DK1113809T3 - Farmaceutisk præparat indeholdende et cyclo-peptid og et kemoterapeutikum eller en angiogeneseinhibitor - Google Patents

Farmaceutisk præparat indeholdende et cyclo-peptid og et kemoterapeutikum eller en angiogeneseinhibitor

Info

Publication number
DK1113809T3
DK1113809T3 DK99969031T DK99969031T DK1113809T3 DK 1113809 T3 DK1113809 T3 DK 1113809T3 DK 99969031 T DK99969031 T DK 99969031T DK 99969031 T DK99969031 T DK 99969031T DK 1113809 T3 DK1113809 T3 DK 1113809T3
Authority
DK
Denmark
Prior art keywords
cyclo
peptide
pharmaceutical preparation
chemotherapeutic agent
preparation containing
Prior art date
Application number
DK99969031T
Other languages
Danish (da)
English (en)
Inventor
Alfred Jonczyk
Simon Goodman
Astrid Perschl
Sigrid Roesener
Jutta Haunschild
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of DK1113809T3 publication Critical patent/DK1113809T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK99969031T 1998-09-16 1999-09-09 Farmaceutisk præparat indeholdende et cyclo-peptid og et kemoterapeutikum eller en angiogeneseinhibitor DK1113809T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19842415A DE19842415A1 (de) 1998-09-16 1998-09-16 Pharmazeutische Zubereitung
PCT/EP1999/006654 WO2000015244A2 (de) 1998-09-16 1999-09-09 Pharmazeutische zubereitung enthaltend ein cyclo-peptide und ein chemotherapeutikum oder einen angiogeneseinhibitor

Publications (1)

Publication Number Publication Date
DK1113809T3 true DK1113809T3 (da) 2005-08-08

Family

ID=7881169

Family Applications (2)

Application Number Title Priority Date Filing Date
DK04006076T DK1466615T3 (da) 1998-09-16 1999-09-09 Farmaceutisk præparat
DK99969031T DK1113809T3 (da) 1998-09-16 1999-09-09 Farmaceutisk præparat indeholdende et cyclo-peptid og et kemoterapeutikum eller en angiogeneseinhibitor

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK04006076T DK1466615T3 (da) 1998-09-16 1999-09-09 Farmaceutisk præparat

Country Status (31)

Country Link
US (1) US6683051B1 (pt)
EP (2) EP1113809B1 (pt)
JP (2) JP2002524526A (pt)
KR (1) KR100703253B1 (pt)
CN (2) CN1201812C (pt)
AR (2) AR022382A1 (pt)
AT (2) ATE432707T1 (pt)
AU (1) AU765073B2 (pt)
BR (1) BR9913737A (pt)
CA (1) CA2344151A1 (pt)
CO (1) CO5140070A1 (pt)
CZ (1) CZ302908B6 (pt)
DE (3) DE19842415A1 (pt)
DK (2) DK1466615T3 (pt)
ES (2) ES2327331T3 (pt)
HU (1) HUP0103521A3 (pt)
ID (1) ID29226A (pt)
IL (2) IL141516A0 (pt)
MY (1) MY129572A (pt)
NO (1) NO331734B1 (pt)
NZ (1) NZ510040A (pt)
PE (1) PE20001046A1 (pt)
PL (1) PL201902B1 (pt)
PT (2) PT1113809E (pt)
RU (1) RU2227041C2 (pt)
SI (1) SI1113809T1 (pt)
SK (1) SK287012B6 (pt)
TR (1) TR200100765T2 (pt)
TW (1) TW576744B (pt)
WO (1) WO2000015244A2 (pt)
ZA (1) ZA200103073B (pt)

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US7740841B1 (en) * 2000-01-28 2010-06-22 Sunnybrook Health Science Center Therapeutic method for reducing angiogenesis
EP1349574A2 (en) * 2001-01-09 2003-10-08 MERCK PATENT GmbH Combination therapy using receptor tyrosine kinase inhibitors and angiogenesis inhibitors
JP4542783B2 (ja) * 2002-03-05 2010-09-15 エーザイ・アール・アンド・ディー・マネジメント株式会社 スルホンアミド含有複素環化合物及び血管新生抑制剤とを組み合わせてなる抗腫瘍剤
US20050226865A1 (en) * 2004-04-02 2005-10-13 Regents Of The University Of California Methods and compositions for treating and preventing diseases associated with alphavbeta5 integrin
BRPI0618050A2 (pt) * 2005-11-02 2011-08-16 Univ Duke uso de peptìdeo egfrviii e vacina antitumor em combinação com outros componentes para o tratamento de tumor
US20110165150A1 (en) * 2006-01-18 2011-07-07 Merck Patent Gmbh Isolated organ perfusion combination therapy of cancer
US20090130098A1 (en) * 2006-01-18 2009-05-21 Merck Patent Gmbh Specific therapy using integrin ligands for treating cancer
ES2399159T3 (es) 2007-01-18 2013-03-26 Merck Patent Gmbh Terapia y medicamento específicos usando ligandos de integrinas para el tratamiento del cáncer
WO2009010290A2 (en) 2007-07-17 2009-01-22 Merck Patent Gmbh Engineered anti-alpha v- integrin hybrid antibodies
WO2010051667A1 (zh) * 2008-11-10 2010-05-14 复旦大学 一种环肽纳米管药物组合物及其应用
US20110230423A1 (en) * 2008-11-20 2011-09-22 Martin Andreas Picard Therapy and medicament using integrin ligands for treating cancer
SG176103A1 (en) 2009-05-25 2011-12-29 Merck Patent Gmbh Continuous administration of cilengitide in cancer treatments
BR112012001463A2 (pt) 2009-07-24 2016-03-15 Univ California métodos e composições para tratar e prevenir doença associada à integrina alfavbeta5
EP2509583B1 (en) 2009-12-10 2019-05-15 Merck Patent GmbH Pharmaceutical composition comprising oligopeptides, preferably cilengitide
CN103153328A (zh) 2010-07-16 2013-06-12 默克专利股份有限公司 肽在乳腺癌和/或骨转移灶的治疗中的用途
WO2012069149A1 (en) 2010-11-23 2012-05-31 Merck Patent Gmbh Solution comprising cyclic oligopeptides
PT2672994T (pt) 2011-02-11 2018-10-22 Merck Patent Gmbh Anticorpo anti-integrina alfa-v para o tratamento do cancro da próstata
WO2012110200A1 (en) 2011-02-18 2012-08-23 Merck Patent Gmbh Cyclic peptide cyclo (l -arginyl - glycyl - l -aspartyl - d - phenylalanyl - n-methyl - l -valyl), compositions thereof, and use thereof in methods for treating graft -versus - host disease
AU2012266803B2 (en) 2011-06-09 2017-02-02 Merck Patent Gmbh Treatment of cancers and metastases with suspensions of cilengitide in carrier
WO2013130775A1 (en) * 2012-03-01 2013-09-06 Dizerega, Gere, S. Methods for treating patients undergoing multi-cycle chemotherapy
CN103333227B (zh) * 2013-06-07 2015-10-07 东南大学 转移肿瘤缺失蛋白小分子环肽抑制剂及其制备方法与应用
EP3510407A1 (en) 2016-09-08 2019-07-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for diagnosing and treating nephrotic syndrome
JP2019208422A (ja) * 2018-06-04 2019-12-12 コリア・インスティテュート・オブ・サイエンス・アンド・テクノロジー ヒアルロニダーゼを含む新規な組換えエキソソーム及びその用途
GB201911816D0 (en) * 2019-08-16 2019-10-02 Univ London Queen Mary Treatment
GB202103122D0 (en) * 2021-03-05 2021-04-21 Univ London Queen Mary Treatment

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JPH04367367A (ja) 1991-06-11 1992-12-18 Nkk Corp ロータリノズル
US5786373A (en) 1992-10-14 1998-07-28 Merck & Co., Inc. Fibrinogen receptor antagonists
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Also Published As

Publication number Publication date
IL141516A (en) 2009-09-22
WO2000015244A2 (de) 2000-03-23
CN1329499A (zh) 2002-01-02
KR20010073155A (ko) 2001-07-31
PT1113809E (pt) 2005-08-31
US6683051B1 (en) 2004-01-27
SK3372001A3 (en) 2001-11-06
PL348026A1 (en) 2002-05-06
NO20011308D0 (no) 2001-03-15
ID29226A (id) 2001-08-16
EP1113809B1 (de) 2005-04-06
JP2011252012A (ja) 2011-12-15
EP1466615B1 (de) 2009-06-03
CN1201812C (zh) 2005-05-18
WO2000015244A3 (de) 2000-06-22
AR022382A1 (es) 2002-09-04
TW576744B (en) 2004-02-21
EP1466615A1 (de) 2004-10-13
DE59915033D1 (de) 2009-07-16
PL201902B1 (pl) 2009-05-29
KR100703253B1 (ko) 2007-04-03
CZ2001932A3 (cs) 2001-09-12
CN1636590A (zh) 2005-07-13
CA2344151A1 (en) 2000-03-23
PE20001046A1 (es) 2000-10-14
IL141516A0 (en) 2002-03-10
TR200100765T2 (tr) 2001-08-21
RU2227041C2 (ru) 2004-04-20
ES2241363T3 (es) 2005-10-16
DK1466615T3 (da) 2009-08-31
ZA200103073B (en) 2002-08-21
SI1113809T1 (en) 2005-10-31
AU5975899A (en) 2000-04-03
JP2002524526A (ja) 2002-08-06
DE59911881D1 (de) 2005-05-12
SK287012B6 (sk) 2009-09-07
BR9913737A (pt) 2001-06-05
ATE432707T1 (de) 2009-06-15
NO20011308L (no) 2001-03-15
MY129572A (en) 2007-04-30
CZ302908B6 (cs) 2012-01-18
CO5140070A1 (es) 2002-03-22
ATE292470T1 (de) 2005-04-15
AR078175A2 (es) 2011-10-19
DE19842415A1 (de) 2000-03-23
NO331734B1 (no) 2012-03-12
AU765073B2 (en) 2003-09-11
PT1466615E (pt) 2009-09-07
HUP0103521A3 (en) 2002-05-28
HUP0103521A2 (hu) 2002-02-28
ES2327331T3 (es) 2009-10-28
CN100352494C (zh) 2007-12-05
NZ510040A (en) 2003-12-19
EP1113809A2 (de) 2001-07-11

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