BR0108959A - Composições de polox‰mero ou poloxamina melhoradas para distribuição de ácido nucléico - Google Patents

Composições de polox‰mero ou poloxamina melhoradas para distribuição de ácido nucléico

Info

Publication number
BR0108959A
BR0108959A BR0108959-5A BR0108959A BR0108959A BR 0108959 A BR0108959 A BR 0108959A BR 0108959 A BR0108959 A BR 0108959A BR 0108959 A BR0108959 A BR 0108959A
Authority
BR
Brazil
Prior art keywords
compositions
nucleic acid
poloxamine
acid delivery
improved
Prior art date
Application number
BR0108959-5A
Other languages
English (en)
Inventor
Francois Nicol
Jijun Wang
Michael Coleman
Fiona Maclaughlin
Alain Rolland
Original Assignee
Valentis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Valentis Inc filed Critical Valentis Inc
Publication of BR0108959A publication Critical patent/BR0108959A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/208—IL-12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Inorganic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

"COMPOSIçõES DE POLOX‰MERO OU POLOXAMINA MELHORADAS PARA DISTRIBUIçãO DE áCIDO NUCLéICO". A presente invenção refere-se a composições e métodos para a introdução de uma molécula de ácido nucléico em uma célula, preferivelmente por um método de distribuição de voltagem de pulso, para a expressão de uma proteína, peptídeo, RNA anti-sentido, ribozima ou polipeptídeo.
BR0108959-5A 2000-03-03 2001-03-02 Composições de polox‰mero ou poloxamina melhoradas para distribuição de ácido nucléico BR0108959A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18723600P 2000-03-03 2000-03-03
US24227700P 2000-10-20 2000-10-20
PCT/US2001/006831 WO2001065911A2 (en) 2000-03-03 2001-03-02 Improved poloxamer and poloxamine compositions for nucleic acid delivery

Publications (1)

Publication Number Publication Date
BR0108959A true BR0108959A (pt) 2003-10-14

Family

ID=26882846

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0108959-5A BR0108959A (pt) 2000-03-03 2001-03-02 Composições de polox‰mero ou poloxamina melhoradas para distribuição de ácido nucléico

Country Status (7)

Country Link
US (2) US20030206910A1 (pt)
EP (1) EP1309904A4 (pt)
JP (1) JP2003525613A (pt)
AU (1) AU2001241958A1 (pt)
BR (1) BR0108959A (pt)
CA (1) CA2401239A1 (pt)
WO (1) WO2001065911A2 (pt)

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EP1278551A2 (en) 2000-04-21 2003-01-29 Vical Incorporated Compositions and methods for (in vivo) delivery of polynucleotide-based therapeutics
ATE503463T1 (de) * 2000-10-20 2011-04-15 Vical Inc Gen-abgabeformulierungen zur behandlung ischämischer zustände
EP1232758A1 (fr) * 2001-02-19 2002-08-21 Aventis Pasteur Polynucléotide formulé en vue d'un transfert intracellulaire amélioré
FR2835749B1 (fr) * 2002-02-08 2006-04-14 Inst Nat Sante Rech Med Composition pharmaceutique ameliorant le transfert de gene in vivo
EP1545432A4 (en) * 2002-09-26 2007-03-14 Pfizer Prod Inc USE OF AUXILIARY SUBSTANCES TO INCREASE DNA RECEPTION BY PIG MUSCLE CELLS
WO2004060059A2 (en) 2002-12-23 2004-07-22 Vical Incorporated Method for freeze-drying nucleic acid/block copolymer/cationic surfactant complexes
CA2508281C (en) 2002-12-23 2011-08-09 Vical Incorporated Method for producing sterile polynucleotide based medicaments
US20060134221A1 (en) * 2004-12-03 2006-06-22 Vical Incorporated Methods for producing block copolymer/amphiphilic particles
US7850645B2 (en) 2005-02-11 2010-12-14 Boston Scientific Scimed, Inc. Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power
US20110189262A1 (en) * 2005-02-11 2011-08-04 Duke University Methods and Compositions for Reducing Systemic Toxicity of Vectors
US8480651B2 (en) * 2007-08-02 2013-07-09 Covidien Lp Cannula system
CN107029277A (zh) * 2007-11-29 2017-08-11 健赞公司 使用纯化的逆向热敏聚合物的内镜粘膜切除
US20090202467A1 (en) * 2008-02-08 2009-08-13 Bock Richard W Sclerotherapy for varicose veins
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WO2009108891A2 (en) * 2008-02-29 2009-09-03 Egen, Inc. Modified poloxamers for gene expression and associated methods
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CN103002919B (zh) * 2010-02-04 2015-03-25 得克萨斯系统大学评议会 纳米聚合物对免疫调节剂的肿瘤靶向递送
AU2012279001A1 (en) * 2011-07-05 2014-01-23 The Research Foundation For The State University Of New York Compositions and methods for spinal disc repair and other surgical and non-surgical indications
EP2820138B1 (en) * 2012-02-29 2020-10-28 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Retroviral transduction using poloxamers
WO2014194137A1 (en) * 2013-05-29 2014-12-04 Biogen Idec Ma Inc. Methods of evaluating cell culture additives
US11179478B2 (en) * 2014-04-01 2021-11-23 Institut National De La Sante Et De La Recherche Medicale (Inserm) Capped and uncapped RNA molecules and block copolymers for intracellular delivery of RNA
TWI688392B (zh) 2014-07-07 2020-03-21 美商救生筏生物科技公司 無長循環材料之泊洛沙姆組成物以及其製造方法和用途
US9757411B2 (en) 2014-07-07 2017-09-12 Aires Pharmaceuticals, Inc. Poloxamer therapy for heart failure
FR3030147B1 (fr) 2014-12-11 2018-03-16 Mmt Sa Actionneur avec modules statorique et rotorique enrobes
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WO2017214468A1 (en) * 2016-06-09 2017-12-14 Tien Yang Der Nanodroplet compositions for the efficient delivery of anti-cancer agents
EP3728471A1 (en) * 2017-12-21 2020-10-28 Sigma Aldrich Co. LLC Poloxamer compositions and methods of making and using same
CA3110297A1 (en) * 2018-08-23 2020-02-27 Zion Medical B.V Pharmaceutical compositions comprising integration-promoting peptides
JP2022511026A (ja) * 2018-12-04 2022-01-28 シリオン・バイオテック・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング ポロキサミンを使用するウイルスの形質導入
AU2020234003A1 (en) * 2019-03-11 2021-11-11 Evaxion Biotech A/S Nucleic acid vaccination using neo-epitope encoding constructs
WO2020247814A1 (en) * 2019-06-05 2020-12-10 Orchard Therapeutics (Europe) Limited Compositions and methods for modifying eukaryotic cells
CA3157966A1 (en) * 2019-10-16 2021-04-22 Orchard Therapeutics (Europe) Limited Compositions and methods for modifying eukaryotic cells
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Also Published As

Publication number Publication date
US20060013883A1 (en) 2006-01-19
EP1309904A4 (en) 2006-03-29
CA2401239A1 (en) 2001-09-13
US20030206910A1 (en) 2003-11-06
AU2001241958A1 (en) 2001-09-17
JP2003525613A (ja) 2003-09-02
WO2001065911A9 (en) 2005-11-17
WO2001065911A2 (en) 2001-09-13
EP1309904A1 (en) 2003-05-14

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1963 DE 19.08.2008.