATE78871T1 (de) 1992-08-15
EP0150735A2 (de) 1985-08-07
NL300120I1 (nl) 2003-06-02
DK150992A (da) 1992-12-17
DE3586402T3 (de) 2004-12-23
DK165506C (da) 1993-04-19
DK169708B1 (da) 1995-01-16
EP1006182A3 (de) 2000-06-14

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8366 Restricted maintained after opposition proceedings