DK0969821T3 - Pellets, der har en kerne coatet med et antifungalt middel og en polymer - Google Patents

Pellets, der har en kerne coatet med et antifungalt middel og en polymer

Info

Publication number
DK0969821T3
DK0969821T3 DK98919155T DK98919155T DK0969821T3 DK 0969821 T3 DK0969821 T3 DK 0969821T3 DK 98919155 T DK98919155 T DK 98919155T DK 98919155 T DK98919155 T DK 98919155T DK 0969821 T3 DK0969821 T3 DK 0969821T3
Authority
DK
Denmark
Prior art keywords
pellets
polymer
antifungal agent
core coated
coated
Prior art date
Application number
DK98919155T
Other languages
Danish (da)
English (en)
Inventor
Roger Petrus Gerebe Vandecruys
Paul Marie Victor Gilis
Jozef Peeters
Conde Valentin Florent Vict De
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of DK0969821T3 publication Critical patent/DK0969821T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DK98919155T 1997-03-26 1998-03-18 Pellets, der har en kerne coatet med et antifungalt middel og en polymer DK0969821T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97200914 1997-03-26
PCT/EP1998/001773 WO1998042318A1 (en) 1997-03-26 1998-03-18 Pellets having a core coated with an antifungal and a polymer

Publications (1)

Publication Number Publication Date
DK0969821T3 true DK0969821T3 (da) 2003-09-15

Family

ID=8228147

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98919155T DK0969821T3 (da) 1997-03-26 1998-03-18 Pellets, der har en kerne coatet med et antifungalt middel og en polymer

Country Status (31)

Country Link
EP (1) EP0969821B1 (pt)
JP (1) JP3608800B2 (pt)
KR (1) KR100520936B1 (pt)
CN (1) CN1206984C (pt)
AP (1) AP1227A (pt)
AT (1) ATE241969T1 (pt)
AU (1) AU734248B2 (pt)
BG (1) BG64434B1 (pt)
BR (1) BR9806174A (pt)
CA (1) CA2269501C (pt)
CY (1) CY2384B1 (pt)
CZ (1) CZ295502B6 (pt)
DE (1) DE69815316T2 (pt)
DK (1) DK0969821T3 (pt)
EE (1) EE03904B1 (pt)
ES (1) ES2201485T3 (pt)
HK (1) HK1022840A1 (pt)
HU (1) HU224217B1 (pt)
ID (1) ID21477A (pt)
IL (1) IL129575A (pt)
NO (1) NO325102B1 (pt)
NZ (1) NZ335364A (pt)
OA (1) OA11162A (pt)
PL (1) PL190566B1 (pt)
PT (1) PT969821E (pt)
RU (1) RU2218153C2 (pt)
SI (1) SI0969821T1 (pt)
SK (1) SK284813B6 (pt)
TR (1) TR199900990T2 (pt)
UA (1) UA60318C2 (pt)
WO (1) WO1998042318A1 (pt)

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ES2157731B1 (es) 1998-07-21 2002-05-01 Liconsa Liberacion Controlada Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion.
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KR100432949B1 (ko) * 2000-06-13 2004-05-31 코오롱제약주식회사 생체이용율이 향상된 이트라코나졸의 분립체 조성물과이를 이용한 이트라코나졸 제제 및 그 제조방법
US6663897B2 (en) * 2001-02-06 2003-12-16 Dsm Ip Assets B.V. Oral itraconazole formulations and methods of making the same
CN100369904C (zh) 2001-02-14 2008-02-20 泰博特克药品有限公司 2-(取代-氨基)-苯并噻唑磺酰胺hiv蛋白酶抑制剂
AR035819A1 (es) 2001-04-09 2004-07-14 Tibotec Pharm Ltd 2-(amino sustituido)-benzoxazol sulfonamidas, inhibidoras de la proteasa del hiv, composiciones farmaceuticas que comprenden dichos compuestos, metodo in vitro para inhibir la replicacion retroviral y uso de dichos compuestos en la fabricacion de medicamentos
PT1387842E (pt) 2001-05-11 2009-07-20 Tibotec Pharm Ltd 2-aminobenzoxazolsulfonamidas inibidoras de largo espectro da protease hiv
WO2002100407A1 (en) * 2001-06-12 2002-12-19 Smartrix Technologies Inc. Itraconazole granulations: pharmaceutical formulations for oral administration and method of preparing same
US8071133B2 (en) 2001-08-20 2011-12-06 Stiefel Laboratories, Inc. Oral dosage forms of water insoluble drugs and methods of making the same
EP1463502B1 (en) 2001-12-21 2011-07-13 Tibotec Pharmaceuticals Broadspectrum heterocyclic substituted phenyl containing sulfonamide hiv protease inhibitors
MY142238A (en) 2002-03-12 2010-11-15 Tibotec Pharm Ltd Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors
SI1517899T1 (sl) 2002-05-17 2008-02-29 Tibotec Pharm Ltd Substituirani benzoksazol sulfonamidi sirokega spektra, ki so HIV proteazni inhibitorji
KR100994759B1 (ko) 2002-08-14 2010-11-16 티보텍 파마슈티컬즈 광역스펙트럼의 치환된 옥신돌 설폰아미드 ｈｉｖ프로테아제 저해제
KR100557680B1 (ko) * 2002-11-23 2006-03-07 한국유나이티드제약 주식회사 이트라코나졸의 용해도 개선을 위한 펠렛제제 및 그제조방법
EP1438960B2 (en) * 2003-01-14 2012-12-19 Acino Pharma AG Compostion of itraconazole dispersed in a hydrophilic polymer having enhanced bioavailability
DK1438961T4 (da) * 2003-01-14 2014-11-17 Acino Pharma Ag Bioækvivalent sammensætning af itraconazol dispergeret i en hydrofil polymer
AU2004263130A1 (en) * 2003-08-06 2005-02-17 Nirmal Mulye Pharmaceutical composition containing water soluble drug
WO2005023242A1 (en) 2003-09-11 2005-03-17 Tibotec Pharmaceuticals Ltd. Entry inhibitors of the hiv virus
EP1568369A1 (en) 2004-02-23 2005-08-31 Boehringer Ingelheim Vetmedica Gmbh Use of meloxicam for the treatment of respiratory diseases in pigs
AR048650A1 (es) 2004-05-04 2006-05-10 Tibotec Pharm Ltd Derivados de (1,10b-dihidro-2-(aminocarbonil-fenil)-5h-pirazolo[1,5 c][1,3]benzoxazin-5-il)fenil metanona como inhibidores de la replicacion viral del vih
AU2005244121B2 (en) 2004-05-07 2012-01-19 Sequoia Pharmaceuticals, Inc. Resistance-repellent retroviral protease inhibitors
CN1976930B (zh) 2004-05-17 2011-01-19 泰博特克药品有限公司 用作抗感染药物的6,7,8,9-取代的1-苯基-1,5-二氢吡啶并(3,2-b)吲哚-2-酮
JP4879889B2 (ja) 2004-05-17 2012-02-22 テイボテク・フアーマシユーチカルズ・リミテツド ４−置換−１，５−ジヒドロ−ピリド［３，２−ｂ］インドール−２−オン
EA012330B1 (ru) 2004-05-17 2009-08-28 Тиботек Фармасьютикалз Лтд. 1-ГЕТЕРОЦИКЛИЛ-1,5-ДИГИДРОПИРИДО[3,2-b]ИНДОЛ-2-ОНЫ
WO2007113290A1 (en) 2006-04-03 2007-10-11 Tibotec Pharmaceuticals Ltd. Hiv inhibiting 3,4-dihydro-imidazo[4,5-b]pyridin-5-ones
KR20090065524A (ko) * 2006-09-04 2009-06-22 파나세아 바이오테크 리미티드 프로그래머블 부력전달기술
KR100809903B1 (ko) * 2006-09-05 2008-03-06 주식회사유한양행 안정화된 클로피도그렐-함유 입자, 그의 제조방법, 및 이를포함하는 약학 조성물
CN101283984B (zh) * 2007-04-12 2010-05-26 永胜药品工业股份有限公司 高生物使用率的经杀真菌剂和聚合物涂覆的核心微粒状物
JP2008280254A (ja) * 2007-05-08 2008-11-20 Everest Pharm Industrial Co Ltd 生体に使用される比率が高い、殺菌剤と重合物を塗粧してる核心微粒状物
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Also Published As

Publication number Publication date
NO992114D0 (no) 1999-04-30
SI0969821T1 (en) 2003-10-31
CN1206984C (zh) 2005-06-22
CY2384B1 (en) 2004-06-04
SK284813B6 (sk) 2005-12-01
AU734248B2 (en) 2001-06-07
KR20000052971A (ko) 2000-08-25
PL335542A1 (en) 2000-04-25
UA60318C2 (uk) 2003-10-15
AP1227A (en) 2003-11-24
ATE241969T1 (de) 2003-06-15
PT969821E (pt) 2003-10-31
DE69815316T2 (de) 2004-04-29
HK1022840A1 (en) 2000-08-25
ES2201485T3 (es) 2004-03-16
IL129575A0 (en) 2000-02-29
BR9806174A (pt) 1999-10-19
NO992114L (no) 1999-08-26
NZ335364A (en) 2000-08-25
PL190566B1 (pl) 2005-12-30
CA2269501C (en) 2005-11-08
CN1244796A (zh) 2000-02-16
AP9901516A0 (en) 1999-06-30
BG64434B1 (en) 2005-02-28
JP3608800B2 (ja) 2005-01-12
HUP0002056A3 (en) 2001-01-29
DE69815316D1 (de) 2003-07-10
IL129575A (en) 2004-06-20
EP0969821B1 (en) 2003-06-04
OA11162A (en) 2003-04-16
TR199900990T2 (xx) 1999-10-21
NO325102B1 (no) 2008-02-04
CZ295502B6 (cs) 2005-08-17
EE03904B1 (et) 2002-12-16
AU7210798A (en) 1998-10-20
CA2269501A1 (en) 1998-10-01
BG103356A (en) 2000-03-31
EP0969821A1 (en) 2000-01-12
JP2001520663A (ja) 2001-10-30
RU2218153C2 (ru) 2003-12-10
SK54499A3 (en) 2000-01-18
KR100520936B1 (ko) 2005-10-17
HU224217B1 (hu) 2005-06-28
EE9900453A (et) 2000-04-17
ID21477A (id) 1999-06-17
WO1998042318A1 (en) 1998-10-01
HUP0002056A2 (hu) 2000-12-28
CZ139899A3 (cs) 1999-10-13

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