WO2004030706A3 - Bioactive implants - Google Patents

Bioactive implants Download PDF

Info

Publication number
WO2004030706A3
WO2004030706A3 PCT/US2003/030979 US0330979W WO2004030706A3 WO 2004030706 A3 WO2004030706 A3 WO 2004030706A3 US 0330979 W US0330979 W US 0330979W WO 2004030706 A3 WO2004030706 A3 WO 2004030706A3
Authority
WO
WIPO (PCT)
Prior art keywords
electrode
myogenic cells
cells
electrodes
coated
Prior art date
Application number
PCT/US2003/030979
Other languages
French (fr)
Other versions
WO2004030706A2 (en
Inventor
Peter K Law
Marvin A Motsenbocker
Original Assignee
Peter K Law
Marvin A Motsenbocker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Peter K Law, Marvin A Motsenbocker filed Critical Peter K Law
Priority to AU2003272805A priority Critical patent/AU2003272805A1/en
Publication of WO2004030706A2 publication Critical patent/WO2004030706A2/en
Publication of WO2004030706A3 publication Critical patent/WO2004030706A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/005—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0658—Skeletal muscle cells, e.g. myocytes, myotubes, myoblasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/08—Muscles; Tendons; Ligaments
    • A61F2002/0894—Muscles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/30—Materials or treatment for tissue regeneration for muscle reconstruction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Prostheses (AREA)
  • Electrotherapy Devices (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Bioactive electrodes for implantation into existing muscles are provided that enhance the functioning of the muscles. The electrodes may be coated with myogenic cells and may be transplanted as a living package, surrounded by a biologically degradable covering, into a weak muscle. Electrode surfaces may be coated with biologically active substances such as scaffold proteins that encourage migration and binding of myogenic cells and precursors to neurons. An electrode may slowly release trophic factors and may pre-train associated myogenic cells and/or nerve cell precursors by repeated electrical stimulation of the electrode in vitro in the presence of the cells. By transplanting myogenic cells along with the electrode, a new and powerful tool for muscle boosting, repair or augmentation is provided.
PCT/US2003/030979 2002-10-01 2003-10-01 Bioactive implants WO2004030706A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003272805A AU2003272805A1 (en) 2002-10-01 2003-10-01 Bioactive implants

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41466502P 2002-10-01 2002-10-01
US60/414,665 2002-10-01

Publications (2)

Publication Number Publication Date
WO2004030706A2 WO2004030706A2 (en) 2004-04-15
WO2004030706A3 true WO2004030706A3 (en) 2004-06-24

Family

ID=32069754

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/030979 WO2004030706A2 (en) 2002-10-01 2003-10-01 Bioactive implants

Country Status (2)

Country Link
AU (1) AU2003272805A1 (en)
WO (1) WO2004030706A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8874204B2 (en) 2004-12-20 2014-10-28 Cardiac Pacemakers, Inc. Implantable medical devices comprising isolated extracellular matrix

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7509166B2 (en) 2003-12-24 2009-03-24 Cardiac Pacemakers, Inc. Automatic baroreflex modulation responsive to adverse event
US8938300B2 (en) 2004-05-04 2015-01-20 University Of Rochester Leadless implantable intravascular electrophysiologic device for neurologic/cardiovascular sensing and stimulation
US8849416B2 (en) 2004-05-04 2014-09-30 University Of Rochester Implantable bio-electro-physiologic interface matrix
US8060219B2 (en) * 2004-12-20 2011-11-15 Cardiac Pacemakers, Inc. Epicardial patch including isolated extracellular matrix with pacing electrodes
US7981065B2 (en) 2004-12-20 2011-07-19 Cardiac Pacemakers, Inc. Lead electrode incorporating extracellular matrix
EP2347774B1 (en) 2005-12-13 2017-07-26 The President and Fellows of Harvard College Scaffolds for cell transplantation
US8798737B2 (en) 2006-09-22 2014-08-05 Sapiens Steering Brain Stimulation B.V. Implantable multi-electrode device
WO2009002401A2 (en) 2007-06-21 2008-12-31 President And Fellows Of Harvard College Scaffolds for cell collection or elimination
US7894914B2 (en) 2007-08-28 2011-02-22 Cardiac Pacemakers, Inc. Medical device electrodes including nanostructures
US7991480B2 (en) 2007-08-28 2011-08-02 Cardiac Pacemakers, Inc. Medical device electrodes having cells disposed on nanostructures
US10328133B2 (en) 2008-02-13 2019-06-25 President And Fellows Of Harvard College Continuous cell programming devices
US9370558B2 (en) 2008-02-13 2016-06-21 President And Fellows Of Harvard College Controlled delivery of TLR agonists in structural polymeric devices
US9012399B2 (en) 2008-05-30 2015-04-21 President And Fellows Of Harvard College Controlled release of growth factors and signaling molecules for promoting angiogenesis
CA2758208A1 (en) 2009-04-09 2010-10-14 Jordan Lancaster Cellular seeding and co-culture of a three dimensional fibroblast construct
WO2010120749A2 (en) 2009-04-13 2010-10-21 President And Fellow Of Harvard College Harnessing cell dynamics to engineer materials
WO2011014871A1 (en) 2009-07-31 2011-02-03 President And Fellows Of Harvard College Programming of cells for tolerogenic therapies
US9610328B2 (en) 2010-03-05 2017-04-04 President And Fellows Of Harvard College Enhancement of skeletal muscle stem cell engraftment by dual delivery of VEGF and IGF-1
US9693954B2 (en) 2010-06-25 2017-07-04 President And Fellows Of Harvard College Co-delivery of stimulatory and inhibitory factors to create temporally stable and spatially restricted zones
JP6104806B2 (en) 2010-10-06 2017-03-29 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ Injectable pore-forming hydrogel for material-based cell therapy
WO2012064697A2 (en) 2010-11-08 2012-05-18 President And Fellows Of Harvard College Materials presenting notch signaling molecules to control cell behavior
WO2012148684A1 (en) 2011-04-27 2012-11-01 President And Fellows Of Harvard College Cell-friendly inverse opal hydrogels for cell encapsulation, drug and protein delivery, and functional nanoparticle encapsulation
US10045947B2 (en) 2011-04-28 2018-08-14 President And Fellows Of Harvard College Injectable preformed macroscopic 3-dimensional scaffolds for minimally invasive administration
US9675561B2 (en) 2011-04-28 2017-06-13 President And Fellows Of Harvard College Injectable cryogel vaccine devices and methods of use thereof
US9486512B2 (en) 2011-06-03 2016-11-08 President And Fellows Of Harvard College In situ antigen-generating cancer vaccine
EP2838515B1 (en) 2012-04-16 2019-11-20 President and Fellows of Harvard College Mesoporous silica compositions for modulating immune responses
US20150050300A1 (en) 2013-08-16 2015-02-19 Peter K. Law Disease prevention and alleviation by human myoblast transplantation
JP7348708B2 (en) 2014-04-30 2023-09-21 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ Combination vaccine device and method for killing cancer cells
KR102501552B1 (en) 2015-01-11 2023-03-21 어씨러스 메디컬, 엘엘씨 Hybrid device for surgical aortic repair
EP3250250A4 (en) 2015-01-30 2019-05-22 President and Fellows of Harvard College Peritumoral and intratumoral materials for cancer therapy
JP7094533B2 (en) 2015-04-10 2022-07-04 プレジデント アンド フェローズ オブ ハーバード カレッジ Immune cell capture device and its manufacture and use
JP7138864B2 (en) 2016-02-06 2022-09-20 プレジデント アンド フェローズ オブ ハーバード カレッジ Recapitulation of the hematopoietic niche to reconstitute immunity
CN109789092A (en) 2016-07-13 2019-05-21 哈佛学院院长等 Antigen presenting cell simulates bracket and its preparation and application
MX2019015321A (en) 2017-06-16 2020-07-20 Avery Therapeutics Inc Three dimensional tissue compositions and methods of use.
JP7050183B2 (en) 2018-03-13 2022-04-07 インスティテュート キミセ デ サリア セツ ファンダシオ プリバーダ Vascular repair patch
CN111359009B (en) * 2020-03-25 2022-06-24 天衍医疗器材有限公司 Porous tantalum implant with biological activity function and processing technology

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6087324A (en) * 1993-06-24 2000-07-11 Takeda Chemical Industries, Ltd. Sustained-release preparation
US6284242B1 (en) * 1999-04-16 2001-09-04 Regents Of The University Of Michigan Method for enhancing myoblast migration and invasion in the context of gene therapy
US6444642B1 (en) * 1991-04-10 2002-09-03 Cenes Pharmaceuticals, Inc. Methods of increasing myotube formation or survival or muscle cell mitogenesis, differentiation or survival using a neuregulin

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6444642B1 (en) * 1991-04-10 2002-09-03 Cenes Pharmaceuticals, Inc. Methods of increasing myotube formation or survival or muscle cell mitogenesis, differentiation or survival using a neuregulin
US6087324A (en) * 1993-06-24 2000-07-11 Takeda Chemical Industries, Ltd. Sustained-release preparation
US6284242B1 (en) * 1999-04-16 2001-09-04 Regents Of The University Of Michigan Method for enhancing myoblast migration and invasion in the context of gene therapy
US20010055590A1 (en) * 1999-04-16 2001-12-27 Kotoku Kurachi Method for enhancing myoblast migration and invasion in the context of gene therapy

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8874204B2 (en) 2004-12-20 2014-10-28 Cardiac Pacemakers, Inc. Implantable medical devices comprising isolated extracellular matrix

Also Published As

Publication number Publication date
AU2003272805A1 (en) 2004-04-23
WO2004030706A2 (en) 2004-04-15
AU2003272805A8 (en) 2004-04-23

Similar Documents

Publication Publication Date Title
WO2004030706A3 (en) Bioactive implants
ATE287277T1 (en) DEVICE FOR SELECTIVE EXTERNAL RETINA STIMULATION
WO2009023543A3 (en) Systems and methods of neuromodulation stimulation for the restoration of sexual function
ATE531421T1 (en) ELECTRODE-LEAD CONNECTION WITH POST-IMPLANTATION IMAGING
DE60135019D1 (en) ELECTRICALLY PROCESSED COLLAGEN
US5814094A (en) Iontopheretic system for stimulation of tissue healing and regeneration
WO2010065761A3 (en) Implantable neurostimulators having reduced pocket stimulation
WO2007120305A3 (en) Electrode arrangement for nerve stimulation and methods of treating disorders
WO2005051480A3 (en) Electrical stimulation system, lead, and method providing reduced neuroplasticity effects
EP1652538A3 (en) Autologous platelet gel on a stent graft
WO2007059343A3 (en) Implantable stimulator configured to be implanted within a patient in a pre-determined orientation
DE69431467D1 (en) COCHLEARE IMPLANT EQUIPMENT
WO2006083675A3 (en) A stimulating device
WO2007015907A3 (en) Stimulation electrode array
WO2002018441A3 (en) Electroprocessed fibrin-based matrices and tissues
ATE508765T1 (en) IMPLANTABLE STIMULATION ELECTRODE WITH A COATING TO INCREASE TISSUE COMPATIBILITY
WO2004080533A8 (en) Apparatus and method for delivering electrical signals to modify gene expression in cardiac tissue
WO2005072764A3 (en) Fibrin-bound angiogenic factors to stimulate vascularization of transplant site of encapsulated cells
WO2002060029A8 (en) Power supply for a cochlear implant
WO2007117728A3 (en) Non-linear electrode array
WO2007087626A3 (en) Method of neurosimulation of distinct neural structures using single paddle lead
WO2000032749A3 (en) Methods and articles for regenerating living tissue
ATE543509T1 (en) MATERIALS AND METHODS FOR PROMOTING NERVOUS TISSUE REPAIR
MX353245B (en) METHODS FOR REPROGRAMMING CELLS and USES THEREOF.
WO2005086849A3 (en) Implant scaffold combined with autologous or allogenic tissue

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP