DK3031826T3 - Farmaceutisk sammensætning til behandling og/eller forebyggelse af cancer - Google Patents
Farmaceutisk sammensætning til behandling og/eller forebyggelse af cancer Download PDFInfo
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- DK3031826T3 DK3031826T3 DK14834828.7T DK14834828T DK3031826T3 DK 3031826 T3 DK3031826 T3 DK 3031826T3 DK 14834828 T DK14834828 T DK 14834828T DK 3031826 T3 DK3031826 T3 DK 3031826T3
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Classifications
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Claims (13)
1. Antistof, som omfatter en tungkæde-variabel region omfattende komplementaritetsbestemmende regioner med SEQ ID NOs: 1,2 og 3 og en letkæde-variabel region omfattende komplementaritetsbestemmende regioner med SEQ ID NOs: 4, 5 og 6 og har immunologisk reaktivitet med et CAPRIN-1 -protein eller et fragment deraf.
2. Antistof eller fragment deraf ifølge krav 1, hvor: (i) den tunge kædes variable region omfatter aminosyresekvensen med SEQ ID NO: 8, og den lette kædes variable region omfatter aminosyresekvensen med SEQ ID NO: 15; eller (ii) den tunge kædes variable region omfatter aminosyresekvensen med SEQ ID NO: 10, og den lette kædes variable region omfatter aminosyresekvensen med SEQ ID NO: 15; eller (iii) den tunge kædes variable region omfatter aminosyresekvensen med SEQ ID NO: 7, og den lette kædes variable region omfatter aminosyresekvensen med SEQ ID NO: 15; eller (iv) den tunge kædes variable region omfatter aminosyresekvensen med SEQ ID NO: 8, og den lette kædes variable region omfatter aminosyresekvensen med SEQ ID NO: 13; eller (v) den tunge kædes variable region omfatter aminosyresekvensen med SEQ ID NO: 7, og den lette kædes variable region omfatter aminosyresekvensen med SEQ ID NO: 12; (vi) den tunge kædes variable region omfatter aminosyresekvensen med SEQ ID NO: 8, og den lette kædes variable region omfatter aminosyresekvensen med SEQ ID NO: 12; eller (vii) den tunge kædes variable region omfatter aminosyresekvensen med SEQ ID NO: 7, og den lette kædes variable region omfatter aminosyresekvensen med SEQ ID NO: 13; eller (viii) den tunge kædes variable region omfatter aminosyresekvensen med SEQ ID NO: 10, og den lette kædes variable region omfatter aminosyresekvensen med SEQ ID NO: 14; eller (ix) den tunge kædes variable region omfatter aminosyresekvensen med SEQ ID NO: 8, og den lette kædes variable region omfatter aminosyresekvensen med SEQ ID NO: 11; eller (x) den tunge kædes variable region omfatter aminosyresekvensen med SEQ ID NO: 7, og den lette kædes variable region omfatter aminosyresekvensen med SEQ ID NO: 11; eller (xi) den tunge kædes variable region omfatter aminosyresekvensen med SEQ ID NO: 9, og den lette kædes variable region omfatter aminosyresekvensen med SEQ ID NO: 15; eller (xii) den tunge kædes variable region omfatter aminosyresekvensen med SEQ ID NO: 20, og den lette kædes variable region omfatter aminosyresekvensen med SEQ ID NO: 21.
3. Antistof eller fragment deraf ifølge krav 1 eller 2, hvor antistoffet er et humaniseret antistof, et kimært antistof, et enkeltkædet antistof eller et multispecifikt antistof.
4. Antistof eller fragment deraf ifølge krav 1 eller 2, hvor antistoffet eller fragmentet er konjugeret med et antitumormiddel.
5. Antistof ifølge et hvilket som helst af kravene 1 til 4, hvor antistoffet omfatter substitution af en eller flere aminosyrer i den tunge kædes konstante region.
6. Antistof ifølge et hvilket som helst af kravene 1 til 5, hvor antistoffet er et antistof, der ikke har fucose tilsat til N-acetylglucosamin ved den sukkerkæde-reducerende ende af en N-glycosid-bundet sukkerkæde knyttet til den tunge kædes konstane region.
7. Antistofsammensætning omfattende et antistof ifølge krav 6 og et antistof ifølge et hvilket som helst af kravene 1 til 5 med fucose tilsat til N-acetylglucosamin ved den sukkerkæde-reducerende ende af en N-glycosid-bundet sukkerkæde knyttet til den tunge kædes konstante region.
8. Celle, der producerer et antistof ifølge krav 6 eller en antistofsammensætning ifølge krav 7.
9. Farmaceutisk sammensætning omfattende et antistof eller et fragment deraf ifølge et hvilket som helst af kravene 1 til 4, et antistof ifølge krav 5 eller 6 eller en antistofsammensætning ifølge krav 7 som en aktiv bestanddel.
10. Kombinationslægemiddelprodukt omfattende en farmaceutisk sammensætning ifølge krav 9 og en farmaceutisk sammensætning, der omfatter et antitumormiddel.
11. DNA, der koder for et antistof eller et fragment deraf ifølge et hvilket som helst af kravene 1 til 5.
12. Antistof eller fragment deraf ifølge et hvilket som helst af kravene 1 til 5, antistof ifølge krav 6, antistofsammensætning ifølge krav 7, farmaceutisk sammensætning ifølge krav 9 eller kombinationslægemiddelprodukt ifølge krav 10, til anvendelse i en fremgangsmåde til behandling og/eller forebyggelse af en cancer.
13. Antistof, fragment, antistofsammensætning, farmaceutisk sammensætning eller kombinationslægemiddelprodukt til anvendelse ifølge krav 12, hvor canceren er brystcancer, nyrecancer, pancreascancer, kolorektal cancer, lungecancer, hjernetumor, mavecancer, livmodercancer, ovariecancer, prostata-cancer, blærecancer, øsofaguscancer, leukæmi, lymfom, levercancer, galdeblærecancer, sarkom, mastocytom, melanom, binyrebarkcancer, Ewings tumor, Hodgkins lymfom, mesoteliom, myelomatose, testikelcancer, thyreoi-deacancer eller hoved- og halscancer.
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Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2502940T3 (es) * | 2008-08-05 | 2014-10-06 | Toray Industries, Inc. | Composición farmacéutica para el tratamiento y la prevención del cáncer |
PL2325648T3 (pl) | 2008-08-05 | 2014-09-30 | Toray Industries | Sposób wykrywania nowotworów |
WO2013018885A1 (ja) | 2011-08-04 | 2013-02-07 | 東レ株式会社 | 膵臓癌の検出方法 |
KR102255616B1 (ko) | 2013-08-09 | 2021-05-25 | 도레이 카부시키가이샤 | 암의 치료 및/또는 예방용 의약 조성물 |
JP7011764B2 (ja) | 2016-07-07 | 2022-01-27 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 抗体アジュバント複合体 |
JP7206590B2 (ja) * | 2016-10-28 | 2023-01-18 | 東レ株式会社 | 癌の治療及び/又は予防用医薬組成物 |
BR112020019935A2 (pt) | 2018-03-30 | 2021-01-26 | Toray Industries, Inc. | medicamento para o tratamento e/ou prevenção do câncer, agentes que aumentam a eficácia de um fármaco e método de tratamento e/ou prevenção do câncer |
KR20220004634A (ko) | 2019-03-15 | 2022-01-11 | 볼트 바이오테라퓨틱스 인코퍼레이티드 | Her2를 표적으로 하는 면역접합체 |
KR20220034784A (ko) | 2019-06-13 | 2022-03-18 | 볼트 바이오테라퓨틱스 인코퍼레이티드 | 아미노벤즈아제핀 화합물, 면역접합체, 및 이의 용도 |
CA3152601A1 (en) | 2019-09-30 | 2021-04-08 | Bolt Biotherapeutics, Inc. | Amide-linked, aminobenzazepine immunoconjugates, and uses thereof |
JP2022553702A (ja) | 2019-10-25 | 2022-12-26 | ボルト バイオセラピューティクス、インコーポレーテッド | チエノアゼピン、イムノコンジュゲート、及びそれらの使用 |
JPWO2021182571A1 (da) | 2020-03-12 | 2021-09-16 | ||
CA3175129A1 (en) | 2020-03-12 | 2021-09-19 | Toray Industries, Inc. | Medicament for treatment and/or prevention of cancer |
BR112022018157A2 (pt) | 2020-03-12 | 2022-10-25 | Toray Industries | Medicamento para o tratamento e/ou prevenção do câncer, agentes que aumentam a eficácia de um fármaco e método para o tratamento e/ou prevenção do câncer |
WO2021182570A1 (ja) | 2020-03-12 | 2021-09-16 | 東レ株式会社 | 癌の治療及び/又は予防のための医薬品 |
KR20220151684A (ko) | 2020-03-12 | 2022-11-15 | 도레이 카부시키가이샤 | 암의 치료 및/또는 예방을 위한 의약품 |
EP4146282A1 (en) | 2020-05-08 | 2023-03-15 | Bolt Biotherapeutics, Inc. | Elastase-substrate, peptide linker immunoconjugates, and uses thereof |
IL300316A (en) | 2020-08-13 | 2023-04-01 | Bolt Biotherapeutics Inc | Immune conjugates of pyrazolozapines and their uses |
CN117460532A (zh) | 2021-06-23 | 2024-01-26 | 东丽株式会社 | 用于癌的治疗和/或预防的药品 |
WO2022270523A1 (ja) | 2021-06-23 | 2022-12-29 | 東レ株式会社 | 癌の治療及び/又は予防のための医薬品 |
AU2022316644A1 (en) | 2021-07-27 | 2024-02-29 | Toray Industries, Inc. | Medicament for treatment and/or prevention of cancer |
JPWO2023008462A1 (da) | 2021-07-27 | 2023-02-02 | ||
WO2023008459A1 (ja) | 2021-07-27 | 2023-02-02 | 東レ株式会社 | 癌の治療及び/又は予防のための医薬品 |
WO2023033129A1 (ja) | 2021-09-03 | 2023-03-09 | 東レ株式会社 | 癌の治療及び/又は予防用医薬組成物 |
CA3234604A1 (en) | 2021-10-29 | 2023-05-04 | Shelley Erin ACKERMAN | Tlr agonist immunoconjugates with cysteine-mutant antibodies, and uses thereof |
WO2024005123A1 (ja) * | 2022-06-30 | 2024-01-04 | 東レ株式会社 | 癌の治療及び/又は予防用医薬組成物 |
Family Cites Families (104)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
ATE340590T1 (de) | 1994-07-13 | 2006-10-15 | Chugai Pharmaceutical Co Ltd | Gegen menschliches interleukin-8 gerichteter, rekonstituierter menschlicher antikörper |
CA2197490A1 (en) | 1994-09-19 | 1996-03-28 | Ricardo J. Moro | Detection and treatment of cancer |
US5698396A (en) | 1995-06-07 | 1997-12-16 | Ludwig Institute For Cancer Research | Method for identifying auto-immunoreactive substances from a subject |
WO2001032910A2 (en) | 1999-10-29 | 2001-05-10 | Human Genome Sciences, Inc. | 27 human secreted proteins |
FR2761994B1 (fr) | 1997-04-11 | 1999-06-18 | Centre Nat Rech Scient | Preparation de recepteurs membranaires a partir de baculovirus extracellulaires |
CA2325346A1 (en) | 1998-04-03 | 1999-10-14 | Chugai Seiyaku Kabushiki Kaisha | Humanized antibody against human tissue factor (tf) and process for constructing humanized antibody |
DK2180007T4 (da) | 1998-04-20 | 2017-11-27 | Roche Glycart Ag | Glycosyleringsteknik for antistoffer til forbedring af antistofafhængig cellecytotoxicitet |
US20030118599A1 (en) | 1999-04-02 | 2003-06-26 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
JP2002520054A (ja) | 1998-07-14 | 2002-07-09 | コリクサ コーポレイション | 前立腺癌の治療及び診断のための組成物及び方法 |
RU2234942C2 (ru) | 1998-07-14 | 2004-08-27 | Корикса Корпорейшн | Выделенный опухолевый полипептид предстательной железы и кодирующий его полинуклеотид |
AU5285899A (en) | 1998-07-21 | 2000-02-14 | Connex Gesellschaft Zur Optimierung Von Forschung Und Entwicklung Mbh | Anti hepatitis c virus antibody and uses thereof |
GB9815909D0 (en) | 1998-07-21 | 1998-09-16 | Btg Int Ltd | Antibody preparation |
US6969518B2 (en) | 1998-12-28 | 2005-11-29 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of breast cancer |
US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
AU3316600A (en) | 1999-02-22 | 2000-09-21 | Torben F. Orntoft | Gene expression in bladder tumors |
US6444425B1 (en) | 1999-04-02 | 2002-09-03 | Corixa Corporation | Compounds for therapy and diagnosis of lung cancer and methods for their use |
EP1187915A2 (en) | 1999-04-02 | 2002-03-20 | Corixa Corporation | Compounds for therapy and diagnosis of lung cancer and methods for their use |
DK2270147T4 (da) * | 1999-04-09 | 2020-08-31 | Kyowa Kirin Co Ltd | Fremgangsmåde til at kontrollere aktiviteten af immunologisk funktionelt molekyle |
US6949245B1 (en) | 1999-06-25 | 2005-09-27 | Genentech, Inc. | Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies |
US20020006404A1 (en) | 1999-11-08 | 2002-01-17 | Idec Pharmaceuticals Corporation | Treatment of cell malignancies using combination of B cell depleting antibody and immune modulating antibody related applications |
CZ20023567A3 (cs) | 2000-03-29 | 2003-11-12 | Corixa Corporation | Sloučeniny a způsoby pro terapii a diagnostiku karcinomu plic |
FR2807767B1 (fr) | 2000-04-12 | 2005-01-14 | Lab Francais Du Fractionnement | Anticorps monoclonaux anti-d |
US7919467B2 (en) | 2000-12-04 | 2011-04-05 | Immunotope, Inc. | Cytotoxic T-lymphocyte-inducing immunogens for prevention, treatment, and diagnosis of cancer |
US7408041B2 (en) | 2000-12-08 | 2008-08-05 | Alexion Pharmaceuticals, Inc. | Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof |
US20040029114A1 (en) | 2001-01-24 | 2004-02-12 | Eos Technology, Inc. | Methods of diagnosis of breast cancer, compositions and methods of screening for modulators of breast cancer |
RU2306952C2 (ru) | 2001-01-31 | 2007-09-27 | Байоджен Айдек Инк. | Лечение в-клеточных злокачественных опухолей с использованием комбинации применений, связанных с антителами, уменьшающими количество b-клеток, и с иммуномодулирующими антителами |
WO2002078524A2 (en) | 2001-03-28 | 2002-10-10 | Zycos Inc. | Translational profiling |
WO2002083070A2 (en) | 2001-04-10 | 2002-10-24 | Corixa Corporation | Compounds for immunotherapy and diagnosis of colon cancer and methods for their use |
AU2002311909A1 (en) | 2001-05-11 | 2002-11-25 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
US20030190640A1 (en) | 2001-05-31 | 2003-10-09 | Mary Faris | Genes expressed in prostate cancer |
US7101977B2 (en) | 2001-07-17 | 2006-09-05 | Research Development Foundation | Therapeutic agents comprising pro-apoptotic proteins |
RU2319709C2 (ru) | 2001-07-17 | 2008-03-20 | Рисерч Дивелопмент Фаундейшн | Терапевтические агенты, содержащие проапоптозные белки |
US20040142325A1 (en) | 2001-09-14 | 2004-07-22 | Liat Mintz | Methods and systems for annotating biomolecular sequences |
CA2476518A1 (en) | 2002-02-22 | 2003-09-04 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
US20050003390A1 (en) | 2002-05-17 | 2005-01-06 | Axenovich Sergey A. | Targets for controlling cellular growth and for diagnostic methods |
US20040126379A1 (en) | 2002-08-21 | 2004-07-01 | Boehringer Ingelheim International Gmbh | Compositions and methods for treating cancer using cytotoxic CD44 antibody immunoconjugates and chemotherapeutic agents |
EP2179742A1 (en) | 2002-11-26 | 2010-04-28 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
US7355008B2 (en) | 2003-01-09 | 2008-04-08 | Macrogenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
WO2004076682A2 (en) | 2003-02-26 | 2004-09-10 | Surromed, Inc. | Targets for controlling cellular growth and for diagnostic methods |
US8388955B2 (en) | 2003-03-03 | 2013-03-05 | Xencor, Inc. | Fc variants |
EP1629119A2 (en) | 2003-04-29 | 2006-03-01 | Wyeth | Methods for diagnosing aml and mds by differential gene expression |
US20060019256A1 (en) | 2003-06-09 | 2006-01-26 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
WO2005007830A2 (en) | 2003-07-14 | 2005-01-27 | Mayo Foundation For Medical Education And Research | Methods and compositions for diagnosis, staging and prognosis of prostate cancer |
US20050032113A1 (en) | 2003-07-17 | 2005-02-10 | Mitsubishi Pharma Corporation | Membrane protein library for proteome analysis and method for preparing same |
DE10359795A1 (de) | 2003-12-19 | 2005-07-21 | Bayer Technology Services Gmbh | Strangverdampfervorrichtung |
EP2361929A1 (en) | 2004-01-26 | 2011-08-31 | Debiovision Inc. | Neoplasm-specific polypeptides and their use |
AU2005224267B2 (en) | 2004-03-19 | 2011-07-21 | Imclone Llc | Human anti-epidermal growth factor receptor antibody |
RU2429245C2 (ru) | 2004-03-30 | 2011-09-20 | Глаксо Груп Лимитед | Иммуноглобулины |
WO2005100998A2 (en) | 2004-04-16 | 2005-10-27 | Europroteome Ag | Membrane markers for use in cancer diagnosis and therapy |
WO2006002378A2 (en) | 2004-06-23 | 2006-01-05 | Avalon Pharmaceuticals | Determining cancer-linked genes and therapeutic targets using molecular cytogenetic methods |
RU2297241C2 (ru) | 2004-11-22 | 2007-04-20 | Государственное учреждение Российский научный центр рентгенорадиологии Министерства здравоохранения и социального развития | Химерный белок для лечения злокачественных лимфом |
DE602006013094D1 (de) | 2005-01-19 | 2010-05-06 | Zeria Pharm Co Ltd | Krebsmittel |
KR20200058588A (ko) | 2005-01-21 | 2020-05-27 | 제넨테크, 인크. | Her 항체의 고정 용량 투여법 |
EP1849002A4 (en) | 2005-02-18 | 2008-08-20 | Childrens Medical Center | CYR61 AS A BIOMARKER FOR THE DIAGNOSIS AND PROGNOSIS OF CANCERS OF EPITHELIAL ORIGIN |
CA2602088C (en) | 2005-03-11 | 2021-07-27 | Ciphergen Biosystems, Inc. | Biomarkers for ovarian cancer and endometrial cancer |
JP2006318040A (ja) | 2005-05-10 | 2006-11-24 | Ricoh Co Ltd | サービス提供システム、プログラムおよび記録媒体 |
JP2006316040A (ja) | 2005-05-13 | 2006-11-24 | Genentech Inc | Herceptin(登録商標)補助療法 |
US8014957B2 (en) | 2005-12-15 | 2011-09-06 | Fred Hutchinson Cancer Research Center | Genes associated with progression and response in chronic myeloid leukemia and uses thereof |
EP2591794A1 (en) | 2006-01-05 | 2013-05-15 | The Ohio State University Research Foundation | MicroRNA expressions abnormalities in pancreatic endocrine and acinar tumors |
EP1991701A4 (en) | 2006-02-14 | 2010-03-17 | Dana Farber Cancer Inst Inc | COMPOSITIONS, KITS, AND METHODS FOR IDENTIFYING, EVALUATING, PREVENTING, AND TREATING CANCER |
WO2008073162A2 (en) | 2006-08-17 | 2008-06-19 | Cell Signaling Technology, Inc. | Lysine acetylation sites |
US20080107668A1 (en) | 2006-08-30 | 2008-05-08 | Immunotope, Inc. | Cytotoxic t-lymphocyte-inducing immunogens for prevention, treatment, and diagnosis of cancer |
WO2008031041A2 (en) | 2006-09-07 | 2008-03-13 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Melanoma gene signature |
WO2008059252A2 (en) | 2006-11-15 | 2008-05-22 | Oxford Biomedica (Uk) Limited | Methods and composition fro t cell receptors which recognize 5t4 antigen |
DK3106873T3 (da) | 2007-10-25 | 2019-09-23 | Toray Industries | Fremgangsmåde til detektering af cancer |
JP5663834B2 (ja) * | 2008-03-14 | 2015-02-04 | 東ソー株式会社 | 遺伝子組換え抗体の製造方法 |
TWI574698B (zh) | 2008-03-18 | 2017-03-21 | 建南德克公司 | 抗her2抗體-藥物結合物及化療劑之組合及使用方法 |
MX339277B (es) | 2008-08-05 | 2016-05-19 | Toray Industries | Agente inductor de inmunidad. |
ES2502940T3 (es) | 2008-08-05 | 2014-10-06 | Toray Industries, Inc. | Composición farmacéutica para el tratamiento y la prevención del cáncer |
PL2325648T3 (pl) | 2008-08-05 | 2014-09-30 | Toray Industries | Sposób wykrywania nowotworów |
WO2010018883A1 (en) | 2008-08-14 | 2010-02-18 | Myungjoo Kwon | Magnetic-piezoelectric combine sensor using piezoelectric single crystal |
JP5918129B2 (ja) | 2009-06-22 | 2016-05-18 | メディミューン,エルエルシー | 部位特異的共役のための操作されたFc領域 |
EA032728B1 (ru) * | 2009-08-19 | 2019-07-31 | Мерк Патент Гмбх | Антитела для выявления комплексов интегрина в ffpe материале |
PL2480671T3 (pl) * | 2009-09-22 | 2015-12-31 | Probiogen Ag | Proces produkcji cząsteczek zawierających specjalne struktury glikanowe |
HUE030102T2 (en) | 2010-02-04 | 2017-04-28 | Toray Industries | A pharmaceutical composition comprising anti-caprin-1 antibodies for the treatment and / or prevention of cancer |
PL2532365T3 (pl) * | 2010-02-04 | 2016-12-30 | Kompozycja farmaceutyczna do leczenia i/lub zapobiegania nowotworowi | |
KR101843807B1 (ko) | 2010-02-04 | 2018-03-30 | 도레이 카부시키가이샤 | 암의 치료 및/또는 예방을 위한 의약품 |
US8937160B2 (en) | 2010-02-04 | 2015-01-20 | Toray Industries, Inc. | Pharmaceutical composition for treating and/or preventing cancer |
PT2532680E (pt) * | 2010-02-04 | 2015-09-14 | Toray Industries | Composição medicinal para tratar e/ou prevenir o cancro |
CN102822335B (zh) | 2010-02-04 | 2015-09-30 | 东丽株式会社 | 癌的治疗和/或预防用药物组合物 |
EP2360965A1 (en) | 2010-02-12 | 2011-08-24 | ST-Ericsson SA | Handling of measurements for selecting a cell in a network |
EP2552957A4 (en) | 2010-03-29 | 2013-11-20 | Zymeworks Inc | ANTIBODIES HAVING ENHANCED OR DELETED EFFECTIVE FUNCTION |
WO2012005550A2 (ko) | 2010-07-08 | 2012-01-12 | 강원대학교산학협력단 | 담낭암 치료용 약제학적 조성물 및 이를 이용한 담낭암의 성장, 전이 억제 및 치료 방법 |
JP5726305B2 (ja) | 2010-07-26 | 2015-05-27 | レ ラボラトワール セルヴィエ | 肝ガン治療のための方法及び組成物 |
EP2740798B1 (en) | 2011-08-04 | 2016-12-07 | Toray Industries, Inc. | Cancer treatment and/or prevention drug composition |
US9273128B2 (en) | 2011-08-04 | 2016-03-01 | Toray Industries, Inc | Pharmaceutical composition for treatment and/or prophylaxis of cancer |
JP6065590B2 (ja) | 2011-08-04 | 2017-01-25 | 東レ株式会社 | 癌の治療及び/又は予防用医薬組成物 |
BR112014002619A2 (pt) | 2011-08-04 | 2018-10-09 | Toray Industries, Inc | composição farmacêutica e método de tratamento e/ou prevenção de câncer pancreático e combinação farmacêutica |
WO2013018889A1 (ja) | 2011-08-04 | 2013-02-07 | 東レ株式会社 | 癌の治療及び/又は予防用医薬組成物 |
TR201802089T4 (tr) | 2011-08-04 | 2018-03-21 | Toray Industries | Kanserin tedavisi ve/veya önlenmesi amacına yönelik ilaç bileşimi. |
WO2013018885A1 (ja) | 2011-08-04 | 2013-02-07 | 東レ株式会社 | 膵臓癌の検出方法 |
JP5855969B2 (ja) | 2012-02-15 | 2016-02-09 | 株式会社神戸製鋼所 | 金属板の曲げ加工方法 |
BR112014021101A2 (pt) | 2012-02-21 | 2022-03-22 | Toray Industries | Anticorpo, composição farmacêutica, droga de combinação, dna e método de tratamento e/ou prevenção de câncer, uso de um anticorpo |
BR112014021102A2 (pt) | 2012-02-21 | 2021-12-28 | Toray Ind Inc | Anticorpo, composição farmacêutica, droga de combinação, dna, método de tratamento e uso de anticorpo |
KR102009236B1 (ko) | 2012-02-21 | 2019-08-09 | 도레이 카부시키가이샤 | 암의 치료 및/또는 예방용 의약 조성물 |
ES2749672T3 (es) | 2012-02-21 | 2020-03-23 | Toray Industries | Composición farmacéutica para tratar y/o prevenir el cáncer |
JP5733546B2 (ja) | 2012-03-28 | 2015-06-10 | 国立大学法人広島大学 | インテグリンα8β1の機能を阻害する事による線維化の抑制 |
JPWO2013147189A1 (ja) | 2012-03-30 | 2015-12-14 | 積水化学工業株式会社 | 蒸着用硬化性樹脂組成物、樹脂保護膜、有機光デバイス、及び、有機光デバイスの製造方法 |
DK2832366T3 (da) | 2012-03-30 | 2018-01-22 | Toray Industries | Farmaceutisk sammensætning til behandling og/eller forebyggelse af galdeblærecancer |
RU2640245C2 (ru) | 2012-03-30 | 2017-12-27 | Торэй Индастриз, Инк. | Фармацевтическая композиция для лечения и/или предотвращения рака печени |
CA2879185C (en) | 2012-07-19 | 2021-08-24 | Toray Industries, Inc. | Method for detecting cancer |
KR102056654B1 (ko) | 2012-07-19 | 2019-12-17 | 도레이 카부시키가이샤 | 암의 검출 방법 |
KR102255616B1 (ko) | 2013-08-09 | 2021-05-25 | 도레이 카부시키가이샤 | 암의 치료 및/또는 예방용 의약 조성물 |
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2014
- 2014-08-08 KR KR1020167004263A patent/KR102255616B1/ko active IP Right Grant
- 2014-08-08 PT PT14834828T patent/PT3031826T/pt unknown
- 2014-08-08 AU AU2014303375A patent/AU2014303375B2/en active Active
- 2014-08-08 BR BR112016001753-6A patent/BR112016001753B1/pt active IP Right Grant
- 2014-08-08 ES ES14834828T patent/ES2704909T3/es active Active
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- 2014-08-08 DK DK14834828.7T patent/DK3031826T3/da active
- 2014-08-08 JP JP2014548217A patent/JP6447130B2/ja active Active
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- 2014-08-08 CN CN201480044559.2A patent/CN105452294B/zh active Active
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Also Published As
Publication number | Publication date |
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KR20160038892A (ko) | 2016-04-07 |
CA2918989A1 (en) | 2015-02-12 |
BR112016001753B1 (pt) | 2023-10-03 |
US9862774B2 (en) | 2018-01-09 |
EP3031826A4 (en) | 2017-03-29 |
CN105452294B (zh) | 2019-08-02 |
RU2678138C2 (ru) | 2019-01-23 |
KR102255616B1 (ko) | 2021-05-25 |
RU2016107884A (ru) | 2017-09-14 |
EP3031826A1 (en) | 2016-06-15 |
TR201819812T4 (tr) | 2019-01-21 |
CN105452294A (zh) | 2016-03-30 |
JPWO2015020212A1 (ja) | 2017-03-02 |
ES2704909T3 (es) | 2019-03-20 |
AU2014303375B2 (en) | 2019-07-04 |
CA2918989C (en) | 2021-11-02 |
MX2016001640A (es) | 2016-06-02 |
HUE042081T2 (hu) | 2019-06-28 |
PL3031826T3 (pl) | 2019-03-29 |
US20160297889A1 (en) | 2016-10-13 |
WO2015020212A1 (ja) | 2015-02-12 |
AU2014303375A1 (en) | 2016-03-03 |
BR112016001753A2 (pt) | 2017-08-29 |
JP6447130B2 (ja) | 2019-01-09 |
PT3031826T (pt) | 2019-01-18 |
MX360671B (es) | 2018-11-13 |
EP3031826B1 (en) | 2018-10-10 |
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