ATE231509T1 - 1,5-dihydro-pyrazolo 3,4-d)-pyrimidinon-derivate - Google Patents
1,5-dihydro-pyrazolo 3,4-d)-pyrimidinon-derivateInfo
- Publication number
- ATE231509T1 ATE231509T1 AT98913595T AT98913595T ATE231509T1 AT E231509 T1 ATE231509 T1 AT E231509T1 AT 98913595 T AT98913595 T AT 98913595T AT 98913595 T AT98913595 T AT 98913595T AT E231509 T1 ATE231509 T1 AT E231509T1
- Authority
- AT
- Austria
- Prior art keywords
- pyrazolo
- dihydro
- pyrimidinone derivatives
- diseases
- medicaments
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Vascular Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19709877A DE19709877A1 (de) | 1997-03-11 | 1997-03-11 | 1,5-Dihydro-pyrazolo[3,4-d]-pyrimidinon-derivate |
| PCT/EP1998/001086 WO1998040384A1 (de) | 1997-03-11 | 1998-02-26 | 1,5-dihydro-pyrazolo[3,4-d]-pyrimidinon-derivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE231509T1 true ATE231509T1 (de) | 2003-02-15 |
Family
ID=7822900
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98913595T ATE231509T1 (de) | 1997-03-11 | 1998-02-26 | 1,5-dihydro-pyrazolo 3,4-d)-pyrimidinon-derivate |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6174884B1 (enExample) |
| EP (1) | EP0973774B1 (enExample) |
| JP (1) | JP2001514638A (enExample) |
| KR (1) | KR20000076124A (enExample) |
| CN (1) | CN1151155C (enExample) |
| AT (1) | ATE231509T1 (enExample) |
| AU (1) | AU727615B2 (enExample) |
| BR (1) | BR9807995A (enExample) |
| CA (1) | CA2283211A1 (enExample) |
| DE (2) | DE19709877A1 (enExample) |
| DK (1) | DK0973774T3 (enExample) |
| ES (1) | ES2191294T3 (enExample) |
| HU (1) | HUP0001805A3 (enExample) |
| IL (1) | IL131450A0 (enExample) |
| NZ (1) | NZ337724A (enExample) |
| RU (1) | RU2219180C2 (enExample) |
| WO (1) | WO1998040384A1 (enExample) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9823103D0 (en) * | 1998-10-23 | 1998-12-16 | Pfizer Ltd | Pharmaceutically active compounds |
| WO2002009713A2 (de) * | 2000-08-01 | 2002-02-07 | Bayer Aktiengesellschaft | Selektive pde 2-inhibitoren als arzneimittel zur verbesserung der wahrnehmung |
| US20040063730A1 (en) * | 2000-12-19 | 2004-04-01 | Hans-Michael Eggenweiler | Pharmacuetical formulation comprising puyrazolo[4,-3-d]pyrimidines and antithrombotics, calcium antagonists, or prostaglandins or prostaglandin derivatives |
| DE10064105A1 (de) | 2000-12-21 | 2002-06-27 | Bayer Ag | Neue Substituierte Imidazotriazinone |
| CA2437085A1 (en) * | 2001-02-02 | 2002-08-15 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Pharmaceutical formulation comprising pyrazolo[4,3-d]pyrimidines and endothelin receptor antagonists or thienopyrimidines and endothelin receptor antagonists |
| KR100393160B1 (ko) * | 2001-06-14 | 2003-07-31 | 한국과학기술연구원 | 신규한 피라졸로피리미딘티온 유도체, 그의 제법 및발기부전 치료제로서의 용도 |
| US6479493B1 (en) | 2001-08-23 | 2002-11-12 | Cell Pathways, Inc. | Methods for treatment of type I diabetes |
| EP1436265A4 (en) * | 2001-09-27 | 2004-12-15 | Smithkline Beecham Corp | CHEMICALS |
| FR2842809A1 (fr) * | 2002-07-26 | 2004-01-30 | Greenpharma Sas | NOUVELLES PYRAZOLO[1,5-a]-1,3,5-TRIAZINES SUBSTITUEES ET LEURS ANALOGUES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, UTILISATION A TITRE DE MEDICAMENT ET PROCEDES POUR LEUR PREPARATION |
| DE10238723A1 (de) * | 2002-08-23 | 2004-03-11 | Bayer Ag | Phenyl-substituierte Pyrazolyprimidine |
| DE10238722A1 (de) | 2002-08-23 | 2004-03-11 | Bayer Ag | Selektive Phosphodiesterase 9A-Inhibitoren als Arzneimittel zur Verbesserung kognitiver Prozesse |
| DE10238724A1 (de) | 2002-08-23 | 2004-03-04 | Bayer Ag | Alkyl-substituierte Pyrazolpyrimidine |
| CN100397023C (zh) * | 2003-01-04 | 2008-06-25 | 胡云北 | 黄磷废渣载热量及反应尾气发热量的回收与综合利用方法 |
| EP1601675A1 (en) * | 2003-03-04 | 2005-12-07 | ALTANA Pharma AG | Purin-6-one-derivatives |
| US8044060B2 (en) | 2003-05-09 | 2011-10-25 | Boehringer Ingelheim International Gmbh | 6-cyclylmethyl- and 6-alkylmethyl pyrazolo[3,4-D]pyrimidines, methods for their preparation and methods for their use to treat impairments of perception, concentration learning and/or memory |
| DE10320785A1 (de) * | 2003-05-09 | 2004-11-25 | Bayer Healthcare Ag | 6-Arylmethyl-substituierte Pyrazolopyrimidine |
| DE102004004142A1 (de) | 2003-05-09 | 2004-11-25 | Bayer Healthcare Ag | 6-Cyclylmethyl- und 6-Alkylmethyl-substituierte Pyrazolopyrimidine |
| DE10328479A1 (de) | 2003-06-25 | 2005-01-13 | Bayer Ag | 6-Arylamino-5-cyano-4-pyrimidinone |
| CA2536458A1 (en) * | 2003-08-28 | 2005-03-10 | Altana Pharma Ag | Composition comprising a pulmonary surfactant and a pde2 inhibitor |
| DE102004001873A1 (de) | 2004-01-14 | 2005-09-29 | Bayer Healthcare Ag | Cyanopyrimidinone |
| KR100844864B1 (ko) * | 2004-02-27 | 2008-07-09 | 에프. 호프만-라 로슈 아게 | 헤테로아릴-융합 피라졸로 유도체 |
| CN101397299B (zh) * | 2007-09-29 | 2011-11-16 | 温州大学 | 一种吡唑[3,4-d]嘧啶酮的合成方法 |
| CA2706018C (en) * | 2007-11-30 | 2015-11-24 | Boehringer Ingelheim International Gmbh | 1, 5-dihydro-pyrazolo [3,4-d]pyrimidin-4-one derivatives and their use as pde9a modulators for the treatment of cns disorders |
| UA105362C2 (en) | 2008-04-02 | 2014-05-12 | Бьорингер Ингельхайм Интернациональ Гмбх | 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators |
| CA2736304A1 (en) | 2008-09-08 | 2010-03-11 | Boehringer Ingelheim International Gmbh | Pyrazolopyrimidines and their use for the treatment of cns disorders |
| GEP20146098B (en) * | 2009-03-31 | 2014-05-27 | Boehringer Ingelheim Int | 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their usage as pde9a modulators |
| TW201100398A (en) | 2009-03-31 | 2011-01-01 | Arqule Inc | Substituted indolo-pyridinone compounds |
| TW201118099A (en) * | 2009-08-12 | 2011-06-01 | Boehringer Ingelheim Int | New compounds for the treatment of CNS disorders |
| BR112013003097B1 (pt) | 2010-08-12 | 2021-03-16 | Boehringer Ingelheim International Gmbh | 6-cicloalquil-pirazolopirimidinonas e composição farmacêutica |
| US20130040971A1 (en) | 2011-02-14 | 2013-02-14 | Boehringer Ingelheim International Gmbh | 6-cycloalkyl-pyrazolopyrimidinones for the treatment of cns disorders |
| US8809345B2 (en) | 2011-02-15 | 2014-08-19 | Boehringer Ingelheim International Gmbh | 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders |
| ES2602794T3 (es) | 2011-03-31 | 2017-02-22 | Pfizer Inc | Piridinonas bicíclicas novedosas |
| WO2012172449A1 (en) | 2011-06-13 | 2012-12-20 | Pfizer Inc. | Lactams as beta secretase inhibitors |
| EP2751116B1 (en) | 2011-08-31 | 2016-10-12 | Pfizer Inc | Hexahydropyrano [3,4-d][1,3]thiazin-2-amine compounds |
| JO3407B1 (ar) | 2012-05-31 | 2019-10-20 | Eisai R&D Man Co Ltd | مركبات رباعي هيدرو بيرازولو بيريميدين |
| UA110688C2 (uk) | 2012-09-21 | 2016-01-25 | Пфайзер Інк. | Біциклічні піридинони |
| MA38333A1 (fr) | 2013-02-19 | 2017-02-28 | Pfizer | Composés d'azabenzimidazole en tant qu'inhibiteurs d'isozymes pde4 pour le traitement de troubles du snc et d'autres affections |
| EP3052495B1 (en) | 2013-10-04 | 2019-06-26 | Pfizer Inc | Novel bicyclic pyridinones as gamma-secretase modulators |
| WO2015150957A1 (en) | 2014-04-01 | 2015-10-08 | Pfizer Inc. | Chromene and 1,1 a,2,7b-tetrahydrocyclopropa[c]chromene pyridopyrazinediones as gamma-secretase modulators |
| EP3172210B1 (en) | 2014-07-24 | 2020-01-15 | Pfizer Inc | Pyrazolopyrimidine compounds |
| DK3177624T3 (da) | 2014-08-06 | 2019-07-01 | Pfizer | Imidazopyridazinforbindelser |
| WO2016125048A1 (en) | 2015-02-03 | 2016-08-11 | Pfizer Inc. | Novel cyclopropabenzofuranyl pyridopyrazinediones |
| JO3627B1 (ar) | 2015-04-30 | 2020-08-27 | H Lundbeck As | إيميدازو بيرازينونات على هيئة مثبطات pde1 |
| WO2016179059A1 (en) * | 2015-05-05 | 2016-11-10 | Merck Sharp & Dohme Corp. | Heteroaryl-pyrimidinone compounds as pde2 inhibitors |
| UA125334C2 (uk) | 2015-06-17 | 2022-02-23 | Пфайзер Інк. | Трициклічні сполуки та їх застосування як інгібіторів фосфодіестерази |
| AU2017223132B2 (en) | 2016-02-23 | 2019-12-05 | Pfizer Inc. | 6,7-Dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds |
| TWI729109B (zh) | 2016-04-12 | 2021-06-01 | 丹麥商H 朗德貝克公司 | 作爲PDE1抑制劑的1,5-二氫-4H-吡唑并[3,4-d]嘧啶-4-酮和1,5-二氫-4H-吡唑并[4,3-c]吡啶-4-酮 |
| CN109641898B (zh) | 2016-07-01 | 2022-04-08 | 辉瑞公司 | 用于治疗神经和神经退行性疾病的5,7-二氢-吡咯并-吡啶衍生物 |
| EP3529250B1 (en) * | 2016-10-18 | 2023-12-06 | H. Lundbeck A/S | Imidazopyrazinones, pyrazolopyrimidinones and pyrazolopyridinones as pde1 inhibitors |
| MA46611B1 (fr) | 2016-10-28 | 2020-08-31 | H Lundbeck As | Traitements combinés comprenant des imidazopyrazinones pour le traitement de troubles psychiatriques et/ou cognitifs |
| US10912773B2 (en) | 2016-10-28 | 2021-02-09 | H. Lundbeck A/S | Combinations comprising substituted imidazo[1,5-a]pyrazinones as PDE1 inhibitors |
| EP3562828A1 (en) | 2016-12-28 | 2019-11-06 | Dart NeuroScience LLC | Substituted pyrazolopyrimidinone compounds as pde2 inhibitors |
| JP2020523309A (ja) | 2017-06-08 | 2020-08-06 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | ピラゾロピリミジンpde9インヒビター |
| IL271290B2 (en) | 2017-06-22 | 2023-11-01 | Pfizer | Dihydro-pyrrolo-pyridine derivatives |
| WO2019104285A1 (en) | 2017-11-27 | 2019-05-31 | Dart Neuroscience, Llc | Substituted furanopyrimidine compounds as pde1 inhibitors |
| PT3768669T (pt) | 2018-03-23 | 2023-04-24 | Pfizer | Derivados de piperazina azaspiro |
| USD1029414S1 (en) * | 2021-01-19 | 2024-05-28 | Averia Electronics, Inc. | Wearable light emitting module with a removable band |
| USD1021287S1 (en) * | 2021-01-19 | 2024-04-02 | Averia Electronics, Inc. | Wearable light emitting module with a removable band |
| US12144815B2 (en) | 2021-02-23 | 2024-11-19 | Hoth Therapeutics, Inc. | Use of aprepitant for treating Alzheimer's disease |
| WO2024118524A1 (en) | 2022-11-28 | 2024-06-06 | Cerevel Therapeutics, Llc | Azaindole compounds and their use as phosphodiesterase inhibitors |
| WO2025145091A1 (en) | 2023-12-29 | 2025-07-03 | Pfizer Inc. | Crystalline forms of a muscarinic m4 receptor modulator and methods of treating diseases |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3165520A (en) * | 1965-01-12 | Certificate of correction | ||
| US3211732A (en) | 1965-10-12 | Pyrazolob:x-d]pyrlil/hdines | ||
| CH398626A (de) * | 1960-05-11 | 1966-03-15 | Ciba Geigy | Verfahren zur Herstellung neuer Pyrazolopyrimidine |
| DE1153023B (de) * | 1960-05-11 | 1963-08-22 | Ciba Geigy | Verfahren zur Herstellung von 4-Hydroxy-pyrazolo[3,4-d] pyrimidinen |
| CH633297A5 (de) | 1977-09-16 | 1982-11-30 | Sandoz Ag | Verfahren zur herstellung von fluorenphosphoniten. |
| GB9121028D0 (en) | 1991-10-03 | 1991-11-13 | Pfizer Ltd | Therapeutic agents |
| US5294612A (en) * | 1992-03-30 | 1994-03-15 | Sterling Winthrop Inc. | 6-heterocyclyl pyrazolo [3,4-d]pyrimidin-4-ones and compositions and method of use thereof |
| CA2133346A1 (en) * | 1992-04-21 | 1993-10-28 | Shri Niwas | 7-disubstituted-methyl-4-oxo-3h,5h-pyrrolo[3,2-d]pyrimidine and pharmaceutical uses and compositions containing the same |
| US5656629A (en) * | 1995-03-10 | 1997-08-12 | Sanofi Winthrop, Inc. | 6-substituted pyrazolo (3,4-d)pyrimidin-4-ones and compositions and methods of use thereof |
| AU708809B2 (en) * | 1995-03-10 | 1999-08-12 | Sanofi Pharmaceuticals, Inc. | 6-aryl pyrazolo{3,4-d}pyrimidin-4-ones and compositions and methods of use thereof |
-
1997
- 1997-03-11 DE DE19709877A patent/DE19709877A1/de not_active Withdrawn
-
1998
- 1998-02-26 AT AT98913595T patent/ATE231509T1/de not_active IP Right Cessation
- 1998-02-26 CN CNB988049872A patent/CN1151155C/zh not_active Expired - Fee Related
- 1998-02-26 DK DK98913595T patent/DK0973774T3/da active
- 1998-02-26 NZ NZ337724A patent/NZ337724A/xx unknown
- 1998-02-26 AU AU68240/98A patent/AU727615B2/en not_active Ceased
- 1998-02-26 US US09/367,538 patent/US6174884B1/en not_active Expired - Fee Related
- 1998-02-26 HU HU0001805A patent/HUP0001805A3/hu unknown
- 1998-02-26 KR KR1019997008213A patent/KR20000076124A/ko not_active Ceased
- 1998-02-26 RU RU99121518/04A patent/RU2219180C2/ru not_active IP Right Cessation
- 1998-02-26 CA CA002283211A patent/CA2283211A1/en not_active Abandoned
- 1998-02-26 IL IL13145098A patent/IL131450A0/xx not_active IP Right Cessation
- 1998-02-26 BR BR9807995-6A patent/BR9807995A/pt not_active IP Right Cessation
- 1998-02-26 JP JP53913598A patent/JP2001514638A/ja not_active Withdrawn
- 1998-02-26 EP EP98913595A patent/EP0973774B1/de not_active Expired - Lifetime
- 1998-02-26 ES ES98913595T patent/ES2191294T3/es not_active Expired - Lifetime
- 1998-02-26 DE DE59807011T patent/DE59807011D1/de not_active Expired - Fee Related
- 1998-02-26 WO PCT/EP1998/001086 patent/WO1998040384A1/de not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0001805A2 (hu) | 2000-11-28 |
| ES2191294T3 (es) | 2003-09-01 |
| US6174884B1 (en) | 2001-01-16 |
| EP0973774B1 (de) | 2003-01-22 |
| KR20000076124A (ko) | 2000-12-26 |
| CN1255133A (zh) | 2000-05-31 |
| DE19709877A1 (de) | 1998-09-17 |
| NZ337724A (en) | 2000-08-25 |
| CN1151155C (zh) | 2004-05-26 |
| DK0973774T3 (da) | 2003-05-05 |
| RU2219180C2 (ru) | 2003-12-20 |
| AU727615B2 (en) | 2000-12-14 |
| BR9807995A (pt) | 2000-03-08 |
| EP0973774A1 (de) | 2000-01-26 |
| DE59807011D1 (de) | 2003-02-27 |
| JP2001514638A (ja) | 2001-09-11 |
| AU6824098A (en) | 1998-09-29 |
| WO1998040384A1 (de) | 1998-09-17 |
| IL131450A0 (en) | 2001-01-28 |
| HUP0001805A3 (en) | 2002-09-30 |
| HK1028035A1 (en) | 2001-02-02 |
| CA2283211A1 (en) | 1998-09-17 |
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