DK0973774T3 - 1,5-Dihydro-pyrazolo[3,4-d]-pyrimidinon-derivater - Google Patents
1,5-Dihydro-pyrazolo[3,4-d]-pyrimidinon-derivaterInfo
- Publication number
- DK0973774T3 DK0973774T3 DK98913595T DK98913595T DK0973774T3 DK 0973774 T3 DK0973774 T3 DK 0973774T3 DK 98913595 T DK98913595 T DK 98913595T DK 98913595 T DK98913595 T DK 98913595T DK 0973774 T3 DK0973774 T3 DK 0973774T3
- Authority
- DK
- Denmark
- Prior art keywords
- pyrazolo
- dihydro
- pyrimidinone derivatives
- diseases
- medicaments
- Prior art date
Links
- RAEVFJQVGBSKJO-UHFFFAOYSA-N 1,2,4,7-tetrahydropyrazolo[3,4-d]pyrimidin-3-one Chemical class N1=CNCC2=C1NNC2=O RAEVFJQVGBSKJO-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000026106 cerebrovascular disease Diseases 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 210000005259 peripheral blood Anatomy 0.000 abstract 1
- 239000011886 peripheral blood Substances 0.000 abstract 1
- 150000003217 pyrazoles Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Vascular Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19709877A DE19709877A1 (de) | 1997-03-11 | 1997-03-11 | 1,5-Dihydro-pyrazolo[3,4-d]-pyrimidinon-derivate |
| PCT/EP1998/001086 WO1998040384A1 (de) | 1997-03-11 | 1998-02-26 | 1,5-dihydro-pyrazolo[3,4-d]-pyrimidinon-derivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0973774T3 true DK0973774T3 (da) | 2003-05-05 |
Family
ID=7822900
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98913595T DK0973774T3 (da) | 1997-03-11 | 1998-02-26 | 1,5-Dihydro-pyrazolo[3,4-d]-pyrimidinon-derivater |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6174884B1 (enExample) |
| EP (1) | EP0973774B1 (enExample) |
| JP (1) | JP2001514638A (enExample) |
| KR (1) | KR20000076124A (enExample) |
| CN (1) | CN1151155C (enExample) |
| AT (1) | ATE231509T1 (enExample) |
| AU (1) | AU727615B2 (enExample) |
| BR (1) | BR9807995A (enExample) |
| CA (1) | CA2283211A1 (enExample) |
| DE (2) | DE19709877A1 (enExample) |
| DK (1) | DK0973774T3 (enExample) |
| ES (1) | ES2191294T3 (enExample) |
| HU (1) | HUP0001805A3 (enExample) |
| IL (1) | IL131450A0 (enExample) |
| NZ (1) | NZ337724A (enExample) |
| RU (1) | RU2219180C2 (enExample) |
| WO (1) | WO1998040384A1 (enExample) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9823103D0 (en) * | 1998-10-23 | 1998-12-16 | Pfizer Ltd | Pharmaceutically active compounds |
| ES2233685T3 (es) | 2000-08-01 | 2005-06-16 | Bayer Healthcare Ag | Inhibidores selectivos de pde 2 como medicamentos para mejorar la percepcion. |
| EP1343506A1 (de) * | 2000-12-19 | 2003-09-17 | MERCK PATENT GmbH | Pharmazeutische formulierung enthaltend pyrazolo 4,3-d]pyrimidine und antithrombotica, calcium-antagonisten, prostaglandine oder prostaglandinderivate |
| DE10064105A1 (de) | 2000-12-21 | 2002-06-27 | Bayer Ag | Neue Substituierte Imidazotriazinone |
| BR0206853A (pt) * | 2001-02-02 | 2004-01-13 | Merck Patent Ges Mit Beschroen | Formulação farmacêutica compreendendo pirazolo[4,3-d]pirimidinas e antagonistas de receptor de endotelina ou tienopirimidinas e antagonistas de receptor de endotelina |
| KR100393160B1 (ko) * | 2001-06-14 | 2003-07-31 | 한국과학기술연구원 | 신규한 피라졸로피리미딘티온 유도체, 그의 제법 및발기부전 치료제로서의 용도 |
| US6479493B1 (en) | 2001-08-23 | 2002-11-12 | Cell Pathways, Inc. | Methods for treatment of type I diabetes |
| EP1436265A4 (en) * | 2001-09-27 | 2004-12-15 | Smithkline Beecham Corp | CHEMICALS |
| FR2842809A1 (fr) * | 2002-07-26 | 2004-01-30 | Greenpharma Sas | NOUVELLES PYRAZOLO[1,5-a]-1,3,5-TRIAZINES SUBSTITUEES ET LEURS ANALOGUES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, UTILISATION A TITRE DE MEDICAMENT ET PROCEDES POUR LEUR PREPARATION |
| DE10238723A1 (de) * | 2002-08-23 | 2004-03-11 | Bayer Ag | Phenyl-substituierte Pyrazolyprimidine |
| DE10238722A1 (de) * | 2002-08-23 | 2004-03-11 | Bayer Ag | Selektive Phosphodiesterase 9A-Inhibitoren als Arzneimittel zur Verbesserung kognitiver Prozesse |
| DE10238724A1 (de) | 2002-08-23 | 2004-03-04 | Bayer Ag | Alkyl-substituierte Pyrazolpyrimidine |
| CN100397023C (zh) * | 2003-01-04 | 2008-06-25 | 胡云北 | 黄磷废渣载热量及反应尾气发热量的回收与综合利用方法 |
| CA2517336A1 (en) * | 2003-03-04 | 2004-10-21 | Altana Pharma Ag | Purin-6-one-derivatives |
| DE10320785A1 (de) * | 2003-05-09 | 2004-11-25 | Bayer Healthcare Ag | 6-Arylmethyl-substituierte Pyrazolopyrimidine |
| US8044060B2 (en) | 2003-05-09 | 2011-10-25 | Boehringer Ingelheim International Gmbh | 6-cyclylmethyl- and 6-alkylmethyl pyrazolo[3,4-D]pyrimidines, methods for their preparation and methods for their use to treat impairments of perception, concentration learning and/or memory |
| DE102004004142A1 (de) | 2003-05-09 | 2004-11-25 | Bayer Healthcare Ag | 6-Cyclylmethyl- und 6-Alkylmethyl-substituierte Pyrazolopyrimidine |
| DE10328479A1 (de) | 2003-06-25 | 2005-01-13 | Bayer Ag | 6-Arylamino-5-cyano-4-pyrimidinone |
| AU2004268387A1 (en) * | 2003-08-28 | 2005-03-10 | Nycomed Gmbh | Composition comprising a pulmonary surfactant and a PDE2 inhibitor |
| DE102004001873A1 (de) | 2004-01-14 | 2005-09-29 | Bayer Healthcare Ag | Cyanopyrimidinone |
| MXPA06009462A (es) * | 2004-02-27 | 2007-03-15 | Hoffmann La Roche | Derivados pirazolo heteroaril fusionados. |
| CN101397299B (zh) * | 2007-09-29 | 2011-11-16 | 温州大学 | 一种吡唑[3,4-d]嘧啶酮的合成方法 |
| EP2217602B1 (en) | 2007-11-30 | 2018-08-29 | Boehringer Ingelheim International GmbH | 1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one derivatives and their use as pde9a modulators for the treatment of cns disorders |
| UA105362C2 (en) * | 2008-04-02 | 2014-05-12 | Бьорингер Ингельхайм Интернациональ Гмбх | 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators |
| US9079905B2 (en) | 2008-09-08 | 2015-07-14 | Boehringer Ingelheim International Gmbh | Compounds for the treatment of CNS disorders |
| MA33152B1 (fr) | 2009-03-31 | 2012-03-01 | Boehringer Ingelheim Int | Dérivés 1-hétérocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one et leur utilisation en tant que modulateurs de pde9a |
| AU2010232729A1 (en) | 2009-03-31 | 2011-10-20 | Arqule, Inc. | Substituted indolo-pyridinone compounds |
| TW201118099A (en) * | 2009-08-12 | 2011-06-01 | Boehringer Ingelheim Int | New compounds for the treatment of CNS disorders |
| MY170189A (en) | 2010-08-12 | 2019-07-09 | Boehringer Ingelheim Int | 6-cycloalkyl-1, 5-dihydro-pyrazolo[3,4-d] pyrimidin-4-one derivatives and their use as pde9a inhibitors |
| US20130040971A1 (en) | 2011-02-14 | 2013-02-14 | Boehringer Ingelheim International Gmbh | 6-cycloalkyl-pyrazolopyrimidinones for the treatment of cns disorders |
| US8809345B2 (en) | 2011-02-15 | 2014-08-19 | Boehringer Ingelheim International Gmbh | 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders |
| JP5767393B2 (ja) | 2011-03-31 | 2015-08-19 | ファイザー・インク | 新規二環式ピリジノン |
| WO2012172449A1 (en) | 2011-06-13 | 2012-12-20 | Pfizer Inc. | Lactams as beta secretase inhibitors |
| JP6043355B2 (ja) | 2011-08-31 | 2016-12-14 | ファイザー・インク | ヘキサヒドロピラノ[3,4−d][1,3]チアジン−2−アミン化合物 |
| JO3407B1 (ar) | 2012-05-31 | 2019-10-20 | Eisai R&D Man Co Ltd | مركبات رباعي هيدرو بيرازولو بيريميدين |
| UA110688C2 (uk) | 2012-09-21 | 2016-01-25 | Пфайзер Інк. | Біциклічні піридинони |
| JP6505023B2 (ja) | 2013-02-19 | 2019-04-24 | ファイザー・インク | Cnsおよび他の障害を治療するための、pde4アイソザイムの阻害薬としてのアザベンゾイミダゾール化合物 |
| JP6425717B2 (ja) | 2013-10-04 | 2018-11-21 | ファイザー・インク | ガンマセクレターゼモジュレーターとしての新規二環式ピリジノン |
| MX369074B (es) | 2014-04-01 | 2019-10-28 | Pfizer | Cromeno y 1,1a,2,7b-tetrahidrociclopropa[c]cromeno piridopirazinadionas como moduladores de la gamma secretasa. |
| JP6713982B2 (ja) | 2014-07-24 | 2020-06-24 | ファイザー・インク | ピラゾロピリミジン化合物 |
| CN106795165B (zh) | 2014-08-06 | 2019-09-10 | 辉瑞公司 | 咪唑并哒嗪化合物 |
| MX368391B (es) | 2015-02-03 | 2019-09-30 | Pfizer | Ciclopropabenzofuranil-piridopirazindionas novedosas. |
| JO3627B1 (ar) | 2015-04-30 | 2020-08-27 | H Lundbeck As | إيميدازو بيرازينونات على هيئة مثبطات pde1 |
| US10195201B2 (en) | 2015-05-05 | 2019-02-05 | Merck Sharp & Dohme Corp. | Heteroaryl-pyrimidinone compounds as PDE2 inhibitors |
| US11472805B2 (en) | 2015-06-17 | 2022-10-18 | Pfizer, Inc. | Tricyclic compounds and their use as phosphodiesterase inhibitors |
| ES2775674T3 (es) | 2016-02-23 | 2020-07-27 | Pfizer | Compuestos de 6,7-dihidro-5H-pirazolo[5,1-b][1,3]oxazina-2-carboxamida |
| TWI729109B (zh) | 2016-04-12 | 2021-06-01 | 丹麥商H 朗德貝克公司 | 作爲PDE1抑制劑的1,5-二氫-4H-吡唑并[3,4-d]嘧啶-4-酮和1,5-二氫-4H-吡唑并[4,3-c]吡啶-4-酮 |
| AU2017286868B2 (en) | 2016-07-01 | 2021-11-11 | Pfizer Inc. | 5,7-dihydro-pyrrolo-pyridine derivatives for treating neurological and neurodegenerative diseases |
| JP7112413B2 (ja) * | 2016-10-18 | 2022-08-03 | ハー・ルンドベック・アクチエゼルスカベット | Pde1阻害剤としてのイミダゾピラジノン、ピラゾロピリミジノンおよびピラゾロピリジノン |
| WO2018078038A1 (en) | 2016-10-28 | 2018-05-03 | H. Lundbeck A/S | Combination treatments comprising imidazopyrazinones for the treatment of psychiatric and/or cognitive disorders |
| WO2018078042A1 (en) | 2016-10-28 | 2018-05-03 | H. Lundbeck A/S | Combination treatments comprising administration of imidazopyrazinones |
| JP7111720B2 (ja) | 2016-12-28 | 2022-08-02 | ダート・ニューロサイエンス・エルエルシー | Pde2阻害剤としての置換ピラゾロピリミジノン化合物 |
| MX2019014597A (es) | 2017-06-08 | 2020-02-05 | Merck Sharp & Dohme | Inhibidores de pirazolopirimidina de pde9. |
| ES2937236T3 (es) | 2017-06-22 | 2023-03-27 | Pfizer | Derivados de dihidro-pirrolo-piridina |
| US11434247B1 (en) | 2017-11-27 | 2022-09-06 | Dart Neuroscience Llc | Substituted furanopyrimidine compounds as PDE1 inhibitors |
| AR115015A1 (es) | 2018-03-23 | 2020-11-18 | Pfizer | Derivados de azaespiro piperazina |
| USD1029414S1 (en) * | 2021-01-19 | 2024-05-28 | Averia Electronics, Inc. | Wearable light emitting module with a removable band |
| USD1021287S1 (en) * | 2021-01-19 | 2024-04-02 | Averia Electronics, Inc. | Wearable light emitting module with a removable band |
| EP4297868A4 (en) | 2021-02-23 | 2025-01-08 | Hoth Therapeutics, Inc. | USE OF APREPITANT TO TREAT ALZHEIMER'S |
| WO2024118524A1 (en) | 2022-11-28 | 2024-06-06 | Cerevel Therapeutics, Llc | Azaindole compounds and their use as phosphodiesterase inhibitors |
| WO2025145091A1 (en) | 2023-12-29 | 2025-07-03 | Pfizer Inc. | Crystalline forms of a muscarinic m4 receptor modulator and methods of treating diseases |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3211732A (en) | 1965-10-12 | Pyrazolob:x-d]pyrlil/hdines | ||
| US3165520A (en) * | 1965-01-12 | Certificate of correction | ||
| DE1153023B (de) * | 1960-05-11 | 1963-08-22 | Ciba Geigy | Verfahren zur Herstellung von 4-Hydroxy-pyrazolo[3,4-d] pyrimidinen |
| CH398626A (de) * | 1960-05-11 | 1966-03-15 | Ciba Geigy | Verfahren zur Herstellung neuer Pyrazolopyrimidine |
| CH633297A5 (de) | 1977-09-16 | 1982-11-30 | Sandoz Ag | Verfahren zur herstellung von fluorenphosphoniten. |
| GB9121028D0 (en) | 1991-10-03 | 1991-11-13 | Pfizer Ltd | Therapeutic agents |
| US5294612A (en) * | 1992-03-30 | 1994-03-15 | Sterling Winthrop Inc. | 6-heterocyclyl pyrazolo [3,4-d]pyrimidin-4-ones and compositions and method of use thereof |
| FI944933A7 (fi) * | 1992-04-21 | 1994-10-20 | Biocryst Pharm Inc | 7-disubstitoitu metyyli-4-okso-3H,5H-pyrrolo(3,2-d) pyrimidiini ja sit ä sisältäviä farmaseuttisia käyttöjä ja koostumuksia |
| US5656629A (en) | 1995-03-10 | 1997-08-12 | Sanofi Winthrop, Inc. | 6-substituted pyrazolo (3,4-d)pyrimidin-4-ones and compositions and methods of use thereof |
| NZ303886A (en) | 1995-03-10 | 1998-11-25 | Sanofi Winthrop Inc | 1-cyclopentyl (or tert butyl)-6-aryl (or heteroaryl)-pyrazolo[3,4-d]pyrimidin-4-one derivatives and medicaments |
-
1997
- 1997-03-11 DE DE19709877A patent/DE19709877A1/de not_active Withdrawn
-
1998
- 1998-02-26 NZ NZ337724A patent/NZ337724A/xx unknown
- 1998-02-26 DE DE59807011T patent/DE59807011D1/de not_active Expired - Fee Related
- 1998-02-26 BR BR9807995-6A patent/BR9807995A/pt not_active IP Right Cessation
- 1998-02-26 AT AT98913595T patent/ATE231509T1/de not_active IP Right Cessation
- 1998-02-26 IL IL13145098A patent/IL131450A0/xx not_active IP Right Cessation
- 1998-02-26 WO PCT/EP1998/001086 patent/WO1998040384A1/de not_active Ceased
- 1998-02-26 HU HU0001805A patent/HUP0001805A3/hu unknown
- 1998-02-26 DK DK98913595T patent/DK0973774T3/da active
- 1998-02-26 CA CA002283211A patent/CA2283211A1/en not_active Abandoned
- 1998-02-26 JP JP53913598A patent/JP2001514638A/ja not_active Withdrawn
- 1998-02-26 ES ES98913595T patent/ES2191294T3/es not_active Expired - Lifetime
- 1998-02-26 AU AU68240/98A patent/AU727615B2/en not_active Ceased
- 1998-02-26 US US09/367,538 patent/US6174884B1/en not_active Expired - Fee Related
- 1998-02-26 RU RU99121518/04A patent/RU2219180C2/ru not_active IP Right Cessation
- 1998-02-26 KR KR1019997008213A patent/KR20000076124A/ko not_active Ceased
- 1998-02-26 EP EP98913595A patent/EP0973774B1/de not_active Expired - Lifetime
- 1998-02-26 CN CNB988049872A patent/CN1151155C/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE19709877A1 (de) | 1998-09-17 |
| NZ337724A (en) | 2000-08-25 |
| HUP0001805A2 (hu) | 2000-11-28 |
| EP0973774B1 (de) | 2003-01-22 |
| ES2191294T3 (es) | 2003-09-01 |
| US6174884B1 (en) | 2001-01-16 |
| IL131450A0 (en) | 2001-01-28 |
| KR20000076124A (ko) | 2000-12-26 |
| CN1255133A (zh) | 2000-05-31 |
| CN1151155C (zh) | 2004-05-26 |
| BR9807995A (pt) | 2000-03-08 |
| HUP0001805A3 (en) | 2002-09-30 |
| WO1998040384A1 (de) | 1998-09-17 |
| EP0973774A1 (de) | 2000-01-26 |
| CA2283211A1 (en) | 1998-09-17 |
| RU2219180C2 (ru) | 2003-12-20 |
| ATE231509T1 (de) | 2003-02-15 |
| AU6824098A (en) | 1998-09-29 |
| HK1028035A1 (en) | 2001-02-02 |
| DE59807011D1 (de) | 2003-02-27 |
| JP2001514638A (ja) | 2001-09-11 |
| AU727615B2 (en) | 2000-12-14 |
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