SI1105382T1 - Method for the preparation of citalopram - Google Patents

Method for the preparation of citalopram

Info

Publication number
SI1105382T1
SI1105382T1 SI9930039T SI9930039T SI1105382T1 SI 1105382 T1 SI1105382 T1 SI 1105382T1 SI 9930039 T SI9930039 T SI 9930039T SI 9930039 T SI9930039 T SI 9930039T SI 1105382 T1 SI1105382 T1 SI 1105382T1
Authority
SI
Slovenia
Prior art keywords
citalopram
preparation
Prior art date
Application number
SI9930039T
Other languages
English (en)
Slovenian (sl)
Inventor
Hans Petersen
Michael Harold Rock
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of SI1105382T1 publication Critical patent/SI1105382T1/xx

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/22—Organic complexes
    • B01J31/2282—Unsaturated compounds used as ligands
    • B01J31/2295—Cyclic compounds, e.g. cyclopentadienyls
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
    • B01J31/2404—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/40—Substitution reactions at carbon centres, e.g. C-C or C-X, i.e. carbon-hetero atom, cross-coupling, C-H activation or ring-opening reactions
    • B01J2231/42—Catalytic cross-coupling, i.e. connection of previously not connected C-atoms or C- and X-atoms without rearrangement
    • B01J2231/4205—C-C cross-coupling, e.g. metal catalyzed or Friedel-Crafts type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/84—Metals of the iron group
    • B01J2531/847—Nickel

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Furan Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
SI9930039T 1999-06-25 1999-11-19 Method for the preparation of citalopram SI1105382T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA199900921 1999-06-25
EP99968206A EP1105382B1 (fr) 1999-06-25 1999-11-19 Procede de preparation de citaloprame
PCT/DK1999/000643 WO2000011926A2 (fr) 1999-06-25 1999-11-19 Procede de preparation de citaloprame

Publications (1)

Publication Number Publication Date
SI1105382T1 true SI1105382T1 (en) 2002-06-30

Family

ID=8099044

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9930039T SI1105382T1 (en) 1999-06-25 1999-11-19 Method for the preparation of citalopram

Country Status (36)

Country Link
US (1) US6750358B2 (fr)
EP (1) EP1105382B1 (fr)
JP (1) JP3389571B2 (fr)
KR (1) KR100491369B1 (fr)
CN (1) CN1129593C (fr)
AR (1) AR020573A1 (fr)
AT (3) AT409960B (fr)
AU (2) AU2001100433B4 (fr)
BG (1) BG106190A (fr)
BR (1) BR9917367A (fr)
CA (1) CA2290125C (fr)
CH (1) CH691304A5 (fr)
CZ (1) CZ292174B6 (fr)
DE (2) DE19983486C2 (fr)
DK (1) DK1105382T3 (fr)
EA (1) EA002661B1 (fr)
ES (1) ES2172356T3 (fr)
FI (1) FI108538B (fr)
GB (1) GB2354240B (fr)
HK (1) HK1047745B (fr)
HU (1) HUP0103417A3 (fr)
IL (1) IL145960A0 (fr)
IS (1) IS5862A (fr)
IT (1) ITMI991579A1 (fr)
MX (1) MXPA01010986A (fr)
NO (1) NO20010318L (fr)
NZ (1) NZ514982A (fr)
PL (1) PL345971A1 (fr)
PT (1) PT1105382E (fr)
SE (1) SE516689C2 (fr)
SI (1) SI1105382T1 (fr)
SK (1) SK18412001A3 (fr)
TR (1) TR200103700T2 (fr)
UA (1) UA62023C2 (fr)
WO (1) WO2000011926A2 (fr)
ZA (1) ZA200108855B (fr)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1140886E (pt) 1998-12-23 2003-08-29 Lundbeck & Co As H Metodo para a preparacao de 5- cianoftalida
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
DE69907037T3 (de) 1999-04-14 2010-02-18 H. Lundbeck A/S Verfahren zur herstellung von citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ES2229774T3 (es) 1999-10-25 2005-04-16 H. Lundbeck A/S Metodo para la preparacion de citalopram.
ES2282365T3 (es) 1999-10-25 2007-10-16 H. Lundbeck A/S Metodo para la preparacion de citalopram.
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
CN1398263A (zh) 1999-12-28 2003-02-19 H·隆德贝克有限公司 制备西酞普兰的方法
PL198803B1 (pl) 1999-12-30 2008-07-31 Lundbeck & Co As H Sposób wytwarzania 5-cyjano-3H-izobenzofuran-1-onu
IL150561A0 (en) 2000-01-14 2003-02-12 Lundbeck & Co As H Method for the preparation of 5-cyanophthalide
FR2805812A1 (fr) 2000-02-24 2001-09-07 Lundbeck & Co As H Procede de preparation du citalopram
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
CN1427835A (zh) * 2000-03-13 2003-07-02 H·隆德贝克有限公司 5－取代的1－(4－氟苯基)－1,3－二氢异苯并呋喃的分步烷基化
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
JP2003527387A (ja) 2000-03-13 2003-09-16 ハー・ルンドベック・アクチエゼルスカベット シタロプラムの製造方法
SK14512002A3 (sk) 2000-03-14 2003-03-04 H. Lundbeck A/S Spôsob výroby citalopramu, medziprodukt a citalopram výrobený týmto spôsobom
EP1274699A1 (fr) * 2000-03-16 2003-01-15 H. Lundbeck A/S Procede de preparation de 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
IL148525A0 (en) * 2000-07-06 2002-09-12 Lundbeck & Co As H Method for the preparation of citalopram
CA2354877C (fr) * 2000-08-18 2006-05-02 H. Lundbeck A/S Methode de preparation de citalopram
DE60105926T2 (de) 2000-12-22 2005-11-24 H. Lundbeck A/S, Valby Verfahren zur vorbereitung von reinem citalopram
AU2001100399B4 (en) 2000-12-28 2002-03-21 H Lundbeck As Process for the preparation of pure citalopram
WO2002060886A1 (fr) 2001-01-30 2002-08-08 Orion Corporation, Fermion Procede de preparation de 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
US20050085534A1 (en) * 2001-03-09 2005-04-21 Sujay Biwas Process for the preparation of citalopram
PT1414435E (pt) * 2001-07-31 2005-05-31 Lundbeck & Co As H Composicao cristalina contendo escitalopram
AU2003222435A1 (en) 2002-01-07 2003-07-24 Sun Pharmaceutical Industries Limited Process for the preparation of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
PE20040991A1 (es) 2002-08-12 2004-12-27 Lundbeck & Co As H Separacion de intermediarios para la preparacion de escitalopram
WO2004085416A1 (fr) * 2003-03-24 2004-10-07 Hetero Drugs Limited Formes cristallines d'oxalate de (s)-citaloprame
EP1486492A3 (fr) * 2003-06-10 2005-02-23 Sun Pharmaceuticals Industries Ltd. Un procédé de hydrogenolyse de [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofurane
TWI339651B (en) 2004-02-12 2011-04-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
JP2006008603A (ja) * 2004-06-25 2006-01-12 Sumitomo Chemical Co Ltd 光学活性シタロプラムの製造方法、その中間体およびその製造方法
WO2006021971A2 (fr) 2004-08-23 2006-03-02 Sun Pharmaceutical Industries Limited Procede de preparation de citalopram et d'enantiomeres
WO2006103550A1 (fr) * 2005-03-31 2006-10-05 Ranbaxy Laboratories Limited Processus de preparation du citalopram et son intermediaire, le 5-aminophthalide
TWI358407B (en) 2005-06-22 2012-02-21 Lundbeck & Co As H Crystalline base of escitalopram and orodispersibl
US7834201B2 (en) 2005-06-22 2010-11-16 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
EP2017271A1 (fr) 2007-07-06 2009-01-21 Aurobindo Pharma Limited Procédé de préparation d'escitalopram

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143703A (fr) 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
CA2010159A1 (fr) 1989-02-21 1990-08-21 James J. Maul Cyanation de composes aromatiques halogenes a l'aide de catalyseurs generes in situ a partir de nicl ou de nicl.6h2o
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19706648A1 (de) 1997-02-20 1998-08-27 Bayer Ag Verfahren zur Herstellung von aromatischen Nitrilen
EA001728B1 (ru) 1997-07-08 2001-08-27 Х.Лундбекк А/С Способ получения циталопрама
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
EP1042310B1 (fr) 1997-11-11 2002-07-31 H. Lundbeck A/S Procédé de préparation de citaloprame
HU228576B1 (en) 1998-10-20 2013-04-29 Lundbeck & Co As H Method for the preparation of citalopram
PT1140886E (pt) 1998-12-23 2003-08-29 Lundbeck & Co As H Metodo para a preparacao de 5- cianoftalida
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
DE10015280A1 (de) 1999-03-29 2001-01-04 Nissan Chemical Ind Ltd Verfahren zur Herstellung von Benzonitrilverbindungen
DE69907037T3 (de) 1999-04-14 2010-02-18 H. Lundbeck A/S Verfahren zur herstellung von citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ES2229774T3 (es) 1999-10-25 2005-04-16 H. Lundbeck A/S Metodo para la preparacion de citalopram.
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
DE60105926T2 (de) 2000-12-22 2005-11-24 H. Lundbeck A/S, Valby Verfahren zur vorbereitung von reinem citalopram
AU2001100399B4 (en) 2000-12-28 2002-03-21 H Lundbeck As Process for the preparation of pure citalopram

Also Published As

Publication number Publication date
HUP0103417A2 (hu) 2002-01-28
EP1105382A2 (fr) 2001-06-13
GB2354240B (en) 2001-05-23
US6750358B2 (en) 2004-06-15
HK1047745A1 (en) 2003-03-07
IL145960A0 (en) 2002-07-25
DE19983486C2 (de) 2002-09-05
ITMI991579A0 (it) 1999-07-15
PL345971A1 (en) 2002-01-14
NO20010318D0 (no) 2001-01-19
CN1356993A (zh) 2002-07-03
IS5862A (is) 2001-02-23
PT1105382E (pt) 2002-07-31
TR200103700T2 (tr) 2002-05-21
HK1047745B (zh) 2004-09-10
AR020573A1 (es) 2002-05-15
NO20010318L (no) 2001-02-20
US20020061925A1 (en) 2002-05-23
EP1105382B1 (fr) 2002-02-13
BG106190A (en) 2002-08-30
ATE213237T1 (de) 2002-02-15
EA200101071A1 (ru) 2002-02-28
MXPA01010986A (es) 2002-06-04
AU2001100433A4 (en) 2001-11-01
CH691304A5 (de) 2001-06-29
AT4366U1 (de) 2001-06-25
KR100491369B1 (ko) 2005-05-24
CA2290125A1 (fr) 2000-12-25
CZ292174B6 (cs) 2003-08-13
JP2002523432A (ja) 2002-07-30
GB0101508D0 (en) 2001-03-07
CZ2001319A3 (en) 2001-05-16
ATA904099A (de) 2002-05-15
NZ514982A (en) 2004-01-30
DE19983486T1 (de) 2001-10-18
AU1374800A (en) 2000-03-21
WO2000011926A3 (fr) 2000-06-29
SK18412001A3 (sk) 2002-05-09
HUP0103417A3 (en) 2003-01-28
SE0100194L (sv) 2001-04-25
ZA200108855B (en) 2002-08-28
SE516689C2 (sv) 2002-02-12
BR9917367A (pt) 2002-03-05
JP3389571B2 (ja) 2003-03-24
CA2290125C (fr) 2004-08-10
ITMI991579A1 (it) 2001-01-15
UA62023C2 (en) 2003-12-15
AU2001100433B4 (en) 2002-01-17
DK1105382T3 (da) 2002-05-27
CN1129593C (zh) 2003-12-03
GB2354240A (en) 2001-03-21
SE0100194D0 (sv) 2001-01-24
ES2172356T3 (es) 2002-09-16
FI20010154A (fi) 2001-02-09
FI108538B (fi) 2002-02-15
WO2000011926A2 (fr) 2000-03-09
AT409960B (de) 2002-12-27
EA002661B1 (ru) 2002-08-29
KR20020011982A (ko) 2002-02-09
DE69900891D1 (de) 2002-03-21

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