DK1023107T3 - Fremgangsmåde til indgivelse af farmaceutiske præparater og nucleinsyrer i skeletmuskulaturen - Google Patents

Fremgangsmåde til indgivelse af farmaceutiske præparater og nucleinsyrer i skeletmuskulaturen

Info

Publication number
DK1023107T3
DK1023107T3 DK98909691T DK98909691T DK1023107T3 DK 1023107 T3 DK1023107 T3 DK 1023107T3 DK 98909691 T DK98909691 T DK 98909691T DK 98909691 T DK98909691 T DK 98909691T DK 1023107 T3 DK1023107 T3 DK 1023107T3
Authority
DK
Denmark
Prior art keywords
muscle
nucleic acids
skeletal muscle
administration
pharmaceutical compositions
Prior art date
Application number
DK98909691T
Other languages
Danish (da)
English (en)
Inventor
Terje Lomo
Iacob Mathiesen
Original Assignee
Electrofect As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Electrofect As filed Critical Electrofect As
Application granted granted Critical
Publication of DK1023107T3 publication Critical patent/DK1023107T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/04Mycobacterium, e.g. Mycobacterium tuberculosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/20Applying electric currents by contact electrodes continuous direct currents
    • A61N1/205Applying electric currents by contact electrodes continuous direct currents for promoting a biological process
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014External stimulators, e.g. with patch electrodes
    • A61N1/36017External stimulators, e.g. with patch electrodes with leads or electrodes penetrating the skin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Electrotherapy Devices (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK98909691T 1997-04-03 1998-04-03 Fremgangsmåde til indgivelse af farmaceutiske præparater og nucleinsyrer i skeletmuskulaturen DK1023107T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4259497P 1997-04-03 1997-04-03

Publications (1)

Publication Number Publication Date
DK1023107T3 true DK1023107T3 (da) 2006-12-27

Family

ID=21922760

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98909691T DK1023107T3 (da) 1997-04-03 1998-04-03 Fremgangsmåde til indgivelse af farmaceutiske præparater og nucleinsyrer i skeletmuskulaturen

Country Status (16)

Country Link
US (1) US6110161A (fr)
EP (1) EP1023107B1 (fr)
JP (2) JP2001520537A (fr)
KR (1) KR100427786B1 (fr)
CN (1) CN1198665C (fr)
AT (1) ATE337794T1 (fr)
AU (1) AU733628B2 (fr)
CA (1) CA2285056C (fr)
DE (1) DE69835761T2 (fr)
DK (1) DK1023107T3 (fr)
EA (1) EA002087B1 (fr)
ES (1) ES2273408T3 (fr)
IL (1) IL132103A0 (fr)
NO (1) NO327806B1 (fr)
NZ (1) NZ337853A (fr)
WO (1) WO1998043702A2 (fr)

Families Citing this family (126)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5702359A (en) * 1995-06-06 1997-12-30 Genetronics, Inc. Needle electrodes for mediated delivery of drugs and genes
US5993434A (en) * 1993-04-01 1999-11-30 Genetronics, Inc. Method of treatment using electroporation mediated delivery of drugs and genes
US6261281B1 (en) * 1997-04-03 2001-07-17 Electrofect As Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells
EP0991425B1 (fr) * 1997-06-30 2005-03-09 Institut Gustave Roussy Amelioration du transfert d'acide nucleique dans les cellules d'organismes eucaryotes pluricellulaires et combinaison permettant la mise en oeuvre du procede
BR9810369A (pt) 1997-06-30 2000-09-05 Rhone Poulenc Rorer Sa Processo de transferência de ácido nucleico para o interior de um ou mais músculos estriados, in vivo, composição, ácido mucleico e campo elétrico, e, produto de combinação
US6241701B1 (en) 1997-08-01 2001-06-05 Genetronics, Inc. Apparatus for electroporation mediated delivery of drugs and genes
US6055453A (en) 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
US20040229363A1 (en) * 1998-06-24 2004-11-18 Ed Nolan High efficiency transfection based on low electric field strength, long pulse length
EP1100579B1 (fr) 1998-07-13 2015-09-02 Inovio Pharmaceuticals, Inc. Therapie genique par champ electrique pulse visant la peau et les muscles
US6678556B1 (en) 1998-07-13 2004-01-13 Genetronics, Inc. Electrical field therapy with reduced histopathological change in muscle
US7922709B2 (en) 1998-07-13 2011-04-12 Genetronics, Inc. Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation
AU2868200A (en) * 1999-02-08 2000-08-25 Chiron Corporation Electrically-mediated enhancement of dna vaccine immunity and efficacy in vivo
US6593130B1 (en) 1999-04-16 2003-07-15 The Regents Of The University Of California Method and apparatus for ex vivo and in vivo cellular electroporation of gene protein or drug therapy
BR0108959A (pt) * 2000-03-03 2003-10-14 Valentis Inc Composições de polox‰mero ou poloxamina melhoradas para distribuição de ácido nucléico
JP2004532654A (ja) 2000-05-22 2004-10-28 マーク・アンド・カンパニー・インコーポレイテッド 薬剤投与システム性能評価システム及び方法
US6733485B1 (en) 2001-05-25 2004-05-11 Advanced Bionics Corporation Microstimulator-based electrochemotherapy methods and systems
US20040204669A1 (en) * 2001-07-05 2004-10-14 Hofmann Gunter A. Apparatus for electroporation mediated delivery for drugs and genes
US7713740B2 (en) * 2001-08-24 2010-05-11 University Of South Florida Method of using electric fields to facilitate the entry of molecules into cells in vivo
CA2461380C (fr) 2001-10-11 2011-03-22 Merck & Co., Inc. Vaccin contre le virus de l'hepatite c
PT1436397E (pt) 2001-10-11 2010-07-15 Angeletti P Ist Richerche Bio Vacina de v�rus da hepatite c
US7252819B2 (en) * 2001-11-08 2007-08-07 The Regents Of The University Of California Methods and compositions for correction of cardiac conduction disturbances
WO2003051454A2 (fr) * 2001-12-14 2003-06-26 Genetronics, Inc. Procedes d'immunisation assistee par particules reposant sur l'utilisation d'un champ electrique pulse
JP2005527490A (ja) * 2002-01-18 2005-09-15 イノヴィオ アーエス 筋肉内投与のための二重特異性抗体dna構築物
US8209006B2 (en) 2002-03-07 2012-06-26 Vgx Pharmaceuticals, Inc. Constant current electroporation device and methods of use
CA2477872A1 (fr) 2002-03-07 2003-09-18 Merck & Co., Inc. Seringue clinique avec des aspects de stimulation electrique
US7245963B2 (en) * 2002-03-07 2007-07-17 Advisys, Inc. Electrode assembly for constant-current electroporation and use
US6912417B1 (en) 2002-04-05 2005-06-28 Ichor Medical Systmes, Inc. Method and apparatus for delivery of therapeutic agents
DE60322523D1 (de) 2002-04-16 2008-09-11 Cyto Pulse Sciences Inc Ien mit übersetzenden elektrischen feldern und elektroden-polaritäts-umkehr
US20040106896A1 (en) * 2002-11-29 2004-06-03 The Regents Of The University Of California System and method for forming a non-ablative cardiac conduction block
US7328064B2 (en) 2002-07-04 2008-02-05 Inovio As Electroporation device and injection apparatus
PT1729848E (pt) 2004-03-08 2015-08-28 Ichor Medical Systems Inc Dispositivo melhorado para uma administração electricamente mediada de agentes terapêuticos
TW200613554A (en) 2004-06-17 2006-05-01 Wyeth Corp Plasmid having three complete transcriptional units and immunogenic compositions for inducing an immune response to HIV
CA2598134A1 (fr) * 2005-03-19 2006-09-28 The Regents Of The University Of California Administration ex vivo, dans des cellules, de genes, de proteines et de medicaments mediee par un reseau de champ electrique de force ultrafaible (lsefn)
EP2570423B1 (fr) 2005-06-17 2023-05-03 MSD Italia S.r.l. Vaccin à acide nucléique contre l'hépatite C
AU2007215328A1 (en) * 2006-02-13 2007-08-23 Oncolytics Biotech Inc. Use of local immune suppression to enhance oncolytic viral therapy
WO2008063555A2 (fr) 2006-11-17 2008-05-29 Genetronics, Inc. Méthodes accroissant la réponse immunitaire par vaccination assistée par électroporation, et renfort
EP2612868B1 (fr) 2007-11-01 2018-08-15 Astellas Pharma Inc. Acides nucléiques et polypeptides immunosuppresseurs
US8852609B2 (en) * 2008-04-04 2014-10-07 The Trustees Of The University Of Pennsylvania Consensus sequences of chikungunya viral proteins, nucleic acid molecules encoding the same, and compositions and methods for using the same
CA2720168C (fr) 2008-04-04 2024-04-30 David B. Weiner Vaccins et agents immunotherapeutiques utilisant il-28 et compositions et methodes les utilisant
EP2147697A1 (fr) 2008-07-21 2010-01-27 Centre National De La Recherche Scientifique-CNRS Procédé et dispositif pour appliquer des champs électriques dans un matériau conducteur
EP2156860A1 (fr) 2008-08-20 2010-02-24 Centre National De La Recherche Scientifique-CNRS Procédé de fabrication d'électrodes isolées pour l'application de champs électriques dans un matériau conducteur
US20100298697A1 (en) * 2009-05-19 2010-11-25 Medtronic, Inc. Method and devices for improved efficiency of rna delivery to cells
US8207138B2 (en) 2009-05-19 2012-06-26 Medtronic, Inc. Methods and devices for improved efficiency of RNA delivery to cells
KR20120093163A (ko) 2009-09-14 2012-08-22 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 Il-15 수용체 알파 및/또는 이를 인코딩하는 핵산 분자를 포함하는 백신 및 면역 치료제, 및 이를 이용하는 방법
KR102138780B1 (ko) 2009-11-02 2020-07-29 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 구제역 바이러스(fmdv) 공통 단백질, 이를 위한 코딩 서열 및 이로부터 만들어진 백신
US8298820B2 (en) 2010-01-26 2012-10-30 The Trustees Of The University Of Pennsylvania Influenza nucleic acid molecules and vaccines made therefrom
KR101784177B1 (ko) 2010-02-08 2017-10-11 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 Rantes를 암호화하는 핵산 분자, 그리고 이를 포함하는 조성물 및 이의 사용 방법
WO2012047679A2 (fr) 2010-09-27 2012-04-12 The Trustees Of The University Of Pennsylvania Produits de synthèse d'antigène consensus et vaccins fabriqués à partir de ceux-ci, et procédés d'utilisation de ceux-ci pour traiter le paludisme
AU2011325893B2 (en) 2010-11-12 2016-01-14 Inovio Pharmaceuticals, Inc Consensus prostate antigens nucleic acid molecule encoding the same and vaccine and uses comprising the same
JP6099573B2 (ja) 2011-01-31 2017-03-22 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 新規なヘルペス抗原をコードする核酸分子、それを含むワクチン及びその使用方法
US9238679B2 (en) 2011-02-11 2016-01-19 The Trustees Of The University Of Pennslyvania Nucleic acid molecule encoding hepatitis B virus core protein and surface antigen protein and vaccine comprising the same
PT2672992T (pt) 2011-02-11 2020-07-27 Univ Pennsylvania Molécula de ácidos nucleicos codificando proteína nuclear do vírus da hepatite b e vacina compreendendo a mesma
CN103717249B (zh) 2011-06-15 2017-03-22 克洛恩泰克制药股份公司 注射针和装置
CA2841852C (fr) 2011-07-11 2020-06-30 Inovio Pharmaceuticals, Inc. Vaccins fournissant une protection croisee contre les arenavirus et leur procede d'utilisation
US9750795B2 (en) 2011-12-12 2017-09-05 The Trustees Of The University Of Pennsylvania Proteins comprising MRSA PBP2a and fragments thereof, nucleic acids encoding the same, and compositions and their use to prevent and treat MRSA infections
EP3336096A1 (fr) 2011-12-12 2018-06-20 The Trustees Of The University Of Pennsylvania Compositions comprenant des constructions génétiques d'il-12 améliorés et des vaccins améliorés, produits immunothérapeutiques et procédés d'utilisation associés
CN104619719A (zh) 2012-04-10 2015-05-13 宾夕法尼亚大学理事会 人呼吸道合胞病毒共有抗原、由其制备的核酸构建体和疫苗及其使用方法
CA2870293C (fr) 2012-04-12 2023-05-09 The Trustees Of The University Of Pennsylvania Antigenes consensus de filovirus, constructions d'acides nucleiques et vaccins a base de ceux-ci, et leurs methodes d'utilisation
DE102012013534B3 (de) 2012-07-05 2013-09-19 Tobias Sokolowski Vorrichtung für repetitive Nervenstimulation zum Abbau von Fettgewebe mittels induktiver Magnetfelder
WO2014064534A2 (fr) 2012-10-05 2014-05-01 Chrontech Pharma Ab Aiguille d'injection, dispositif, compositions immunogènes et procédé d'utilisation
KR20230038607A (ko) 2012-12-13 2023-03-20 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 Wt1 백신
WO2015089492A2 (fr) 2013-12-13 2015-06-18 The Trustees Of The University Of Pennsylvania Constructions d'anticorps d'adn et procédé d'utilisation
KR20210088754A (ko) 2013-03-15 2021-07-14 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 구제역 바이러스 (fmdv) 공통 단백질, 그에 대한 코딩 서열 및 그로부터 제조된 백신
EA034110B1 (ru) 2013-03-15 2019-12-27 Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания Противораковые вакцины и способы лечения с их применением
KR20160037196A (ko) 2013-07-31 2016-04-05 더 보드 오브 트러스티스 오브 더 유니버시티 오브 아칸소 종양 연관된 탄수화물 항원을 표적으로 하는 암을 치료하고 예방하기 위한 조성물과 방법
US11278619B2 (en) 2014-12-01 2022-03-22 The Trustees Of The University Of Pennsylvania DNA antibody constructs and method of using same
US11491342B2 (en) 2015-07-01 2022-11-08 Btl Medical Solutions A.S. Magnetic stimulation methods and devices for therapeutic treatments
US11266850B2 (en) 2015-07-01 2022-03-08 Btl Healthcare Technologies A.S. High power time varying magnetic field therapy
US20180001107A1 (en) 2016-07-01 2018-01-04 Btl Holdings Limited Aesthetic method of biological structure treatment by magnetic field
US10695575B1 (en) 2016-05-10 2020-06-30 Btl Medical Technologies S.R.O. Aesthetic method of biological structure treatment by magnetic field
WO2017055522A1 (fr) 2015-09-29 2017-04-06 Academisch Medisch Centrum Protéines env stabilisées du vih
US11253717B2 (en) 2015-10-29 2022-02-22 Btl Healthcare Technologies A.S. Aesthetic method of biological structure treatment by magnetic field
CA3013718C (fr) 2016-02-05 2023-09-26 Jian Yan Vaccins anticancereux et methodes de traitement les utilisant
AU2017241925B2 (en) 2016-03-28 2022-01-13 Ichor Medical Systems, Inc. Method and apparatus for delivery of therapeutic agents
JP7250520B2 (ja) 2016-04-13 2023-04-03 ヤンセン ファーマシューティカルズ,インコーポレーテッド 組換えアルテリウイルスレプリコン系およびその使用
US11464993B2 (en) 2016-05-03 2022-10-11 Btl Healthcare Technologies A.S. Device including RF source of energy and vacuum system
US11247039B2 (en) 2016-05-03 2022-02-15 Btl Healthcare Technologies A.S. Device including RF source of energy and vacuum system
US11534619B2 (en) 2016-05-10 2022-12-27 Btl Medical Solutions A.S. Aesthetic method of biological structure treatment by magnetic field
US10583287B2 (en) 2016-05-23 2020-03-10 Btl Medical Technologies S.R.O. Systems and methods for tissue treatment
US10556122B1 (en) 2016-07-01 2020-02-11 Btl Medical Technologies S.R.O. Aesthetic method of biological structure treatment by magnetic field
WO2018075235A1 (fr) 2016-10-17 2018-04-26 Synthetic Genomics, Inc. Systèmes réplicons de virus recombinants et leurs utilisations
US11845939B2 (en) 2016-12-05 2023-12-19 Janssen Pharmaceuticals, Inc. Compositions and methods for enhancing gene expression
WO2019042950A1 (fr) 2017-08-26 2019-03-07 Academisch Medisch Centrum Immunogènes glycoprotéiques d'enveloppe de vih améliorés
EP3737397B1 (fr) 2017-12-13 2022-11-30 Inovio Pharmaceuticals, Inc. Vaccins anticancéreux ciblant l'antigène exprimé de façon préférentielle dans le mélanome (prame) et ses utilisations
EP3723812A4 (fr) 2017-12-13 2022-02-16 Inovio Pharmaceuticals, Inc. Vaccins anticancer ciblant muc16 et leurs utilisations
AU2018383658B2 (en) 2017-12-13 2022-02-10 Inovio Pharmaceuticals, Inc. Cancer vaccines targeting mesothelin and uses thereof
EA202091517A1 (ru) 2017-12-19 2020-11-03 Янссен Сайенсиз Айрлэнд Анлимитед Компани Способы и устройство для доставки вакцин против вируса гепатита b (hbv)
MA51311A (fr) 2017-12-19 2020-10-28 Janssen Sciences Ireland Unlimited Co Vaccins contre le virus de l'hépatite b (vhb) et utilisations associées
EA202091513A1 (ru) 2017-12-19 2020-09-09 Янссен Сайенсиз Айрлэнд Анлимитед Компани Вакцины против вируса гепатита b (hbv) и их применение
EA202091516A1 (ru) 2017-12-19 2020-11-03 Янссен Сайенсиз Айрлэнд Анлимитед Компани Способы и композиции для индукции иммунного ответа против вируса гепатита b (hbv)
KR20200100745A (ko) 2017-12-19 2020-08-26 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 B형 간염 바이러스(hbv)에 대한 면역 반응 유도를 위한 방법 및 조성물
US11083786B2 (en) 2018-01-19 2021-08-10 Janssen Pharmaceuticals, Inc. Induce and enhance immune responses using recombinant replicon systems
AU2020270557C1 (en) 2019-04-11 2022-01-20 Btl Medical Solutions A.S. Methods and devices for aesthetic treatment of biological structures by radiofrequency and magnetic energy
KR20220041080A (ko) 2019-06-18 2022-03-31 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 B형 간염 바이러스(hbv) 백신 및 항-pd-1 또는 항-pc-l1 항체의 조합
CA3140708A1 (fr) 2019-06-18 2020-12-24 Helen Horton Association de vaccins contre le virus de l'hepatite b (vhb) et de derives de pyridopyrimidine
US20220233684A1 (en) 2019-06-18 2022-07-28 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and pd-l1 inhibitors
WO2020255010A1 (fr) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combinaison d'une construction d'interleukine 12 recombinante et de vaccins contre le virus de l'hépatite b (vhb)
WO2020255039A1 (fr) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Association de vaccins contre le virus de l'hépatite b (vhb) et de dérivés de quinazoline
AU2020297008A1 (en) 2019-06-18 2022-02-17 Janssen Sciences Ireland Unlimited Company Combination of hepatitis B virus (HBV) vaccines and HBV-targeting RNAi
WO2020255019A1 (fr) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combinaison de vaccins contre le virus de l'hépatite b (vhb) et d'un dérivé de la quinazoline
WO2020254876A1 (fr) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Administration de particules de type viral de vaccins contre le virus de l'hépatite b (vhb)
WO2020255013A1 (fr) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combinaison de vaccins contre le virus de l'hépatite b (vhb) et de modulateurs d'assemblage de capside qui sont des dérivés d'amide
CA3141323A1 (fr) 2019-06-18 2020-12-24 Helen Horton Construction de l'interleukine 12 recombinante et ses utilisations
CA3140690A1 (fr) 2019-06-18 2020-12-24 Helen Horton Combinaison de vaccins contre le virus de l'hepatite b (vhb) et de derives de dihydropyrimidine en tant que modulateurs d'assemblage de capside
CA3140702A1 (fr) 2019-06-18 2020-12-24 Helen Horton Combinaison de vaccins contre le virus de l'hepatite b (vhb) et de derives de dihydropyrimidine en tant que modulateurs d'assemblage de capside
WO2020255042A1 (fr) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combinaison de vaccins contre le virus de l'hépatite b (vhb) et d'un dérivé de pyrimidine
EP3986562A1 (fr) 2019-06-18 2022-04-27 Janssen Sciences Ireland Unlimited Company Combinaison de vaccins contre le virus de l'hépatite b (vhb) et d'arni ciblant le virus de l'hépatite b
EP3986460A2 (fr) 2019-06-18 2022-04-27 Janssen Sciences Ireland Unlimited Company Combinaison de vaccins contre le virus de l'hépatite b (vhb) et d'anticorps anti-pd-1
US20220305114A1 (en) 2019-06-18 2022-09-29 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and small molecule pdl1 or pd1 inhibitor
WO2020255035A1 (fr) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combinaison de vaccins contre le virus de l'hépatite b (vhb) et de dérivés de pyrimidine
WO2020255022A1 (fr) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combinaison de vaccins contre le virus de l'hépatite b (vhb) et de dérivés d'aminopyridine en tant qu'inhibiteurs de hpk1
US20220324916A1 (en) 2019-06-18 2022-10-13 Janssen Sciences Ireland Unlimited Company Hepatitis B Virus (HBV) Vaccines and Uses Thereof
WO2020255016A1 (fr) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combinaison de vaccins contre le virus de l'hépatite b (vhb) et de dérivés de dihydropyrimidine en tant que modulateurs de l'assemblage des capsides
TWI772823B (zh) 2019-06-18 2022-08-01 愛爾蘭商健生科學愛爾蘭無限公司 B型肝炎病毒(hbv)疫苗與蛋白殼組裝調節劑之組合
US20220305108A1 (en) 2019-06-20 2022-09-29 Janssen Sciences Ireland Unlimited Company Lipid nanoparticle or liposome delivery of hepatitis b virus (hbv) vaccines
EP3986457A1 (fr) 2019-06-20 2022-04-27 Janssen Sciences Ireland Unlimited Company Administration par nanoporteurs glucidiques, de vaccins contre le virus de l'hépatite b (vhb)
US11878167B2 (en) 2020-05-04 2024-01-23 Btl Healthcare Technologies A.S. Device and method for unattended treatment of a patient
MX2022013485A (es) 2020-05-04 2022-11-30 Btl Healthcare Tech A S Dispositivo y metodo para el tratamiento sin atencion del paciente.
AU2021289600A1 (en) 2020-06-12 2023-01-19 University Of Rochester Encoding and expression of ACE-tRNAs
WO2022008613A1 (fr) 2020-07-08 2022-01-13 Janssen Sciences Ireland Unlimited Company Vaccins à base de réplicon d'arn contre le vhb
WO2022133230A1 (fr) 2020-12-18 2022-06-23 Janssen Pharmaceuticals, Inc. Polythérapie pour le traitement d'une infection par le virus de l'hépatite b
JP2024501022A (ja) 2020-12-28 2024-01-10 アークトゥルス セラピューティクス, インコーポレイテッド Hbvを標的とする転写活性化因子様エフェクターヌクレアーゼ(talen)
US11896816B2 (en) 2021-11-03 2024-02-13 Btl Healthcare Technologies A.S. Device and method for unattended treatment of a patient
WO2023150753A1 (fr) 2022-02-07 2023-08-10 University Of Rochester Séquences optimisées pour une expression d'adn améliorée et/ou une suppression de mutation non sens
WO2023233290A1 (fr) 2022-05-31 2023-12-07 Janssen Sciences Ireland Unlimited Company Agents d'arni ciblant pd-l1
WO2024129459A1 (fr) 2022-12-16 2024-06-20 University Of Rochester Réparation d'un dysfonctionnement de la barrière dans l'œsophage

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5389069A (en) * 1988-01-21 1995-02-14 Massachusetts Institute Of Technology Method and apparatus for in vivo electroporation of remote cells and tissue
US5501662A (en) * 1992-05-22 1996-03-26 Genetronics, Inc. Implantable electroporation method and apparatus for drug and gene delivery
US5304120A (en) * 1992-07-01 1994-04-19 Btx Inc. Electroporation method and apparatus for insertion of drugs and genes into endothelial cells
US5273525A (en) * 1992-08-13 1993-12-28 Btx Inc. Injection and electroporation apparatus for drug and gene delivery
US5318514A (en) * 1992-08-17 1994-06-07 Btx, Inc. Applicator for the electroporation of drugs and genes into surface cells
US5468223A (en) * 1992-11-30 1995-11-21 C.N.R.S. Paris Electrochemotherapy
FR2703253B1 (fr) * 1993-03-30 1995-06-23 Centre Nat Rech Scient Applicateur d'impulsions electriques pour traitement de tissus biologiques.
US5993434A (en) * 1993-04-01 1999-11-30 Genetronics, Inc. Method of treatment using electroporation mediated delivery of drugs and genes
US5702359A (en) * 1995-06-06 1997-12-30 Genetronics, Inc. Needle electrodes for mediated delivery of drugs and genes
IL108775A (en) * 1994-02-25 2003-09-17 Univ Ramot Method for efficient incorporation of molecules into cells
JPH10502858A (ja) * 1995-05-02 1998-03-17 フィリップス エレクトロニクス エヌ ベー 対象の磁気共鳴画像化方法及び装置
US5944710A (en) * 1996-06-24 1999-08-31 Genetronics, Inc. Electroporation-mediated intravascular delivery
EP0991425B1 (fr) * 1997-06-30 2005-03-09 Institut Gustave Roussy Amelioration du transfert d'acide nucleique dans les cellules d'organismes eucaryotes pluricellulaires et combinaison permettant la mise en oeuvre du procede

Also Published As

Publication number Publication date
NZ337853A (en) 2002-03-28
US6110161A (en) 2000-08-29
DE69835761D1 (de) 2006-10-12
WO1998043702A2 (fr) 1998-10-08
EP1023107B1 (fr) 2006-08-30
EA002087B1 (ru) 2001-12-24
JP2001520537A (ja) 2001-10-30
DE69835761T2 (de) 2007-09-13
ES2273408T3 (es) 2007-05-01
JP2006061701A (ja) 2006-03-09
CA2285056A1 (fr) 1998-10-08
ATE337794T1 (de) 2006-09-15
IL132103A0 (en) 2001-03-19
CN1198665C (zh) 2005-04-27
NO994820D0 (no) 1999-10-04
CA2285056C (fr) 2004-12-14
CN1276740A (zh) 2000-12-13
NO994820L (no) 1999-12-03
AU6990698A (en) 1998-10-22
EP1023107A1 (fr) 2000-08-02
KR20010005932A (ko) 2001-01-15
NO327806B1 (no) 2009-09-28
EA199900882A1 (ru) 2001-02-26
AU733628B2 (en) 2001-05-17
KR100427786B1 (ko) 2004-04-30

Similar Documents

Publication Publication Date Title
DK1023107T3 (da) Fremgangsmåde til indgivelse af farmaceutiske præparater og nucleinsyrer i skeletmuskulaturen
ATE275423T1 (de) Verabreichung der nukleinsäure in den quergestreiften muskel
Gratieri et al. Non-invasive iontophoretic delivery of peptides and proteins across the skin
AR017866A1 (es) Metodo para incrementar las inmunorespuestas de vacunas de acidos nucleicos, composiciones farmaceuticas de aplicacion en dicho metodo, procedimientopara preparar dichas composiciones y vacunas utilizadas en dicho metodo.
DK0559884T4 (da) Rekombinante virusvektorer til ekspression i muskelceller
DK0939590T3 (da) Nukleinsyre til anvendelse i genterapi, der involverer ekspression af tarmcellegener
ATE332725T1 (de) Verfahren zur elektropermeabilisation einzelner zellulärer und organeller strukturen
ATE323169T1 (de) Plasmid zur verabreichung von nukleine säuren und verwendungsverfahren
ATE406936T1 (de) Vorrichtung zur elektroporation von genen, proteinen oder zur verabreichung von medikamenten
DE69837274D1 (de) Verfahren zur verkapselung von nukleinsäuren in lipiddoppelschichten
DE69535853D1 (de) Kompaktnukleinsäure und ihre verabreichung in zellen
CA2087087C (fr) Molecules pour administration par ionophorese
EA200100856A1 (ru) Способ инкапсулирования биологически активных комплексов в липосомы
WO2003099225A3 (fr) Compositions conçues pour administrer des acides nucleiques aux cellules
IT1232827B (it) Proteine biologicamente attive, formulazioni che le contengono e metodo per prepararle ed applicarle
ATE88500T1 (de) Dna-sequenzen, die fuer proteine mit der biologischen aktivitaet der husi-typi-inhibitoren codieren, gentechnologische verfahren zur herstellung dieser proteine und diese proteine enthaltende arzneimittel.
EE200000102A (et) Meetodid ja kompositsioonid teraapiaks, kasutades sekreteeritavaid valke, näiteks interferoon-beetat kodeerivaid geene
IL131436A0 (en) Compositions for treatment of disorders involving programmed cell death
US20010023317A1 (en) Needle with electrodes for electroporation-mediated gene therapy
OA08355A (fr) Nouveaux benzamides, leur procédé de préparation et leur application dans le domaine thérapeutique.
CN1270225A (zh) Epo基因的电针转移技术
Park et al. On the possible fusion-promoting factor secreted from cultured myoblasts
WO2004028442A3 (fr) Utilisation d'excipients afin d'augmenter la prise d'adn par des cellules musculaires de porc
BR9708855A (pt) Cromossomas artificiais, usos dos mesmos e processos para preparar cromossomas artificiais