ATE332725T1 - Verfahren zur elektropermeabilisation einzelner zellulärer und organeller strukturen - Google Patents
Verfahren zur elektropermeabilisation einzelner zellulärer und organeller strukturenInfo
- Publication number
- ATE332725T1 ATE332725T1 AT98953145T AT98953145T ATE332725T1 AT E332725 T1 ATE332725 T1 AT E332725T1 AT 98953145 T AT98953145 T AT 98953145T AT 98953145 T AT98953145 T AT 98953145T AT E332725 T1 ATE332725 T1 AT E332725T1
- Authority
- AT
- Austria
- Prior art keywords
- electrodes
- cell structure
- cell
- microelectrodes
- organel
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 238000004520 electroporation Methods 0.000 title abstract 2
- 230000001413 cellular effect Effects 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 6
- 229920000049 Carbon (fiber) Polymers 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000004917 carbon fiber Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000005684 electric field Effects 0.000 abstract 1
- 239000012510 hollow fiber Substances 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 210000003463 organelle Anatomy 0.000 abstract 1
- 230000008823 permeabilization Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
- C12M35/02—Electrical or electromagnetic means, e.g. for electroporation or for cell fusion
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
- A61N1/303—Constructional details
- A61N1/306—Arrangements where at least part of the apparatus is introduced into the body
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Electromagnetism (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Sustainable Development (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Manufacture Of Macromolecular Shaped Articles (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Electrotherapy Devices (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9704076A SE9704076D0 (sv) | 1997-11-06 | 1997-11-06 | Method for permeabilisation of cell structures and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE332725T1 true ATE332725T1 (de) | 2006-08-15 |
Family
ID=20408900
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98953145T ATE332725T1 (de) | 1997-11-06 | 1998-11-06 | Verfahren zur elektropermeabilisation einzelner zellulärer und organeller strukturen |
Country Status (10)
Country | Link |
---|---|
US (2) | US6521430B1 (de) |
EP (1) | EP1028778B1 (de) |
JP (1) | JP4321962B2 (de) |
CN (1) | CN1280513A (de) |
AT (1) | ATE332725T1 (de) |
AU (1) | AU1059399A (de) |
CA (1) | CA2308397A1 (de) |
DE (1) | DE69835228T2 (de) |
SE (1) | SE9704076D0 (de) |
WO (1) | WO1999024110A1 (de) |
Families Citing this family (84)
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JP4175662B2 (ja) | 1996-01-08 | 2008-11-05 | インパルス ダイナミクス エヌ.ヴイ. | 電気的筋肉制御装置 |
US9289618B1 (en) | 1996-01-08 | 2016-03-22 | Impulse Dynamics Nv | Electrical muscle controller |
US9713723B2 (en) | 1996-01-11 | 2017-07-25 | Impulse Dynamics Nv | Signal delivery through the right ventricular septum |
CA2296632A1 (en) | 1997-07-16 | 1999-01-28 | Impulse Dynamics (Israel) Ltd. | Smooth muscle controller |
WO2003046171A1 (en) * | 2001-11-27 | 2003-06-05 | Cellectricon Ab | A method for combined sequential agent delivery and electroporation for cell structures and use thereof |
SE9704076D0 (sv) | 1997-11-06 | 1997-11-06 | Holdingbolaget Vid Goeteborgs | Method for permeabilisation of cell structures and use thereof |
US7456012B2 (en) | 1997-11-06 | 2008-11-25 | Cellectricon Ab | Method and apparatus for spatially confined electroporation |
WO2006073671A1 (en) | 2004-12-09 | 2006-07-13 | Impulse Dynamics Nv | Protein activity modification |
US9101765B2 (en) | 1999-03-05 | 2015-08-11 | Metacure Limited | Non-immediate effects of therapy |
US7190997B1 (en) | 1999-06-04 | 2007-03-13 | Impulse Dynamics Nv | Drug delivery device |
US7092753B2 (en) | 1999-06-04 | 2006-08-15 | Impulse Dynamics Nv | Drug delivery device |
US7171263B2 (en) | 1999-06-04 | 2007-01-30 | Impulse Dynamics Nv | Drug delivery device |
WO2000074773A1 (en) * | 1999-06-04 | 2000-12-14 | Impulse Dynamics N.V. | Drug delivery device |
US20020095157A1 (en) * | 1999-07-23 | 2002-07-18 | Bowman Steven M. | Graft fixation device combination |
WO2001048180A2 (en) * | 1999-12-22 | 2001-07-05 | Innovation And Development Corporation | Method and apparatus for targeting localised electroporation |
DE10031179A1 (de) * | 2000-06-27 | 2002-01-31 | Amaxa Gmbh | Verfahren zur Einbringung von Nukleinsäuren und anderen biologisch aktiven Molekülen in den Kern höherer eukaryontischer Zellen mit Hilfe elektrischen Stroms |
US6846306B1 (en) * | 2000-10-10 | 2005-01-25 | Cold Spring Harbor Laboratory | Single cell electroporation |
SE0003841D0 (sv) * | 2000-10-20 | 2000-10-20 | Daniel Chiu | A method and apparatus for penetration of lipid bilayer membranes |
CA2365376C (en) | 2000-12-21 | 2006-03-28 | Ethicon, Inc. | Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration |
DE10119901A1 (de) * | 2001-04-23 | 2002-10-24 | Amaxa Gmbh | Schaltungsanordnung zur Einbringung von Nukleinsäuren und anderen biologisch aktiven Molekülen in den Kern höherer eukaryontischer Zellen mit Hilfe elektrischen Stroms |
EP2347824A3 (de) | 2002-02-12 | 2012-03-07 | Cellectricon Ab | Systeme und Verfahren zur schnellen Änderung der Lösungsumgebung um Sensoren |
JP4326343B2 (ja) * | 2002-02-12 | 2009-09-02 | 株式会社モレニアムラボラトリーズ | 分子振動装置 |
US7470518B2 (en) | 2002-02-12 | 2008-12-30 | Cellectricon Ab | Systems and method for rapidly changing the solution environment around sensors |
DE60334580D1 (de) | 2002-08-21 | 2010-11-25 | Cellectricon Ab | System zur Gewinnung und Erhaltung hochresistenter Verschlüsse bei Patch-Clamp-Aufzeichnungen |
AU2003278461A1 (en) | 2002-10-16 | 2004-05-04 | Cellectricon Ab | Nanoelectrodes and nanotips for recording transmembrane currents in a plurality of cells |
US20040078090A1 (en) | 2002-10-18 | 2004-04-22 | Francois Binette | Biocompatible scaffolds with tissue fragments |
US7824701B2 (en) | 2002-10-18 | 2010-11-02 | Ethicon, Inc. | Biocompatible scaffold for ligament or tendon repair |
US8197837B2 (en) | 2003-03-07 | 2012-06-12 | Depuy Mitek, Inc. | Method of preparation of bioabsorbable porous reinforced tissue implants and implants thereof |
US11439815B2 (en) | 2003-03-10 | 2022-09-13 | Impulse Dynamics Nv | Protein activity modification |
US8226715B2 (en) | 2003-06-30 | 2012-07-24 | Depuy Mitek, Inc. | Scaffold for connective tissue repair |
US8455228B2 (en) * | 2003-07-16 | 2013-06-04 | University Of South Florida | Method to facilitate directed delivery and electroporation using a charged stream |
US10583220B2 (en) | 2003-08-11 | 2020-03-10 | DePuy Synthes Products, Inc. | Method and apparatus for resurfacing an articular surface |
US7316822B2 (en) | 2003-11-26 | 2008-01-08 | Ethicon, Inc. | Conformable tissue repair implant capable of injection delivery |
US7901461B2 (en) * | 2003-12-05 | 2011-03-08 | Ethicon, Inc. | Viable tissue repair implants and methods of use |
US11395865B2 (en) | 2004-02-09 | 2022-07-26 | DePuy Synthes Products, Inc. | Scaffolds with viable tissue |
US11779768B2 (en) | 2004-03-10 | 2023-10-10 | Impulse Dynamics Nv | Protein activity modification |
US8548583B2 (en) | 2004-03-10 | 2013-10-01 | Impulse Dynamics Nv | Protein activity modification |
US6897069B1 (en) | 2004-06-08 | 2005-05-24 | Ambion, Inc. | System and method for electroporating a sample |
KR100853102B1 (ko) * | 2004-06-12 | 2008-08-21 | 주식회사 디지탈바이오테크놀러지 | 중공구조를 갖는 전기천공 장치 |
ES2465467T3 (es) * | 2004-06-14 | 2014-06-05 | Lonza Cologne Ag | Procedimiento y disposición de circuito para el tratamiento de material biológico |
US20090239215A1 (en) * | 2004-12-16 | 2009-09-24 | Brandeis University | Clonable Tag for Purification and Electron Microscopy Labeling |
US8101169B2 (en) * | 2005-02-23 | 2012-01-24 | The Board Of Trustees Of The Leland Stanford Junior University | Ocular gene therapy using avalanche-mediated transfection |
US7923251B2 (en) * | 2005-02-23 | 2011-04-12 | The Board Of Trustees Of The Leland Stanford Junior University | Method and apparatus for avalanche-mediated transfer of agents into cells |
US20070134814A1 (en) * | 2005-12-09 | 2007-06-14 | Kajander E O | Methods and compositions for the detection of calcifying nano-particles, identification and quantification of associated proteins thereon, and correlation to disease |
EP1984723B1 (de) | 2006-02-01 | 2019-05-15 | Ecole Polytechnique Federale de Lausanne (EPFL) | Vorrichtung zur impedanzmessung von partikeln in einem mikrokanal |
CN100494389C (zh) * | 2006-04-03 | 2009-06-03 | 西北农林科技大学 | 一种用于细胞核移植/克隆电融合的针状微电极 |
HUP0600444A2 (en) * | 2006-05-29 | 2007-11-28 | Istvan Magyar | Microcurrent therapy device |
DE102006031871B4 (de) * | 2006-07-10 | 2008-10-23 | Gerlach, Jörg, Dr.med. | 3-D Petri-Schale zur Züchtung und Untersuchung von Zellen |
US20110183407A1 (en) | 2008-03-12 | 2011-07-28 | Cellectricon Ab | Apparatus and method for tip alignment in multiwell plates |
KR101084528B1 (ko) | 2008-04-15 | 2011-11-18 | 인비트로겐 싱가포르 피티이. 엘티디. | 전기천공 장치용 파이펫 팁 |
US9616245B2 (en) | 2009-03-16 | 2017-04-11 | Rajah Vijay Kumar | Method of treating cells with drug and radiation according to proton density |
WO2011092710A2 (en) | 2010-02-01 | 2011-08-04 | Metacure Limited | Gastrointestinal electrical therapy |
JP2013527009A (ja) * | 2010-06-03 | 2013-06-27 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | エレクトロポレーション電極構造および方法 |
CN102959452B (zh) * | 2010-08-06 | 2016-06-29 | 日本精工株式会社 | 机械手系统及微小操作对象物的操作方法 |
ES2764105T3 (es) | 2011-10-17 | 2020-06-02 | Massachusetts Inst Technology | Administración intracelular |
WO2013075131A1 (en) * | 2011-11-17 | 2013-05-23 | Brigham Young University | Cytoplasm to organelle delivery system and associated methods |
US9573297B2 (en) * | 2011-11-21 | 2017-02-21 | Reza Reza Youssefi | Method and system for enhancing polymerization and nanoparticle production |
US9003943B2 (en) * | 2011-12-16 | 2015-04-14 | Saab Ab | Object-focussed decision support |
PT2814513T (pt) | 2012-02-14 | 2018-03-02 | Univ California | Entrega sistémica e expressão regulada de genes parácrinos para doenças cardiovasculares e outras doenças |
WO2015085162A1 (en) | 2013-12-05 | 2015-06-11 | Rfemb Holdings, Llc | Cancer immunotherapy by radiofrequency electrical membrane breakdown (rf-emb) |
AU2014306423B2 (en) | 2013-08-16 | 2019-04-18 | Massachusetts Institute Of Technology | Selective delivery of material to cells |
BR112016022854A2 (pt) | 2014-04-03 | 2018-01-16 | Univ California | método para tratar, aliviar ou proteger (prevenir), diminuir o progresso ou reverter uma doença, método para tratar, aliviar ou proteger (prevenir) uma doença, uso, e, ácido nucleico ou gene |
CN104173287B (zh) * | 2014-07-23 | 2016-10-05 | 华南理工大学 | 用于靶向释放药物载体的脉冲电场敏感脂质体的制备方法 |
SG11201703044PA (en) | 2014-10-31 | 2017-05-30 | Massachusetts Inst Technology | Delivery of biomolecules to immune cells |
CN107002089B (zh) | 2014-11-14 | 2021-09-07 | 麻省理工学院 | 化合物和组合物向细胞中的破坏和场实现的递送 |
WO2016115179A1 (en) | 2015-01-12 | 2016-07-21 | Massachusetts Institute Of Technology | Gene editing through microfluidic delivery |
KR101672399B1 (ko) * | 2015-04-13 | 2016-11-03 | 명지대학교 산학협력단 | 광학 현미경과 이온 전류 측정을 이용한 전기 천공 방법 및 전기 천공 장치 |
EP3320082B1 (de) | 2015-07-09 | 2023-05-24 | Massachusetts Institute of Technology | Abgabe von materialien an kernlose zellen |
FR3038785B1 (fr) * | 2015-07-10 | 2017-08-04 | Commissariat Energie Atomique | Laser injecte et procede de generation d'impulsions laser multimode longitudinal |
DK3386527T3 (da) | 2015-12-10 | 2021-08-23 | Univ California | Sammensætninger til anvendelse i behandling eller forbedring af neuroinflammation, neurodegeneration, neuropatisk smerte og migræne |
US10702690B2 (en) | 2017-02-03 | 2020-07-07 | Infinitesimal Llc | Electroporation system with micromanipulator and probe |
CN110741076A (zh) * | 2017-04-26 | 2020-01-31 | 拉瓦塔解决方案股份有限公司 | 用于电穿孔的微电极技术 |
US10391154B2 (en) | 2017-07-19 | 2019-08-27 | Leadiant Biosciences Ltd. | Compositions and methods for treating or ameliorating fibrosis, systemic sclerosis and scleroderma |
EP3599243B1 (de) | 2018-07-26 | 2023-04-12 | CVIE Therapeutics Limited | 17beta-heterocyclyl-digitalis-ähnliche verbindungen zur behandlung von herzinsuffizienz |
CN110872560B (zh) * | 2018-09-03 | 2023-04-07 | 深圳先进技术研究院 | 一种电极间距可调的微间距电穿孔装置 |
WO2020163310A1 (en) * | 2019-02-04 | 2020-08-13 | Rutgers, The State University Of New Jersey | Device for tissue electrotransfer using a microelectrode |
BR112021017009A2 (pt) | 2019-03-05 | 2021-11-09 | Windtree Therapeutics Inc | Formulação intravenosa contendo istaroxima para o tratamento da insuficiência cardíaca aguda (ahf) |
WO2021030337A1 (en) * | 2019-08-12 | 2021-02-18 | Trustees Of Tufts College | Modularized field-effect transistor biosensors |
ES2970792T3 (es) | 2019-10-09 | 2024-05-30 | Windtree Therapeutics Inc | Derivados de androstano con actividad como estimuladores puros o predominantemente puros de SERCA2A para el tratamiento de la insuficiencia cardíaca |
EP4308233A1 (de) | 2021-03-18 | 2024-01-24 | The Regents of the University of California | Zusammensetzungen und verfahren zum targeting von entzündlichen oder arktivierten zellen und zur behandlung oder linderung von entzündlichen erkrankungen und schmerzen |
JP2024515808A (ja) * | 2021-04-27 | 2024-04-10 | カイトペン コーポレイション | 電気機械的トランスフェクションの方法 |
CN113322181A (zh) * | 2021-06-10 | 2021-08-31 | 上海大学 | 一种细胞裂解装置及基于细胞裂解装置的细胞纯化和/或细胞裂解的方法 |
CN113832033A (zh) * | 2021-09-10 | 2021-12-24 | 北京大学 | 细胞高活性分选及改造的原位电穿孔芯片、装置及方法 |
WO2023205183A1 (en) | 2022-04-20 | 2023-10-26 | Windtree Therapeutics, Inc. | Istaroxime-containing intravenous formulation for the treatment of pre-cardiogenic shock and cardiogenic shock |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE131081T1 (de) * | 1988-01-21 | 1995-12-15 | Massachusetts Inst Technology | Molekültransport durch gewebe mit der verwendung von elektroporation. |
US5389069A (en) | 1988-01-21 | 1995-02-14 | Massachusetts Institute Of Technology | Method and apparatus for in vivo electroporation of remote cells and tissue |
US5137817A (en) * | 1990-10-05 | 1992-08-11 | Amoco Corporation | Apparatus and method for electroporation |
US5501662A (en) | 1992-05-22 | 1996-03-26 | Genetronics, Inc. | Implantable electroporation method and apparatus for drug and gene delivery |
US5993434A (en) * | 1993-04-01 | 1999-11-30 | Genetronics, Inc. | Method of treatment using electroporation mediated delivery of drugs and genes |
US5702359A (en) | 1995-06-06 | 1997-12-30 | Genetronics, Inc. | Needle electrodes for mediated delivery of drugs and genes |
JPH07133907A (ja) | 1993-11-10 | 1995-05-23 | Tokyo Gas Co Ltd | 窒素酸化物低発生交番燃焼バ−ナ |
DE19529371C3 (de) * | 1995-08-10 | 2003-05-28 | Nmi Univ Tuebingen | Mikroelektroden-Anordnung |
US5874268A (en) * | 1996-09-23 | 1999-02-23 | Duke University | Method of introducing exogenous compounds into cells by electroporation and apparatus for same |
US6352535B1 (en) * | 1997-09-25 | 2002-03-05 | Nanoptics, Inc. | Method and a device for electro microsurgery in a physiological liquid environment |
US6241701B1 (en) * | 1997-08-01 | 2001-06-05 | Genetronics, Inc. | Apparatus for electroporation mediated delivery of drugs and genes |
SE9704076D0 (sv) | 1997-11-06 | 1997-11-06 | Holdingbolaget Vid Goeteborgs | Method for permeabilisation of cell structures and use thereof |
AU2150300A (en) | 1998-12-07 | 2000-06-26 | Acacia Biosciences Inc. | Multi-channel electrode arrays |
US6713291B2 (en) * | 1999-01-28 | 2004-03-30 | Alan D. King | Electrodes coated with treating agent and uses thereof |
US6300108B1 (en) | 1999-07-21 | 2001-10-09 | The Regents Of The University Of California | Controlled electroporation and mass transfer across cell membranes |
WO2001048180A2 (en) | 1999-12-22 | 2001-07-05 | Innovation And Development Corporation | Method and apparatus for targeting localised electroporation |
US6846306B1 (en) | 2000-10-10 | 2005-01-25 | Cold Spring Harbor Laboratory | Single cell electroporation |
US7101703B2 (en) * | 2001-03-09 | 2006-09-05 | Cornell Research Foundation, Inc. | Electrofusion microelectrode |
US7127284B2 (en) * | 2001-06-11 | 2006-10-24 | Mercator Medsystems, Inc. | Electroporation microneedle and methods for its use |
US6749792B2 (en) * | 2001-07-09 | 2004-06-15 | Lifescan, Inc. | Micro-needles and methods of manufacture and use thereof |
-
1997
- 1997-11-06 SE SE9704076A patent/SE9704076D0/xx unknown
-
1998
- 1998-11-06 WO PCT/SE1998/002012 patent/WO1999024110A1/en active IP Right Grant
- 1998-11-06 DE DE69835228T patent/DE69835228T2/de not_active Expired - Lifetime
- 1998-11-06 CN CN98811613.8A patent/CN1280513A/zh active Pending
- 1998-11-06 CA CA002308397A patent/CA2308397A1/en not_active Abandoned
- 1998-11-06 EP EP98953145A patent/EP1028778B1/de not_active Expired - Lifetime
- 1998-11-06 AT AT98953145T patent/ATE332725T1/de not_active IP Right Cessation
- 1998-11-06 AU AU10593/99A patent/AU1059399A/en not_active Abandoned
- 1998-11-06 JP JP2000520193A patent/JP4321962B2/ja not_active Expired - Lifetime
-
2000
- 2000-04-25 US US09/557,979 patent/US6521430B1/en not_active Expired - Lifetime
-
2002
- 2002-12-19 US US10/325,691 patent/US7109034B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP2001522666A (ja) | 2001-11-20 |
DE69835228D1 (de) | 2006-08-24 |
CA2308397A1 (en) | 1999-05-20 |
EP1028778A1 (de) | 2000-08-23 |
EP1028778B1 (de) | 2006-07-12 |
SE9704076D0 (sv) | 1997-11-06 |
US20040023394A1 (en) | 2004-02-05 |
WO1999024110A1 (en) | 1999-05-20 |
US7109034B2 (en) | 2006-09-19 |
AU1059399A (en) | 1999-05-31 |
CN1280513A (zh) | 2001-01-17 |
DE69835228T2 (de) | 2007-06-14 |
JP4321962B2 (ja) | 2009-08-26 |
US6521430B1 (en) | 2003-02-18 |
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