DK0970103T3 - Antigenstagent steroider med floureret 17alfa-alkylkæde - Google Patents

Antigenstagent steroider med floureret 17alfa-alkylkæde

Info

Publication number
DK0970103T3
DK0970103T3 DK98905419T DK98905419T DK0970103T3 DK 0970103 T3 DK0970103 T3 DK 0970103T3 DK 98905419 T DK98905419 T DK 98905419T DK 98905419 T DK98905419 T DK 98905419T DK 0970103 T3 DK0970103 T3 DK 0970103T3
Authority
DK
Denmark
Prior art keywords
17alpha
steroids
antigenic
fluorinated
alkyl chain
Prior art date
Application number
DK98905419T
Other languages
Danish (da)
English (en)
Inventor
Wolfgang Schwede
Arwed Cleve
Ulrich Klar
Guenter Neef
Kristof Chwalisz
Martin Schneider
Ulrike Fuhrmann
Holger Hess-Stumpp
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of DK0970103T3 publication Critical patent/DK0970103T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Pregnancy & Childbirth (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK98905419T 1997-02-07 1998-02-09 Antigenstagent steroider med floureret 17alfa-alkylkæde DK0970103T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19706061A DE19706061A1 (de) 1997-02-07 1997-02-07 Antigestagen wirksame Steroide mit fluorierter 17alpha-Alkylkette
PCT/EP1998/000752 WO1998034947A1 (de) 1997-02-07 1998-02-09 ANTIGESTAGEN WIRKSAME STEROIDE MIT FLUORIERTER 17α-ALKYLKETTE

Publications (1)

Publication Number Publication Date
DK0970103T3 true DK0970103T3 (da) 2002-07-22

Family

ID=7820508

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98905419T DK0970103T3 (da) 1997-02-07 1998-02-09 Antigenstagent steroider med floureret 17alfa-alkylkæde

Country Status (35)

Country Link
US (4) US6316432B1 (ko)
EP (1) EP0970103B1 (ko)
JP (1) JP4324249B2 (ko)
KR (1) KR100511815B1 (ko)
CN (2) CN1246865A (ko)
AR (1) AR010887A1 (ko)
AT (1) ATE216397T1 (ko)
AU (1) AU742834B2 (ko)
BG (1) BG63875B1 (ko)
BR (1) BR9807667A (ko)
CA (1) CA2280041C (ko)
CL (1) CL2004001191A1 (ko)
CZ (1) CZ296328B6 (ko)
DE (2) DE19706061A1 (ko)
DK (1) DK0970103T3 (ko)
EA (1) EA003092B1 (ko)
EE (1) EE03831B1 (ko)
ES (1) ES2175673T3 (ko)
HK (1) HK1040718B (ko)
HU (1) HUP0000968A3 (ko)
ID (1) ID22643A (ko)
IL (1) IL131226A (ko)
IS (1) IS2190B (ko)
MY (1) MY118508A (ko)
NO (1) NO313554B1 (ko)
NZ (1) NZ336989A (ko)
PL (1) PL191808B1 (ko)
PT (1) PT970103E (ko)
SI (1) SI0970103T1 (ko)
SK (1) SK283155B6 (ko)
TR (1) TR199901855T2 (ko)
TW (1) TW499434B (ko)
UA (1) UA66783C2 (ko)
WO (1) WO1998034947A1 (ko)
ZA (1) ZA98985B (ko)

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DE10051609A1 (de) * 2000-10-18 2002-05-02 Schering Ag Hemmung der Wachstumsfaktorabhängigkeit von Tumorzellen
UY26965A1 (es) * 2000-10-18 2002-06-20 Schering Ag Uso de antiprogestinas para la profilaxis y el tratamiento de enfermedades dependientes de hormonas
PL366415A1 (en) * 2000-10-18 2005-01-24 Schering Aktiengesellschaft Inhibition of the growth factor dependency of tumor cells
UY26966A1 (es) * 2000-10-18 2002-06-20 Schering Ag Uso de antiprogestinas para la inducción de apoptosis en una célula
UA76729C2 (uk) * 2000-10-18 2006-09-15 Шерінг Акцієнгезельшафт ЗАСТОСУВАННЯ АНТИПРОГЕСТИНУ 11<font face="Symbol">b</font>-(4-АЦЕТИЛФЕНІЛ)-17<font face="Symbol">b</font>-ГІДРОКСИ-17<font face="Symbol">a</font>-(1,1,2,2,2-ПЕНТАФТОРЕТИЛ)ЕСТРА-4,9-ДІЄН-3-ОНУ ДЛЯ ЛІКУВАННЯ РАКУ ШЛЯХОМ ІНДУКУВАННЯ АПОПТОЗУ КЛІТИНИ
JP2004511522A (ja) * 2000-10-18 2004-04-15 シエーリング　アクチエンゲゼルシャフト ホルモン−依存性疾病の予防及び処理のための抗黄体ホルモンの使用
PL361689A1 (en) * 2001-01-09 2004-10-04 Schering Aktiengesellschaft The use of antigestagens for inhibiting accelerated endometrial maturation during infertility treatment
US20020143000A1 (en) * 2001-01-09 2002-10-03 Christa Hegele-Hartung Use of antigestagens for inhibiting accelerated endometrial maturation during infertility treatment
UY27301A1 (es) * 2001-05-25 2003-02-28 Schering Ag Uso y composiciones de antiprogestinas para el tratamiento de enfermedades de la próstata
US20030013694A1 (en) * 2001-05-25 2003-01-16 Jens Hoffmann Use and compositions of antiprogestins for treatment of prostate diseases
DE10159217A1 (de) 2001-11-27 2003-06-05 Schering Ag 17alpha-Alkyl-17ß-oxy-estratriene und Zwischenprodukte zu deren Herstellung, Verwendung der 17alpha-Alkyl-17ß-oxy-estratriene zur Herstellung von Arzneimitteln sowie pharmazeutische Präparate
DE10221034A1 (de) * 2002-05-03 2003-11-20 Schering Ag 17alpha-Fluoralkyl-11ß-benzaldoxim-Steroide, Verfahren zu deren Herstellung, diese Steroide enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
JP2005536463A (ja) * 2002-05-03 2005-12-02 シエーリング アクチエンゲゼルシャフト １７α−フルオロアルキル−１１β−ベンズアルドキシムステロイド、それらの製造方法、これらのステロイド類を含有する製剤及び医薬品製造のためのそれらの使用
US20040242551A1 (en) * 2003-05-28 2004-12-02 Schering Ag Composition comprising antiprogestins and pure antiestrogens for prophylaxis and treatment of hormone-dependent diseases
NZ580384A (en) 2003-07-23 2011-03-31 Bayer Pharmaceuticals Corp 4{4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy}-pyridine-2-carboxylic acid methylamide and metabolites for the treatment and prevention of diseases and conditions
US7593347B2 (en) * 2003-12-29 2009-09-22 Intel Corporation Method and apparatus to exchange channel information
EP1862468A1 (de) * 2006-06-02 2007-12-05 Bayer Schering Pharma Aktiengesellschaft Kristallines 11beta-(4-Acetylphenyl)-20,20,21,21,21-pentafluor-17-hydroxy-19-nor-17alpha-pregna-4,9-dien-3-on
EP3693376A1 (en) 2006-10-24 2020-08-12 Allergan Pharmaceuticals International Limited Compositions for suppressing endometrial proliferation
DE102006054535A1 (de) 2006-11-15 2008-05-21 Bayer Schering Pharma Aktiengesellschaft Progesteronrezeptorantagonisten
US20080268041A1 (en) * 2007-04-23 2008-10-30 Jens Hoffmann Combination of progesterone-receptor antagonist together with none-steroidal antiestrogen for use in brca mediated diseases
JP2010524997A (ja) * 2007-04-23 2010-07-22 バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト Ｂｒｃａ単独での、又は抗エストロゲン薬を伴った組み合わせ物としての使用のためのプロゲステロン受容体拮抗薬
TWI539953B (zh) 2008-04-28 2016-07-01 瑞波若斯治療學公司 用於治療乳癌之組成物和方法
EP2123279A1 (de) * 2008-05-14 2009-11-25 Bayer Schering Pharma Aktiengesellschaft Sequentielle Verabreichung von 20,20,21,21,21-Pentafluor-17-hydroxy-1 1beta-[4-(hydroxyacetyl) phenyl]-19-nor-17alpha-pregna-4,9-dien-3-on und einem oder mehreren Gestagenen zur Behandlung gynäkologischer Erkrankungen
US20100087402A1 (en) * 2008-09-29 2010-04-08 Vivus, Inc. Methods and compositions for the treatment of estrogen-dependent hyperproliferative uterine disorders
DE102009034366A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-methylenoxyalkylenaryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034362A1 (de) * 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034368A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-acyloxyalkylenphenyl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
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DE102010030538A1 (de) 2010-06-25 2011-12-29 Bayer Schering Pharma Aktiengesellschaft 6,7-Dihydro-5H-benzo[7]annulen-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
DE102011004899A1 (de) 2011-03-01 2012-09-06 Bayer Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
US20130029953A1 (en) * 2011-07-28 2013-01-31 Klaus Nickisch Progesterone antagonists
DE102011087987A1 (de) 2011-12-08 2013-06-13 Bayer Intellectual Property Gmbh 6,7-Dihydro-5H-benzo[7]annulen-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
EP2983671B1 (en) 2013-04-11 2018-10-24 Bayer Pharma Aktiengesellschaft Progesterone receptor antagonist dosage form
US9096641B2 (en) 2013-06-05 2015-08-04 Evestra, Inc. Imidazolyl progesterone antagonists
EP2868321A1 (en) 2013-11-03 2015-05-06 Flamina Holding AG A composition or group of compositions for inhibiting autocrine HCG production in adult human cells
US9603856B2 (en) 2013-11-03 2017-03-28 Flamina Holding Ag Pharmaceutical composition or group of compositions for inhibiting autocrine HCG production in adult human cells
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ZA8231B (en) * 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
FR2639045B2 (fr) 1982-03-01 1994-07-29 Roussel Uclaf Nouveaux produits derives de la structure 3-ceto-delta-4,9-19-nor steroides et leur application comme medicaments
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Also Published As

Publication number Publication date
EA003092B1 (ru) 2002-12-26
EP0970103B1 (de) 2002-04-17
CZ296328B6 (cs) 2006-02-15
HK1040718A1 (en) 2002-06-21
US6316432B1 (en) 2001-11-13
US6503895B2 (en) 2003-01-07
PT970103E (pt) 2002-09-30
CL2004001191A1 (es) 2005-03-28
ATE216397T1 (de) 2002-05-15
BG103603A (en) 2000-06-30
NO313554B1 (no) 2002-10-21
AR010887A1 (es) 2000-07-12
DE19706061A1 (de) 1998-08-13
PL334878A1 (en) 2000-03-27
NZ336989A (en) 2001-04-27
MY118508A (en) 2004-11-30
UA66783C2 (en) 2004-06-15
BG63875B1 (bg) 2003-04-30
SK283155B6 (sk) 2003-03-04
EP0970103A1 (de) 2000-01-12
CA2280041C (en) 2007-10-23
TR199901855T2 (xx) 2000-04-21
SI0970103T1 (en) 2002-10-31
JP4324249B2 (ja) 2009-09-02
EE9900339A (et) 2000-02-15
US20020045774A1 (en) 2002-04-18
BR9807667A (pt) 2000-02-15
SK103899A3 (en) 2000-05-16
EE03831B1 (et) 2002-08-15
TW499434B (en) 2002-08-21
NO993811D0 (no) 1999-08-06
PL191808B1 (pl) 2006-07-31
WO1998034947A1 (de) 1998-08-13
US20030134834A1 (en) 2003-07-17
IS5147A (is) 1999-08-04
CN1246865A (zh) 2000-03-08
AU6100598A (en) 1998-08-26
AU742834B2 (en) 2002-01-10
KR100511815B1 (ko) 2005-09-05
CA2280041A1 (en) 1998-08-13
ID22643A (id) 1999-12-02
IL131226A0 (en) 2001-01-28
ZA98985B (en) 1999-08-03
JP2001510479A (ja) 2001-07-31
IS2190B (is) 2007-01-15
HK1040718B (zh) 2005-12-09
IL131226A (en) 2004-12-15
NO993811L (no) 1999-10-04
US20050080060A1 (en) 2005-04-14
US6806263B2 (en) 2004-10-19
KR20000070835A (ko) 2000-11-25
EA199900644A1 (ru) 2000-04-24
DE59803856D1 (de) 2002-05-23
ES2175673T3 (es) 2002-11-16
CN1202120C (zh) 2005-05-18
HUP0000968A2 (hu) 2000-10-28
US7148213B2 (en) 2006-12-12
HUP0000968A3 (en) 2001-03-28
CZ280599A3 (cs) 2000-01-12
CN1324802A (zh) 2001-12-05

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