DK0988060T3 - Syrelabile og enzymatisk spaltelige farvestofforbindelser til diagnose med nærinfrarödt lys og til terapi - Google Patents
Syrelabile og enzymatisk spaltelige farvestofforbindelser til diagnose med nærinfrarödt lys og til terapiInfo
- Publication number
- DK0988060T3 DK0988060T3 DK98929212T DK98929212T DK0988060T3 DK 0988060 T3 DK0988060 T3 DK 0988060T3 DK 98929212 T DK98929212 T DK 98929212T DK 98929212 T DK98929212 T DK 98929212T DK 0988060 T3 DK0988060 T3 DK 0988060T3
- Authority
- DK
- Denmark
- Prior art keywords
- diagnosis
- therapy
- infrared light
- acid labile
- dye compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 238000003745 diagnosis Methods 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 239000000032 diagnostic agent Substances 0.000 abstract 2
- 229940039227 diagnostic agent Drugs 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000005855 radiation Effects 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0052—Small organic molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0058—Antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
- C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
- C09B23/086—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines more than five >CH- groups
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B69/00—Dyes not provided for by a single group of this subclass
- C09B69/10—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/583—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with non-fluorescent dye label
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19717904A DE19717904A1 (de) | 1997-04-23 | 1997-04-23 | Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie |
PCT/DE1998/001001 WO1998047538A2 (de) | 1997-04-23 | 1998-04-02 | Säurelabile und enzymatisch spaltbare farbstoffkonstrukte zur diagnostik mit nahinfrarotlicht und zur therapie |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0988060T3 true DK0988060T3 (da) | 2007-10-15 |
Family
ID=7827982
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK98929212T DK0988060T3 (da) | 1997-04-23 | 1998-04-02 | Syrelabile og enzymatisk spaltelige farvestofforbindelser til diagnose med nærinfrarödt lys og til terapi |
Country Status (16)
Country | Link |
---|---|
US (1) | US6534041B1 (da) |
EP (1) | EP0988060B1 (da) |
JP (2) | JP5118790B2 (da) |
KR (1) | KR100613306B1 (da) |
CN (1) | CN1253507A (da) |
AT (1) | ATE364404T1 (da) |
AU (1) | AU733757B2 (da) |
CA (1) | CA2287262C (da) |
CY (1) | CY1106860T1 (da) |
DE (2) | DE19717904A1 (da) |
DK (1) | DK0988060T3 (da) |
ES (1) | ES2289786T3 (da) |
HU (1) | HU226812B1 (da) |
NO (1) | NO327495B1 (da) |
PT (1) | PT988060E (da) |
WO (1) | WO1998047538A2 (da) |
Families Citing this family (139)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4445065A1 (de) * | 1994-12-07 | 1996-06-13 | Diagnostikforschung Inst | Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung |
DE19717904A1 (de) * | 1997-04-23 | 1998-10-29 | Diagnostikforschung Inst | Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie |
US6592847B1 (en) | 1998-05-14 | 2003-07-15 | The General Hospital Corporation | Intramolecularly-quenched near infrared flourescent probes |
US6083486A (en) * | 1998-05-14 | 2000-07-04 | The General Hospital Corporation | Intramolecularly-quenched near infrared fluorescent probes |
US7547721B1 (en) | 1998-09-18 | 2009-06-16 | Bayer Schering Pharma Ag | Near infrared fluorescent contrast agent and fluorescence imaging |
JP2000095758A (ja) * | 1998-09-18 | 2000-04-04 | Schering Ag | 近赤外蛍光造影剤および蛍光造影方法 |
DE19917713A1 (de) * | 1999-04-09 | 2000-10-19 | Diagnostikforschung Inst | Kurzkettige Peptid-Farbstoffkonjugate als Konstrastmittel für die optische Diagnostik |
US7175953B2 (en) | 1999-04-09 | 2007-02-13 | Institute Fuer Diagnostik Forschung | Short-warp peptide-dye conjugate as contrast agent for optical diagnostic |
US6114350A (en) * | 1999-04-19 | 2000-09-05 | Nen Life Science Products, Inc. | Cyanine dyes and synthesis methods thereof |
FR2793414B1 (fr) * | 1999-05-10 | 2003-05-23 | Centre Nat Rech Scient | Conjugue acide nucleique-anticorps pour delivrer un acide nucleique etranger dans les cellules |
WO2001089584A2 (en) * | 2000-05-23 | 2001-11-29 | Amersham Health As | Contrast agents |
DE10046215B4 (de) * | 2000-09-19 | 2004-04-15 | Institut für Chemo- und Biosensorik Münster e.V. i.Ins. | Fluorochrome und deren Verwendung |
US7597878B2 (en) * | 2000-09-19 | 2009-10-06 | Li-Cor, Inc. | Optical fluorescent imaging |
US6673334B1 (en) * | 2000-10-16 | 2004-01-06 | Mallinkcrodt, Inc. | Light sensitive compounds for instant determination of organ function |
US20070092450A1 (en) * | 2000-10-16 | 2007-04-26 | Mallinckrodt Inc. | Tissue-specific exogenous optical agents |
US6716413B1 (en) * | 2000-10-16 | 2004-04-06 | Mallinckrodt, Inc. | Indole compounds as tissue-specific exogenous optical agents |
US20040180809A1 (en) * | 2000-10-16 | 2004-09-16 | Mallinckrodt Inc. | Tissue-specific exogenous optical agents |
US7383076B2 (en) | 2000-11-27 | 2008-06-03 | The General Hospital Corporation | Fluorescence-mediated molecular tomography |
US6984373B2 (en) | 2000-12-23 | 2006-01-10 | Dyax Corp. | Fibrin binding moieties useful as imaging agents |
US20030044353A1 (en) * | 2001-01-05 | 2003-03-06 | Ralph Weissleder | Activatable imaging probes |
US20030031627A1 (en) * | 2001-07-31 | 2003-02-13 | Mallinckrodt Inc. | Internal image antibodies for optical imaging and therapy |
US8623822B2 (en) | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
US7794693B2 (en) | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
ES2506142T3 (es) | 2002-03-01 | 2014-10-13 | Dyax Corp. | Péptidos de unión a KDR y a VEGF/KDR y su uso en diagnóstico |
US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
WO2004065621A1 (en) | 2002-03-01 | 2004-08-05 | Dyax Corp. | Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy |
AU2003225763A1 (en) * | 2002-03-11 | 2003-09-29 | Visen Medical, Inc. | Optical imaging probes |
GB0208989D0 (en) | 2002-04-19 | 2002-05-29 | Amersham Biosciences Uk Ltd | Methods for measuring enzyme activity |
US7226577B2 (en) | 2003-01-13 | 2007-06-05 | Bracco Imaging, S. P. A. | Gastrin releasing peptide compounds |
KR20050103907A (ko) * | 2003-01-24 | 2005-11-01 | 쉐링 악티엔게젤샤프트 | 형광 진단을 위한 친수성의 티올-반응성 시아닌 염료 및그의 생체분자와의 접합체 |
EP1603935A4 (en) | 2003-03-03 | 2007-03-21 | Dyax Corp | SPECIFIC TO HGF RECEPTOR (cMET) BINDING PEPTIDES AND THEIR USE |
US20050106100A1 (en) * | 2003-09-03 | 2005-05-19 | Harris Thomas D. | Compounds containing matrix metalloproteinase substrates and methods of their use |
JP2005170812A (ja) * | 2003-12-09 | 2005-06-30 | Konica Minolta Medical & Graphic Inc | 蛍光造影剤及び蛍光造影方法 |
US7018775B2 (en) * | 2003-12-15 | 2006-03-28 | Eastman Kodak Company | Infrared absorbing N-alkylsulfate cyanine compounds |
CN101203248A (zh) * | 2005-06-21 | 2008-06-18 | 马林克罗特公司 | 光学成像造影剂 |
US8227621B2 (en) * | 2005-06-30 | 2012-07-24 | Li-Cor, Inc. | Cyanine dyes and methods of use |
US20070014721A1 (en) * | 2005-06-30 | 2007-01-18 | Harris Thomas D | Hydrazide conjugates as imaging agents |
EP1745739A3 (en) * | 2005-07-14 | 2009-04-22 | Bundesrepublik Deutschland, vertr. d.d. Bundes- ministerium f. Wirtschaft- und Technologie, dieses vertr. d.d. Präs. d. Phys.-Techn. Bundesanstalt | Optical imaging of rheumatoid arthritis |
CN101296927A (zh) | 2005-09-02 | 2008-10-29 | Visen医药公司 | 生物相容的含n,n-二取代磺酰胺的荧光染料标记 |
JP5416970B2 (ja) | 2005-09-02 | 2014-02-12 | ビセン メディカル, インコーポレイテッド | ニコチン酸及びピコリン酸誘導近赤外線蛍光団 |
US7947256B2 (en) * | 2005-09-02 | 2011-05-24 | Visen Medical, Inc. | Biocompatible fluorescent imaging agents |
DE102006029454A1 (de) | 2005-12-05 | 2007-06-06 | Dyomics Gmbh | Hydrophile Marker auf Basis von diasteromeren |
US20070148094A1 (en) * | 2005-12-22 | 2007-06-28 | Uzgiris Egidijus E | Polymeric imaging agents and medical imaging methods |
US9913917B2 (en) | 2005-12-22 | 2018-03-13 | Visen Medical, Inc. | Biocompatible fluorescent metal oxide nanoparticles |
US7629125B2 (en) | 2006-11-16 | 2009-12-08 | General Electric Company | Sequential analysis of biological samples |
US9201063B2 (en) * | 2006-11-16 | 2015-12-01 | General Electric Company | Sequential analysis of biological samples |
US7741045B2 (en) * | 2006-11-16 | 2010-06-22 | General Electric Company | Sequential analysis of biological samples |
CN101558081B (zh) | 2006-12-11 | 2014-08-20 | 伯拉考成像股份公司 | 用于诊断和治疗应用的纤维蛋白结合肽缀合体 |
WO2008100817A2 (en) | 2007-02-09 | 2008-08-21 | Visen Medical, Inc. | Polycyclo dyes and use thereof |
WO2008109832A2 (en) * | 2007-03-08 | 2008-09-12 | Visen Medical, Inc. | Viable near-infrared fluorochrome labeled cells and methods of making and using same |
US7906106B2 (en) * | 2007-06-27 | 2011-03-15 | General Electric Company | In vivo cell trafficking |
US8021647B2 (en) * | 2007-06-29 | 2011-09-20 | General Electric Company | In vivo optical imaging |
DK2244741T3 (da) | 2008-01-18 | 2015-05-26 | Visen Medical Inc | Fluorescerende billeddannelsesmidler |
WO2009129220A2 (en) | 2008-04-14 | 2009-10-22 | The Gereral Hospital Corporation | Plectin-1 targeted agents for detection and treatment of pancreatic ductal adenocarcinoma |
EP2147684A1 (en) | 2008-07-22 | 2010-01-27 | Bracco Imaging S.p.A | Diagnostic Agents Selective Against Metalloproteases |
US7951959B2 (en) | 2008-09-17 | 2011-05-31 | Thermo Fisher Scientific (Milwaukee) LLC | Hydrophilic labels for biomolecules |
WO2010057944A1 (en) * | 2008-11-20 | 2010-05-27 | Ge Healthcare As | Dye conjugate imaging agents |
US8864821B2 (en) * | 2008-11-26 | 2014-10-21 | Visen Medical, Inc. | Methods and compositions for identifying subjects at risk of developing stent thrombosis |
CN102459469A (zh) * | 2009-04-17 | 2012-05-16 | 利康股份有限公司 | 用取代的花青染料进行荧光成像 |
US20110021908A1 (en) | 2009-05-27 | 2011-01-27 | Lumicell Diagnostics, Inc. | Methods and systems for spatially identifying abnormal cells |
US9155471B2 (en) | 2009-05-27 | 2015-10-13 | Lumicell, Inc'. | Methods and systems for spatially identifying abnormal cells |
CA2766861A1 (en) | 2009-07-09 | 2011-01-13 | F. Hoffmann-La Roche Ag | In vivo tumor vasculature imaging |
WO2011012646A2 (en) | 2009-07-28 | 2011-02-03 | F. Hoffmann-La Roche Ag | Non-invasive in vivo optical imaging method |
DK2470887T3 (da) | 2009-08-28 | 2020-04-06 | Visen Medical Inc | Systemer til tomografisk billeddannelse i diffuse medier ved at anvende en hybrid inversionsteknik |
WO2011038006A1 (en) | 2009-09-22 | 2011-03-31 | Visen Medical, Inc. | Systems and methods for virtual index-matching of diffusive media |
US9677125B2 (en) * | 2009-10-21 | 2017-06-13 | General Electric Company | Detection of plurality of targets in biological samples |
RU2012148816A (ru) | 2010-05-07 | 2014-06-20 | Ф. Хоффманн-Ля Рош Аг | Метод диагностики для определения клеток ex vivo |
WO2012003334A2 (en) * | 2010-06-30 | 2012-01-05 | Case Western Reserve University | Molecular probes for imaging of myelin |
US8524239B2 (en) | 2010-07-09 | 2013-09-03 | The United States of America as represented by the Secrectary, Department of Health and Human Services | Photosensitizing antibody-fluorophore conjugates |
EP2618849B1 (en) | 2010-09-20 | 2020-10-21 | Caliper Life Sciences, Inc. | Multivalent fluorescent probes |
EP2630196B1 (en) | 2010-10-20 | 2017-09-06 | Li-Cor, Inc. | Cyanine dyes and their conjugates |
JP5978220B2 (ja) | 2010-10-29 | 2016-08-24 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 核酸ナノ構造バーコードプローブ |
WO2012061403A1 (en) * | 2010-11-02 | 2012-05-10 | Life Technologies Corporation | Modified hydrocyanine dyes for the detection of reactive oxygen species |
US9314304B2 (en) | 2010-12-08 | 2016-04-19 | Lumicell, Inc. | Methods and system for image guided cell ablation with microscopic resolution |
WO2012088007A1 (en) | 2010-12-21 | 2012-06-28 | Pierce Biotechnology, Inc. | Fluorescent compounds |
EP2683413A1 (en) | 2011-03-07 | 2014-01-15 | F.Hoffmann-La Roche Ag | In vivo selection of therapeutically active antibodies |
JP6100704B2 (ja) | 2011-03-07 | 2017-03-22 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 治療用抗体についてのインビボ試験の手段および方法 |
ES2445940T1 (es) | 2011-03-25 | 2014-03-06 | Almac Sciences (Scotland) Limited | Ensayos enzimáticos |
AU2012253502C1 (en) | 2011-05-09 | 2017-12-14 | Visen Medical, Inc. | Carbonic anhydrase targeting agents and methods of using same |
CN103781495A (zh) * | 2011-07-11 | 2014-05-07 | 美国政府(由卫生和人类服务部的部长所代表) | 光敏抗体-荧光团缀合物 |
US8889884B1 (en) | 2011-07-14 | 2014-11-18 | Pierce Biotechnology, Inc. | Phosphine derivatives of fluorescent compounds |
US9249307B2 (en) | 2011-08-16 | 2016-02-02 | Pierce Biotechnology, Inc. | Benzocyanine compounds |
US9610370B2 (en) * | 2011-10-07 | 2017-04-04 | University Of Virginia Patent Foundation | Compositions and methods for tumor imaging and targeting by a class of organic heptamethine cyanine dyes that possess dual nuclear and near-infrared properties |
US9751868B2 (en) | 2012-02-28 | 2017-09-05 | Pierce Biotechnology, Inc. | Benzocyanine compounds |
CN104395306B (zh) | 2012-03-02 | 2019-04-23 | 皮尔斯生物科技有限公司 | 作为生物分子的标记染料的吲哚衍生物 |
CN104395407B (zh) * | 2012-03-30 | 2016-07-13 | 生命科技公司 | 用于检测活性氧的经修饰的结合核酸的花青染料 |
CN104245954A (zh) | 2012-03-30 | 2014-12-24 | 文森医学公司 | 细菌成像剂及其使用方法 |
CA2882019C (en) | 2012-08-15 | 2021-02-09 | Visen Medical, Inc. | Prostate specific antigen agents and methods of using same for prostate cancer imaging |
WO2014035712A1 (en) | 2012-08-28 | 2014-03-06 | Pierce Biotechnology, Inc. | Benzopyrylium compounds |
WO2014062716A1 (en) | 2012-10-15 | 2014-04-24 | Visen Medical, Inc. | Systems, methods, and apparatus for imaging of diffuse media featuring cross-modality weighting of fluorescent and bioluminescent sources |
EP2912464B1 (en) | 2012-10-24 | 2017-04-26 | Becton Dickinson and Company | Hydroxamate substituted azaindoline-cyanine dyes and bioconjugates of the same |
NL2010040C2 (en) * | 2012-12-21 | 2014-06-24 | Internat Inst For Diagnostic And Analitical Affairs B V | Cleavable coating material having microbial functionality. |
US11813338B2 (en) * | 2013-03-12 | 2023-11-14 | The Trustees Of The University Of Pennsylvania | Diagnosing and treating cancer |
CA2906056A1 (en) | 2013-03-14 | 2014-09-25 | Lumicell, Inc. | Medical imaging device and methods of use |
CA2903994C (en) * | 2013-03-15 | 2017-08-22 | Philip S. Low | Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors |
CA2901000C (en) | 2013-03-15 | 2023-03-14 | Visen Medical, Inc. | 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof |
EP2970342B1 (en) | 2013-03-15 | 2024-01-24 | VisEn Medical, Inc. | Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection |
CN105531377A (zh) | 2013-07-30 | 2016-04-27 | 哈佛学院院长及董事 | 基于dna的定量成像和超分辨成像 |
EP3019559A4 (en) | 2013-08-22 | 2017-04-05 | Sony Corporation | Water soluble fluorescent or colored dyes and methods for their use |
WO2015038968A1 (en) | 2013-09-13 | 2015-03-19 | The General Hospital Corporation | Activatable fibrin-binding probes |
AU2014373656B2 (en) | 2013-12-31 | 2019-12-05 | Cornell University | Systems, methods, and apparatus for multichannel imaging of fluorescent sources in real time |
CN105874012B (zh) | 2014-01-16 | 2018-06-15 | 索尼公司 | 水溶性荧光染料或有色染料 |
BR112016018314A2 (pt) | 2014-03-11 | 2017-10-17 | Harvard College | formação de imagem de alto desempenho e altamente multiplexada com sondas programáveis de ácido nucleico |
EP2944326B1 (en) * | 2014-05-16 | 2018-11-21 | Cyanagen Srl | Tricarbocyanine-cyclodextrin-conjugates and their use for the diagnosis of kidney diseases |
ES2743458T5 (es) | 2014-08-08 | 2023-06-08 | Us Health | Eliminación fotocontrolada de dianas in vitro e in vivo |
CN107249647A (zh) | 2014-12-15 | 2017-10-13 | 纪念斯隆-凯特琳癌症中心 | 具有增强的神经结合选择性的环状肽、与所述环状肽结合的纳米颗粒和此二者用于实时体内神经组织成像的用途 |
US10124111B2 (en) | 2015-02-24 | 2018-11-13 | The Board Of Trustees Of The Leland Stanford Junior University | Small molecule dye for molecular imaging and photothermal therapy |
US11084932B2 (en) | 2015-02-26 | 2021-08-10 | Sony Group Corporation | Phenylethynylnaphthalene dyes and methods for their use |
JP6806694B2 (ja) | 2015-02-26 | 2021-01-06 | ソニー株式会社 | 共役基を含む水溶性蛍光染料または有色染料 |
KR20180005650A (ko) | 2015-05-11 | 2018-01-16 | 소니 주식회사 | 초휘도 이량체성 또는 중합체성 염료 |
KR102557419B1 (ko) | 2015-08-07 | 2023-07-19 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 단백질-단백질 상호작용의 초해상도 영상화 |
WO2017027247A1 (en) | 2015-08-07 | 2017-02-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Near infrared photoimmunotherapy (nir-pit) of suppressor cells to treat cancer |
ES2889904T3 (es) | 2015-08-18 | 2022-01-14 | Rakuten Medical Inc | Conjugados de colorante de ftalocianina y su almacenamiento |
NZ739780A (en) | 2015-08-18 | 2024-02-23 | Rakuten Medical Inc | Compositions, combinations and related methods for photoimmunotherapy |
CN105199430B (zh) * | 2015-11-05 | 2017-03-22 | 济宁博联生物科技有限公司 | 一种上皮组织染色剂及其制备方法 |
US20190090750A1 (en) | 2015-12-15 | 2019-03-28 | Memorial Sloan Kettering Cancer Center | Imaging systems and methods for tissue differentiation, e.g., for intraoperative visualization |
WO2017173348A1 (en) | 2016-04-01 | 2017-10-05 | Sony Corporation | Ultra bright dimeric or polymeric dyes with rigid spacing groups |
CN114806218A (zh) | 2016-04-01 | 2022-07-29 | 索尼公司 | 超亮二聚或多聚染料 |
CA3019951A1 (en) | 2016-04-06 | 2017-10-12 | Sony Corporation | Ultra bright dimeric or polymeric dyes with spacing linker groups |
JP2019519490A (ja) | 2016-05-10 | 2019-07-11 | ソニー株式会社 | ペプチド骨格を有する超明色ポリマー染料 |
JP7068192B2 (ja) | 2016-05-10 | 2022-05-16 | ソニーグループ株式会社 | ポリマー染料およびシクロデキストリンを含む組成物、ならびにその使用 |
BR112018073199A2 (pt) | 2016-05-11 | 2019-04-16 | Sony Corporation | corantes diméricos ou poliméricos ultrabrilhantes |
WO2017214165A1 (en) * | 2016-06-06 | 2017-12-14 | Sony Corporation | Ionic polymers comprising fluorescent or colored reporter groups |
EP3548096A1 (en) | 2016-11-30 | 2019-10-09 | Memorial Sloan Kettering Cancer Center | Inhibitor-functionalized ultrasmall nanoparticles and methods thereof |
JP2020504600A (ja) | 2016-12-09 | 2020-02-13 | アルティヴュー, インク. | 標識化核酸イメージング剤を使用した多重イメージングのための改善された方法 |
EP3568689A1 (en) | 2017-01-10 | 2019-11-20 | Sun Chemical Corporation | In-line coating weight and radiant energy exposure measurement |
US20210032277A1 (en) | 2017-10-05 | 2021-02-04 | Sony Corporation | Programmable polymeric drugs |
KR20200083605A (ko) | 2017-11-16 | 2020-07-08 | 소니 주식회사 | 프로그램가능한 중합체성 약물 |
WO2019182765A1 (en) | 2018-03-19 | 2019-09-26 | Sony Corporation | Use of divalent metals for enhancement of fluorescent signals |
CN112119083B (zh) | 2018-03-21 | 2024-05-24 | 索尼公司 | 具有连接体基团的聚合串联染料 |
WO2019190549A1 (en) | 2018-03-30 | 2019-10-03 | Perkinelmer Health Sciences, Inc. | Systems and methods for 3d reconstruction of anatomical organs and inclusions using short-wave infrared (swir) projection tomography |
JP2021529194A (ja) | 2018-06-27 | 2021-10-28 | ソニーグループ株式会社 | デオキシリボースを含むリンカー基を有するポリマー色素 |
KR102132885B1 (ko) * | 2018-09-03 | 2020-07-10 | (주)씨바이오멕스 | 생체물질과 연결될 수 있는 양쪽성 형광물질 |
JP7239904B2 (ja) | 2019-09-26 | 2023-03-15 | ソニーグループ株式会社 | リンカー基を有するポリマータンデム色素 |
KR102336507B1 (ko) * | 2020-02-21 | 2021-12-06 | 한림대학교 산학협력단 | 국소뇌산소포화도를 이용한 지연성 뇌허혈 진단 방법 |
KR102369155B1 (ko) * | 2020-07-07 | 2022-02-28 | 한림대학교 산학협력단 | 근적외선 분광분석법을 이용한 지연성 뇌허혈 진단 방법 |
CN112062797B (zh) * | 2020-08-19 | 2021-09-21 | 华南理工大学 | 一种二聚体前药及其制备方法和应用 |
EP4015004A1 (en) | 2020-12-18 | 2022-06-22 | Phi Pharma SA | Proteoglycan specific branched peptides |
CN114748640B (zh) * | 2022-05-06 | 2024-02-09 | 南方医科大学珠江医院 | 一种pH响应性的siRNA递送系统 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1986001720A1 (en) * | 1984-09-13 | 1986-03-27 | Cytogen Corporation | Antibody therapeutic agent conjugates |
US5569587A (en) | 1986-04-18 | 1996-10-29 | Carnegie Mellon University | Method for labeling and detecting materials employing luminescent arysulfonate cyanine dyes |
US5066490A (en) * | 1988-06-01 | 1991-11-19 | The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services | Protein crosslinking reagents cleavable within acidified intracellular vesicles |
CA2048089A1 (en) * | 1990-09-17 | 1992-03-18 | Wolfgang A. Wrasidlo | Chemical conjugation of morpholino anthracyclines to antibodies |
JPH07145148A (ja) * | 1992-06-02 | 1995-06-06 | Bio Sensor Kenkyusho:Kk | ポリメチン系化合物およびそれを用いる測定方法 |
GB9310978D0 (en) * | 1993-05-27 | 1993-07-14 | Zeneca Ltd | Compounds |
DE4445065A1 (de) * | 1994-12-07 | 1996-06-13 | Diagnostikforschung Inst | Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung |
AU4497096A (en) * | 1995-01-30 | 1996-08-21 | Daiichi Pure Chemicals Co., Ltd. | Diagnostic marker |
US5741657A (en) * | 1995-03-20 | 1998-04-21 | The Regents Of The University Of California | Fluorogenic substrates for β-lactamase and methods of use |
IT1276833B1 (it) | 1995-10-09 | 1997-11-03 | Sorin Biomedica Cardio Spa | Coloranti fluorescenti della famiglia della solfo benz e indocianina |
DE19539409C2 (de) * | 1995-10-11 | 1999-02-18 | Diagnostikforschung Inst | Kontrastmittel für die Nahinfrarot-Diagnostik |
CA2251985A1 (en) * | 1996-04-19 | 1997-10-30 | Alan Lewis Hamilton | Squarate dyes and their use in fluorescent sequencing method |
DE19649971A1 (de) * | 1996-11-19 | 1998-05-28 | Diagnostikforschung Inst | Optische Diagnostika zur Diagnostik neurodegenerativer Krankheiten mittels Nahinfrarot-Strahlung (NIR-Strahlung) |
DE19717904A1 (de) * | 1997-04-23 | 1998-10-29 | Diagnostikforschung Inst | Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie |
CN1764637A (zh) | 2003-02-28 | 2006-04-26 | 国际壳牌研究有限公司 | 方法 |
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1997
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- 1998-04-02 EP EP98929212A patent/EP0988060B1/de not_active Expired - Lifetime
- 1998-04-02 JP JP54471598A patent/JP5118790B2/ja not_active Expired - Fee Related
- 1998-04-02 WO PCT/DE1998/001001 patent/WO1998047538A2/de active IP Right Grant
- 1998-04-02 DK DK98929212T patent/DK0988060T3/da active
- 1998-04-02 KR KR1019997009757A patent/KR100613306B1/ko not_active IP Right Cessation
- 1998-04-02 HU HU0003132A patent/HU226812B1/hu not_active IP Right Cessation
- 1998-04-02 US US09/403,418 patent/US6534041B1/en not_active Expired - Lifetime
- 1998-04-02 DE DE59814030T patent/DE59814030D1/de not_active Expired - Lifetime
- 1998-04-02 ES ES98929212T patent/ES2289786T3/es not_active Expired - Lifetime
- 1998-04-02 AU AU79057/98A patent/AU733757B2/en not_active Ceased
- 1998-04-02 AT AT98929212T patent/ATE364404T1/de active
- 1998-04-02 CN CN98804489A patent/CN1253507A/zh active Pending
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1999
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JP2010116413A (ja) | 2010-05-27 |
ATE364404T1 (de) | 2007-07-15 |
ES2289786T3 (es) | 2008-02-01 |
PT988060E (pt) | 2007-08-17 |
HUP0003132A3 (en) | 2003-03-28 |
AU733757B2 (en) | 2001-05-24 |
NO327495B1 (no) | 2009-07-20 |
WO1998047538A2 (de) | 1998-10-29 |
EP0988060A2 (de) | 2000-03-29 |
NO995181L (no) | 1999-10-22 |
JP5118790B2 (ja) | 2013-01-16 |
CY1106860T1 (el) | 2012-05-23 |
JP2001521530A (ja) | 2001-11-06 |
CA2287262A1 (en) | 1998-10-29 |
AU7905798A (en) | 1998-11-13 |
CA2287262C (en) | 2007-02-06 |
EP0988060B1 (de) | 2007-06-13 |
WO1998047538A3 (de) | 1999-01-21 |
CN1253507A (zh) | 2000-05-17 |
HU226812B1 (en) | 2009-11-30 |
NO995181D0 (no) | 1999-10-22 |
KR100613306B1 (ko) | 2006-08-17 |
DE19717904A1 (de) | 1998-10-29 |
DE59814030D1 (de) | 2007-07-26 |
KR20010020183A (ko) | 2001-03-15 |
HUP0003132A2 (hu) | 2001-01-29 |
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