NO327806B1 - Anvendelse av promoterforbundet nukleinsyre ved fremstilling av et medikament egnet til avlevering til elektrisk stimulert muskel hos et pattedyr - Google Patents

Anvendelse av promoterforbundet nukleinsyre ved fremstilling av et medikament egnet til avlevering til elektrisk stimulert muskel hos et pattedyr Download PDF

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Publication number
NO327806B1
NO327806B1 NO19994820A NO994820A NO327806B1 NO 327806 B1 NO327806 B1 NO 327806B1 NO 19994820 A NO19994820 A NO 19994820A NO 994820 A NO994820 A NO 994820A NO 327806 B1 NO327806 B1 NO 327806B1
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NO
Norway
Prior art keywords
muscle
muscles
dna
nucleic acid
stimulated
Prior art date
Application number
NO19994820A
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English (en)
Norwegian (no)
Other versions
NO994820L (no
NO994820D0 (no
Inventor
Iacob Mathiesen
Terje Lomo
Original Assignee
Electrofect As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Electrofect As filed Critical Electrofect As
Publication of NO994820D0 publication Critical patent/NO994820D0/no
Publication of NO994820L publication Critical patent/NO994820L/no
Publication of NO327806B1 publication Critical patent/NO327806B1/no

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/04Mycobacterium, e.g. Mycobacterium tuberculosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/20Applying electric currents by contact electrodes continuous direct currents
    • A61N1/205Applying electric currents by contact electrodes continuous direct currents for promoting a biological process
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014External stimulators, e.g. with patch electrodes
    • A61N1/36017External stimulators, e.g. with patch electrodes with leads or electrodes penetrating the skin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Electrotherapy Devices (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
NO19994820A 1997-04-03 1999-10-04 Anvendelse av promoterforbundet nukleinsyre ved fremstilling av et medikament egnet til avlevering til elektrisk stimulert muskel hos et pattedyr NO327806B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4259497P 1997-04-03 1997-04-03
PCT/IB1998/000487 WO1998043702A2 (fr) 1997-04-03 1998-04-03 Methode pour introduire des medicaments et des acides nucleiques dans le muscle squelettique

Publications (3)

Publication Number Publication Date
NO994820D0 NO994820D0 (no) 1999-10-04
NO994820L NO994820L (no) 1999-12-03
NO327806B1 true NO327806B1 (no) 2009-09-28

Family

ID=21922760

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19994820A NO327806B1 (no) 1997-04-03 1999-10-04 Anvendelse av promoterforbundet nukleinsyre ved fremstilling av et medikament egnet til avlevering til elektrisk stimulert muskel hos et pattedyr

Country Status (16)

Country Link
US (1) US6110161A (fr)
EP (1) EP1023107B1 (fr)
JP (2) JP2001520537A (fr)
KR (1) KR100427786B1 (fr)
CN (1) CN1198665C (fr)
AT (1) ATE337794T1 (fr)
AU (1) AU733628B2 (fr)
CA (1) CA2285056C (fr)
DE (1) DE69835761T2 (fr)
DK (1) DK1023107T3 (fr)
EA (1) EA002087B1 (fr)
ES (1) ES2273408T3 (fr)
IL (1) IL132103A0 (fr)
NO (1) NO327806B1 (fr)
NZ (1) NZ337853A (fr)
WO (1) WO1998043702A2 (fr)

Families Citing this family (125)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5702359A (en) * 1995-06-06 1997-12-30 Genetronics, Inc. Needle electrodes for mediated delivery of drugs and genes
US5993434A (en) * 1993-04-01 1999-11-30 Genetronics, Inc. Method of treatment using electroporation mediated delivery of drugs and genes
US6261281B1 (en) * 1997-04-03 2001-07-17 Electrofect As Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells
EP0991426B2 (fr) 1997-06-30 2007-03-28 Institut Gustave Roussy Procede de transfert d'acide nucleique dans le muscle strie
DE69829287T2 (de) * 1997-06-30 2006-04-13 Centre National De La Recherche Scientifique (Cnrs) Verbesserung der verabreichung der nukleinsäure in zellen der plurizellulären eukaryotischen organismen und kombination zur durchführung des verfahrens
US6241701B1 (en) 1997-08-01 2001-06-05 Genetronics, Inc. Apparatus for electroporation mediated delivery of drugs and genes
US6055453A (en) 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
US20040229363A1 (en) * 1998-06-24 2004-11-18 Ed Nolan High efficiency transfection based on low electric field strength, long pulse length
JP2003505114A (ja) 1998-07-13 2003-02-12 ジェネトロニクス、インコーポレーテッド パルス電場による皮膚および筋肉を標的とした遺伝子治療
US7922709B2 (en) 1998-07-13 2011-04-12 Genetronics, Inc. Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation
US6678556B1 (en) * 1998-07-13 2004-01-13 Genetronics, Inc. Electrical field therapy with reduced histopathological change in muscle
EP1148885A4 (fr) * 1999-02-08 2002-05-08 Chiron Corp Augmentation electriquement induite de l'immunite et de l'efficacite de vaccins d'adn in vivo
US6593130B1 (en) 1999-04-16 2003-07-15 The Regents Of The University Of California Method and apparatus for ex vivo and in vivo cellular electroporation of gene protein or drug therapy
CA2401239A1 (fr) * 2000-03-03 2001-09-13 Valentis, Inc. Compositions ameliorees de poloxamere et de poloxamine generatrices d'acide nucleique
JP2004532654A (ja) 2000-05-22 2004-10-28 マーク・アンド・カンパニー・インコーポレイテッド 薬剤投与システム性能評価システム及び方法
US6733485B1 (en) 2001-05-25 2004-05-11 Advanced Bionics Corporation Microstimulator-based electrochemotherapy methods and systems
US20040204669A1 (en) * 2001-07-05 2004-10-14 Hofmann Gunter A. Apparatus for electroporation mediated delivery for drugs and genes
US7713740B2 (en) * 2001-08-24 2010-05-11 University Of South Florida Method of using electric fields to facilitate the entry of molecules into cells in vivo
ATE467680T1 (de) 2001-10-11 2010-05-15 Merck Sharp & Dohme Hepatitis-c-virus-impfstoff
CN1880457B (zh) 2001-10-11 2010-05-26 麦克公司 Ad6重组核酸
CN1612691A (zh) * 2001-11-08 2005-05-04 加利福尼亚大学董事会 纠正心脏传导障碍的方法和组合物
AU2002360648B2 (en) * 2001-12-14 2009-01-08 Genetronics, Inc. Methods for particle-assisted polynucleotide immunization using a pulsed electric field
JP2005527490A (ja) * 2002-01-18 2005-09-15 イノヴィオ アーエス 筋肉内投与のための二重特異性抗体dna構築物
US8209006B2 (en) 2002-03-07 2012-06-26 Vgx Pharmaceuticals, Inc. Constant current electroporation device and methods of use
US7245963B2 (en) * 2002-03-07 2007-07-17 Advisys, Inc. Electrode assembly for constant-current electroporation and use
EP1480692A2 (fr) 2002-03-07 2004-12-01 Merck & Co., Inc. Seringue clinique avec des aspects de stimulation electrique
US6912417B1 (en) * 2002-04-05 2005-06-28 Ichor Medical Systmes, Inc. Method and apparatus for delivery of therapeutic agents
AU2003223351A1 (en) 2002-04-16 2003-11-03 Cyto Pulse Sciences, Inc. Method of treating biological materials with translating electrical fields and electrode polarity reversal
US20040106896A1 (en) * 2002-11-29 2004-06-03 The Regents Of The University Of California System and method for forming a non-ablative cardiac conduction block
US7328064B2 (en) 2002-07-04 2008-02-05 Inovio As Electroporation device and injection apparatus
SG136133A1 (en) 2004-03-08 2007-10-29 Ichor Medical Systems Inc Ca U Improved apparatus for electrically mediated delivery of therapeutic agents
TW200613554A (en) 2004-06-17 2006-05-01 Wyeth Corp Plasmid having three complete transcriptional units and immunogenic compositions for inducing an immune response to HIV
JP2008532560A (ja) 2005-03-19 2008-08-21 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 微弱電界ネットワークを仲介して行う、生体外で細胞内に遺伝子、タンパク質および薬剤を送達する方法および装置
JP5475279B2 (ja) 2005-06-17 2014-04-16 イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・エルレ・エルレ C型肝炎ウイルス核酸ワクチン
US20070190032A1 (en) * 2006-02-13 2007-08-16 Oncolytics Biotech Inc. Use of Local Immune Suppression to Enhance Oncolytic Viral Therapy
CA2668649A1 (fr) 2006-11-17 2008-05-29 Genetronics, Inc. Methodes accroissant la reponse immunitaire par vaccination assistee par electroporation, et renfort
CN101998965B (zh) 2007-11-01 2014-03-12 安斯泰来制药有限公司 免疫抑制性多肽与核酸
JP5744719B2 (ja) * 2008-04-04 2015-07-08 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア チクングニヤウィルスタンパク質の共通配列、これをコードする核酸分子、並びにこれを使用する組成物および方法
JP5873717B2 (ja) * 2008-04-04 2016-03-01 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア Il−28及び組成物を用いたワクチン及び免疫治療薬並びにその使用方法
EP2147697A1 (fr) 2008-07-21 2010-01-27 Centre National De La Recherche Scientifique-CNRS Procédé et dispositif pour appliquer des champs électriques dans un matériau conducteur
EP2156860A1 (fr) 2008-08-20 2010-02-24 Centre National De La Recherche Scientifique-CNRS Procédé de fabrication d'électrodes isolées pour l'application de champs électriques dans un matériau conducteur
US8207138B2 (en) 2009-05-19 2012-06-26 Medtronic, Inc. Methods and devices for improved efficiency of RNA delivery to cells
US20100298697A1 (en) * 2009-05-19 2010-11-25 Medtronic, Inc. Method and devices for improved efficiency of rna delivery to cells
CN102821790A (zh) 2009-09-14 2012-12-12 宾夕法尼亚大学托管会 包含IL-15受体α和/或编码IL-15受体α的核酸分子的疫苗和免疫治疗剂,以及其使用方法
KR20210149203A (ko) 2009-11-02 2021-12-08 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 구제역 바이러스(fmdv) 공통 단백질, 이를 위한 코딩 서열 및 이로부터 만들어진 백신
US8298820B2 (en) 2010-01-26 2012-10-30 The Trustees Of The University Of Pennsylvania Influenza nucleic acid molecules and vaccines made therefrom
CN102781952B (zh) 2010-02-08 2015-09-02 宾夕法尼亚大学托管会 编码rantes的核酸分子、包含其的组合物以及其使用方法
AU2011312465B2 (en) 2010-09-27 2015-07-23 Inovio Pharmaceuticals, Inc Consensus antigen constructs and vaccines made therefrom, and methods of using same to treat malaria
MX346784B (es) 2010-11-12 2017-03-31 Inovio Pharmaceuticals Inc Antigenos prostaticos de consenso, molecula de acido nucleico que los codifica y vacuna y usos que los comprenden.
EP2670443A4 (fr) 2011-01-31 2015-10-14 Univ Pennsylvania Molécules d'acide nucléique codant de nouveaux antigènes d'herpès, vaccin les comprenant et procédés pour les utiliser
PT2672992T (pt) 2011-02-11 2020-07-27 Univ Pennsylvania Molécula de ácidos nucleicos codificando proteína nuclear do vírus da hepatite b e vacina compreendendo a mesma
US9238679B2 (en) 2011-02-11 2016-01-19 The Trustees Of The University Of Pennslyvania Nucleic acid molecule encoding hepatitis B virus core protein and surface antigen protein and vaccine comprising the same
US9457183B2 (en) 2011-06-15 2016-10-04 Tripep Ab Injection needle and device
CA2841852C (fr) 2011-07-11 2020-06-30 Inovio Pharmaceuticals, Inc. Vaccins fournissant une protection croisee contre les arenavirus et leur procede d'utilisation
JP6407028B2 (ja) 2011-12-12 2018-10-17 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア MRSAのPBP2a及びその断片を含むタンパク質、それをコードする核酸、並びにMRSA感染を予防する及び治療するための組成物及びそれらの使用
US9272024B2 (en) 2011-12-12 2016-03-01 The Trustees Of The University Of Pennsylvania Compositions, comprising improved IL-12 genetic constructs and vaccines, immunotherapeutics and methods of using the same
EP2836505B1 (fr) 2012-04-10 2019-01-23 The Trustees Of The University Of Pennsylvania Antigènes consensus du virus syncytial respiratoire humain, constructions d'acide nucléique et vaccins préparés à partir de celles-ci, et leurs procédés d'utilisation
KR20240010758A (ko) 2012-04-12 2024-01-24 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 필로바이러스 공통 항원, 이로부터 제조된 핵산 구조체 및 백신, 및 이를 사용하는 방법
DE102012013534B3 (de) 2012-07-05 2013-09-19 Tobias Sokolowski Vorrichtung für repetitive Nervenstimulation zum Abbau von Fettgewebe mittels induktiver Magnetfelder
WO2014064534A2 (fr) 2012-10-05 2014-05-01 Chrontech Pharma Ab Aiguille d'injection, dispositif, compositions immunogènes et procédé d'utilisation
SI2931304T1 (sl) 2012-12-13 2021-11-30 The Trustees Of The University Of Pennsylvania Cepivo proti WT1
KR20230062674A (ko) 2013-03-15 2023-05-09 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 암 백신 및 이를 이용한 치료 방법
BR112015022582B1 (pt) 2013-03-15 2024-01-09 The Trustees Of The University Of Pennsylvania Molécula de ácido nucleico, plasmídeo, vacina, e, uso de um plasmídeo
WO2015017734A1 (fr) 2013-07-31 2015-02-05 Board Of Trustees Of The University Of Arkansas Compositions et méthodes permettant de traiter et de prévenir le cancer par ciblage des antigènes glucidiques associés à la tumeur
CN105829341A (zh) 2013-12-13 2016-08-03 宾夕法尼亚大学理事会 Dna抗体构建体及其使用方法
CA2969214A1 (fr) 2014-12-01 2016-06-09 The Trustees Of The University Of Pennsylvania Constructions d'anticorps d'adn et leur procede d'utilisation
US11491342B2 (en) 2015-07-01 2022-11-08 Btl Medical Solutions A.S. Magnetic stimulation methods and devices for therapeutic treatments
US10695575B1 (en) 2016-05-10 2020-06-30 Btl Medical Technologies S.R.O. Aesthetic method of biological structure treatment by magnetic field
US20180001107A1 (en) 2016-07-01 2018-01-04 Btl Holdings Limited Aesthetic method of biological structure treatment by magnetic field
US11266850B2 (en) 2015-07-01 2022-03-08 Btl Healthcare Technologies A.S. High power time varying magnetic field therapy
WO2017055522A1 (fr) 2015-09-29 2017-04-06 Academisch Medisch Centrum Protéines env stabilisées du vih
US11253717B2 (en) 2015-10-29 2022-02-22 Btl Healthcare Technologies A.S. Aesthetic method of biological structure treatment by magnetic field
JP7123800B2 (ja) 2016-02-05 2022-08-23 イノビオ ファーマシューティカルズ,インコーポレイティド がんのワクチン及びそれを用いた処置の方法
IL296595A (en) 2016-03-28 2022-11-01 Ichor Medical Systems Inc Method and device for administering medical substances
US10538786B2 (en) 2016-04-13 2020-01-21 Janssen Pharmaceuticals, Inc. Recombinant arterivirus replicon systems and uses thereof
US11247039B2 (en) 2016-05-03 2022-02-15 Btl Healthcare Technologies A.S. Device including RF source of energy and vacuum system
US11464993B2 (en) 2016-05-03 2022-10-11 Btl Healthcare Technologies A.S. Device including RF source of energy and vacuum system
US11534619B2 (en) 2016-05-10 2022-12-27 Btl Medical Solutions A.S. Aesthetic method of biological structure treatment by magnetic field
US10583287B2 (en) 2016-05-23 2020-03-10 Btl Medical Technologies S.R.O. Systems and methods for tissue treatment
US10556122B1 (en) 2016-07-01 2020-02-11 Btl Medical Technologies S.R.O. Aesthetic method of biological structure treatment by magnetic field
KR20190082226A (ko) 2016-10-17 2019-07-09 신테틱 제노믹스, 인코포레이티드. 재조합 바이러스 레플리콘 시스템 및 그의 용도
BR112019011661A2 (pt) 2016-12-05 2020-01-07 Synthetic Genomics, Inc. Composições e métodos para aumentar expressão de gene
US11344618B2 (en) 2017-08-26 2022-05-31 Academisch Medisch Centrum HIV envelope glycoprotein immunogens
EP3723812A4 (fr) 2017-12-13 2022-02-16 Inovio Pharmaceuticals, Inc. Vaccins anticancer ciblant muc16 et leurs utilisations
EP3737397B1 (fr) 2017-12-13 2022-11-30 Inovio Pharmaceuticals, Inc. Vaccins anticancéreux ciblant l'antigène exprimé de façon préférentielle dans le mélanome (prame) et ses utilisations
KR102637862B1 (ko) 2017-12-13 2024-02-19 이노비오 파마수티컬즈, 인크. 메소텔린을 표적으로 하는 암 백신 및 이의 용도
EA202091517A1 (ru) 2017-12-19 2020-11-03 Янссен Сайенсиз Айрлэнд Анлимитед Компани Способы и устройство для доставки вакцин против вируса гепатита b (hbv)
CA3086327A1 (fr) 2017-12-19 2019-06-27 Janssen Sciences Ireland Unlimited Company Vaccins contre le virus de l'hepatite b (vhb) et utilisations associees
US11020476B2 (en) 2017-12-19 2021-06-01 Janssen Sciences Ireland Unlimited Company Methods and compositions for inducing an immune response against Hepatitis B Virus (HBV)
US11021692B2 (en) 2017-12-19 2021-06-01 Janssen Sciences Ireland Unlimited Company Hepatitis B virus (HBV) vaccines and uses thereof
KR20200100745A (ko) 2017-12-19 2020-08-26 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 B형 간염 바이러스(hbv)에 대한 면역 반응 유도를 위한 방법 및 조성물
WO2019143949A2 (fr) 2018-01-19 2019-07-25 Synthetic Genomics, Inc. Induction et amélioration des réponses immunitaires à l'aide de systèmes de réplicon de recombinaison
CA3116569C (fr) 2019-04-11 2023-08-15 Btl Medical Technologies S.R.O. Procedes et dispositifs de traitement esthetique de structures biologiques par radiofrequence et energie magnetique
WO2020255035A1 (fr) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combinaison de vaccins contre le virus de l'hépatite b (vhb) et de dérivés de pyrimidine
TWI772823B (zh) 2019-06-18 2022-08-01 愛爾蘭商健生科學愛爾蘭無限公司 B型肝炎病毒(hbv)疫苗與蛋白殼組裝調節劑之組合
EP3986915A1 (fr) 2019-06-18 2022-04-27 Janssen Sciences Ireland Unlimited Company Construction de l'interleukine 12 recombinante et ses utilisations
WO2020254876A1 (fr) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Administration de particules de type viral de vaccins contre le virus de l'hépatite b (vhb)
JP2022536945A (ja) 2019-06-18 2022-08-22 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー B型肝炎ウイルス(HBV)ワクチンおよびHBVを標的化するRNAiの組合せ
WO2020255038A1 (fr) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Association de vaccins contre le virus de l'hépatite b (vhb) et de dérivés de pyridopyrimidine
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WO2020255019A1 (fr) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combinaison de vaccins contre le virus de l'hépatite b (vhb) et d'un dérivé de la quinazoline
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CA3173876A1 (fr) 2020-05-04 2021-11-11 Tomas SCHWARZ Dispositif et methode pour traitement automatise d'un patient
US11878167B2 (en) 2020-05-04 2024-01-23 Btl Healthcare Technologies A.S. Device and method for unattended treatment of a patient
CA3181680A1 (fr) 2020-06-12 2021-12-16 University Of Rochester Codage et expression d'arnt ace
CA3188801A1 (fr) 2020-07-08 2022-01-13 Janssen Sciences Ireland Unlimited Company Vaccins a base de replicon d'arn contre le vhb
TW202245809A (zh) 2020-12-18 2022-12-01 美商詹森藥物公司 用於治療b型肝炎病毒感染之組合療法
EP4267740A1 (fr) 2020-12-28 2023-11-01 Arcturus Therapeutics, Inc. Nucléases effectrices de type activateur de transcription (talens) ciblant le vhb
US11896816B2 (en) 2021-11-03 2024-02-13 Btl Healthcare Technologies A.S. Device and method for unattended treatment of a patient
WO2023150753A1 (fr) 2022-02-07 2023-08-10 University Of Rochester Séquences optimisées pour une expression d'adn améliorée et/ou une suppression de mutation non sens
WO2023233290A1 (fr) 2022-05-31 2023-12-07 Janssen Sciences Ireland Unlimited Company Agents d'arni ciblant pd-l1

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5389069A (en) * 1988-01-21 1995-02-14 Massachusetts Institute Of Technology Method and apparatus for in vivo electroporation of remote cells and tissue
US5501662A (en) * 1992-05-22 1996-03-26 Genetronics, Inc. Implantable electroporation method and apparatus for drug and gene delivery
US5304120A (en) * 1992-07-01 1994-04-19 Btx Inc. Electroporation method and apparatus for insertion of drugs and genes into endothelial cells
US5273525A (en) * 1992-08-13 1993-12-28 Btx Inc. Injection and electroporation apparatus for drug and gene delivery
US5318514A (en) * 1992-08-17 1994-06-07 Btx, Inc. Applicator for the electroporation of drugs and genes into surface cells
US5468223A (en) * 1992-11-30 1995-11-21 C.N.R.S. Paris Electrochemotherapy
FR2703253B1 (fr) * 1993-03-30 1995-06-23 Centre Nat Rech Scient Applicateur d'impulsions electriques pour traitement de tissus biologiques.
US5993434A (en) * 1993-04-01 1999-11-30 Genetronics, Inc. Method of treatment using electroporation mediated delivery of drugs and genes
US5702359A (en) * 1995-06-06 1997-12-30 Genetronics, Inc. Needle electrodes for mediated delivery of drugs and genes
IL108775A (en) * 1994-02-25 2003-09-17 Univ Ramot Method for efficient incorporation of molecules into cells
JPH10502858A (ja) * 1995-05-02 1998-03-17 フィリップス エレクトロニクス エヌ ベー 対象の磁気共鳴画像化方法及び装置
US5944710A (en) * 1996-06-24 1999-08-31 Genetronics, Inc. Electroporation-mediated intravascular delivery
DE69829287T2 (de) * 1997-06-30 2006-04-13 Centre National De La Recherche Scientifique (Cnrs) Verbesserung der verabreichung der nukleinsäure in zellen der plurizellulären eukaryotischen organismen und kombination zur durchführung des verfahrens

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AU6990698A (en) 1998-10-22
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