ATE467680T1 - Hepatitis-c-virus-impfstoff - Google Patents
Hepatitis-c-virus-impfstoffInfo
- Publication number
- ATE467680T1 ATE467680T1 AT02773740T AT02773740T ATE467680T1 AT E467680 T1 ATE467680 T1 AT E467680T1 AT 02773740 T AT02773740 T AT 02773740T AT 02773740 T AT02773740 T AT 02773740T AT E467680 T1 ATE467680 T1 AT E467680T1
- Authority
- AT
- Austria
- Prior art keywords
- nucleic acid
- hepatitis
- virus vaccine
- ns5b
- hcv
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/108—Plasmid DNA episomal vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
- C12N2810/6009—Vectors comprising as targeting moiety peptide derived from defined protein from viruses dsDNA viruses
- C12N2810/6018—Adenoviridae
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
- C12N2830/003—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor tet inducible
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32865501P | 2001-10-11 | 2001-10-11 | |
US36377402P | 2002-03-13 | 2002-03-13 | |
PCT/US2002/032512 WO2003031588A2 (en) | 2001-10-11 | 2002-10-10 | Hepatitis c virus vaccine |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE467680T1 true ATE467680T1 (de) | 2010-05-15 |
Family
ID=42828995
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02773740T ATE467680T1 (de) | 2001-10-11 | 2002-10-10 | Hepatitis-c-virus-impfstoff |
Country Status (9)
Country | Link |
---|---|
US (3) | US7598362B2 (de) |
EP (1) | EP1436397B1 (de) |
JP (1) | JP4475561B2 (de) |
CN (1) | CN1582337B (de) |
AT (1) | ATE467680T1 (de) |
AU (1) | AU2002337840B2 (de) |
CA (1) | CA2461380C (de) |
DK (1) | DK1436397T3 (de) |
WO (1) | WO2003031588A2 (de) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6562346B1 (en) | 1999-10-27 | 2003-05-13 | Chiron Corporation | Activation of HCV-specific T cells |
KR100801123B1 (ko) | 2000-08-17 | 2008-02-05 | 트리펩 아베 | 리바비린 함유 백신 및 이것의 사용 방법 |
US6680059B2 (en) | 2000-08-29 | 2004-01-20 | Tripep Ab | Vaccines containing ribavirin and methods of use thereof |
US6858590B2 (en) | 2000-08-17 | 2005-02-22 | Tripep Ab | Vaccines containing ribavirin and methods of use thereof |
US7022830B2 (en) | 2000-08-17 | 2006-04-04 | Tripep Ab | Hepatitis C virus codon optimized non-structural NS3/4A fusion gene |
ES2344253T3 (es) * | 2001-10-11 | 2010-08-23 | MERCK SHARP & DOHME CORP. | Vacuna contra el virus de la hepatitis c. |
CA2461380C (en) * | 2001-10-11 | 2011-03-22 | Merck & Co., Inc. | Hepatitis c virus vaccine |
JP2008518591A (ja) * | 2004-11-02 | 2008-06-05 | イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー | 複製欠損アデノウイルスベクターの製造のためのアデノウイルスアンプリコンおよびプロデューサー細胞、その製造方法および用途 |
US8168771B2 (en) | 2005-01-31 | 2012-05-01 | The Johns Hopkins University | Use of consensus sequence as vaccine antigen to enhance recognition of virulent viral variants |
WO2006088664A2 (en) * | 2005-02-17 | 2006-08-24 | The University Of Iowa Research Foundation | Flavivirus ns5a proteins for the treatment of hiv |
DE102005015005A1 (de) * | 2005-04-01 | 2006-10-05 | Qiagen Gmbh | Verfahren zur Behandlung einer Biomoleküle enthaltenden Probe |
WO2007031867A2 (en) | 2005-05-25 | 2007-03-22 | Tripep Ab | A hepatitis c virus non-stru tural ns3/4a fusion gene |
WO2006133911A2 (en) * | 2005-06-17 | 2006-12-21 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa | Hepatitis c virus nucleic acid vaccine |
CN1887350B (zh) * | 2005-06-28 | 2010-10-06 | 深圳市源兴生物医药科技有限公司 | 一种重组疫苗及其用途 |
CN101360821A (zh) * | 2005-11-21 | 2009-02-04 | 圣诺菲·帕斯图尔有限公司 | 重组病毒的稳定制剂 |
MX2009003873A (es) * | 2006-10-12 | 2009-04-22 | Angeletti P Ist Richerche Bio | Proteina de fusion de transcriptasa inversa de telomerasa, nucleotidos que la codifican y usos de la misma. |
EP2117574A4 (de) | 2007-01-24 | 2010-06-16 | Merck Sharp & Dohme | Polypeptide zur induzierung einer schützenden immunantwort gegen staphylococcus epidermidis |
WO2009022236A2 (en) | 2007-08-16 | 2009-02-19 | Tripep Ab | Immunogen platform |
WO2009079834A1 (fr) * | 2007-12-18 | 2009-07-02 | Peking University People's Hospital | Vaccin anti-vhc et procédés de préparation et utilisations de celui-ci |
WO2010014567A2 (en) * | 2008-08-01 | 2010-02-04 | Merck & Co., Inc. | Variant hcmv pp65, ie1, and ie2 polynucleotides and uses thereof |
US8921536B2 (en) | 2008-10-29 | 2014-12-30 | The Trustees Of The University Of Pennsylvania | HCV vaccines and methods for using the same |
KR101609233B1 (ko) | 2008-10-29 | 2016-04-05 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 개량된 hcv 백신 및 이를 이용하는 방법 |
MX2011005578A (es) | 2008-11-26 | 2011-06-30 | Merck Sharp & Dohme | Polipeptidos para inducir una respuesta inmune protectora contra staphylococcus aureus. |
JP2012509665A (ja) | 2008-11-26 | 2012-04-26 | メルク・シャープ・エンド・ドーム・コーポレイション | スタフィロコッカス・アウレウス(staphylococcusaureus)に対する防御免疫応答を誘導するポリペプチド |
KR101763093B1 (ko) | 2009-02-02 | 2017-07-28 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 시미안 아데노바이러스 핵산- 및 아미노산-서열, 이를 포함하는 벡터 및 이의 용도 |
CN102645534B (zh) * | 2012-04-26 | 2015-08-12 | 杭州市萧山区第一人民医院 | 基于量子点编码微球芯片检测丙型肝炎病毒的方法 |
WO2014139587A1 (en) | 2013-03-15 | 2014-09-18 | Okairòs Ag | Improved poxviral vaccines |
WO2017025782A1 (en) | 2014-09-17 | 2017-02-16 | Glaxosmithkline Biologicals Sa | Improved poxviral vaccines |
US20180000926A1 (en) * | 2015-01-15 | 2018-01-04 | Babita Agrawal | Methods of inducing an immune response to hepatitis c virus |
CN108277230A (zh) * | 2018-02-07 | 2018-07-13 | 华中科技大学 | 一种融合dna及其制备的疫苗 |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3584341D1 (de) | 1984-08-24 | 1991-11-14 | Upjohn Co | Rekombinante dna-verbindungen und expression von polypeptiden wie tpa. |
US5585362A (en) * | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
US5747339A (en) | 1990-06-25 | 1998-05-05 | Research Foundation For Microbial Diseases Of Osaka | Non-A, non-B hepatitis virus genomic CDNA and antigen polypeptide |
EP0464287A1 (de) * | 1990-06-25 | 1992-01-08 | The Research Foundation for Microbial Diseases of Osaka University | Non-A, Non-B Hepatitis Virus genomisches DNS und Antigenpolypeptide |
IT1270939B (it) | 1993-05-11 | 1997-05-26 | Angeletti P Ist Richerche Bio | Procedimento per la preparazione di immunogeni e reagenti diagnostici,e immunogeni e reagenti diagnostici cosi' ottenibili. |
US6140087A (en) * | 1993-06-24 | 2000-10-31 | Advec, Inc. | Adenovirus vectors for gene therapy |
IT1272179B (it) | 1994-02-23 | 1997-06-16 | Angeletti P Ist Richerche Bio | Metodologia per riprodurre in vitro l'attivita' proteolitica della proteasi ns3 del virus hcv. |
CA2117668C (en) * | 1994-03-09 | 2005-08-09 | Izumu Saito | Recombinant adenovirus and process for producing the same |
US5505947A (en) | 1994-05-27 | 1996-04-09 | The University Of North Carolina At Chapel Hill | Attenuating mutations in Venezuelan Equine Encephalitis virus |
US6127525A (en) * | 1995-02-21 | 2000-10-03 | Cornell Research Foundation, Inc. | Chimeric adenoviral coat protein and methods of using same |
US5792462A (en) | 1995-05-23 | 1998-08-11 | University Of North Carolina At Chapel Hill | Alphavirus RNA replicon systems |
IT1278077B1 (it) | 1995-05-25 | 1997-11-17 | Angeletti P Ist Richerche Bio | Metodologia per riprodurre in vitro le attivita' di rna polimerasi rna-dipendente e di nucleotidiltransferasi terminale codificate dal |
KR100449181B1 (ko) | 1995-06-15 | 2005-01-24 | 크루셀 홀란드 비.브이. | 유전자요법에사용할수있는사람의재조합아데노바이러스패키징시스템 |
US6127116A (en) * | 1995-08-29 | 2000-10-03 | Washington University | Functional DNA clone for hepatitis C virus (HCV) and uses thereof |
CA2257137A1 (en) * | 1996-06-11 | 1997-12-18 | Merck & Co., Inc. | Synthetic hepatitis c genes |
US7049428B1 (en) * | 1998-03-04 | 2006-05-23 | Washington University | HCV variants |
JP2001520537A (ja) | 1997-04-03 | 2001-10-30 | エレクトロフェクト・アクティーゼルスカブ | 医薬品と核酸の骨格筋への導入方法 |
EP0981606A2 (de) | 1997-05-12 | 2000-03-01 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Verfahren und vektor zur hemmung der zell-migration |
US6221646B1 (en) * | 1997-07-31 | 2001-04-24 | Chiron Corporation | Materials and methods for simplified AAV production |
JP2002501737A (ja) | 1998-01-30 | 2002-01-22 | ザ・ジェネラル・ホスピタル・コーポレイション | C型肝炎ウイルスの非構造蛋白質による遺伝的免疫感作 |
AU3489499A (en) | 1998-04-14 | 1999-11-01 | Merck & Co., Inc. | Needleless administration of polynucleotide formulations |
WO1999057296A1 (en) * | 1998-05-01 | 1999-11-11 | Genzyme Corporation | Partially deleted adenoviral vectors |
GB9810756D0 (en) | 1998-05-19 | 1998-07-15 | Angeletti P Ist Richerche Bio | Mimotopes of hypervariable region 1 of the e2 glycoprotein of hcv and uses thereof |
US6156588A (en) | 1998-06-23 | 2000-12-05 | Vlsi Technology, Inc. | Method of forming anti-fuse structure |
CA2341516A1 (en) | 1998-08-24 | 2000-03-02 | Genzyme Corporation | Cationic complexes of polymer-modified adenovirus |
WO2000042208A1 (en) | 1999-01-14 | 2000-07-20 | The Scripps Research Institute | Adenovirus vectors, packaging cell lines, compositions, and methods for preparation and use |
EP1200622A4 (de) * | 1999-07-06 | 2004-12-22 | Merck & Co Inc | Hiv impfstoff aus einem das gag-gen tragenden adenovirus |
US6627190B2 (en) * | 1999-07-12 | 2003-09-30 | Saint Louis University | Recombinant adenovirus vectors that are replication-competent in tert-expressing cells |
US6511832B1 (en) * | 1999-10-06 | 2003-01-28 | Texas A&M University System | In vitro synthesis of capped and polyadenylated mRNAs using baculovirus RNA polymerase |
US6562346B1 (en) | 1999-10-27 | 2003-05-13 | Chiron Corporation | Activation of HCV-specific T cells |
JP2003516732A (ja) | 1999-11-24 | 2003-05-20 | カイロン コーポレイション | 新規なhcv非構造ポリペプチド |
AU5442501A (en) | 1999-12-01 | 2001-07-09 | Chiron Corporation | Eliciting HCV-specific antibodies |
US6544780B1 (en) * | 2000-06-02 | 2003-04-08 | Genphar, Inc. | Adenovirus vector with multiple expression cassettes |
AU2001294562B2 (en) | 2000-09-15 | 2007-05-24 | Merck & Co., Inc. | Enhanced First Generation Adenovirus Vaccines Expressing Codon Optimized HIV1-Gag, Pol, Nef and Modifications |
CA2461380C (en) * | 2001-10-11 | 2011-03-22 | Merck & Co., Inc. | Hepatitis c virus vaccine |
-
2002
- 2002-10-10 CA CA2461380A patent/CA2461380C/en not_active Expired - Lifetime
- 2002-10-10 AT AT02773740T patent/ATE467680T1/de active
- 2002-10-10 WO PCT/US2002/032512 patent/WO2003031588A2/en active IP Right Grant
- 2002-10-10 JP JP2003534559A patent/JP4475561B2/ja not_active Expired - Lifetime
- 2002-10-10 CN CN028246659A patent/CN1582337B/zh not_active Expired - Lifetime
- 2002-10-10 US US10/492,178 patent/US7598362B2/en active Active
- 2002-10-10 DK DK02773740.2T patent/DK1436397T3/da active
- 2002-10-10 EP EP02773740A patent/EP1436397B1/de not_active Expired - Lifetime
- 2002-10-10 AU AU2002337840A patent/AU2002337840B2/en not_active Expired
-
2009
- 2009-03-03 US US12/396,747 patent/US8142794B2/en not_active Expired - Fee Related
- 2009-12-08 US US12/633,104 patent/US8530234B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA2461380A1 (en) | 2003-04-17 |
US8530234B2 (en) | 2013-09-10 |
CA2461380C (en) | 2011-03-22 |
JP4475561B2 (ja) | 2010-06-09 |
JP2005505286A (ja) | 2005-02-24 |
WO2003031588A3 (en) | 2003-10-30 |
EP1436397B1 (de) | 2010-05-12 |
US20090233992A1 (en) | 2009-09-17 |
US7598362B2 (en) | 2009-10-06 |
EP1436397A4 (de) | 2005-02-16 |
CN1582337B (zh) | 2011-12-14 |
US20100129901A1 (en) | 2010-05-27 |
DK1436397T3 (da) | 2010-08-09 |
WO2003031588A2 (en) | 2003-04-17 |
US8142794B2 (en) | 2012-03-27 |
CN1582337A (zh) | 2005-02-16 |
AU2002337840B2 (en) | 2007-08-09 |
US20040247615A1 (en) | 2004-12-09 |
EP1436397A2 (de) | 2004-07-14 |
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