DE602004016010D1 - Verfahren zur ä11cü-radiomarkierung von phenthiazin und phenothiazinartige verbindungen - Google Patents

Verfahren zur ä11cü-radiomarkierung von phenthiazin und phenothiazinartige verbindungen

Info

Publication number
DE602004016010D1
DE602004016010D1 DE602004016010T DE602004016010T DE602004016010D1 DE 602004016010 D1 DE602004016010 D1 DE 602004016010D1 DE 602004016010 T DE602004016010 T DE 602004016010T DE 602004016010 T DE602004016010 T DE 602004016010T DE 602004016010 D1 DE602004016010 D1 DE 602004016010D1
Authority
DE
Germany
Prior art keywords
sup
sub
group
radiolabelling
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602004016010T
Other languages
English (en)
Inventor
Lutz F Schweiger
Stuart A Craib
Andrew E Welch
Peter F Sharp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Aberdeen
Original Assignee
University of Aberdeen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Aberdeen filed Critical University of Aberdeen
Publication of DE602004016010D1 publication Critical patent/DE602004016010D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/20—[b, e]-condensed with two six-membered rings with hydrogen atoms directly attached to the ring nitrogen atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Cephalosporin Compounds (AREA)
DE602004016010T 2003-09-29 2004-09-27 Verfahren zur ä11cü-radiomarkierung von phenthiazin und phenothiazinartige verbindungen Active DE602004016010D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0322756.8A GB0322756D0 (en) 2003-09-29 2003-09-29 Methods of chemical synthesis
PCT/GB2004/004153 WO2005030676A1 (en) 2003-09-29 2004-09-27 Methods of [11c]-radiolabelling phenothiazine and phenothiazine-like compounds

Publications (1)

Publication Number Publication Date
DE602004016010D1 true DE602004016010D1 (de) 2008-10-02

Family

ID=29287034

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004016010T Active DE602004016010D1 (de) 2003-09-29 2004-09-27 Verfahren zur ä11cü-radiomarkierung von phenthiazin und phenothiazinartige verbindungen

Country Status (14)

Country Link
US (1) US20060275209A1 (de)
EP (1) EP1667947B1 (de)
JP (1) JP2007508282A (de)
CN (2) CN1886353B (de)
AT (1) ATE405533T1 (de)
AU (1) AU2004276071B2 (de)
CA (1) CA2540827A1 (de)
DE (1) DE602004016010D1 (de)
ES (1) ES2313063T3 (de)
GB (1) GB0322756D0 (de)
HK (1) HK1087394A1 (de)
PL (1) PL1667947T3 (de)
SI (1) SI1667947T1 (de)
WO (1) WO2005030676A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9506197D0 (en) 1995-03-27 1995-05-17 Hoffmann La Roche Inhibition of tau-tau association.
GB0100119D0 (en) 2001-01-03 2001-02-14 Univ Aberdeen Materials and methods relating to protein aggregation in neurodegenerative disease
GB0101049D0 (en) 2001-01-15 2001-02-28 Univ Aberdeen Materials and methods relating to protein aggregation in neurodegenerative disease
GB0106953D0 (en) 2001-03-20 2001-05-09 Univ Aberdeen Neufofibrillary labels
GB0117326D0 (en) 2001-07-16 2001-09-05 Univ Aberdeen Napthoquinone-type inhibitors of protein aggregation
US7790881B2 (en) 2004-09-23 2010-09-07 Wista Laboratories Ltd. Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (MTC)
CA2645919C (en) * 2006-03-29 2016-05-31 Wista Laboratories Ltd. Thioninium compounds and their use
PT2004155T (pt) 2006-03-29 2018-05-02 Wista Lab Ltd Inibidores de agregação proteica
EP2013191B3 (de) 2006-03-29 2019-02-27 Wista Laboratories Ltd. 3,7-diamino-10h-phenothiazinsalze und ihre verwendung
DK3121169T3 (da) 2006-07-11 2022-02-28 Wista Lab Ltd Fremgangsmåder til syntese og/eller oprensning af diaminophenothiaziniumforbindelser
PT2954932T (pt) 2007-10-03 2018-12-12 Wista Lab Ltd Utilização terapêutica de diaminofenotiazinas
AU2010299571B2 (en) 2009-09-24 2014-07-31 Wista Laboratories Ltd. Crystalline methylthionium chloride (methylene blue) hydrates
EP2645994B1 (de) 2010-11-30 2017-11-01 WisTa Laboratories Ltd. Formulierungen enthaltend methylthioninium chlorid
SI2673266T1 (sl) 2011-02-11 2016-11-30 Wista Laboratories Ltd. Fenotiazin diaminijeve soli in njihova uporaba
US20130315825A1 (en) * 2012-05-03 2013-11-28 Washington University Tricyclic heteroaromatic compounds as alpha-synuclein ligands
WO2015066296A1 (en) 2013-10-31 2015-05-07 Beth Israel Deaconess Medical Center Near-infrared fluorescent nerve contrast agents and methods of use thereof
JP7023604B2 (ja) 2013-10-31 2022-02-22 ベス・イスラエル・ディーコネス・メディカル・センター，インコーポレイテッド 近赤外蛍光造影バイオイメージング剤及びその使用方法
GB201512678D0 (en) 2015-07-20 2015-08-26 Wista Lab Ltd Methods of chemical synthesis
CN109796465B (zh) * 2017-11-16 2020-07-14 华中科技大学同济医学院附属协和医院 靶向pet显像化合物、包含该化合物的显象剂及其制备方法和用途
US20210011008A1 (en) * 2019-07-09 2021-01-14 Vanderbilt University Amyloid-binding compounds and methods of use thereof
CN115304633B (zh) * 2022-07-20 2023-12-26 山西大学 一种无重原子光动力光敏剂及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000344685A (ja) * 1999-03-26 2000-12-12 Bf Kenkyusho:Kk アズールａ類似化合物によるアミロイドが蓄積する疾患の画像診断プローブおよびそれを含む画像診断用組成物
JP4275819B2 (ja) * 1999-09-17 2009-06-10 飯田 秀博 デメチルラクロプライドの非求核性酸塩およびこれを用いる［ｃ−１１］ラクロプライドの製造法
GB0106953D0 (en) * 2001-03-20 2001-05-09 Univ Aberdeen Neufofibrillary labels
GB0113121D0 (en) * 2001-05-30 2001-07-18 Univ Leeds Biologically active photosensitisers

Also Published As

Publication number Publication date
AU2004276071A1 (en) 2005-04-07
JP2007508282A (ja) 2007-04-05
AU2004276071B2 (en) 2011-02-03
ES2313063T3 (es) 2009-03-01
CN1886353A (zh) 2006-12-27
PL1667947T3 (pl) 2009-01-30
CN1886353B (zh) 2010-06-02
CN101172162A (zh) 2008-05-07
HK1087394A1 (en) 2006-10-13
SI1667947T1 (sl) 2009-02-28
EP1667947A1 (de) 2006-06-14
WO2005030676A1 (en) 2005-04-07
CA2540827A1 (en) 2005-04-07
GB0322756D0 (en) 2003-10-29
ATE405533T1 (de) 2008-09-15
EP1667947B1 (de) 2008-08-20
US20060275209A1 (en) 2006-12-07

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