DK1272527T3 - Fremstilling af antistoffer med ADCC via CD16 og især monoklonale anti-Rhesus D-antistoffer - Google Patents

Fremstilling af antistoffer med ADCC via CD16 og især monoklonale anti-Rhesus D-antistoffer

Info

Publication number
DK1272527T3
DK1272527T3 DK01927974T DK01927974T DK1272527T3 DK 1272527 T3 DK1272527 T3 DK 1272527T3 DK 01927974 T DK01927974 T DK 01927974T DK 01927974 T DK01927974 T DK 01927974T DK 1272527 T3 DK1272527 T3 DK 1272527T3
Authority
DK
Denmark
Prior art keywords
mab
antibodies
effector cells
preparation
antibody
Prior art date
Application number
DK01927974T
Other languages
English (en)
Other versions
DK1272527T4 (da
Inventor
Dominique Bourel
Arnaud Glacet
Romeuf Christophe De
Nicolas Bihoreau
Emmanuel Nony
Roland Beliard
Original Assignee
Lfb Biotechnologies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8849165&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1272527(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lfb Biotechnologies filed Critical Lfb Biotechnologies
Publication of DK1272527T3 publication Critical patent/DK1272527T3/da
Application granted granted Critical
Publication of DK1272527T4 publication Critical patent/DK1272527T4/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/34—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood group antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Reproductive Health (AREA)
  • Virology (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK01927974.4T 2000-04-12 2001-04-12 Fremstilling af antistoffer med adcc via cd16 og især monoklonale anti-rhesus d-antistoffer DK1272527T4 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0004685A FR2807767B1 (fr) 2000-04-12 2000-04-12 Anticorps monoclonaux anti-d
PCT/FR2001/001127 WO2001077181A2 (fr) 2000-04-12 2001-04-12 Anticorps monoclonaux anti-rhesus d

Publications (2)

Publication Number Publication Date
DK1272527T3 true DK1272527T3 (da) 2009-05-04
DK1272527T4 DK1272527T4 (da) 2019-01-02

Family

ID=8849165

Family Applications (3)

Application Number Title Priority Date Filing Date
DK01927974.4T DK1272527T4 (da) 2000-04-12 2001-04-12 Fremstilling af antistoffer med adcc via cd16 og især monoklonale anti-rhesus d-antistoffer
DK10180551.3T DK2341078T3 (da) 2000-04-12 2001-04-12 Antistoffer med forbedret ADCC-aktivitet
DK04028814.4T DK1518864T4 (da) 2000-04-12 2001-04-12 Sammensætning af antistoffer med høj ADCC

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK10180551.3T DK2341078T3 (da) 2000-04-12 2001-04-12 Antistoffer med forbedret ADCC-aktivitet
DK04028814.4T DK1518864T4 (da) 2000-04-12 2001-04-12 Sammensætning af antistoffer med høj ADCC

Country Status (11)

Country Link
US (13) US7579170B2 (da)
EP (4) EP2341078B1 (da)
JP (9) JP5192625B2 (da)
AT (1) ATE419276T2 (da)
AU (3) AU2001254858B2 (da)
CA (1) CA2406033C (da)
DE (1) DE60137210D1 (da)
DK (3) DK1272527T4 (da)
ES (3) ES2525762T5 (da)
FR (1) FR2807767B1 (da)
WO (1) WO2001077181A2 (da)

Families Citing this family (156)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7183387B1 (en) 1999-01-15 2007-02-27 Genentech, Inc. Polypeptide variants with altered effector function
ES2571230T3 (es) 1999-04-09 2016-05-24 Kyowa Hakko Kirin Co Ltd Procedimiento para controlar la actividad de una molécula inmunofuncional
FR2807767B1 (fr) 2000-04-12 2005-01-14 Lab Francais Du Fractionnement Anticorps monoclonaux anti-d
US6946292B2 (en) 2000-10-06 2005-09-20 Kyowa Hakko Kogyo Co., Ltd. Cells producing antibody compositions with increased antibody dependent cytotoxic activity
HUP0600342A3 (en) * 2001-10-25 2011-03-28 Genentech Inc Glycoprotein compositions
US7749753B2 (en) * 2002-04-09 2010-07-06 Kyowa Hakko Kirin Co., Ltd Cells in which activity of the protein involved in transportation of GDP-fucose is reduced or lost
FR2844520B1 (fr) * 2002-09-13 2006-06-09 Lab Francais Du Fractionnement Utilisation d'un anticorps induisant la secretion de cytokines en therapie
FR2844521B1 (fr) * 2002-09-13 2004-12-24 Lab Francais Du Fractionnement Mesure de la production de cytokines comme marqueur d'activation de cellules effectrices
CA2498315C (fr) * 2002-09-13 2013-01-29 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Anticorps induisant la production de cytokines
FR2844513B1 (fr) * 2002-09-13 2007-08-03 Lab Francais Du Fractionnement Anticorps pour adcc et induisant la production de cytokines.
FR2844455B1 (fr) * 2002-09-13 2007-12-14 Lab Francais Du Fractionnement Traitement des pathologies echappant a la reponse immune par des anticorps optimises
WO2004087757A2 (en) * 2003-04-03 2004-10-14 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Antibodies with enhanced ability to immunomodulate cell functions
FR2858235B1 (fr) * 2003-07-31 2006-02-17 Lab Francais Du Fractionnement Utilisation d'anticorps optimises en adcc pour traiter les patients faibles repondeurs
FR2861078B1 (fr) * 2003-10-16 2007-09-21 Lab Francais Du Fractionnement NOUVELLES IgG3 UTILES POUR STIMULER LA PHAGOCYTOSE
GB0324368D0 (en) * 2003-10-17 2003-11-19 Univ Cambridge Tech Polypeptides including modified constant regions
FR2861079B1 (fr) * 2003-10-20 2007-09-28 Lab Francais Du Fractionnement Utilisation de cations metalliques divalents pour l'amelioration de l'activite fonctionnelle des anticorps.
FR2861080B1 (fr) * 2003-10-20 2006-02-17 Lab Francais Du Fractionnement Anticorps presentant un taux de fucose et de galactose optimise
EP1720570A4 (en) * 2004-01-26 2008-09-03 Cangene Corp TREATMENT OF DENGUE H MORRAGIC FIUR
WO2005117270A2 (en) 2004-05-24 2005-12-08 Isis Pharmaceuticals, Inc. Mass spectrometry with selective ion filtration by digital thresholding
CA2624081C (en) * 2005-09-29 2014-09-16 Medimmune, Inc. Method of identifying membrane ig specific antibodies and use thereof for targeting immunoglobulin-producing precursor cells
CA2626542C (en) * 2005-10-21 2018-07-03 Gtc Biotherapeutics, Inc. Antibodies with enhanced antibody-dependent cellular cytotoxicity activity, methods of their production and use
ATE536373T1 (de) * 2005-10-21 2011-12-15 Genzyme Corp Therapiemittel auf antikörperbasis mit erhöhter adcc-aktivität
FR2895086B1 (fr) * 2005-12-16 2012-10-05 Lab Francais Du Fractionnement Potentialisation de l'apoptose par des anticorps monoclonaux
WO2007084672A2 (en) * 2006-01-17 2007-07-26 Medarex, Inc. Monoclonal antibodies against cd30 lacking in fucosyl and xylosyl residues
USRE47123E1 (en) 2006-07-18 2018-11-13 Sanofi EPHA2 receptor antagonist antibodies
EP1933137A1 (fr) * 2006-12-15 2008-06-18 Glycode Méthode d'investigation de la réponse à un traitement par un anticorps monoclonal
DE602007013068D1 (de) * 2006-09-13 2011-04-21 Glycode Verfahren zur untersuchung der reaktion auf eine behandlung mit einem monoklonalen antikörper
EP1918304A1 (en) * 2006-11-02 2008-05-07 Institut National De La Sante Et De La Recherche Medicale (Inserm) Monoclonal antibodies against the human anti-müllerian hormone type II receptor (AMHR-II)
FR2915398B1 (fr) * 2007-04-25 2012-12-28 Lab Francais Du Fractionnement "ensemble de moyens pour le traitement d'une pathologie maligne, d'une maladie auto-immune ou d'une maladie infectieuse"
US9266967B2 (en) 2007-12-21 2016-02-23 Hoffmann-La Roche, Inc. Bivalent, bispecific antibodies
US20090162359A1 (en) 2007-12-21 2009-06-25 Christian Klein Bivalent, bispecific antibodies
MX2011001929A (es) * 2008-08-26 2011-04-21 Symphogen As Tratamiento de trombocitopenia.
US8529903B2 (en) 2008-12-31 2013-09-10 Bharat Serums And Vaccines Ltd. Anti-RhD monoclonal antibodies
US20110313137A1 (en) * 2009-02-25 2011-12-22 Dongxing Zha Her2 antibody compositions
FR2942799B1 (fr) * 2009-03-06 2011-02-25 Lfb Biotechnologies Anticorps monoclonal anti-rhesus d
EP2233500A1 (en) 2009-03-20 2010-09-29 LFB Biotechnologies Optimized Fc variants
US20100247484A1 (en) 2009-03-31 2010-09-30 Heinrich Barchet Combination therapy of an afucosylated antibody and one or more of the cytokines gm csf, m csf and/or il3
EP2414391B1 (en) 2009-04-02 2018-11-28 Roche Glycart AG Multispecific antibodies comprising full length antibodies and single chain fab fragments
WO2010115553A1 (en) 2009-04-07 2010-10-14 Roche Glycart Ag Bispecific anti-erbb-2/anti-c-met antibodies
PL2417156T3 (pl) 2009-04-07 2015-07-31 Roche Glycart Ag Trójwartościowe, bispecyficzne przeciwciała
BRPI1012589A2 (pt) 2009-04-07 2016-03-22 Roche Glycart Ag anticorpos bi-específicos anti-erbb-3/anti-c-met
TWI513818B (zh) 2009-06-02 2015-12-21 Regeneron Pharma 岩藻糖基化（ｆｕｃｏｓｙｌａｔｉｏｎ）－缺乏之細胞
US9676845B2 (en) 2009-06-16 2017-06-13 Hoffmann-La Roche, Inc. Bispecific antigen binding proteins
MA33470B1 (fr) 2009-08-14 2012-07-03 Hoffmann La Roche Polythérapie à base d'un anticorps afucosylé anti-cd20 et de fludarabine et/ou mitoxantrone
TWI409079B (zh) 2009-08-14 2013-09-21 Roche Glycart Ag 非典型岩藻醣化ｃｄ２０抗體與苯達莫斯汀（ｂｅｎｄａｍｕｓｔｉｎｅ）之組合療法
TW201113037A (en) 2009-08-28 2011-04-16 Hoffmann La Roche Antibodies against CDCP1 for the treatment of cancer
TWI412375B (zh) 2009-08-28 2013-10-21 Roche Glycart Ag 人類化抗ｃｄｃｐ１抗體
RU2573915C2 (ru) 2009-09-16 2016-01-27 Дженентек, Инк. Содержащие суперспираль и/или привязку белковые комплексы и их применение
TW201116297A (en) 2009-10-02 2011-05-16 Sanofi Aventis Antibodies that specifically bind to the EphA2 receptor
SI2516457T1 (en) 2009-12-21 2018-08-31 Regeneron Pharmaceuticals, Inc. MUSHROOM WITH HUMANIZED FC GAMES R
US8883496B2 (en) 2009-12-21 2014-11-11 Regeneron Phamaceuticals, Inc. Humanized FcgR mice
AU2010335282B2 (en) 2009-12-22 2015-05-21 Roche Glycart Ag Anti-HER3 antibodies and uses thereof
FR2957598B1 (fr) 2010-03-17 2015-12-04 Lfb Biotechnologies Nouveau peptide signal, et son utilisation pour la production de proteines recombinantes
TW201138821A (en) 2010-03-26 2011-11-16 Roche Glycart Ag Bispecific antibodies
EP2563391B1 (en) 2010-04-27 2020-08-26 Roche Glycart AG Combination therapy of an afucosylated cd20 antibody with a mtor inhibitor
RU2604811C2 (ru) 2010-05-27 2016-12-10 Мерк Шарп Энд Домэ Корп. Способ получения антител с улучшенными свойствами
CA2806148A1 (en) 2010-07-30 2012-02-02 Glycode A yeast artificial chromosome carrying the mammalian glycosylation pathway
AR082693A1 (es) 2010-08-17 2012-12-26 Roche Glycart Ag Terapia de combinacion de un anticuerpo anti-cd20 afucosilado con un anticuerpo anti-vegf
BR112013001847A2 (pt) 2010-08-24 2016-05-31 Hoffmann La Roche anticorpo biespecífico, método de preparação do anticorpo biespecífico, do anticorpo biespecífico trivalente, métodos e composição farmacêutica
TW201302793A (zh) 2010-09-03 2013-01-16 Glaxo Group Ltd 新穎之抗原結合蛋白
BR112013014522A2 (pt) 2010-12-16 2017-09-26 Roche Glycart Ag anticorpo anti-cd20 afucosilado e seu uso, composição e método para tratamento de um paciente que sofre de câncer
SG191153A1 (en) 2010-12-23 2013-07-31 Hoffmann La Roche Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery
FR2971250A1 (fr) 2011-02-07 2012-08-10 Univ Nantes Anticorps anti-gb3 utiles dans le traitement des maladies associees a l'angiogenese
SG10201609665PA (en) 2011-02-25 2017-01-27 Chugai Pharmaceutical Co Ltd FcɣRIIb-SPECIFIC Fc ANTIBODY
EP2681239B8 (en) 2011-02-28 2015-09-09 F. Hoffmann-La Roche AG Antigen binding proteins
MX342034B (es) 2011-02-28 2016-09-12 Hoffmann La Roche Proteinas monovalentes que se unen a antigenos.
US9328170B2 (en) 2011-05-25 2016-05-03 Merck Sharp & Dohme Corp. Method for preparing Fc containing polypeptides having improved properties
FR2976811A1 (fr) 2011-06-22 2012-12-28 Lfb Biotechnologies Utilisation d'un anticorps anti-cd20 a haute adcc pour le traitement de la maladie de waldenstrom
JP5997151B2 (ja) 2011-06-30 2016-09-28 中外製薬株式会社 ヘテロ二量化ポリペプチド
WO2013013193A1 (en) 2011-07-20 2013-01-24 Zepteon, Incorporated Polypeptide separation methods
CN104302668A (zh) 2011-09-23 2015-01-21 罗氏格黎卡特股份公司 双特异性的抗-egfr/抗igf-1r抗体
JP6322411B2 (ja) 2011-09-30 2018-05-09 中外製薬株式会社 複数の生理活性を有する抗原の消失を促進する抗原結合分子
TW201817744A (zh) 2011-09-30 2018-05-16 日商中外製藥股份有限公司 具有促進抗原清除之ＦｃＲｎ結合域的治療性抗原結合分子
FR2981946B1 (fr) 2011-10-28 2015-02-20 Lfb Biotechnologies Unites de transcription et leur utilisation dans des vecteurs d'expression (yb2/0)
US20130302274A1 (en) 2011-11-25 2013-11-14 Roche Glycart Ag Combination therapy
CA3233142A1 (en) 2011-11-30 2013-06-06 Chugai Seiyaku Kabushiki Kaisha Drug containing carrier into cell for forming immune complex
EP2812357B1 (en) 2012-02-10 2020-11-04 F.Hoffmann-La Roche Ag Single-chain antibodies and other heteromultimers
JP6203838B2 (ja) 2012-06-27 2017-09-27 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 少なくとも２つの異なる結合実体を含む、テーラーメイドの高度に選択的かつ多重特異的なターゲティング実体を選択および作製するための方法、ならびにその使用
WO2014001325A1 (en) 2012-06-27 2014-01-03 F. Hoffmann-La Roche Ag Method for making antibody fc-region conjugates comprising at least one binding entity that specifically binds to a target and uses thereof
ES2896493T3 (es) 2012-07-13 2022-02-24 Roche Glycart Ag Anticuerpos biespecíficos anti-VEGF/anti-ANG-2 y su uso en el tratamiento de enfermedades vasculares oculares
US9334332B2 (en) 2012-07-25 2016-05-10 Kolltan Pharmaceuticals, Inc. Anti-kit antibodies
CA2882272C (en) 2012-08-24 2023-08-29 Chugai Seiyaku Kabushiki Kaisha Fc.gamma.riib-specific fc region variant
JP6437441B2 (ja) 2012-11-02 2018-12-12 ティージー セラピューティクス インコーポレイテッド 抗ｃｄ２０抗体およびｐｉ３キナーゼ選択的阻害剤の組み合わせ
FR3003172B1 (fr) * 2013-03-15 2017-12-08 Lab Francais Du Fractionnement Utilisation d'anticorps monoclonaux pour le traitement de l'inflammation et d'infections bacteriennes
CA2894225A1 (fr) 2012-12-17 2014-06-26 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Utilisation d'anticorps monoclonaux pour le traitement de l'inflammation et d'infections bacteriennes
US10766960B2 (en) 2012-12-27 2020-09-08 Chugai Seiyaku Kabushiki Kaisha Heterodimerized polypeptide
AR094403A1 (es) 2013-01-11 2015-07-29 Hoffmann La Roche Terapia de combinación de anticuerpos anti-her3
JP2016508515A (ja) 2013-02-13 2016-03-22 ラボラトワール フランセ デュ フラクショヌマン エ デ ビオテクノロジーＬａｂｏｒａｔｏｉｒｅ Ｆｒａｎｃａｉｓ ｄｕ Ｆｒａｃｔｉｏｎｎｅｍｅｎｔ ｅｔ ｄｅｓ Ｂｉｏｔｅｃｈｎｏｌｏｇｉｅｓ 高ガラクトシル化抗ＴＮＦ−α抗体およびその使用
TW201446962A (zh) 2013-02-13 2014-12-16 Lab Francais Du Fractionnement 具有修飾的糖化作用之蛋白質及其製造方法
FR3003171B1 (fr) * 2013-03-15 2015-04-10 Lab Francais Du Fractionnement Nouveaux medicaments comprenant une composition d'anticorps enrichie en isoforme de charge majoritaire
LT2970980T (lt) 2013-03-15 2018-10-25 Janssen Biotech, Inc. Gamybos būdas kontroliuoti c galinio lizino, galaktozės ir sialo rūgšties kiekį rekombinantiniuose baltymuose
EP2982689B1 (en) 2013-04-02 2020-08-26 Chugai Seiyaku Kabushiki Kaisha Fc region variant
DK3031826T3 (da) 2013-08-09 2018-12-17 Toray Industries Farmaceutisk sammensætning til behandling og/eller forebyggelse af cancer
JP6422956B2 (ja) 2013-10-11 2018-11-14 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 多重特異性ドメイン交換共通可変軽鎖抗体
FR3012453B1 (fr) 2013-10-31 2015-11-13 Lab Francais Du Fractionnement Proteine chimerique dans le traitement de l’amylose
WO2015073721A1 (en) 2013-11-13 2015-05-21 Zymeworks Inc. Monovalent antigen binding constructs targeting egfr and/or her2 and uses thereof
WO2015082446A1 (en) 2013-12-02 2015-06-11 F. Hoffmann-La Roche Ag Treatment of cancer using an anti-cdcp1 antibody and a taxane
US9603927B2 (en) 2014-02-28 2017-03-28 Janssen Biotech, Inc. Combination therapies with anti-CD38 antibodies
US9732154B2 (en) * 2014-02-28 2017-08-15 Janssen Biotech, Inc. Anti-CD38 antibodies for treatment of acute lymphoblastic leukemia
KR102439412B1 (ko) 2014-04-08 2022-09-02 리제너론 파아마슈티컬스, 인크. 인간화된 Fc-감마 수용체를 갖는 비-인간 동물
FR3020063A1 (fr) 2014-04-16 2015-10-23 Gamamabs Pharma Anticorps humain anti-her4
PT3148581T (pt) 2014-05-30 2020-01-06 Henlix Biotech Co Ltd Anticorpos antirrecetor do fator de crescimento epidérmico (egfr)
US10253109B2 (en) * 2014-07-21 2019-04-09 Bloodworks Antibodies that recognize red blood cell antigens
JP6707531B2 (ja) 2014-09-09 2020-06-10 ヤンセン バイオテツク，インコーポレーテツド 抗ｃｄ３８抗体による併用療法
CA2968258A1 (en) 2014-11-27 2016-06-02 Zymeworks Inc. Methods of using bispecific antigen-binding constructs targeting her2
ES2764111T3 (es) 2014-12-03 2020-06-02 Hoffmann La Roche Anticuerpos multiespecíficos
MX2017007208A (es) 2014-12-04 2018-01-30 Janssen Biotech Inc Anticuerpos anti-cd38 para el tratamiento de leucemia mieloide aguda.
SG11201700841QA (en) 2014-12-19 2017-03-30 Chugai Pharmaceutical Co Ltd Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use
CN107108729A (zh) 2015-02-05 2017-08-29 中外制药株式会社 包含离子浓度依赖性的抗原结合结构域的抗体，fc区变体，il‑8‑结合抗体，及其应用
FR3034420A1 (fr) 2015-03-31 2016-10-07 Lab Francais Du Fractionnement Anticorps monoclonaux anti-cd303
EP3091033A1 (en) 2015-05-06 2016-11-09 Gamamabs Pharma Anti-human-her3 antibodies and uses thereof
CR20170526A (es) 2015-05-20 2018-04-03 Janssen Biotech Inc ANTICUERPOS ANTI-CD38 PARA EL TRATAMIENTO DE AMILOIDOSIS DE CADENA LIGERA y OTRAS ENFERMEDADES MALIGNAS HEMATOLÓGICAS POSITIVAS PARA CD38
EP3310386B1 (en) 2015-06-22 2021-07-21 Janssen Biotech, Inc. Combination therapies for heme malignancies with anti-cd38 antibodies and survivin inhibitors
US20170044265A1 (en) 2015-06-24 2017-02-16 Janssen Biotech, Inc. Immune Modulation and Treatment of Solid Tumors with Antibodies that Specifically Bind CD38
EP3108897A1 (en) 2015-06-24 2016-12-28 F. Hoffmann-La Roche AG Antibodies against human csf-1r for use in inducing lymphocytosis in lymphomas or leukemias
FR3038517B1 (fr) * 2015-07-06 2020-02-28 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Utilisation de fragments fc modifies en immunotherapie
LT3827845T (lt) 2015-11-03 2022-06-10 Janssen Biotech, Inc. Poodinės anti-cd38 antikūnų kompozicijos ir jų naudojimas
US10781261B2 (en) 2015-11-03 2020-09-22 Janssen Biotech, Inc. Subcutaneous formulations of anti-CD38 antibodies and their uses
JP7141336B2 (ja) 2015-12-25 2022-09-22 中外製薬株式会社 抗ミオスタチン抗体および使用方法
JP2019517991A (ja) 2016-03-01 2019-06-27 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 低減したａｄｃｐを有するオビヌツズマブ及びリツキシマブ変異体
CA3024123A1 (en) 2016-05-27 2017-11-30 Tg Therapeutics, Inc. Combination of anti-cd20 antibody, p13 kinase-delta selective inhibitor, and btk inhibitor to treat b-cell proliferative disorders
EP3257866A1 (en) 2016-06-17 2017-12-20 Academisch Medisch Centrum Modified anti-tnf antibody and use thereof in the treatment of ibd
FR3053688A1 (fr) 2016-07-06 2018-01-12 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Mutants fc a activite fonctionnelle amelioree
CA3026050A1 (en) 2016-08-05 2018-02-08 Chugai Seiyaku Kabushiki Kaisha Composition for prophylaxis or treatment of il-8 related diseases
KR20190068521A (ko) 2016-09-09 2019-06-18 티지 쎄라퓨틱스, 인코포레이티드 혈액암을 치료하기 위한 항-cd20 항체, pi3 키나아제-델타 억제제, 및 항-pd-1 또는 항-pd-l1 항체의 조합
CA3041979A1 (en) 2016-10-28 2018-05-03 Toray Industries, Inc. Pharmaceutical composition for cancer treatment and/or prevention
FR3064007A1 (fr) 2017-03-20 2018-09-21 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Anticorps pour le traitement de cancers
US20200148785A1 (en) * 2017-03-29 2020-05-14 Glycotope (GmbH) Pd-l1 and ta-muc1 antibodies
WO2019089832A1 (en) 2017-10-31 2019-05-09 Janssen Biotech, Inc. Methods of treating high risk multiple myeloma
EP3498293A1 (en) 2017-12-15 2019-06-19 Institut National De La Sante Et De La Recherche Medicale (Inserm) Treatment of monogenic diseases with an anti-cd45rc antibody
PL3765525T3 (pl) 2018-03-13 2023-12-27 Zymeworks Bc Inc. Koniugaty biparatopowe przeciwciało anty-her2 – lek i sposoby stosowania
SG11202008620VA (en) 2018-03-26 2020-10-29 Regeneron Pharma Humanized rodents for testing therapeutic agents
JP7342701B2 (ja) 2018-03-30 2023-09-12 東レ株式会社 癌の治療及び／又は予防用医薬組成物
PL237868B1 (pl) 2018-04-04 2021-06-14 Gdanski Univ Medyczny Mutanty punktowe czynnika B oraz białka C2 do zastosowania do wzmacniania aktywności cytotoksycznej przeciwciał w leczeniu chorób nowotworowych
AU2019324170A1 (en) 2018-08-23 2021-02-18 Seagen, Inc. Anti-TIGIT antibodies
EP3626265A1 (en) 2018-09-21 2020-03-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Anti-human cd45rc antibodies and uses thereof
SG11202107941TA (en) 2019-01-23 2021-08-30 Encefa Cd31 competitors and uses thereof
CN110320352A (zh) * 2019-07-25 2019-10-11 上海轩锋生物科技有限公司 基于抗体依赖的细胞介导细胞毒性的抗体效价检测方法
WO2021155295A1 (en) 2020-01-31 2021-08-05 The Cleveland Clinic Foundation Anti-müllerian hormone receptor 2 antibodies and methods of use
BR112022018171A2 (pt) 2020-03-12 2022-10-25 Toray Industries Medicamento para o tratamento e/ou a prevenção de câncer, agentes aumentando a eficácia de droga de uma composição farmacêutica e método para tratar e/ou prevenir câncer
KR20220153621A (ko) 2020-03-12 2022-11-18 도레이 카부시키가이샤 암의 치료 및/또는 예방을 위한 의약품
CA3175137A1 (en) 2020-03-12 2021-09-16 Toray Industries, Inc. Medicament for treatment and/or prevention of cancer
KR20220152309A (ko) 2020-03-12 2022-11-15 도레이 카부시키가이샤 암의 치료 및/또는 예방을 위한 의약품
JPWO2021182574A1 (da) 2020-03-12 2021-09-16
US20220143026A1 (en) 2020-11-12 2022-05-12 Tg Therapeutics, Inc. Triple combination to treat b-cell malignancies
JPWO2022270523A1 (da) 2021-06-23 2022-12-29
BR112023026992A2 (pt) 2021-06-23 2024-03-12 Toray Industries Medicamento para o tratamento e/ou prevenção do câncer, agentes que aumentam a eficácia do medicamento em uma composição farmacêutica e método para tratar e/ou prevenir o câncer
KR20240042415A (ko) 2021-07-27 2024-04-02 도레이 카부시키가이샤 암의 치료 및/또는 예방을 위한 의약품
MX2024000965A (es) 2021-07-27 2024-02-09 Toray Ind Inc Medicamento para el tratamiento y/o prevencion de cancer.
WO2023008459A1 (ja) 2021-07-27 2023-02-02 東レ株式会社 癌の治療及び／又は予防のための医薬品
JPWO2023033129A1 (da) 2021-09-03 2023-03-09
CN118369344A (zh) 2021-09-16 2024-07-19 阿博莱斯制药公司 抗人cd45rc结合结构域及其用途
US11807689B1 (en) 2022-06-01 2023-11-07 Tg Therapeutics, Inc. Anti-CD20 antibody compositions
US11884740B1 (en) 2022-06-01 2024-01-30 Tg Therapeutics, Inc. Anti-CD20 antibody compositions
US11965032B1 (en) 2022-06-01 2024-04-23 Tg Therapeutics, Inc. Anti-CD20 antibody compositions
US11814439B1 (en) 2022-06-01 2023-11-14 Tg Therapeutics, Inc. Anti-CD20 antibody compositions

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA406033A (en) 1942-07-14 American Can Company Product packing apparatus
GB1382265A (en) 1971-12-03 1975-01-29 Ml Aviation Co Ltd Transporters
JPS56101171A (en) 1980-01-16 1981-08-13 Fuji Xerox Co Ltd Separation failure detector for transfer paper
EP0043718B1 (en) 1980-07-07 1984-11-28 National Research Development Corporation Improvements in or relating to cell lines
EP0162918A1 (en) 1983-11-28 1985-12-04 The Board Of Trustees Of The Leland Stanford Junior University HUMAN MONOCLONAL ANTIBODY AGAINST Rh(D) ANTIGEN AND ITS USES
US5981216A (en) 1985-04-01 1999-11-09 Alusuisse Holdings A.G. Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same
GB8610106D0 (en) 1986-04-25 1986-05-29 Central Blood Lab Authority Human igm-producing heterohybridoma
FR2600076A1 (fr) 1986-06-12 1987-12-18 Fond Ctre Nal Transfusion Milieu de culture comportant de l'albumine humaine, procede de preparation d'un produit injectable a partir de ce milieu, produit obtenu et son utilisation, composition obtenue
JPS6350710A (ja) 1986-08-21 1988-03-03 Koputeitsuku:Kk 光測定装置
GB8722019D0 (en) 1987-09-18 1987-10-28 Central Blood Lab Authority Human anti-rh(d)monoclonal antibodies
GB8722020D0 (en) 1987-09-18 1987-10-28 Central Blood Lab Authority Human anti-rh(d)monoclonal antibodies
GB8722018D0 (en) 1987-09-18 1987-10-28 Central Blood Lab Authority Human anti-rh(d)monoclonal antibodies
US5843708A (en) * 1988-01-05 1998-12-01 Ciba-Geigy Corporation Chimeric antibodies
DK0493446T3 (da) * 1989-09-15 1997-08-11 Tanox Biosystems Inc Behandling af autoimmunsygdom.
FR2653561A1 (fr) * 1989-10-19 1991-04-26 Fondation Nale Transfusion San Hetero-anticorps anti-rhd et composition pharmaceutique les contenant.
GB8925590D0 (en) 1989-11-13 1990-01-04 Central Blood Lab Authority Monoclonal antibodies
US5272070A (en) * 1991-03-08 1993-12-21 Board Of Regents, The University Of Texas System Method for the preparation of cell lines producing Man3 GlcNac 2 asparagine-linked gylcans and cell lines produced thereby
US5558865A (en) 1991-08-22 1996-09-24 Nissin Shokuhin Kabushiki Kaisha HIV immunotherapeutics
US5880268A (en) 1992-01-27 1999-03-09 Icos Corporation Modulators of the interaction between ICAM-R and αd /CD18
HUT68624A (en) 1992-06-26 1995-07-28 Aetsrn Human monoclonal anti-rhesus (d) antibodies and cell lines producing same
EP0598998B1 (en) * 1992-09-07 2004-05-19 Kyowa Hakko Kogyo Co., Ltd Humanized antibodies reacting with the ganglioside GM2
JP3565572B2 (ja) * 1992-09-07 2004-09-15 協和醗酵工業株式会社 ヒト化抗体
DE69419721T2 (de) 1993-01-12 2000-04-27 Biogen, Inc. Rekombinante anti-vla4 antikörpermoleküle
CA2170034C (en) 1993-08-24 2005-03-15 Joseph William Harris Recombinant humanized anti-human immunodeficiency virus antibody
FR2724182B1 (fr) 1994-09-02 1996-12-13 Pasteur Institut Obtention d'un anticorps monoclonal recombinant a partir d'un anticorps monoclonal humain anti-rhesus d, sa production en cellules d'insecte, et ses utilisations
AU690474B2 (en) * 1995-09-11 1998-04-23 Kyowa Hakko Kirin Co., Ltd. Antibody againts alpha-chain of human interleukin 5 receptor
RU2094462C1 (ru) 1995-11-14 1997-10-27 Оловникова Наталья Ивановна Моноклональный иммуноглобулин человека класса iggi против антигена d системы резус
US6440733B1 (en) * 1996-02-15 2002-08-27 Chugai Seiyaku Kabushiki Kaisha Monoclonal antibodies recognizing antigens on the surface of endothelial cells of tumor vessel
NZ333065A (en) 1996-05-31 2000-05-26 Sankyo Co Treatment or prevention of autoimmune diseases using an insulin resistance improving thiazolidinedione derivative
JPH10212247A (ja) * 1996-05-31 1998-08-11 Sankyo Co Ltd 自己免疫疾患治療剤
AU722127B2 (en) 1996-06-24 2000-07-20 Zlb Behring Ag Polypeptides capable of forming antigen binding structures with specificity for the rhesus D antigens, the DNA encoding them and the process for their preparation and use
JPH1080276A (ja) * 1996-07-19 1998-03-31 Mitsui Petrochem Ind Ltd バイセクト糖鎖調節法
JPH10112531A (ja) 1996-08-13 1998-04-28 Hitachi Ltd 半導体集積回路装置の製造方法
JP4550947B2 (ja) * 1997-03-19 2010-09-22 協和発酵キリン株式会社 ガングリオシドｇｍ２に対するヒト型相補性決定領域（ｃｄｒ）移植抗体
WO1999028349A2 (en) * 1997-12-02 1999-06-10 Medarex, Inc. CELLS EXPRESSING ANTI-Fc RECEPTOR BINDING COMPONENTS
DK2180007T4 (da) * 1998-04-20 2017-11-27 Roche Glycart Ag Glycosyleringsteknik for antistoffer til forbedring af antistofafhængig cellecytotoxicitet
JP2000005908A (ja) 1998-06-18 2000-01-11 Sony Corp 保持具、加工装置および加工方法
ES2571230T3 (es) * 1999-04-09 2016-05-24 Kyowa Hakko Kirin Co Ltd Procedimiento para controlar la actividad de una molécula inmunofuncional
CA2388245C (en) 1999-10-19 2012-01-10 Tatsuya Ogawa The use of serum-free adapted rat cells for producing heterologous polypeptides
EP2251426A1 (en) 1999-10-26 2010-11-17 Stichting Dienst Landbouwkundig Onderzoek Mammalian-type glycosylation in plants
AU2001236073B2 (en) 2000-03-03 2006-10-19 Kyowa Kirin Co., Ltd. Gene recombinant antibody and its fragment
FR2807767B1 (fr) 2000-04-12 2005-01-14 Lab Francais Du Fractionnement Anticorps monoclonaux anti-d
EP2314686B2 (en) 2000-10-06 2023-06-21 Kyowa Kirin Co., Ltd. Cells producing antibody compositions
US7064191B2 (en) * 2000-10-06 2006-06-20 Kyowa Hakko Kogyo Co., Ltd. Process for purifying antibody
CA2424977C (en) 2000-10-06 2008-03-18 Kyowa Hakko Kogyo Co., Ltd. Process for purifying antibody
US6946292B2 (en) * 2000-10-06 2005-09-20 Kyowa Hakko Kogyo Co., Ltd. Cells producing antibody compositions with increased antibody dependent cytotoxic activity
HUP0600342A3 (en) 2001-10-25 2011-03-28 Genentech Inc Glycoprotein compositions
US20040093621A1 (en) 2001-12-25 2004-05-13 Kyowa Hakko Kogyo Co., Ltd Antibody composition which specifically binds to CD20
US20060034829A1 (en) * 2001-12-27 2006-02-16 Gerngross Tillman U Immunoglobulins comprising predominantly a MAN3GLCNAC2 glycoform
US20040259150A1 (en) 2002-04-09 2004-12-23 Kyowa Hakko Kogyo Co., Ltd. Method of enhancing of binding activity of antibody composition to Fcgamma receptor IIIa
US20040132140A1 (en) 2002-04-09 2004-07-08 Kyowa Hakko Kogyo Co., Ltd. Production process for antibody composition
US7749753B2 (en) 2002-04-09 2010-07-06 Kyowa Hakko Kirin Co., Ltd Cells in which activity of the protein involved in transportation of GDP-fucose is reduced or lost
CA2481657A1 (en) * 2002-04-09 2003-10-16 Kyowa Hakko Kogyo Co., Ltd. Cells of which genome is modified
WO2003084569A1 (fr) 2002-04-09 2003-10-16 Kyowa Hakko Kogyo Co., Ltd. Medicament contenant une composition anticorps
WO2003084570A1 (fr) 2002-04-09 2003-10-16 Kyowa Hakko Kogyo Co., Ltd. Medicament contenant une composition d'anticorps appropriee au patient souffrant de polymorphisme fc$g(g)riiia
FR2844455B1 (fr) * 2002-09-13 2007-12-14 Lab Francais Du Fractionnement Traitement des pathologies echappant a la reponse immune par des anticorps optimises
FR2844513B1 (fr) * 2002-09-13 2007-08-03 Lab Francais Du Fractionnement Anticorps pour adcc et induisant la production de cytokines.
EP1666501A4 (en) * 2003-08-11 2008-12-24 Chugai Pharmaceutical Co Ltd ANTI-HM1.24 ANTIBODIES WITH MODIFIED SUGAR CHAIN
US7150443B2 (en) 2005-01-18 2006-12-19 Mills Douglas W Control valve for nitrous oxide injection system
MX2008003054A (es) * 2005-08-31 2008-03-25 Centocor Inc Lineas de celulas hospederas para la produccion de la region constante de anticuerpos, con fusion efectora mejorada.
EP2245734B1 (en) 2008-02-18 2014-07-02 Freescale Semiconductor, Inc. Mixer circuit

Also Published As

Publication number Publication date
US20150266972A1 (en) 2015-09-24
JP5722279B2 (ja) 2015-05-20
JP5192625B2 (ja) 2013-05-08
JP2012193184A (ja) 2012-10-11
US8178093B2 (en) 2012-05-15
JP5837859B2 (ja) 2015-12-24
EP1518864B2 (fr) 2019-10-16
JP2015221827A (ja) 2015-12-10
JP2012191938A (ja) 2012-10-11
US9708409B2 (en) 2017-07-18
US8153124B2 (en) 2012-04-10
US20110052571A1 (en) 2011-03-03
US7541029B2 (en) 2009-06-02
DK2341078T3 (da) 2016-11-28
CA2406033A1 (fr) 2001-10-18
AU5485801A (en) 2001-10-23
ES2525762T3 (es) 2014-12-30
FR2807767B1 (fr) 2005-01-14
DK1518864T3 (da) 2015-01-12
EP2947099A1 (fr) 2015-11-25
US20120258096A1 (en) 2012-10-11
US20150152189A1 (en) 2015-06-04
EP1518864A2 (fr) 2005-03-30
JP2003534781A (ja) 2003-11-25
US20110059073A1 (en) 2011-03-10
AU2010257417B2 (en) 2012-04-05
US20140162356A1 (en) 2014-06-12
US20110059072A1 (en) 2011-03-10
WO2001077181A3 (fr) 2002-03-07
ATE419276T2 (de) 2009-01-15
US20110223658A1 (en) 2011-09-15
JP2017012199A (ja) 2017-01-19
JP5788432B2 (ja) 2015-09-30
US9718889B2 (en) 2017-08-01
AU2007202060B2 (en) 2010-10-14
JP2017214427A (ja) 2017-12-07
DK1518864T4 (da) 2020-01-27
EP1272527B2 (fr) 2018-08-29
US9718890B2 (en) 2017-08-01
JP2015211696A (ja) 2015-11-26
JP5722278B2 (ja) 2015-05-20
US8124078B2 (en) 2012-02-28
JP2013155198A (ja) 2013-08-15
EP2341078B1 (fr) 2016-08-10
EP2341078A3 (fr) 2011-12-21
US20120259095A1 (en) 2012-10-11
ES2320412T5 (es) 2019-02-13
DE60137210D1 (de) 2009-02-12
US10081683B2 (en) 2018-09-25
EP1272527B1 (fr) 2008-12-31
AU2001254858B2 (en) 2001-10-23
JP2012193185A (ja) 2012-10-11
US7579170B2 (en) 2009-08-25
AU2010257417A1 (en) 2011-01-20
EP2341078A2 (fr) 2011-07-06
EP1518864B1 (fr) 2014-10-08
US8685725B2 (en) 2014-04-01
AU2007202060A1 (en) 2007-05-31
DK1272527T4 (da) 2019-01-02
EP1518864A3 (fr) 2009-07-22
US8409572B2 (en) 2013-04-02
WO2001077181A2 (fr) 2001-10-18
US20070009522A1 (en) 2007-01-11
CA2406033C (fr) 2014-05-27
ES2601241T3 (es) 2017-02-14
ES2320412T3 (es) 2009-05-22
ES2525762T5 (es) 2020-06-26
EP1272527A2 (fr) 2003-01-08
US20180002442A1 (en) 2018-01-04
US8357370B2 (en) 2013-01-22
US7931895B2 (en) 2011-04-26
FR2807767A1 (fr) 2001-10-19
US20050249722A1 (en) 2005-11-10
US20030175969A1 (en) 2003-09-18
JP6124958B2 (ja) 2017-05-10

Similar Documents

Publication Publication Date Title
ES2525762T3 (es) Composición de anticuerpos con alta ADCC
WO2004058797A3 (en) Human monoclonal antibodies against interleukin 8 (il-8)
CN107531793B (zh) 对人类cd19具有专一性的抗体药剂和其用途
JP2018046872A5 (da)
WO2004045512A3 (en) Human monoclonal antibodies against cd25
WO2003040169A3 (en) Human monoclonal antibodies to dendritic cells
CA2380783A1 (en) Human monoclonal antibodies to prostate specific membrane antigen
WO2004043989A3 (en) Human monoclonal antibodies to heparanase
KR20200139189A (ko) 다가 항체
ATE208820T1 (de) Humanisierte antikoerper
NO20040752L (no) Humane antistoffer spesifikke for interleukin 15 (IL-15)
AU2004215120A8 (en) Human antibodies specific for interleukin 15 (IL-15)
AU8727291A (en) Bispecific antibodies, method of production, and uses thereof
HK1059442A1 (en) Human monoclonal antibodies to dendritic cells
RU2019121106A (ru) Иммунотерапия с применением антител, связывающих белок 1 программируемой смерти клеток (pd-1)
Teillaud Engineering of monoclonal antibodies and antibody-based fusion proteins: successes and challenges
DK0493446T3 (da) Behandling af autoimmunsygdom.
KR20210111767A (ko) 절단된 다가 다량체
Leibiger et al. Glycosylation analysis of a polyreactive human monoclonal IgG antibody derived from a human-mouse heterohybridoma
Donadel et al. Human polyreactive and monoreactive antibodies: effect of glycosylation antigen binding
Holzlöhner et al. Generation of murine monoclonal antibodies with specificity against conventional camelid IgG1 and heavy-chain only IgG2/3
Chin et al. Production of neutralizing human monoclonal antibody directed to tetanus toxin in CHO cell
AU2004283925A1 (en) Use of metallic cations to improve functional activity of antibodies
Björklund et al. Characterisation of recombinant human IgE-Fc fragments expressed in baculovirus-infected insect cells
Jar et al. Mouse× pig chimeric antibodies expressed in Baculovirus retain the same properties of their parent antibodies