DK156565C - Analogifremgangsmaade til fremstilling af substituerede morpholinderivater - Google Patents
Analogifremgangsmaade til fremstilling af substituerede morpholinderivaterInfo
- Publication number
- DK156565C DK156565C DK022679A DK22679A DK156565C DK 156565 C DK156565 C DK 156565C DK 022679 A DK022679 A DK 022679A DK 22679 A DK22679 A DK 22679A DK 156565 C DK156565 C DK 156565C
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- morpholine derivatives
- substituted morpholine
- analogy procedure
- analogy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
- C07C205/32—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups bound to acyclic carbon atoms and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
- C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
- C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/16—Preparation of ethers by reaction of esters of mineral or organic acids with hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/41—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrogenolysis or reduction of carboxylic groups or functional derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
- C07D265/33—Two oxygen atoms, in positions 3 and 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1945078A IT1111676B (it) | 1978-01-20 | 1978-01-20 | Derivati della 2-fenossimetil-morfolina |
IT1944978 | 1978-01-20 | ||
IT1944978A IT1093255B (it) | 1978-01-20 | 1978-01-20 | Derivati fenossialcanolaminici |
IT1945078 | 1978-01-20 | ||
IT3053378A IT1160301B (it) | 1978-12-05 | 1978-12-05 | Derivati fenossialcanolaminici |
IT3053578 | 1978-12-05 | ||
IT3053478 | 1978-12-05 | ||
IT3053378 | 1978-12-05 | ||
IT30535/78A IT1101724B (it) | 1978-12-05 | 1978-12-05 | Derivati morfolinici e fenossiprofanolaminici e procedimento per la loro preparazione |
IT3053478A IT1160302B (it) | 1978-12-05 | 1978-12-05 | Derivati della 2-fenossimentil-morfolina |
Publications (3)
Publication Number | Publication Date |
---|---|
DK22679A DK22679A (da) | 1979-07-21 |
DK156565B DK156565B (da) | 1989-09-11 |
DK156565C true DK156565C (da) | 1990-02-05 |
Family
ID=27517788
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK022679A DK156565C (da) | 1978-01-20 | 1979-01-18 | Analogifremgangsmaade til fremstilling af substituerede morpholinderivater |
Country Status (24)
Country | Link |
---|---|
US (2) | US4229449A (fr) |
JP (1) | JPS54148739A (fr) |
AT (1) | AT371813B (fr) |
AU (1) | AU525954B2 (fr) |
BG (1) | BG61056B2 (fr) |
CA (1) | CA1128942A (fr) |
CH (1) | CH650245A5 (fr) |
CS (1) | CS413391A3 (fr) |
CY (1) | CY1172A (fr) |
DE (2) | DE2901032C2 (fr) |
DK (1) | DK156565C (fr) |
FI (1) | FI71135C (fr) |
FR (2) | FR2442839A1 (fr) |
GB (1) | GB2014981B (fr) |
HK (1) | HK5783A (fr) |
IE (1) | IE47727B1 (fr) |
IL (1) | IL56369A (fr) |
KE (1) | KE3243A (fr) |
MY (1) | MY8400018A (fr) |
NO (1) | NO146953C (fr) |
NZ (1) | NZ189418A (fr) |
SE (1) | SE446727B (fr) |
SI (1) | SI7910096A8 (fr) |
YU (1) | YU42094B (fr) |
Families Citing this family (77)
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GB8419683D0 (en) * | 1984-08-02 | 1984-09-05 | Erba Farmitalia | 3-substituted derivatives of 1-amino-2-hydroxy-propane |
DE3546929B4 (de) * | 1984-08-02 | 2006-02-09 | Pharmacia Italia S.P.A. | 1,2-substituierte Derivate von 3-Phenoxy-3-Phenylpropan |
GB2167407B (en) * | 1984-11-22 | 1988-05-11 | Erba Farmitalia | Enantiomers of phenoxy derivatives of benzyl morpholine and salts thereof |
GB8823405D0 (en) * | 1988-10-05 | 1988-11-09 | Erba Carlo Spa | Aryloxy-arythio-heteraryloxy-heteroarylthio-alkenylene derivatives of amines |
FR2754709B1 (fr) | 1996-10-23 | 1999-03-05 | Sanofi Sa | Composition cosmetique contenant un antagoniste des recepteurs du neuropeptide gamma et alpha 2 antagonistes susceptibles d'etre incorpores dans une telle composition |
AU9214498A (en) * | 1997-09-23 | 1999-04-12 | Eli Lilly And Company | Treatment of attention-deficit/hyperactivity disorder |
UA56257C2 (uk) * | 1997-09-23 | 2003-05-15 | Елі Ліллі Енд Компані | Спосіб лікування неадекватної визивної поведінки |
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US6586427B2 (en) * | 1998-04-09 | 2003-07-01 | Pharmacia & Upjohn Company | Treatments for nervous disorders |
IT1305322B1 (it) * | 1998-04-23 | 2001-05-04 | Pharmacia & Upjohn Spa | Uso di reboxetina per il trattamento di disturbi nervosi |
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CN1249038C (zh) * | 1998-12-29 | 2006-04-05 | 法玛西雅厄普约翰美国公司 | 芳基醚的制备方法 |
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DK1459751T3 (da) * | 1999-07-01 | 2005-12-19 | Pharmacia & Upjohn Co Llc | (S,S)reboxetin til behandling af migrænehovedpine |
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US20040048860A1 (en) * | 2000-10-31 | 2004-03-11 | Jes Olesen | Use of selective noradrenaline reuptake inhibitors for the treatment of tension-type headache |
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US20040220153A1 (en) * | 2002-09-24 | 2004-11-04 | Jost-Price Edward Roydon | Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines |
US20040152710A1 (en) * | 2002-10-15 | 2004-08-05 | Deecher Darlene Coleman | Use of norepinephrine reuptake modulators for preventing and treating vasomotor symptoms |
US7345096B2 (en) * | 2002-10-15 | 2008-03-18 | Wyeth | Use of norepinephrine reuptake modulators for preventing and treating vasomotor symptoms |
WO2004043904A1 (fr) * | 2002-11-05 | 2004-05-27 | Eli Lilly And Company | Composes pharmaceutiques |
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WO2005011583A2 (fr) * | 2003-07-28 | 2005-02-10 | Leslie Joe Dunaway | Traitement de la rhinite allergique et de l'asthme |
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RU2320369C2 (ru) | 2003-09-12 | 2008-03-27 | Пфайзер Инк. | Комбинации, содержащие альфа-2-дельта лиганды и ингибиторы обратного захвата серотонина/норадреналина |
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US7365076B2 (en) | 2003-10-14 | 2008-04-29 | Wyeth | Substituted aryl cycloalkanol derivatives and methods of their use |
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CA2767372A1 (fr) * | 2009-07-13 | 2011-01-20 | Theravance, Inc. | Composes 3-phenoxymethylpyrrolidines |
ES2495366T3 (es) | 2009-07-21 | 2014-09-17 | Theravance, Inc. | Compuestos de 3-fenoximetilpirrolidina |
EP2523945A1 (fr) | 2010-01-11 | 2012-11-21 | Theravance, Inc. | Composés de type 1-(2-phénoxyméthylphényl)pipérazine comme inhibiteurs du recaptage de la sérotonine et de la norépinéphrine |
WO2011119461A1 (fr) * | 2010-03-22 | 2011-09-29 | Theravance, Inc. | Composés de 1-(2-phénoxyméthylhétéroaryl)pipéridine et pipérazine |
CA2811641A1 (fr) | 2010-10-11 | 2012-04-19 | Theravance, Inc. | Inhibiteurs de la reabsorption de serotonine |
US8501964B2 (en) | 2010-12-03 | 2013-08-06 | Theravance, Inc. | Serotonin reuptake inhibitors |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1138405A (en) * | 1966-12-28 | 1969-01-01 | Ici Ltd | Morpholine derivatives |
BE759013R (fr) * | 1969-11-17 | 1971-05-17 | Ici Ltd | Derives de la |
GB1382526A (en) * | 1972-08-11 | 1975-02-05 | Ici Ltd | Morpholine derivatives |
GB1412546A (en) * | 1973-08-08 | 1975-11-05 | Ici Ltd | Morpholine derivatives |
GB1427097A (en) * | 1973-10-18 | 1976-03-03 | Ici Ltd | Optically-active morpholine derivatives |
GB1469410A (en) * | 1973-12-17 | 1977-04-06 | Christiaens Sa A | Benzodioxole derivatives |
US4314081A (en) * | 1974-01-10 | 1982-02-02 | Eli Lilly And Company | Arloxyphenylpropylamines |
GB1576216A (en) * | 1975-01-29 | 1980-10-01 | Yamanouchi Pharma Co Ltd | 2-(7-indenyloxymethyl)-morpholine derivatives and process of producing them |
CA1064927A (fr) * | 1975-01-29 | 1979-10-23 | Yuji Kawashima | Procede pour la production de derives de la 2-indenyloxymethymorpholine |
CA1085841A (fr) * | 1976-05-19 | 1980-09-16 | Jean-Marie Ferland | Obtention et emploi d'aryloxypropylamines |
-
1979
- 1979-01-04 IL IL56369A patent/IL56369A/xx unknown
- 1979-01-08 US US06/001,604 patent/US4229449A/en not_active Expired - Lifetime
- 1979-01-11 GB GB7901130A patent/GB2014981B/en not_active Expired
- 1979-01-11 CY CY1172A patent/CY1172A/xx unknown
- 1979-01-12 AU AU43327/79A patent/AU525954B2/en not_active Expired
- 1979-01-12 DE DE2901032A patent/DE2901032C2/de not_active Expired - Lifetime
- 1979-01-12 DE DE1998175005 patent/DE19875005I2/de active Active
- 1979-01-17 YU YU96/79A patent/YU42094B/xx unknown
- 1979-01-17 SI SI7910096A patent/SI7910096A8/sl unknown
- 1979-01-17 NZ NZ189418A patent/NZ189418A/xx unknown
- 1979-01-18 DK DK022679A patent/DK156565C/da not_active IP Right Cessation
- 1979-01-19 FR FR7901413A patent/FR2442839A1/fr active Granted
- 1979-01-19 NO NO790205A patent/NO146953C/no unknown
- 1979-01-19 CA CA319,931A patent/CA1128942A/fr not_active Expired
- 1979-01-19 SE SE7900498A patent/SE446727B/sv active Protection Beyond IP Right Term
- 1979-01-19 FI FI790177A patent/FI71135C/fi not_active IP Right Cessation
- 1979-01-19 CH CH582/79A patent/CH650245A5/de not_active IP Right Cessation
- 1979-01-19 AT AT0040679A patent/AT371813B/de not_active IP Right Cessation
- 1979-01-20 JP JP449479A patent/JPS54148739A/ja active Granted
- 1979-01-30 IE IE107/79A patent/IE47727B1/en active Protection Beyond IP Right Term
- 1979-09-11 FR FR7922678A patent/FR2430412B1/fr not_active Expired
-
1980
- 1980-06-20 US US06/161,509 patent/US4271160A/en not_active Expired - Lifetime
-
1982
- 1982-10-25 KE KE3243A patent/KE3243A/xx unknown
-
1983
- 1983-02-08 HK HK57/83A patent/HK5783A/xx not_active IP Right Cessation
-
1984
- 1984-12-31 MY MY8418A patent/MY8400018A/xx unknown
-
1991
- 1991-12-30 CS CS914133A patent/CS413391A3/cs unknown
-
1994
- 1994-02-22 BG BG98513A patent/BG61056B2/bg unknown
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Date | Code | Title | Description |
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CTFF | Application for supplementary protection certificate (spc) filed |
Free format text: CA 1998 00005, 980204 |
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PUP | Patent expired |