DK1137663T3 - Oprensning af Echinocandin-cyclopeptidforbindelser - Google Patents

Oprensning af Echinocandin-cyclopeptidforbindelser

Info

Publication number
DK1137663T3
DK1137663T3 DK99965156T DK99965156T DK1137663T3 DK 1137663 T3 DK1137663 T3 DK 1137663T3 DK 99965156 T DK99965156 T DK 99965156T DK 99965156 T DK99965156 T DK 99965156T DK 1137663 T3 DK1137663 T3 DK 1137663T3
Authority
DK
Denmark
Prior art keywords
acetic acid
fermentation
products
purification
echinocandin
Prior art date
Application number
DK99965156T
Other languages
Danish (da)
English (en)
Inventor
Jeffrey Thomas Vicenzi
John Robert Dobbins
Eugene Paul Kroeff
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK1137663T3 publication Critical patent/DK1137663T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK99965156T 1998-12-09 1999-12-08 Oprensning af Echinocandin-cyclopeptidforbindelser DK1137663T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11152498P 1998-12-09 1998-12-09

Publications (1)

Publication Number Publication Date
DK1137663T3 true DK1137663T3 (da) 2007-01-08

Family

ID=22339024

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99965156T DK1137663T3 (da) 1998-12-09 1999-12-08 Oprensning af Echinocandin-cyclopeptidforbindelser

Country Status (17)

Country Link
US (1) US6506726B1 (enExample)
EP (1) EP1137663B1 (enExample)
JP (1) JP2003511345A (enExample)
KR (1) KR20010101151A (enExample)
CN (1) CN1337968A (enExample)
AT (1) ATE338059T1 (enExample)
AU (1) AU766091B2 (enExample)
BR (1) BR9916101A (enExample)
CA (1) CA2353930A1 (enExample)
DE (1) DE69933046T2 (enExample)
DK (1) DK1137663T3 (enExample)
ES (1) ES2272096T3 (enExample)
IL (1) IL143563A0 (enExample)
PT (1) PT1137663E (enExample)
RU (1) RU2001118849A (enExample)
WO (1) WO2000034315A2 (enExample)
ZA (1) ZA200104621B (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
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US6743777B1 (en) * 1992-03-19 2004-06-01 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
ATE294571T1 (de) * 1999-03-03 2005-05-15 Lilly Co Eli Echinocandin pharmazeutische zusammensetzungen
BR0009248A (pt) 1999-03-03 2001-11-20 Lilly Co Eli Formação e troca de ânion de sais de amÈnioequinocandina cristalinos
KR20020003864A (ko) * 1999-03-03 2002-01-15 피터 지. 스트링거 에키노칸딘/탄수화물 착물
AU771727B2 (en) 1999-03-03 2004-04-01 Eli Lilly And Company Processes for making pharmaceutical oral ECB formulations and compositions
US6991800B2 (en) * 2002-06-13 2006-01-31 Vicuron Pharmaceuticals Inc. Antifungal parenteral products
EP1778301A2 (en) * 2004-06-29 2007-05-02 Reliance Life Sciences Pvt., Ltd. Process for improvement of virus-safe biological fluids
DE102004060750A1 (de) 2004-12-15 2006-07-13 Sanofi-Aventis Deutschland Gmbh Verfahren zur Deacylierung von Lipopeptiden
TW200826957A (en) * 2006-10-16 2008-07-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Purification processes for echinocandin-type compounds
US9394340B2 (en) 2009-03-24 2016-07-19 Cadila Healthcare Limited Purification process for lipopeptides
CN102219832B (zh) * 2010-04-15 2013-08-21 上海天伟生物制药有限公司 一种氮杂环六肽或其盐的纯化方法
CN102336817B (zh) * 2010-07-16 2016-06-15 浙江震元制药有限公司 棘球白素b母核的分离方法
CN102432674B (zh) * 2010-09-29 2014-01-22 上海天伟生物制药有限公司 一种环脂肽化合物或其盐的纯化方法
EP2623611B1 (en) * 2010-09-30 2016-07-13 Shanghai Techwell Biopharmaceutical Co., Ltd Method for purifying cyclic lipopeptide or salt thereof
CN102153616A (zh) * 2010-12-27 2011-08-17 浙江海正药业股份有限公司 一种环己肽类化合物及其盐的分离纯化方法
JP5809296B2 (ja) 2011-03-03 2015-11-10 シーチェイド ファーマシューティカルズ，インコーポレーテッド 抗真菌薬及びそれらの使用
HUE027806T2 (en) * 2011-04-20 2016-11-28 Xellia Pharmaceuticals Aps A method for purifying micafungin
CN102952178B (zh) * 2011-08-24 2016-04-27 华北制药集团新药研究开发有限责任公司 一种高纯度棘白霉素类化合物的制备方法
KR102236462B1 (ko) 2012-03-19 2021-04-08 시다라 세라퓨틱스, 인코포레이티드 에키노칸딘 계열의 화합물에 대한 투여 용법
CN103483427A (zh) * 2012-06-09 2014-01-01 浙江海正药业股份有限公司 一种棘白菌素类化合物的纯化方法
CN103910783B (zh) * 2014-04-23 2016-07-06 华北制药集团新药研究开发有限责任公司 一种高纯度棘白霉素b母核的制备方法
EP3058958B1 (en) 2015-02-23 2018-09-19 Selectchemie AG Anidulafungin composition
CN108883152A (zh) 2016-01-08 2018-11-23 奇达拉治疗公司 防止和治疗肺孢子虫感染的方法
ES2955711T3 (es) 2016-03-16 2023-12-05 Cidara Therapeutics Inc Regímenes de dosificación para el tratamiento de infecciones fúngicas
CN106248857A (zh) * 2016-07-15 2016-12-21 广西医科大学 利用薄层层析快速检测植物环肽的方法
CA3069423C (en) 2017-07-12 2025-04-15 Napp Pharmaceutical Group Limited Formulations for the treatment of fungal infections
CN119504952A (zh) * 2024-11-15 2025-02-25 上海天伟生物制药有限公司 一种棘白菌素药物杂质化合物及其制备方法与应用

Family Cites Families (34)

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US4293489A (en) 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912A nucleus
US4293482A (en) 1979-12-13 1981-10-06 Eli Lilly And Company A-30912A Nucleus
US4320052A (en) 1979-12-13 1982-03-16 Eli Lilly And Company Derivatives of A-30912A nucleus
US4304716A (en) 1979-12-13 1981-12-08 Eli Lilly And Company S 31794/F-1 Nucleus
US4874843A (en) 1987-12-03 1989-10-17 Eli Lilly And Company Chromatographic purification process
EP0294990A3 (en) 1987-06-10 1990-05-09 Eli Lilly And Company Chromatographic purification process
US5166135A (en) 1988-09-12 1992-11-24 Merck & Company, Inc. Method for the control of pneumocystis carinii
DK173802B1 (da) 1988-09-12 2001-11-05 Merck & Co Inc Præparat til behandling af Pneumocystis carinii infeksioner og anvendelse af et cyclohexapeptid til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner
US5310726A (en) 1990-03-19 1994-05-10 Merck & Co., Inc. Lipopeptide compounds
IL98349A (en) 1990-06-07 1995-05-26 Lilly Co Eli Diphylase lipopeptide
IL98506A (en) 1990-06-18 1996-09-12 Fujisawa Pharmaceutical Co Cyclic peptide antibiotics processes for the preparation thereof and pharmaceutical compositions containing them
US5965525A (en) 1992-03-19 1999-10-12 Eli Lilly And Company Cyclic peptide antifungal agents
MY136593A (en) 1992-03-19 2008-10-31 Lilly Co Eli Cyclic peptide antifungal agents and process for preparation thereof
US5541160A (en) 1994-04-04 1996-07-30 Merck & Co., Inc. Antifungal and anti-pneumocystis compounds, compositions containing such compounds, and methods of use
US5646111A (en) 1995-04-07 1997-07-08 Eli Lilly And Company Cyclic peptide antifungal Agents
US5786325A (en) 1995-05-26 1998-07-28 Eli Lilly And Company Cyclic peptide antifungal agents and methods of making and using
US5652213A (en) 1995-05-26 1997-07-29 Eli Lilly And Company Cyclic peptide antifungal agents
US5618787A (en) 1995-05-26 1997-04-08 Eli Lilly And Company Cyclic peptide antifungal agents
US5629290A (en) 1995-05-26 1997-05-13 Eli Lilly And Company Cyclic peptide antifungal agents
US5629289A (en) 1995-07-25 1997-05-13 Eli Lilly And Company Cyclic peptide antifungal agents
EP0881907A4 (en) 1996-02-01 2000-05-10 Lilly Co Eli FUNGICIDES IN THE FORM OF CYCLIC PEPTIDES
US5696084A (en) 1996-08-16 1997-12-09 Abbott Laboratories Amino-lipopetide antifungal agents
CA2301184A1 (en) 1997-08-04 1999-02-11 Eli Lilly And Company Cyclic peptide antifungal agents
EP0931834A3 (en) 1997-12-23 2002-06-26 Eli Lilly And Company Echinocandin binding domain of 1,3-Beta-glucan synthase
US6323176B1 (en) 1998-02-25 2001-11-27 Eli Lilly And Company Cyclic peptide antifungal agents
JP2002528388A (ja) 1998-08-20 2002-09-03 イーライ リリー アンド カンパニー 環改変された環状ペプチドアナログ
EP1107982B1 (en) 1998-08-28 2004-05-19 Eli Lilly & Company Reversible boron complexes of 1,2-(cis)-diol cyclic peptides
AU1517900A (en) 1998-10-28 2000-05-15 Eli Lilly And Company Photochemical process for making 1-deoxy-2-keto derivatives
WO2000035945A1 (en) 1998-12-16 2000-06-22 Eli Lilly And Company Cyclic peptide antifungal agents having a sugar substituent
JP2002535248A (ja) 1998-12-16 2002-10-22 イーライ リリー アンド カンパニー 環式ペプチド抗真菌剤
KR20020003864A (ko) 1999-03-03 2002-01-15 피터 지. 스트링거 에키노칸딘/탄수화물 착물
AU771727B2 (en) 1999-03-03 2004-04-01 Eli Lilly And Company Processes for making pharmaceutical oral ECB formulations and compositions
ATE294571T1 (de) 1999-03-03 2005-05-15 Lilly Co Eli Echinocandin pharmazeutische zusammensetzungen
BR0009248A (pt) 1999-03-03 2001-11-20 Lilly Co Eli Formação e troca de ânion de sais de amÈnioequinocandina cristalinos

Also Published As

Publication number Publication date
US6506726B1 (en) 2003-01-14
DE69933046D1 (de) 2006-10-12
CN1337968A (zh) 2002-02-27
BR9916101A (pt) 2002-06-04
JP2003511345A (ja) 2003-03-25
EP1137663A2 (en) 2001-10-04
AU3113200A (en) 2000-06-26
AU766091B2 (en) 2003-10-09
ATE338059T1 (de) 2006-09-15
WO2000034315A8 (en) 2000-10-26
WO2000034315A3 (en) 2000-12-28
ES2272096T3 (es) 2007-04-16
PT1137663E (pt) 2006-12-29
EP1137663B1 (en) 2006-08-30
RU2001118849A (ru) 2003-08-10
IL143563A0 (en) 2002-04-21
DE69933046T2 (de) 2007-09-13
WO2000034315A2 (en) 2000-06-15
CA2353930A1 (en) 2000-06-15
KR20010101151A (ko) 2001-11-14
ZA200104621B (en) 2002-06-06

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