DK1105382T3 - Fremgangsmåde til fremstilling af citalopram - Google Patents

Fremgangsmåde til fremstilling af citalopram

Info

Publication number
DK1105382T3
DK1105382T3 DK99968206T DK99968206T DK1105382T3 DK 1105382 T3 DK1105382 T3 DK 1105382T3 DK 99968206 T DK99968206 T DK 99968206T DK 99968206 T DK99968206 T DK 99968206T DK 1105382 T3 DK1105382 T3 DK 1105382T3
Authority
DK
Denmark
Prior art keywords
citalopram
preparation
Prior art date
Application number
DK99968206T
Other languages
Danish (da)
English (en)
Inventor
Hans Petersen
Michael Harold Rock
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Application granted granted Critical
Publication of DK1105382T3 publication Critical patent/DK1105382T3/da

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/22Organic complexes
    • B01J31/2282Unsaturated compounds used as ligands
    • B01J31/2295Cyclic compounds, e.g. cyclopentadienyls
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/24Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
    • B01J31/2404Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87Benzo [c] furans; Hydrogenated benzo [c] furans
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/40Substitution reactions at carbon centres, e.g. C-C or C-X, i.e. carbon-hetero atom, cross-coupling, C-H activation or ring-opening reactions
    • B01J2231/42Catalytic cross-coupling, i.e. connection of previously not connected C-atoms or C- and X-atoms without rearrangement
    • B01J2231/4205C-C cross-coupling, e.g. metal catalyzed or Friedel-Crafts type
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80Complexes comprising metals of Group VIII as the central metal
    • B01J2531/84Metals of the iron group
    • B01J2531/847Nickel

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Furan Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
DK99968206T 1999-06-25 1999-11-19 Fremgangsmåde til fremstilling af citalopram DK1105382T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA199900921 1999-06-25
PCT/DK1999/000643 WO2000011926A2 (fr) 1999-06-25 1999-11-19 Procede de preparation de citaloprame

Publications (1)

Publication Number Publication Date
DK1105382T3 true DK1105382T3 (da) 2002-05-27

Family

ID=8099044

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99968206T DK1105382T3 (da) 1999-06-25 1999-11-19 Fremgangsmåde til fremstilling af citalopram

Country Status (36)

Country Link
US (1) US6750358B2 (fr)
EP (1) EP1105382B1 (fr)
JP (1) JP3389571B2 (fr)
KR (1) KR100491369B1 (fr)
CN (1) CN1129593C (fr)
AR (1) AR020573A1 (fr)
AT (3) ATE213237T1 (fr)
AU (2) AU2001100433B4 (fr)
BG (1) BG106190A (fr)
BR (1) BR9917367A (fr)
CA (1) CA2290125C (fr)
CH (1) CH691304A5 (fr)
CZ (1) CZ292174B6 (fr)
DE (2) DE19983486C2 (fr)
DK (1) DK1105382T3 (fr)
EA (1) EA002661B1 (fr)
ES (1) ES2172356T3 (fr)
FI (1) FI108538B (fr)
GB (1) GB2354240B (fr)
HK (1) HK1047745B (fr)
HU (1) HUP0103417A3 (fr)
IL (1) IL145960A0 (fr)
IS (1) IS5862A (fr)
IT (1) ITMI991579A1 (fr)
MX (1) MXPA01010986A (fr)
NO (1) NO20010318L (fr)
NZ (1) NZ514982A (fr)
PL (1) PL345971A1 (fr)
PT (1) PT1105382E (fr)
SE (1) SE516689C2 (fr)
SI (1) SI1105382T1 (fr)
SK (1) SK18412001A3 (fr)
TR (1) TR200103700T2 (fr)
UA (1) UA62023C2 (fr)
WO (1) WO2000011926A2 (fr)
ZA (1) ZA200108855B (fr)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR200101796T2 (tr) 1998-12-23 2001-11-21 H. Lundbeck A/S 5-Siyanofitalitin preparasyonuna yönelik metot
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
ATE237604T1 (de) 1999-04-14 2003-05-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
HUP0200169A3 (en) 1999-10-25 2002-11-28 Lundbeck & Co As H Method for the preparation of citalopram
GB2360281B (en) 1999-10-25 2002-01-16 Lundbeck & Co As H Method for the preparation of citalopram
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
WO2001047909A1 (fr) 1999-12-28 2001-07-05 H. Lundbeck A/S Procede de preparation de citalopram
PL198803B1 (pl) 1999-12-30 2008-07-31 Lundbeck & Co As H Sposób wytwarzania 5-cyjano-3H-izobenzofuran-1-onu
ES2206177T3 (es) 2000-01-14 2004-05-16 H. Lundbeck A/S Metodo para la preparacion de 5-cianoftalida.
NL1017415C1 (nl) 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
IES20010206A2 (en) 2000-03-13 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
CA2402553A1 (fr) 2000-03-13 2001-09-20 H. Lundbeck A/S Alkylation progressive de 1-(4-fluorophenyl)-1,3-dihydroisobenzofuranes 5-substitues
BR0109176A (pt) 2000-03-13 2003-04-22 Lundbeck & Co As H Método para preparação de citalopram e composto da fórmula
IL151488A0 (en) 2000-03-14 2003-04-10 Lundbeck & Co As H Method for the preparation of citalopram
EP1274699A1 (fr) * 2000-03-16 2003-01-15 H. Lundbeck A/S Procede de preparation de 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
EA200200332A1 (ru) * 2000-07-06 2002-06-27 Х.Лундбекк А/С Способ получения циталопрама
CA2354880C (fr) * 2000-08-18 2003-06-03 H. Lundbeck A/S Procede de preparation du citaloprame
IL147226A (en) * 2000-12-22 2006-04-10 Lundbeck & Co As H Process for the preparation of pure cithalopram
PT1181272E (pt) * 2000-12-28 2003-01-31 Lundbeck & Co As H Processo para a preparacao de citalopram puro
CA2435925A1 (fr) 2001-01-30 2002-08-08 Orion Corporation Fermion Procede de preparation de 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
RU2003130073A (ru) * 2001-03-09 2005-04-10 Ранбакси Лабораторис Лимитед (In) Способ получения циталопрама
DE60217932T2 (de) * 2001-07-31 2007-08-30 H. Lundbeck A/S, Valby Kristalline Zusammensetzung enthaltend Escitalopram
AU2003222435A1 (en) 2002-01-07 2003-07-24 Sun Pharmaceutical Industries Limited Process for the preparation of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
PE20040991A1 (es) 2002-08-12 2004-12-27 Lundbeck & Co As H Separacion de intermediarios para la preparacion de escitalopram
US20050154052A1 (en) * 2003-03-24 2005-07-14 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
US7019153B2 (en) 2003-06-10 2006-03-28 Sun Pharmaceutical Industries Limited Process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran acetamido-3-substituted-3-cephem-4-carboxylic acid
TWI339651B (en) 2004-02-12 2011-04-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
JP2006008603A (ja) * 2004-06-25 2006-01-12 Sumitomo Chemical Co Ltd 光学活性シタロプラムの製造方法、その中間体およびその製造方法
KR101166280B1 (ko) 2004-08-23 2013-11-27 썬 파마 글로벌 에프제트이 시탈로프램 및 에난티오머의 제조 방법
WO2006103550A1 (fr) * 2005-03-31 2006-10-05 Ranbaxy Laboratories Limited Processus de preparation du citalopram et son intermediaire, le 5-aminophthalide
TWI347942B (en) 2005-06-22 2011-09-01 Lundbeck & Co As H Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
US7834201B2 (en) 2005-06-22 2010-11-16 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
EP2017271A1 (fr) 2007-07-06 2009-01-21 Aurobindo Pharma Limited Procédé de préparation d'escitalopram

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143702A (fr) 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
CA2010159A1 (fr) 1989-02-21 1990-08-21 James J. Maul Cyanation de composes aromatiques halogenes a l'aide de catalyseurs generes in situ a partir de nicl ou de nicl.6h2o
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19706648A1 (de) 1997-02-20 1998-08-27 Bayer Ag Verfahren zur Herstellung von aromatischen Nitrilen
JP3526581B2 (ja) 1997-07-08 2004-05-17 ハー・ルンドベック・アクティーゼルスカブ シタロプラムの製造方法
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
CZ292911B6 (cs) 1997-11-11 2004-01-14 H. Lundbeck A/S Způsob výroby citalopramu
PL199423B1 (pl) 1998-10-20 2008-09-30 Lundbeck & Co As H Sposób wytwarzania citalopramu
TR200101796T2 (tr) 1998-12-23 2001-11-21 H. Lundbeck A/S 5-Siyanofitalitin preparasyonuna yönelik metot
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
US6331628B1 (en) 1999-03-29 2001-12-18 Nissan Chemical Industries, Ltd. Process for the preparation of benzonitrile compounds
ATE237604T1 (de) 1999-04-14 2003-05-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
GB2360281B (en) 1999-10-25 2002-01-16 Lundbeck & Co As H Method for the preparation of citalopram
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
IL147226A (en) 2000-12-22 2006-04-10 Lundbeck & Co As H Process for the preparation of pure cithalopram
PT1181272E (pt) 2000-12-28 2003-01-31 Lundbeck & Co As H Processo para a preparacao de citalopram puro

Also Published As

Publication number Publication date
AR020573A1 (es) 2002-05-15
AT409960B (de) 2002-12-27
PT1105382E (pt) 2002-07-31
SE0100194L (sv) 2001-04-25
EP1105382A2 (fr) 2001-06-13
SK18412001A3 (sk) 2002-05-09
DE19983486C2 (de) 2002-09-05
AU2001100433A4 (en) 2001-11-01
NO20010318D0 (no) 2001-01-19
SE0100194D0 (sv) 2001-01-24
ATA904099A (de) 2002-05-15
HK1047745A1 (en) 2003-03-07
EA200101071A1 (ru) 2002-02-28
ZA200108855B (en) 2002-08-28
KR100491369B1 (ko) 2005-05-24
WO2000011926A2 (fr) 2000-03-09
CA2290125C (fr) 2004-08-10
SE516689C2 (sv) 2002-02-12
EA002661B1 (ru) 2002-08-29
CN1356993A (zh) 2002-07-03
ATE213237T1 (de) 2002-02-15
ITMI991579A1 (it) 2001-01-15
CN1129593C (zh) 2003-12-03
JP2002523432A (ja) 2002-07-30
NZ514982A (en) 2004-01-30
FI108538B (fi) 2002-02-15
EP1105382B1 (fr) 2002-02-13
NO20010318L (no) 2001-02-20
GB0101508D0 (en) 2001-03-07
CA2290125A1 (fr) 2000-12-25
US6750358B2 (en) 2004-06-15
ES2172356T3 (es) 2002-09-16
TR200103700T2 (tr) 2002-05-21
UA62023C2 (en) 2003-12-15
PL345971A1 (en) 2002-01-14
HK1047745B (zh) 2004-09-10
BG106190A (en) 2002-08-30
CH691304A5 (de) 2001-06-29
US20020061925A1 (en) 2002-05-23
DE19983486T1 (de) 2001-10-18
IL145960A0 (en) 2002-07-25
CZ2001319A3 (en) 2001-05-16
HUP0103417A2 (hu) 2002-01-28
WO2000011926A3 (fr) 2000-06-29
AU2001100433B4 (en) 2002-01-17
MXPA01010986A (es) 2002-06-04
HUP0103417A3 (en) 2003-01-28
AU1374800A (en) 2000-03-21
JP3389571B2 (ja) 2003-03-24
IS5862A (is) 2001-02-23
FI20010154A (fi) 2001-02-09
GB2354240A (en) 2001-03-21
DE69900891D1 (de) 2002-03-21
ITMI991579A0 (it) 1999-07-15
CZ292174B6 (cs) 2003-08-13
SI1105382T1 (en) 2002-06-30
AT4366U1 (de) 2001-06-25
KR20020011982A (ko) 2002-02-09
BR9917367A (pt) 2002-03-05
GB2354240B (en) 2001-05-23

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