DK155036C - Fremgangsmaade til fremstilling af oploesninger eller suspensioner af liposomer i vandige medier. - Google Patents

Fremgangsmaade til fremstilling af oploesninger eller suspensioner af liposomer i vandige medier.

Info

Publication number
DK155036C
DK155036C DK344478A DK344478A DK155036C DK 155036 C DK155036 C DK 155036C DK 344478 A DK344478 A DK 344478A DK 344478 A DK344478 A DK 344478A DK 155036 C DK155036 C DK 155036C
Authority
DK
Denmark
Prior art keywords
liposomes
suspensions
procedure
solutions
preparation
Prior art date
Application number
DK344478A
Other languages
Danish (da)
English (en)
Other versions
DK344478A (da
DK155036B (da
Inventor
Michel Schneider
Original Assignee
Battelle Memorial Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Battelle Memorial Institute filed Critical Battelle Memorial Institute
Publication of DK344478A publication Critical patent/DK344478A/da
Publication of DK155036B publication Critical patent/DK155036B/da
Application granted granted Critical
Publication of DK155036C publication Critical patent/DK155036C/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • A61K9/1277Processes for preparing; Proliposomes
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S516/00Colloid systems and wetting agents; subcombinations thereof; processes of
    • Y10S516/924Significant dispersive or manipulative operation or step in making or stabilizing colloid system
    • Y10S516/929Specified combination of agitation steps, e.g. mixing to make subcombination composition followed by homogenization

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)
DK344478A 1977-08-05 1978-08-03 Fremgangsmaade til fremstilling af oploesninger eller suspensioner af liposomer i vandige medier. DK155036C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH961677A CH624011A5 (el) 1977-08-05 1977-08-05
CH961677 1977-08-05

Publications (3)

Publication Number Publication Date
DK344478A DK344478A (da) 1979-02-06
DK155036B DK155036B (da) 1989-01-30
DK155036C true DK155036C (da) 1989-06-26

Family

ID=4353843

Family Applications (1)

Application Number Title Priority Date Filing Date
DK344478A DK155036C (da) 1977-08-05 1978-08-03 Fremgangsmaade til fremstilling af oploesninger eller suspensioner af liposomer i vandige medier.

Country Status (20)

Country Link
US (1) US4224179A (el)
JP (1) JPS5441279A (el)
AU (1) AU520916B2 (el)
BE (1) BE869490A (el)
CA (1) CA1098410A (el)
CH (1) CH624011A5 (el)
DE (1) DE2834307A1 (el)
DK (1) DK155036C (el)
ES (1) ES472326A1 (el)
FR (1) FR2399242A1 (el)
GB (1) GB2001929B (el)
HU (1) HU179672B (el)
IE (1) IE47067B1 (el)
IL (1) IL55154A (el)
IT (1) IT1097928B (el)
LU (1) LU80071A1 (el)
NL (1) NL7808167A (el)
SE (1) SE433169B (el)
SU (1) SU1158031A3 (el)
ZA (1) ZA784407B (el)

Families Citing this family (293)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4356167A (en) * 1978-01-27 1982-10-26 Sandoz, Inc. Liposome drug delivery systems
IT1111367B (it) * 1978-11-17 1986-01-13 Serono Ist Farm Processo per la preparazione estemporanea di liposomi e liposomi cosi' ottenuti
DE3068743D1 (en) 1980-01-16 1984-08-30 Weder Hans G Process and dialysis-installation for the preparation of bilayer-vesicles and their use
US4302459A (en) * 1980-03-19 1981-11-24 The United States Of America As Represented By The Secretary Of The Army Liposome carriers in leishmaniasis chemotherapy with 8-aminoquinoline derivatives
EP0043327B1 (fr) * 1980-07-01 1984-01-18 L'oreal Procédé d'obtention de dispersions stables dans une phase aqueuse d'au moins une phase liquide non miscible à l'eau et dispersions correspondantes
EP0047480B1 (en) * 1980-09-05 1986-02-05 Institut Armand Frappier Formation of an immunosome exclusively made of viral antigens reconstituted on an artificial membrane
GR77320B (el) * 1980-12-22 1984-09-11 Procter & Gamble
US4394372A (en) * 1980-12-22 1983-07-19 The Procter & Gamble Company Process for making lipid membrane structures
DE3269389D1 (en) * 1981-08-10 1986-04-03 Wellcome Found Pharmaceutical formulations containing antimony
NL193099C (nl) * 1981-10-30 1998-11-03 Novo Industri As Gestabiliseerde insuline-oplossing.
EP0088046B1 (de) * 1982-02-17 1987-12-09 Ciba-Geigy Ag Lipide in wässriger Phase
US4416872A (en) * 1982-03-17 1983-11-22 The United States Of America As Represented By The Secretary Of The Army Treatment of malaria with liposomes containing 8-aminoquinoline derivatives and glycoconjugates
AU564876B2 (en) * 1982-03-29 1987-08-27 Liposome Company, Inc., The Stable plurilamellar vesicles
US4522803A (en) * 1983-02-04 1985-06-11 The Liposome Company, Inc. Stable plurilamellar vesicles, their preparation and use
US5441745A (en) * 1982-03-30 1995-08-15 Vestar, Inc. Method of delivering micellular particles encapsulating chemotherapeutic agents to tumors in a body
US5435989A (en) 1982-03-30 1995-07-25 Vestar, Inc. Method of targeting a specific location in a body
US4612370A (en) * 1982-04-02 1986-09-16 The Regents Of The University Of California Lipid-saccharide reaction products
US4425334A (en) 1982-04-02 1984-01-10 The Regents Of The University Of California Functional oxygen transport system
US4522811A (en) * 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
EP0100964A3 (de) * 1982-07-31 1984-06-13 Reifenrath, Rainer, Dr. Pharmazeutisches Erzeugnis zur Behandlung und Prophylaxe von Infektionen sowie von Husten und obstruktiven Atemwegserkrankungen sowie Verfahren zu seiner Herstellung
US4485054A (en) * 1982-10-04 1984-11-27 Lipoderm Pharmaceuticals Limited Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
US4501728A (en) * 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
FR2540381B1 (fr) * 1983-02-08 1986-05-30 Dior Sa Parfums Christian Procede pour stimuler la croissance des cellules; composition cosmetique, pharmaceutique et composition complementaire pour milieu de culture cellulaire appliquant ce procede
US5387410A (en) * 1983-03-18 1995-02-07 Mallinckrodt, Inc. Method for enhancing magnetic resonance with compositions containing paramagnetic elements carried by liposomes
US4588578A (en) * 1983-08-08 1986-05-13 The Liposome Company, Inc. Lipid vesicles prepared in a monophase
US5186941A (en) * 1983-05-06 1993-02-16 Vestar, Inc. Vesicle formulation for the controlled release of therapeutic agents
FR2561101B1 (fr) * 1984-03-13 1986-10-31 Paris Sud Universite Procede de preparation de liposomes et liposomes ainsi obtenus
US4610868A (en) * 1984-03-20 1986-09-09 The Liposome Company, Inc. Lipid matrix carriers for use in drug delivery systems
US5231112A (en) * 1984-04-12 1993-07-27 The Liposome Company, Inc. Compositions containing tris salt of cholesterol hemisuccinate and antifungal
US4921706A (en) * 1984-11-20 1990-05-01 Massachusetts Institute Of Technology Unilamellar lipid vesicles and method for their formation
US4857319A (en) * 1985-01-11 1989-08-15 The Regents Of The University Of California Method for preserving liposomes
US4707453A (en) * 1985-04-05 1987-11-17 Becton Dickinson And Company Vesicle including a metal marker for use in an assay
US4698263A (en) * 1985-05-23 1987-10-06 Becton Dickinson And Company Sac having a marker linked thereto
US5409704A (en) * 1985-06-26 1995-04-25 The Liposome Company, Inc. Liposomes comprising aminoglycoside phosphates and methods of production and use
US4861580A (en) * 1985-10-15 1989-08-29 The Liposome Company, Inc. Composition using salt form of organic acid derivative of alpha-tocopheral
US5041278A (en) * 1985-10-15 1991-08-20 The Liposome Company, Inc. Alpha tocopherol-based vesicles
FR2591105B1 (fr) 1985-12-11 1989-03-24 Moet Hennessy Rech Composition pharmaceutique, notamment dermatologique, ou cosmetique, a base de phases lamellaires lipidiques hydratees ou de liposomes contenant un retinoide ou un analogue structural dudit retinoide tel qu'un carotenoide.
JPH0751496B2 (ja) * 1986-04-02 1995-06-05 武田薬品工業株式会社 リポソ−ムの製造法
FR2597345B1 (fr) * 1986-04-22 1990-08-03 Oreal Composition cosmetique ou pharmaceutique a base d'une dispersion aqueuse de spherules lipidiques.
US6759057B1 (en) 1986-06-12 2004-07-06 The Liposome Company, Inc. Methods and compositions using liposome-encapsulated non-steroidal anti-inflammatory drugs
US5252263A (en) * 1986-06-16 1993-10-12 The Liposome Company, Inc. Induction of asymmetry in vesicles
WO1987007530A1 (en) * 1986-06-16 1987-12-17 The Liposome Company, Inc. Induction of asymmetry in vesicles
US5204112A (en) * 1986-06-16 1993-04-20 The Liposome Company, Inc. Induction of asymmetry in vesicles
WO1988003797A1 (en) * 1986-11-28 1988-06-02 The Liposome Company, Inc. Phospholipid composition
US4783220A (en) * 1986-12-18 1988-11-08 Xerox Corporation Vesicle ink compositions
JP2528153B2 (ja) * 1986-12-23 1996-08-28 ザ リポソーム カンパニー,インコーポレイテッド リポソ―ム製剤および抗生物質
GB8704171D0 (en) * 1987-02-23 1987-04-01 Clayton Found Res Multivesicular liposomes
US5723147A (en) * 1987-02-23 1998-03-03 Depotech Corporation Multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride
US4963297A (en) * 1987-12-22 1990-10-16 The Liposome Company, Inc. Spontaneous vesticulation of multilamellar liposomes
MX9203808A (es) * 1987-03-05 1992-07-01 Liposome Co Inc Formulaciones de alto contenido de medicamento: lipido, de agentes liposomicos-antineoplasticos.
US5616334A (en) * 1987-03-05 1997-04-01 The Liposome Company, Inc. Low toxicity drug-lipid systems
US6406713B1 (en) 1987-03-05 2002-06-18 The Liposome Company, Inc. Methods of preparing low-toxicity drug-lipid complexes
US5925375A (en) * 1987-05-22 1999-07-20 The Liposome Company, Inc. Therapeutic use of multilamellar liposomal prostaglandin formulations
MX9203804A (es) * 1987-10-19 1992-07-01 Liposome Co Inc Sistemas farmaceuticos a base de tocoferol.
US4873035A (en) * 1987-11-25 1989-10-10 Abbott Laboratories Preparation of sized populations of liposomes
US5017501A (en) * 1987-11-25 1991-05-21 Abbott Laboratories Preparation of uniformly sized liposomes encapsulating an aqueous liquid
KR900000848B1 (ko) * 1987-12-30 1990-02-17 태평양화학 주식회사 리포좀을 함유한 화장료의 제조방법
US5807572A (en) * 1988-02-18 1998-09-15 Depotech Corporation Multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride
US5013497A (en) * 1988-03-03 1991-05-07 Micro-Pak, Inc. Method and apparatus for producing lipid vesicles
US5948441A (en) * 1988-03-07 1999-09-07 The Liposome Company, Inc. Method for size separation of particles
US5422120A (en) * 1988-05-30 1995-06-06 Depotech Corporation Heterovesicular liposomes
CA1339034C (en) * 1988-08-22 1997-04-01 Paul A. Tremblay Platinum complexes of single isomer neoalkyl acids
US4906476A (en) * 1988-12-14 1990-03-06 Liposome Technology, Inc. Novel liposome composition for sustained release of steroidal drugs in lungs
US5043165A (en) * 1988-12-14 1991-08-27 Liposome Technology, Inc. Novel liposome composition for sustained release of steroidal drugs
US5116615A (en) * 1989-01-27 1992-05-26 Immunolytics, Inc. Method for treating benign prostatic hypertrophy
DE69019141T2 (de) 1989-01-27 1996-01-18 Immunolytics Inc Zusammensetzung und verfahren für die behandlung gutartiger prostata-hypertrophie.
US5078986A (en) * 1989-02-15 1992-01-07 Mallinckrodt Medical, Inc. Method for enhancing magnetic resonance imaging using an image altering agent containing an excess of chelating agent
US5100662A (en) * 1989-08-23 1992-03-31 The Liposome Company, Inc. Steroidal liposomes exhibiting enhanced stability
US5227165A (en) * 1989-11-13 1993-07-13 Nova Pharmaceutical Corporation Liposphere delivery systems for local anesthetics
IE904098A1 (en) * 1989-11-13 1991-05-22 Nova Pharm Corp Lipospheres for controlled delivery of substances
US5221535A (en) * 1989-11-13 1993-06-22 Nova Pharmaceutical Corporation Sustained release formulations of insect repellent
US5188837A (en) * 1989-11-13 1993-02-23 Nova Pharmaceutical Corporation Lipsopheres for controlled delivery of substances
US6551576B1 (en) 1989-12-22 2003-04-22 Bristol-Myers Squibb Medical Imaging, Inc. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5352435A (en) * 1989-12-22 1994-10-04 Unger Evan C Ionophore containing liposomes for ultrasound imaging
US5656211A (en) * 1989-12-22 1997-08-12 Imarx Pharmaceutical Corp. Apparatus and method for making gas-filled vesicles of optimal size
US5542935A (en) * 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5922304A (en) 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
US5580575A (en) * 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5733572A (en) * 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
US6001335A (en) * 1989-12-22 1999-12-14 Imarx Pharmaceutical Corp. Contrasting agents for ultrasonic imaging and methods for preparing the same
US5773024A (en) * 1989-12-22 1998-06-30 Imarx Pharmaceutical Corp. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5705187A (en) * 1989-12-22 1998-01-06 Imarx Pharmaceutical Corp. Compositions of lipids and stabilizing materials
US5469854A (en) * 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US5305757A (en) * 1989-12-22 1994-04-26 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US5585112A (en) * 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US20020150539A1 (en) 1989-12-22 2002-10-17 Unger Evan C. Ultrasound imaging and treatment
US5776429A (en) * 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US6146657A (en) * 1989-12-22 2000-11-14 Imarx Pharmaceutical Corp. Gas-filled lipid spheres for use in diagnostic and therapeutic applications
ZA911974B (en) * 1990-03-21 1994-08-22 Res Dev Foundation Heterovesicular liposomes
US20010024638A1 (en) * 1992-11-02 2001-09-27 Michel Schneider Stable microbubble suspensions as enhancement agents for ultrasound echography and dry formulations thereof
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
US5578292A (en) 1991-11-20 1996-11-26 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
USRE39146E1 (en) 1990-04-02 2006-06-27 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US7083778B2 (en) * 1991-05-03 2006-08-01 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US20040208826A1 (en) * 1990-04-02 2004-10-21 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
IN172208B (el) * 1990-04-02 1993-05-01 Sint Sa
US6989141B2 (en) * 1990-05-18 2006-01-24 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US6613306B1 (en) 1990-04-02 2003-09-02 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
US20030194376A1 (en) * 1990-05-18 2003-10-16 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
ATE138803T1 (de) * 1990-07-31 1996-06-15 Liposome Co Inc Anhäufung von aminosäuren und peptiden in liposomen
WO1992004010A1 (en) * 1990-09-06 1992-03-19 S.C. Johnson & Son, Inc. Stabilized liposome process and compositions containing them
US5874062A (en) * 1991-04-05 1999-02-23 Imarx Pharmaceutical Corp. Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US5567432A (en) * 1991-08-02 1996-10-22 Lau; John R. Masking of liposomes from RES recognition
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them
US5455044A (en) * 1993-05-14 1995-10-03 Depotech Corporation Method for treating neurological disorders
CA2160118A1 (en) * 1993-05-21 1994-12-08 Patrick L. Ahl Reduction of liposome-induced adverse physiological reactions
RU2160093C2 (ru) * 1993-11-16 2000-12-10 Скайефарма Инк. Везикулы с регулируемым высвобождением активных ингредиентов
US7083572B2 (en) 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
AU679295B2 (en) * 1993-12-15 1997-06-26 Bracco Suisse S.A. Gas mixtures useful as ultrasound contrast media
ATE241340T1 (de) * 1994-02-17 2003-06-15 New York Blood Ct Inc Biologische bioadhäsive präparate, die fibrinkleber und liposomen enthalten, verfahren für ihre herstellung und verwendung
US5736121A (en) * 1994-05-23 1998-04-07 Imarx Pharmaceutical Corp. Stabilized homogenous suspensions as computed tomography contrast agents
US6455304B1 (en) * 1994-07-01 2002-09-24 The Board Of Regents Of The University Of Oklahoma Hyaluronate synthase gene and uses thereof
US7091008B1 (en) * 1994-07-01 2006-08-15 The Board Of Regents Of The University Of Oklahoma Hyaluronan synthase genes and expression thereof in Bacillus hosts
US6951743B2 (en) 1997-10-31 2005-10-04 University Of Oklahoma Board Of Regents Hyaluronan synthase genes and expression thereof in bacillus hosts
US5993850A (en) * 1994-09-13 1999-11-30 Skyepharma Inc. Preparation of multivesicular liposomes for controlled release of encapsulated biologically active substances
US6743779B1 (en) 1994-11-29 2004-06-01 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US5830430A (en) * 1995-02-21 1998-11-03 Imarx Pharmaceutical Corp. Cationic lipids and the use thereof
US5800833A (en) * 1995-02-27 1998-09-01 University Of British Columbia Method for loading lipid vesicles
US5824638A (en) * 1995-05-22 1998-10-20 Shire Laboratories, Inc. Oral insulin delivery
US5997898A (en) * 1995-06-06 1999-12-07 Imarx Pharmaceutical Corp. Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery
US6139819A (en) * 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US6033645A (en) * 1996-06-19 2000-03-07 Unger; Evan C. Methods for diagnostic imaging by regulating the administration rate of a contrast agent
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
US6231834B1 (en) 1995-06-07 2001-05-15 Imarx Pharmaceutical Corp. Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same
US5931809A (en) * 1995-07-14 1999-08-03 Depotech Corporation Epidural administration of therapeutic compounds with sustained rate of release
JPH11510795A (ja) 1995-07-14 1999-09-21 グリコテック コーポレイション Egfレセプターに関連する癌の処置のための化合物および方法、ならびにegfレセプターの精製
US6022500A (en) * 1995-09-27 2000-02-08 The United States Of America As Represented By The Secretary Of The Army Polymer encapsulation and polymer microsphere composites
US6447800B2 (en) 1996-01-18 2002-09-10 The University Of British Columbia Method of loading preformed liposomes using ethanol
US6143287A (en) * 1996-02-27 2000-11-07 New York Blood Center, Inc. Method and composition for hair removal
JP2001507207A (ja) 1996-05-01 2001-06-05 イマアーレクス・フアーマシユーチカル・コーポレーシヨン 化合物を細胞に送達する方法
US6414139B1 (en) 1996-09-03 2002-07-02 Imarx Therapeutics, Inc. Silicon amphiphilic compounds and the use thereof
WO1998010798A1 (en) * 1996-09-11 1998-03-19 Imarx Pharmaceutical Corp. Improved methods for diagnostic imaging using a contrast agent and a vasodilator
US5846517A (en) 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
US5997899A (en) 1996-10-01 1999-12-07 Skyepharma Inc. Method for producing liposomes with increased percent of compound encapsulated
US5891467A (en) 1997-01-31 1999-04-06 Depotech Corporation Method for utilizing neutral lipids to modify in vivo release from multivesicular liposomes
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US6090800A (en) * 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US6537246B1 (en) 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US6143276A (en) * 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
US7452551B1 (en) 2000-10-30 2008-11-18 Imarx Therapeutics, Inc. Targeted compositions for diagnostic and therapeutic use
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
EP2113247A3 (en) 1997-05-14 2010-05-05 The University Of British Columbia High efficiency encapsulation of nucleic acids in lipid vesicles
EP1027033B1 (en) * 1997-05-14 2009-07-22 The University Of British Columbia High efficiency encapsulation of nucleic acids in lipid vesicles
WO1999002139A1 (en) * 1997-07-10 1999-01-21 Keith Baker Methods for universally distributing therapeutic agents to the brain
US6306432B1 (en) 1997-09-08 2001-10-23 Chiron Corporation High and low load formulations of IGF-I in multivesicular liposomes
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
NZ503513A (en) * 1997-09-18 2004-12-24 Skyepharma Inc Sustained-release liposomal anesthetic compositions
KR20010031682A (ko) * 1997-10-31 2001-04-16 존 팔머 히알우로난 합성효소 유전자 및 그의 용도
CN101113436B (zh) * 1997-10-31 2013-02-06 俄克拉何马大学董事会 透明质酸合酶基因及其应用
IL135989A0 (en) * 1997-11-14 2001-05-20 Skyepharma Inc Processes for the production of multivesicular liposomes
US6123923A (en) * 1997-12-18 2000-09-26 Imarx Pharmaceutical Corp. Optoacoustic contrast agents and methods for their use
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
US6727079B1 (en) * 1998-02-25 2004-04-27 The United States Of America As Represented By The Department Of Health And Human Services cDNA encoding a gene BOG (B5T Over-expressed Gene) and its protein product
US20060188966A1 (en) * 1998-04-02 2006-08-24 Deangelis Paul L Natural, chimeric and hybrid glycosaminoglycan polymers and methods of making and using same
US20080108110A1 (en) * 1998-04-02 2008-05-08 Deangelis Paul L Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
US7223571B2 (en) * 1998-04-02 2007-05-29 The Board Of Regents Of The Universtiy Of Oklahoma Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
US6987023B2 (en) * 1998-04-02 2006-01-17 The Board Of Regents Of The University Of Oklahoma DNA encoding hyaluronan synthase from Pasteurella multocida and methods of use
US7169410B1 (en) * 1998-05-19 2007-01-30 Sdg, Inc. Targeted liposomal drug delivery system
US7094581B2 (en) * 1998-10-26 2006-08-22 The Board Of Regents Of The University Of Oklahoma Hyaluronan synthases and methods of making and using same
AU2001252958A1 (en) 2000-03-23 2001-10-03 Elan Pharmaceuticals, Inc. Compounds and methods to treat alzheimer's disease
US6992081B2 (en) 2000-03-23 2006-01-31 Elan Pharmaceuticals, Inc. Compounds to treat Alzheimer's disease
US20050287638A1 (en) * 2000-04-25 2005-12-29 Weigel Paul H Hyaluronan receptor for endocytosis, variants thereof, and methods of making and using same
ATE302751T1 (de) 2000-06-30 2005-09-15 Elan Pharm Inc Verbindungen zur behandlung der alzheimerischen krankheit
US20030096864A1 (en) * 2000-06-30 2003-05-22 Fang Lawrence Y. Compounds to treat alzheimer's disease
US6846813B2 (en) 2000-06-30 2005-01-25 Pharmacia & Upjohn Company Compounds to treat alzheimer's disease
PE20020276A1 (es) 2000-06-30 2002-04-06 Elan Pharm Inc COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER
BR0115260A (pt) * 2000-11-09 2005-08-16 Neopharm Inc Complexos de sn-38 com lipìdeos e seus usos no tratamento de doenças
US20110301569A1 (en) 2001-01-20 2011-12-08 Gordon Wayne Dyer Methods and apparatus for the CVCS
US20020150566A1 (en) * 2001-03-23 2002-10-17 Kun-Liang Guan Method of inhibiting cancerous cell proliferation using Ras mutants of GDP-bound conformation
WO2003030864A1 (en) * 2001-05-29 2003-04-17 Neopharm, Inc. Liposomal formulation of irinotecan
US6982264B2 (en) * 2001-06-27 2006-01-03 Elan Pharmaceuticals, Inc. Substituted alcohols useful in treatment of Alzheimer's disease
US20030068361A1 (en) * 2001-10-09 2003-04-10 Rimona Margalit Liposome-encapsulated insulin formulations
BRPI0105509B8 (pt) 2001-11-05 2021-05-25 Univ Minas Gerais formulações do peptídeo angiotensina-(1-7) usando as ciclodextrinas, lipossomas e o polímero plga
AU2002340662B2 (en) * 2001-11-07 2008-07-03 Tekmira Pharmaceuticals Corporation Mucosal adjuvants comprising an oligonucleotide and a cationic lipid
US7476400B2 (en) * 2001-11-13 2009-01-13 Ferndale Ip, Inc. High-concentration lidocaine compositions and methods for their preparation
US20070020737A1 (en) * 2001-12-03 2007-01-25 Pummill Philip E Hyaluronan synthases and methods of making and using same
US20030134423A1 (en) * 2002-01-04 2003-07-17 Chu Yong Liang Compounds for delivering substances into cells
WO2003059280A2 (en) * 2002-01-09 2003-07-24 Elan Pharmaceuticals, Inc. Efficient liposomal encapsulation
US20030180348A1 (en) * 2002-03-22 2003-09-25 Levinson R. Saul Transcellular drug delivery system
US20040013649A1 (en) * 2002-05-10 2004-01-22 Inex Pharmaceuticals Corporation Cancer vaccines and methods of using the same
US20040009943A1 (en) * 2002-05-10 2004-01-15 Inex Pharmaceuticals Corporation Pathogen vaccines and methods for using the same
US20060030578A1 (en) * 2002-08-20 2006-02-09 Neopharm, Inc. Pharmaceutically active lipid based formulation of irinotecan
WO2004035032A2 (en) * 2002-08-20 2004-04-29 Neopharm, Inc. Pharmaceutical formulations of camptothecine derivatives
CN1747738B (zh) 2002-10-29 2010-11-24 川塞夫有限公司 缓释抗感染剂
EP1599183A2 (en) * 2002-11-26 2005-11-30 Gilead Sciences, Inc. Method of drug loading in liposomes by gradient
US6866856B2 (en) * 2002-12-31 2005-03-15 Avon Products, Inc. Compositions and delivery methods for the treatment of wrinkles, fine lines and hyperhidrosis
JPWO2005053643A1 (ja) * 2003-12-01 2007-06-28 三菱ウェルファーマ株式会社 リポソーム
US7504385B2 (en) * 2003-12-17 2009-03-17 Avon Products, Inc. si-RNA-mediated gene silencing technology to inhibit tyrosinase and reduce pigmentation
US8022279B2 (en) 2004-04-22 2011-09-20 Celator Pharmaceuticals, Inc. Liposomal formulations of anthracycline agents and cytidine analogs
AU2005269800B8 (en) 2004-07-19 2011-12-01 Celator Pharmaceuticals, Inc. Particulate constructs for release of active agents
WO2006052767A2 (en) 2004-11-05 2006-05-18 Inex Pharmaceuticals Corporation Compositions and methods for stabilizing liposomal camptothecin formulations
KR100651728B1 (ko) * 2004-11-10 2006-12-06 한국전자통신연구원 정착기를 갖는 전자 소자용 화합물 및 이를 포함하는 전자소자와 이들의 제조 방법
US7459529B2 (en) 2004-11-24 2008-12-02 Seoul National University Industry Foundation AIMP2-DX2 and its uses
US9944713B2 (en) 2004-11-24 2018-04-17 Medicinal Bioconvergence Research Center Antibody specific to the AIMP2-DX2
AU2005318928B2 (en) * 2004-12-20 2010-06-03 Australian Nuclear Science & Technology Organisation Controlled release of biological entities
JP5593030B2 (ja) * 2004-12-20 2014-09-17 オーストラリアン ニュークリア サイエンス アンド テクノロジー オーガニゼーション 生物学的物質の調節放出
AU2006257726B2 (en) * 2005-06-17 2010-09-09 Australian Nuclear Science And Technology Organisation Particles having hydrophobic material therein
US8815291B2 (en) * 2005-06-17 2014-08-26 Austrailian Nuclear Science & Technology Organisation Particles comprising a releasable dopant therein
AU2006257727B2 (en) * 2005-06-17 2010-09-09 Encap Hive Pty Ltd Particles comprising a releasable dopant therein
CA2612175A1 (en) * 2005-06-17 2006-12-21 Australian Nuclear Science And Technology Organisation Particles having hydrophobic material therein
WO2007032225A1 (ja) * 2005-09-15 2007-03-22 Kyoto University リポソーム、リポソームの製造方法及び微小反応空間内での反応制御方法
EP2395012B8 (en) 2005-11-02 2018-06-06 Arbutus Biopharma Corporation Modified siRNA molecules and uses thereof
US9107824B2 (en) 2005-11-08 2015-08-18 Insmed Incorporated Methods of treating cancer with high potency lipid-based platinum compound formulations administered intraperitoneally
WO2007070705A2 (en) * 2005-12-15 2007-06-21 The Trustees Of The University Of Pennsylvania Cationic lipid-mediated vectors
US20080094573A1 (en) * 2006-04-04 2008-04-24 Vermette Patrick Surface-modified materials, such as contact lenses, methods and kits for their preparation, and uses thereof
EP2492278A1 (en) 2006-09-18 2012-08-29 Compugen Ltd. Antibodies against an agonist of G-protein coupled receptors and its use indiagnosis and therapy
CA2701601C (en) 2006-10-03 2020-06-30 The Board Of Regents Of The University Of Oklahoma Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
WO2008130641A1 (en) * 2007-04-20 2008-10-30 Biocure, Inc. Drug delivery vehicle containing vesicles in a hydrogel base
JP5355561B2 (ja) 2007-07-12 2013-11-27 コンピュゲン エルティーディー. 生物活性ペプチドおよびその使用方法
ITRM20070394A1 (it) * 2007-07-16 2009-01-17 Uni Cattolica Del Sacro Cuo Re Liposomi asimmetrici e loro usi in campo medico.
WO2009097011A1 (en) 2007-08-17 2009-08-06 Celator Pharmaceuticals, Inc. Improved platinum drug formulations
EP2231195B1 (en) 2007-12-04 2017-03-29 Arbutus Biopharma Corporation Targeting lipids
ES2916498T3 (es) 2007-12-06 2022-07-01 Genalyte Inc Método para identificar una secuencia de nucleótidos en una especie desconocida de ácido nucleico; y dispositivo para llevar a cabo el método
WO2009072136A1 (en) * 2007-12-06 2009-06-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Particulate drug carriers as desensitizing agents
JP5697988B2 (ja) 2007-12-27 2015-04-08 プロチバ バイオセラピューティクス インコーポレイティッド 干渉rnaを使用したポロ様キナーゼ発現のサイレンシング方法
WO2009086558A1 (en) 2008-01-02 2009-07-09 Tekmira Pharmaceuticals Corporation Improved compositions and methods for the delivery of nucleic acids
JP2011516094A (ja) 2008-04-15 2011-05-26 プロチバ バイオセラピューティクス インコーポレイティッド 干渉rnaを用いたcsn5遺伝子発現のサイレンシング方法
US8058069B2 (en) 2008-04-15 2011-11-15 Protiva Biotherapeutics, Inc. Lipid formulations for nucleic acid delivery
EP2330910B1 (en) 2008-09-11 2017-08-16 Israeli Biotechnology Research Ltd. Cosmetic use of leucojum bulb extracts
CN104119242B (zh) 2008-10-09 2017-07-07 泰米拉制药公司 改善的氨基脂质和递送核酸的方法
EP3572796B8 (en) 2008-10-27 2023-01-18 Genalyte, Inc. Biosensors based on optical probing and sensing
CA3039251C (en) 2008-11-10 2024-01-09 Arbutus Biopharma Corporation Novel lipids and compositions for the delivery of therapeutics
CA2751342C (en) 2009-01-29 2019-05-07 Alnylam Pharmaceuticals, Inc. Lipid formulations comprising cationic lipid and a targeting lipid comprising n-acetyl galactosamine for delivery of nucleic acid
CN102316852A (zh) 2009-02-11 2012-01-11 丽卡实验有限公司 脂质胞二磷胆碱注射液
WO2010105209A1 (en) 2009-03-12 2010-09-16 Alnylam Pharmaceuticals, Inc. LIPID FORMULATED COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF Eg5 AND VEGF GENES
JP5487666B2 (ja) * 2009-03-23 2014-05-07 コニカミノルタ株式会社 内水相を固定化することを特徴とするリポソームの製造方法
SG10201911942UA (en) 2009-05-05 2020-02-27 Muthiah Manoharan Lipid compositions
CA3045126A1 (en) 2009-05-05 2010-11-11 Arbutus Biopharma Corporation Methods of delivering oligonucleotides to immune cells
LT2440183T (lt) 2009-06-10 2018-08-10 Arbutus Biopharma Corporation Patobulinta lipido kompozicija
ES2613498T3 (es) 2009-07-01 2017-05-24 Protiva Biotherapeutics Inc. Nuevas formulaciones de lípidos para el suministro de agentes terapéuticos a tumores sólidos
FR2948035B1 (fr) * 2009-07-20 2015-04-24 Centre Nat Rech Scient Procede de fabrication de capsules, capsules ainsi obtenues et utilisation desdites capsules
US8716464B2 (en) 2009-07-20 2014-05-06 Thomas W. Geisbert Compositions and methods for silencing Ebola virus gene expression
EP2464336A4 (en) 2009-08-14 2013-11-20 Alnylam Pharmaceuticals Inc COMPOSITIONS FORMULATED IN LIPIDS AND METHODS OF INHIBITING THE EXPRESSION OF EBOLA VIRUS GENE
WO2011038160A2 (en) 2009-09-23 2011-03-31 Protiva Biotherapeutics, Inc. Compositions and methods for silencing genes expressed in cancer
WO2011056682A1 (en) 2009-10-27 2011-05-12 The University Of British Columbia Reverse head group lipids, lipid particle compositions comprising reverse headgroup lipids, and methods for the delivery of nucleic acids
CA3044884A1 (en) 2009-12-07 2011-06-16 Arbutus Biopharma Corporation Compositions for nucleic acid delivery
ES2749426T3 (es) 2009-12-18 2020-03-20 Univ British Columbia Métodos y composiciones para administración de ácidos nucleicos
WO2011141705A1 (en) 2010-05-12 2011-11-17 Protiva Biotherapeutics, Inc. Novel cationic lipids and methods of use thereof
WO2011141704A1 (en) 2010-05-12 2011-11-17 Protiva Biotherapeutics, Inc Novel cyclic cationic lipids and methods of use
CN103096875B (zh) 2010-06-03 2016-08-17 阿尔尼拉姆医药品有限公司 用于递送活性剂的生物可降解脂质
US20130202652A1 (en) 2010-07-30 2013-08-08 Alnylam Pharmaceuticals, Inc. Methods and compositions for delivery of active agents
WO2012016184A2 (en) 2010-07-30 2012-02-02 Alnylam Pharmaceuticals, Inc. Methods and compositions for delivery of active agents
CA2816995C (en) 2010-11-05 2019-12-31 THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, a body corporate and politic Optical analyte detection systems and methods of use
CN103201386A (zh) 2010-11-09 2013-07-10 加利福尼亚大学董事会 皮肤穿透及细胞进入(space)肽及其使用方法
CA2824526C (en) 2011-01-11 2020-07-07 Alnylam Pharmaceuticals, Inc. Pegylated lipids and their use for drug delivery
JP2014510045A (ja) 2011-02-08 2014-04-24 ハロザイム インコーポレイテッド ヒアルロナン分解酵素の組成物および脂質製剤ならびに良性前立腺肥大症の治療のためのその使用
CN103619325A (zh) 2011-07-04 2014-03-05 国立血清研究所 用于生产脂质体的方法
EP3456317A1 (en) 2011-09-27 2019-03-20 Alnylam Pharmaceuticals, Inc. Di-aliphatic substituted pegylated lipids
AU2012340086A1 (en) 2011-11-17 2014-05-29 The Regents Of The University Of California Therapeutic RNA switches compositions and methods of use
EP2606897A1 (en) 2011-12-22 2013-06-26 Laboratorios Del. Dr. Esteve, S.A. Methods and compositions for the treatment of diseases caused by enveloped viruses
US9035039B2 (en) 2011-12-22 2015-05-19 Protiva Biotherapeutics, Inc. Compositions and methods for silencing SMAD4
EP3988104A1 (en) 2012-02-24 2022-04-27 Arbutus Biopharma Corporation Trialkyl cationic lipids and methods of use thereof
EP2825885B1 (en) 2012-03-12 2021-05-12 The Board of Trustees of the University of Illinois Optical analyte detection systems with magnetic enhancement
EP2666456A1 (en) 2012-05-21 2013-11-27 Natura Bisse International, S.A. Cometic compositions comprising magnetosomes and uses thereof
CN115414384A (zh) 2012-09-04 2022-12-02 埃莱森制药有限责任公司 用顺铂脂质复合物预防癌症的肺部复发
WO2015011633A1 (en) 2013-07-23 2015-01-29 Protiva Biotherapeutics, Inc. Compositions and methods for delivering messenger rna
KR101465365B1 (ko) * 2013-10-15 2014-11-25 성균관대학교산학협력단 리포좀 내 고분자 충진된 다중 기능 복합 입자체 및 이의 제조방법
KR101638156B1 (ko) 2013-10-29 2016-07-08 가톨릭대학교 산학협력단 C형 간염 바이러스 감염 질환의 예방 또는 치료용 약학 조성물
PL3186281T3 (pl) 2014-08-28 2019-10-31 Halozyme Inc Terapia skojarzona enzymem rozkładającym hialuronian i inhibitorem punktu kontrolnego odpowiedzi immunologicznej
CR20170174A (es) 2014-10-02 2017-11-07 Protiva Biotherapeutics Inc Composiciones y métodos para el silenciamiento de la expresión cénica del virus de la hepatitis b
AU2015364508A1 (en) 2014-12-18 2017-07-06 Alnylam Pharmaceuticals, Inc. ReversirTM compounds
JP6316182B2 (ja) 2014-12-19 2018-04-25 富士フイルム株式会社 リポソームの製造方法及びリポソーム製造装置
EA201791437A1 (ru) 2014-12-31 2017-12-29 Лантеус Медикал Имэджинг, Инк. Композиции микросфер c инкапсулированным в липиде газом и соответствующие способы
US9931298B2 (en) 2015-05-26 2018-04-03 Comfort Care For Animals Llc Liposome loading
WO2016197132A1 (en) 2015-06-04 2016-12-08 Protiva Biotherapeutics Inc. Treating hepatitis b virus infection using crispr
EP3329003A2 (en) 2015-07-29 2018-06-06 Arbutus Biopharma Corporation Compositions and methods for silencing hepatitis b virus gene expression
US10429302B2 (en) 2015-08-11 2019-10-01 Scintillon Institute For Biomedical And Bioenergy Research Optical analyses of particles and vesicles
CN108136023B (zh) 2015-08-12 2021-07-27 北卡罗莱纳州立大学 血小板膜包覆的药物递送系统
EP4218739A3 (en) 2016-01-08 2023-08-09 The Regents of The University of California Mesoporous silica nanoparticles with lipid bilayer coating for cargo delivery
US10188749B2 (en) 2016-04-14 2019-01-29 Fred Hutchinson Cancer Research Center Compositions and methods to program therapeutic cells using targeted nucleic acid nanocarriers
SG11201807593TA (en) 2016-04-14 2018-10-30 Hutchinson Fred Cancer Res Compositions and methods to program therapeutic cells using targeted nucleic acid nanocarriers
CN115531560B (zh) 2016-05-04 2024-05-17 蓝瑟斯医学影像公司 用于制备超声波造影剂的方法及装置
CA3034681A1 (en) 2016-06-30 2018-01-04 Arbutus Biopharma Corporation Compositions and methods for delivering messenger rna
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
EP4371584A2 (en) 2016-12-21 2024-05-22 Fred Hutchinson Cancer Center Scaffolds to treat solid tumor cells and escape variants
CN110121336A (zh) 2017-01-05 2019-08-13 弗莱德哈钦森癌症研究中心 改善疫苗功效的系统和方法
TW201936201A (zh) 2017-12-14 2019-09-16 美商堅固生物科技公司 基因之非病毒生產及遞送
US20220305108A1 (en) 2019-06-20 2022-09-29 Janssen Sciences Ireland Unlimited Company Lipid nanoparticle or liposome delivery of hepatitis b virus (hbv) vaccines
US20210023023A1 (en) * 2019-07-25 2021-01-28 Vasayo, Llc Liposomal nutraceutical compositions and methods of making the same
WO2022133230A1 (en) 2020-12-18 2022-06-23 Janssen Pharmaceuticals, Inc. Combination therapy for treating hepatitis b virus infection
US11033495B1 (en) 2021-01-22 2021-06-15 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11357727B1 (en) 2021-01-22 2022-06-14 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11278494B1 (en) 2021-01-22 2022-03-22 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
WO2022212863A1 (en) 2021-04-01 2022-10-06 Vestaron Corporation Liposome formulations for pesticide delivery and methods for producing and using the same
WO2023018990A2 (en) 2021-08-12 2023-02-16 Life Technologies Corporation Lipids for nucleic acid delivery
WO2023144798A1 (en) 2022-01-31 2023-08-03 Genevant Sciences Gmbh Ionizable cationic lipids for lipid nanoparticles
WO2023144792A1 (en) 2022-01-31 2023-08-03 Genevant Sciences Gmbh Poly(alkyloxazoline)-lipid conjugates and lipid particles containing same
WO2023233290A1 (en) 2022-05-31 2023-12-07 Janssen Sciences Ireland Unlimited Company Rnai agents targeting pd-l1
NL2035417A (en) 2022-07-19 2024-01-26 Coty Inc Cosmetic composition
WO2024031051A1 (en) 2022-08-05 2024-02-08 Life Technologies Corporation Lipids for nucleic acid delivery

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3361680A (en) * 1963-05-13 1968-01-02 Sun Oil Co Use of ultrasonic vibrations to disperse a liquid in another liquid
BE744162A (fr) * 1969-01-16 1970-06-15 Fuji Photo Film Co Ltd Procede d'encapsulage
DE2249552A1 (de) * 1971-10-12 1973-05-30 Inchema S A Verfahren zur inkapsulation von insbesondere wasserloeslichen verbindungen
US3932657A (en) * 1973-11-12 1976-01-13 The United States Of America As Represented By The United States Energy Research And Development Administration Liposome encapsulation of chelating agents
GB1502774A (en) * 1974-06-25 1978-03-01 Nat Res Dev Immunological preparations
CH588887A5 (el) * 1974-07-19 1977-06-15 Battelle Memorial Institute
JPS5126213A (ja) * 1974-08-21 1976-03-04 Tanabe Seiyaku Co Johoseibiryushiseizaino seiho
FR2315991A1 (fr) * 1975-06-30 1977-01-28 Oreal Procede de fabrication de dispersions aqueuses de spherules lipidiques et nouvelles compositions correspondantes
IL51791A0 (en) * 1976-04-14 1977-05-31 Exxon Research Engineering Co New injectable medicinal compositions
JPS5323872A (en) * 1976-08-17 1978-03-04 Takeda Chem Ind Ltd Preparation of microcapsule
US4107106A (en) * 1976-11-22 1978-08-15 Union Carbide Corporation Phenol-aldehyde-amine resin/glycol curatives for energy absorbing polyurethanes
EP0493380B1 (en) * 1989-09-05 1997-10-29 University Of Utah Research Institute Method and compositions for noninvasive dose-to-effect administration of lipophilic drugs

Also Published As

Publication number Publication date
JPS5441279A (en) 1979-04-02
SE7808356L (sv) 1979-02-06
ES472326A1 (es) 1979-02-16
IT1097928B (it) 1985-08-31
ZA784407B (en) 1979-07-25
SE433169B (sv) 1984-05-14
BE869490A (fr) 1979-02-05
IE47067B1 (en) 1983-12-14
IE781574L (en) 1979-02-05
DE2834307A1 (de) 1979-02-15
CA1098410A (en) 1981-03-31
JPS6355978B2 (el) 1988-11-07
GB2001929B (en) 1982-07-28
DK344478A (da) 1979-02-06
GB2001929A (en) 1979-02-14
DK155036B (da) 1989-01-30
US4224179A (en) 1980-09-23
IT7826441A0 (it) 1978-08-03
FR2399242A1 (fr) 1979-03-02
FR2399242B1 (el) 1983-01-07
AU520916B2 (en) 1982-03-04
AU3866678A (en) 1980-02-07
CH624011A5 (el) 1981-07-15
SU1158031A3 (ru) 1985-05-23
HU179672B (en) 1982-11-29
LU80071A1 (fr) 1979-05-15
IL55154A0 (en) 1978-09-29
IL55154A (en) 1981-09-13
NL7808167A (nl) 1979-02-07

Similar Documents

Publication Publication Date Title
DK155036C (da) Fremgangsmaade til fremstilling af oploesninger eller suspensioner af liposomer i vandige medier.
DK160459C (da) Fremgangsmaade til fremstilling af denatureringsbestandige vandige proteinoploesninger
IT7825498A0 (it) Procedimento per la preparazione di soluzioni di cellulosa in ossido di ammina.
DK156765C (da) Fremgangsmaade til fremstilling af et liposomforstadium, som kan dispergeres i et egnet vandigt medium til fremstilling af et vandigt liposompraeparat
SE433759B (sv) Standare for recken eller dylikt
NL7903992A (nl) Membraan.
DK409478A (da) Semipermeable membraner
ATA776477A (de) Waesseriges, enzymatisches fluessigschamittel
DK352176A (da) Fremgangsmade til femstilling af acyl-3-oxo-1,2-benzisothiazoliner eller acylsacchariner
AT367649B (de) Semipermeable membranen
DK392877A (da) Fremgangsmaade til fremstilling af phenylethylaminer eller syreadditionssalte heraf
DK138893B (da) Analogifremgangsmåde til fremstilling af 1-(indolyl-3-alkyl)-4-ureido-piperidiner eller -thioureido-piperidiner eller syreadditionssalte deraf.
NO790827L (no) Membraner for elektrolyse.
DK75878A (da) Fremgangsmaade til fremstilling af 20,21,-di-noreburnameninderivater eller additionssalte deraf
DK296477A (da) Fremgangsmade til fremstilling af 2-brom-6-fluor-n-2-imidazolidinylidenbenzamin eller syreadditionssalte heraf
DK134580A (da) Fremgangsmaade til fremstilling af 2,6-diaminonebulariner eller syreadditionssalte deraf
DK110279A (da) Fremgangsmaade til forbedring af semipermeable membraners egenskaber
DK58677A (da) Fremgangsmade til fremstilling af m-trifluormethylphenylpiperidinderivater eller additionssalte deraf
NL7613027A (nl) Vloeistofmembranen.
JPS553890A (en) Asymmetric ultrafiltration membrane of triacetyl celluloseebase
NO158656C (no) Fremgangsmaate ved fremstilling av en vandig opploesning avsulfonamid-potensiator-aldehydkombinasjoner.
DK516480A (da) Fremgangsmaade til fremstilling af 2-amino-ethanol-derivater eller syreadditionssalte deraf
DK422879A (da) Fremgangsmaade til fremstilling af n-(1-methyl-2-pyrrolidinylmethyl)-2,3-dimethoxy-5-methylsulfamoyl-benzamid eller derivater deraf
NO793301L (no) Isokinolinderivat.
NL188882C (nl) Membraanophangconstructie.

Legal Events

Date Code Title Description
PBP Patent lapsed